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Results for "

Arc

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (4) Adrenergic Receptor (5) Amyloid-β (3) Bacterial (2) Biochemical Assay Reagents (2) Complement System (4) Cytochrome P450 (1) Dopamine Receptor (3) Drug Derivative (1) Drug Metabolite (1) Epigenetic Reader Domain (2) ERK (2) Factor VIIa (3) Factor Xa (3) Fluorescent Dye (2) G Protein-coupled Receptor Kinase (GRK) (1) iGluR (3) Integrin (2) Isotope-Labeled Compounds (4) Monocarboxylate Transporter (4) mTOR (3) nAChR (2) Neuropeptide S Receptor (1) NF-κB (4) NO Synthase (2) P-selectin (1) P2Y Receptor (7) Parasite (1) PARP (2) PGC-1α (4) Phospholipase (1) Reference Standards (4) Sirtuin (2) Small Interfering RNA (siRNA) (7) Tau Protein (3) Thrombin (1) Tissue Factor Pathway Inhibitor (TFPI) (3) Topoisomerase (1)
By Research Areas:	Cancer (9) Cardiovascular Disease (16) Infection (2) Inflammation/Immunology (20) Metabolic Disease (5) Neurological Disease (19)
Oligonucleotides:	Aptamers (13) Rat Pre-designed siRNA Sets (2) Mouse Pre-designed siRNA Sets (2) siRNA drugs (1) Human Pre-designed siRNA Sets (2) siRNAs (7)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10064

Ticagrelor 10+ Cited Publications AZD6140; AR-C 126532XX	P2Y Receptor	Cardiovascular Disease Cancer
Ticagrelor (AZD6140) is a reversible oral P2Y12 receptor antagonist for the treatment of platelet aggregation.

HY-13248

AR-C155858 Maximum Cited Publications 50 Publications Verification	Monocarboxylate Transporter	Others
AR-C155858 is a selective monocarboxylate transporter MCT1 and MCT2 inhibitor with K_is of 2.3 nM and 10 nM, respectively.

HY-147080

Avacincaptad pegol sodium Arc1905	Complement System	Others
Avacincaptad pegol (ARC1905) sodium is a 40KDa PEG-conjugated aptamer. Avacincaptad pegol sodium targets complement factor 5 (C5), inhibits the cleavage of C5 into C5a and C5b, limits inflammatory stimulation and complement membrane attack complex (MAC), and is used to study age-related macular degeneration (AMD). Avacincaptad pegol sodium limits irregular cell apoptosis by targeting downstream factors in the complement cascade while preserving the early steps of the complement system .

HY-110126

AR-C118925XX 3 Publications Verification	P2Y Receptor	Inflammation/Immunology Cancer
AR-C118925XX is a selective P2Y2 receptor antagonist. AR-C118925XX inhibits ATP-induced IL-6 production and phosphorylation of p38. AR-C118925XX also inhibits Bleomycin (HY-108345)-induced dermal fibrosis in mice. AR-C118925XX also inhibits ATP-induced tumor growth .

HY-148826

Rovunaptabin Arc 183; BC 007	G Protein-coupled Receptor Kinase (GRK)	Cardiovascular Disease
Rovunaptabin (ARC 183) is an aptamer, a single-stranded DNA molecule composed of 15 deoxynucleotides. It acts as a broad-spectrum neutralizer of pathogenic G-protein-coupled receptor autoantibodies. Rovunaptabin can be used in research related to cardiomyopathy and pulmonary hypertension .

HY-139142

Simufilam 1 Publications Verification PTI-125	mTOR iGluR Amyloid-β Tau Protein	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Simufilam (PTI-125) is an orally active FLNA modulator. Simufilam restores NMDAR signaling and *Arc* expression. Simufilam inhibits overactive mTOR signaling by restoring the normal conformation of FLNA, improves insulin sensitivity, reduces Aβ₄₂-induced neuroinflammation and tau protein hyperphosphorylation. Simufilam can be used for research of Alzheimer's disease .

HY-B0678

Metaxalone AHR438; NSC170959	NF-κB PGC-1α	Neurological Disease Inflammation/Immunology
Metaxalone (AHR438; NSC170959) is an FDA-approved muscle relaxant. Metaxalone acts mainly on the central nervous system and achieves muscle relaxation by inhibiting polysynaptic reflex arcs. In addition, Metaxalone is an inhibitor of MAO-A, which has anti-inflammatory and antioxidant effects. Metaxalone inhibits IL-1β-induced inflammatory phenotype, modulates NF-κB and other related signaling pathways, and decreases MAO-A expression and activity in IL-1β-treated microglia .

HY-153492A

Olpasiran sodium AMG 890 sodium; Arc-LPA sodium	Small Interfering RNA (siRNA)	Inflammation/Immunology
Olpasiran (AMG 890, ARC-LPA) sodium is an N-acetyl galactosamine (GalNAc)-conjugated, hepatocyte-targeted siRNA. Olpasiran sodium directly inhibits LPA messenger RNA translation in hepatocytes and potently reduce Lp(a) concentration. Olpasiran sodium can be used for the research of cardiovascular disease, such as atherosclerosis .

HY-126112

Mephenoxalone	Drug Derivative	Neurological Disease
Mephenoxalone is a muscle relaxant with anti-anxiety activity. Mephenoxalone has neuropharmacologic activity in vivo. Mephenoxalone inhibits neuron transmission and can relax skeletal muscles by inhibiting the reflex arc .

HY-19638

Cangrelor AR-C69931MX	P2Y Receptor	Cardiovascular Disease Inflammation/Immunology
Cangrelor (AR-C69931MX), an adenosine triphosphate analogue, is an intravenous, reversible and selective platelet P2Y12 antagonist, with prompt and potent antiplatelet effects. Cangrelor directly blocks adenosine diphosphate (ADP)-induced activation and aggregation of platelets. Cangrelor is also a nonspecific GPR17 antagonist .

HY-139142B

Simufilam hydrochloride 1 Publications Verification PTI-125 hydrochloride	mTOR iGluR Amyloid-β Tau Protein	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Simufilam hydrochloride (PTI-125 hydrochloride) is an orally active FLNA modulator. Simufilam hydrochloride restores NMDAR signaling and *Arc* expression. Simufilam hydrochloride inhibits overactive mTOR signaling by restoring the normal conformation of FLNA, improves insulin sensitivity, reduces Aβ₄₂-induced neuroinflammation and tau protein hyperphosphorylation. Simufilam hydrochloride can be used for research of Alzheimer's disease .

HY-153480A

ARC19499 sodium 1 Publications Verification BAX499 sodium	Factor Xa Factor VIIa Tissue Factor Pathway Inhibitor (TFPI)	Others
ARC19499 sodium is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 sodium blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 sodium corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.

HY-12122A

AR-C102222 hydrochloride	NO Synthase	Neurological Disease Inflammation/Immunology
AR-C102222 hydrochloride is a potent, competitive, orally active and highly selective inducible nitric oxide synthase (iNOS) inhibitor, with an IC₅₀ of 37 nM . AR-C102222 hydrochloride has antinociception and anti-inflammatory activities .

HY-N2673

5-Heptadecylresorcinol 5-n-Heptadecylresorcinol; AR-C17	Sirtuin	Cardiovascular Disease Metabolic Disease
5-Heptadecylresorcinol (AR-C17), a phenolic lipid component, is also an orally active mitochondrial protector. 5-Heptadecylresorcinol improves mitochondrial function via sirtuin3 signaling pathway, thus alleviates endothelial cell damage and apoptosis. 5-Heptadecylresorcinol induces sirtuin3-mediated autophagy. 5-Heptadecylresorcinol reduces the atherosclerotic plaques in the aortic root region of mice heart. 5-Heptadecylresorcinol can be used for research of atherosclerosis prevention and obesity .

HY-119996A

AR-C141990 hydrochloride 1 Publications Verification	Monocarboxylate Transporter	Inflammation/Immunology
AR-C141990 hydrochloride is a potent lactate transporters (monocarboxylate transporters; MCTs) inhibitor with pK_i values of 7.6, 6.6 for MCT-1 and MCT-2, respectively . AR-C141990 hydrochloride has immunosuppressive properties and inhibits graft versus host response .

HY-78542

Deshydroxyethoxy ticagrelor 1 Publications Verification AR-C124910	Bacterial	Infection Cardiovascular Disease
Deshydroxyethoxy ticagrelor (AR-C124910) is a metabolite of Ticagrelor (HY-10064) with antimicrobial and antiplatelet activities against MRSA .

HY-77734

AR-C133913XX	Drug Metabolite	Cardiovascular Disease
AR-C124910XX is a metabolite of Ticagrelor (HY-10064 ). Ticagrelor is a reversible oral P2Y12 receptor antagonist, and can be used for study of platelet aggregation .

HY-139142A

Simufilam dihydrochloride PTI-125 dihydrochloride	Tau Protein Amyloid-β mTOR iGluR	Neurological Disease
Simufilam dihydrochloride (PTI-125 dihydrochloride) is an orally active FLNA modulator. Simufilam dihydrochloride restores NMDAR signaling and *Arc* expression. Simufilam dihydrochloride inhibits overactive mTOR signaling by restoring the normal conformation of FLNA, improves insulin sensitivity, reduces Aβ₄₂-induced neuroinflammation and tau protein hyperphosphorylation. Simufilam dihydrochloride can be used for research of Alzheimer's disease .

HY-177800

ARC5690 sodium	P-selectin	Inflammation/Immunology
ARC5690 sodium is an anti-mouse P-selectin aptamer. ARC5690 bound to recombinant mouse P-selectin with a KD of approximately 15pM in vitro. ARC5690 showed a significant anti-inflammatory effect

HY-153480

ARC19499 BAX499	Factor Xa Factor VIIa Tissue Factor Pathway Inhibitor (TFPI)	Others
ARC19499 is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.

HY-147079

Egaptivon pegol Arc 1779	Integrin	Cardiovascular Disease
Egaptivon pegol (ARC1779) is an aptamer, which blocks binding of the von Willebrand Factor (VWF) to platelet GPIb receptors. Egaptivon pegol has anti-thrombotic efficacy.

HY-118942

Topovale Arc 111	Topoisomerase	Cancer
Topovale (ARC 111) is a topoisomerase I inhbitor. Topovale is an antitumor agent, and shows low nM cytotoxicity against a panel of cancer cells. Topovale induces reversible topoisomerase I (TOP1) cleavage complexes in tumor cells .

HY-147079A

Egaptivon pegol sodium Arc 1779 sodium	Integrin	Cardiovascular Disease
Egaptivon pegol sodium is an aptamer, which blocks binding of the von Willebrand Factor (VWF) to platelet GPIb receptors. Egaptivon pegol sodium has anti-thrombotic efficacy.

HY-153098

ARC186	Complement System	Cardiovascular Disease Inflammation/Immunology
ARC186 (sodium) is an unconjugated 40KDa PEG aptamer with a sequence identical to HY-147080 Avacincaptad pegol (ARC1905) sodium. ARC1905 is highly potent complement inhibitors that function by blocking the convertase-catalyzed activation of C5.

HY-12709

ARC 239 1 Publications Verification	Adrenergic Receptor 5-HT Receptor	Neurological Disease
ARC 239 is an α2B/C-adrenergic receptor antagonist with pK_i of 7.06 and 6.95 for rat kidney α2B and human α2C, respectively. ARC 239 also inhibits 5-HT1A receptor with a K_i of 63.1 nM .

HY-12709A

ARC 239 dihydrochloride 1 Publications Verification	Adrenergic Receptor	Cardiovascular Disease Inflammation/Immunology
ARC 239 dihydrochloride is a selective α2B/2C adrenoceptor antagonist (pK_d values are 5.95, 7.41 and 7.56 at α2A, α2B, and α2C receptors respectively). ARC 239 dihydrochloride binds to CHO cell membranes expressing human recombinant a2A-, a2B- or a2C-adrenoceptor subtypes with pK_is of 5.6, 8.4, and 7.08, respectively .

HY-148300

AR-C66096	P2Y Receptor	Cardiovascular Disease
AR-C66096 is a potent and selective antagonist of the Gi-coupled P2Y12 receptor. AR-C66096 suppresses platelet thrombus stability under physiological flow conditions. AR-C66096 inhibits ADP-induced aggregation in whole blood aggregometry. AR-C66096 can be used for antithrombotic research .

HY-108633

BYK 49187	PARP	Cancer
AR-C66096 (FPL 66096) tetrasodium is a selective platelet P2Y_T receptor antagonist. AR-C66096 tetrasodium effectively blocks ADP-induced platelet aggregation. AR-C66096 tetrasodium can be used in the research of thromboembolism .

HY-P10979

Buccalin	Neuropeptide S Receptor	Neurological Disease
Buccalin is a neuropeptide that colocalizes with small molecule cardioactive peptides in neuronal B15. When exogenously applied to the ARC neuromuscular junction, Buccalin reduces the amplitude of muscle contraction induced by motor neuron firing and acts only presynaptically. Buccalin has no effect on the rate of muscle relaxation and reduces motor neuron-induced ARC excitatory junction potentials without affecting contraction produced by direct acetylcholine action on the muscle .

HY-N2673R

5-Heptadecylresorcinol (Standard) 5-n-Heptadecylresorcinol (Standard); AR-C17 (Standard)	Reference Standards Sirtuin	Cardiovascular Disease Metabolic Disease
5-Heptadecylresorcinol (AR-C17), a phenolic lipid component, is also an orally active mitochondrial protector. 5-Heptadecylresorcinol improves mitochondrial function via sirtuin3 signaling pathway, thus alleviates endothelial cell damage and apoptosis. 5-Heptadecylresorcinol induces sirtuin3-mediated autophagy. 5-Heptadecylresorcinol reduces the atherosclerotic plaques in the aortic root region of mice heart. 5-Heptadecylresorcinol can be used for research of atherosclerosis prevention and obesity .

HY-59201A

A-582941 dihydrochloride	ERK 5-HT Receptor Epigenetic Reader Domain nAChR	Neurological Disease Metabolic Disease
A-582941 dihydrochloride is a selective, orally active, blood-brain barrier-permeable α7 nAChR agonist, with K_i values of 10.8 nM and 17 nM in rat brain and human frontal cortex, respectively. A-582941 dihydrochloride exhibits agonistic activity at 5-HT3 receptors, with a K_i of 150 nM. A-582941 dihydrochloride triggers phosphorylation of ERK1/2 and CREB, inhibits GSK-3β via Ser-9 phosphorylation, increases acetylcholine release, induces the expression of Arc and c-Fos, activates brain regions associated with working memory and attention, and reduces cell death caused by nerve growth factor (NGF) deprivation. A-582941 dihydrochloride is applicable for the research of Alzheimer's disease and schizophrenia .

HY-12709R

ARC 239 (Standard)	Adrenergic Receptor 5-HT Receptor	Neurological Disease
ARC 239 (Standard) is the analytical standard of ARC 239. This product is intended for research and analytical applications. ARC 239 is an α2B/C-adrenergic receptor antagonist with pKi of 7.06 and 6.95 for rat kidney α2B and human α2C, respectively. ARC 239 also inhibits 5-HT1A receptor with a Ki of 63.1 nM .

HY-153098A

ARC186 sodium	Complement System	Inflammation/Immunology
ARC186 (sodium) is an unconjugated 40KDa PEG aptamer with a sequence identical to HY-147080 Avacincaptad pegol (ARC1905) sodium. ARC1905 is highly potent complement inhibitors that function by blocking the convertase-catalyzed activation of C5.

HY-153611

ARC12	Biochemical Assay Reagents	Others
ARC12 is a secondary metabolism probe that modulates the production of Streptomyces coelicolor secondary metabolites. ARC12 reduces the production of germicidin .

HY-153610

ARC7	Bacterial	Others
ARC7 can act as a probe for secondary metabolism in S. coelicolor. ARC7 is a tool for studying secondary metabolism and the streptomycete life cycle .

HY-153785

*NH2-C6-ARC186 sodium*	Complement System	Inflammation/Immunology
NH2-C6-ARC186 sodium is a modified ARC186 (HY-153098) with NH₂-C₆ that can be coupled to other peptides or molecules. ARC186 is a aptamer and a highly potent complement inhibitor that function by blocking the convertase-catalyzed activation of C5 .

HY-RS00890

ARC Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ARC Human Pre-designed siRNA Set A contains three designed siRNAs for ARC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ARC Human Pre-designed siRNA Set A ARC Human Pre-designed siRNA Set A

HY-172971

ARCher-142	PARP	Cancer
ARCher-142 (compound S8) is a potent tankyrase inhibitor. ARCher-142 selectively binds to ARC4 with potency of 8 µM .

HY-114602

AR-C117977	Monocarboxylate Transporter	Inflammation/Immunology
AR-C117977 is a potent monocarboxylate transporter (MCT1) inhibitor. AR-C117977 prolongs the survival of skin and heart sllograft. AR-C117977 inhibits the development of transplant arteriosclerosis in aortic allografts partially, but was unable to inhibit alloantibody production after transplantation. AR-C117977 shows potent immunosuppressive properties in vivo effectively preventing acute but not chronic allograft rejection in the mouse .

HY-12122

AR-C102222	NO Synthase	Neurological Disease
AR-C102222 is a spirocyclic fluoropiperidine quinazoline selective iNOS inhibitor. AR-C102222 can be used for the research of neuropathic pain .

HY-122048

AR-C67085 AR-C67085MX; PSB 0413; FPL 67085	P2Y Receptor	Cardiovascular Disease
AR-C67085 (PSB 0413; FPL 67085) is a potent platelet P_2T receptor antagonist with an pIC₅₀ value of 8.60. AR-C67085 inhibits ADP-induced platelet aggregation .

HY-119996

AR-C141990	Monocarboxylate Transporter Cytochrome P450	Inflammation/Immunology
AR-C141990 (Compound 30) is a potent blocker of the monocarboxylate transporter MCT1 with a K_i of 4.8 nM. AR-C141990 (Compound 30) inhibits CYP3A4 and CYP2C9 with IC₅₀ values of 16 μM .

HY-78542S

Deshydroxyethoxy Ticagrelor-d7	Isotope-Labeled Compounds	Others
Deshydroxyethoxy Ticagrelor-d₇ is deuterium labeled AR-C 124910XX.

HY-RS18487

Nol3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Nol3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nol3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nol3 Mouse Pre-designed siRNA Set A Nol3 Mouse Pre-designed siRNA Set A

HY-RS09414

NOL3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NOL3 Human Pre-designed siRNA Set A contains three designed siRNAs for NOL3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NOL3 Human Pre-designed siRNA Set A NOL3 Human Pre-designed siRNA Set A

HY-146769

Antimalarial agent 11	Parasite	Infection
Antimalarial agent 11 (compound 1), a spirocyclic chromane, is a potent antimalarial agent. Antimalarial agent 11 exhibits excellent potency with an EC₅₀ of 350 nM against the Chloroquine-resistant Dd2 strain. Antimalarial agent 11 has EC₅₀s of 1.48 µM and 1.81 µM against D6 and ARC08-022 strains, respectively .

HY-19845

Ordopidine ACR-325	Dopamine Receptor	Neurological Disease
Ordopidine is a dopamine D2 receptor antagonist. Ordopidine can inhibit hyperactivity caused by psychostimulants. Ordopidine can be used in neurological research .

HY-10064R

Ticagrelor (Standard) AZD6140 (Standard); AR-C 126532XX (Standard)	Reference Standards P2Y Receptor	Cardiovascular Disease Cancer
Ticagrelor (Standard) is the analytical standard of Ticagrelor. This product is intended for research and analytical applications. Ticagrelor (AZD6140) is a reversible oral P2Y12 receptor antagonist for the treatment of platelet aggregation.

HY-126112R

Mephenoxalone (Standard)	Biochemical Assay Reagents Reference Standards	Neurological Disease
Mephenoxalone (Standard) is the analytical standard of Mephenoxalone. This product is intended for research and analytical applications. Mephenoxalone is a muscle relaxant with anti-anxiety activity. Mephenoxalone has neuropharmacologic activity in vivo. Mephenoxalone inhibits neuron transmission and can relax skeletal muscles by inhibiting the reflex arc .

HY-124270

Sibenadet hydrochloride AR-C68397AA	Dopamine Receptor Adrenergic Receptor	Inflammation/Immunology
Sibenadet hydrochloride (AR-C68397AA) is a dual D2 dopamine receptor, beta2-adrenoceptor agonist with bronchodilator activity. Investigation in animal models of key chronic obstructive pulmonary disease (COPD) symptoms has demonstrated that Sibenadet hydrochloride effectively inhibits sensory nerve activity, thereby reducing reflex cough, mucus production and tachypnoea.

Cat. No.	Product Name	Target	Research Area

HY-P10979

Buccalin	Neuropeptide S Receptor	Neurological Disease
Buccalin is a neuropeptide that colocalizes with small molecule cardioactive peptides in neuronal B15. When exogenously applied to the ARC neuromuscular junction, Buccalin reduces the amplitude of muscle contraction induced by motor neuron firing and acts only presynaptically. Buccalin has no effect on the rate of muscle relaxation and reduces motor neuron-induced ARC excitatory junction potentials without affecting contraction produced by direct acetylcholine action on the muscle .

HY-P4889

(Gly22)-amyloid beta-protein(1-40)	Peptides	Neurological Disease
(Gly22)-amyloid beta-protein(1-40) (Arctic variant Ab40ARC (E22G)) is a peptide. (Gly22)-amyloid beta-protein(1-40) can be used for the research of Alzheimer's disease .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990376

Anti-Complement C5aR1 Antibody	Inhibitory Antibodies	Inflammation/Immunology
Anti-Complement C5aR1 Antibody is a human recombinant antibody expressed in CHO cells, targeting C5AR/C5AR1 /C5R1. Anti-Complement C5aR1 Antibody has a huIgG4SP type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 146.4 kDa. The isotype control for Anti-Complement C5aR1 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2673

5-Heptadecylresorcinol 5-n-Heptadecylresorcinol; AR-C17	Gramineae Secale cereale Phenols Polyphenols Plants Source Classification	Sirtuin
5-Heptadecylresorcinol (AR-C17), a phenolic lipid component, is also an orally active mitochondrial protector. 5-Heptadecylresorcinol improves mitochondrial function via sirtuin3 signaling pathway, thus alleviates endothelial cell damage and apoptosis. 5-Heptadecylresorcinol induces sirtuin3-mediated autophagy. 5-Heptadecylresorcinol reduces the atherosclerotic plaques in the aortic root region of mice heart. 5-Heptadecylresorcinol can be used for research of atherosclerosis prevention and obesity .

HY-N2673R

5-Heptadecylresorcinol (Standard) 5-n-Heptadecylresorcinol (Standard); AR-C17 (Standard)	Structural Classification Gramineae Secale cereale Phenols Polyphenols Plants Source Classification	Reference Standards Sirtuin
5-Heptadecylresorcinol (AR-C17), a phenolic lipid component, is also an orally active mitochondrial protector. 5-Heptadecylresorcinol improves mitochondrial function via sirtuin3 signaling pathway, thus alleviates endothelial cell damage and apoptosis. 5-Heptadecylresorcinol induces sirtuin3-mediated autophagy. 5-Heptadecylresorcinol reduces the atherosclerotic plaques in the aortic root region of mice heart. 5-Heptadecylresorcinol can be used for research of atherosclerosis prevention and obesity .

Species:	Human (4) Cynomolgus (1)
Tag:	His (3) Tag Free (2) Avi (1) GST (1) Flag (1)
Source:	HEK293 (2) Sf9 insect cells (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P7540

	ARC Protein, Human rHuArc; NOL3; Arc	Human	E. coli
	ARC Protein, Human that exists in monomeric, oligomeric forms and is capable of reversible self-oligomerization. ARC Protein is a master regulator of long-term synaptic plasticity and memory.

HY-P700708

	Cadherin-1/CD324 Protein, Cynomolgus (HEK293, His) Cadherin-1; Cadherin1; E-Cadherin; E Cadherin; Epithelial cadherin; CDH1; CD324; Arc-1; CAD1; ECAD; E-CAD; LCAM; UVO; L-CAM;	Cynomolgus	HEK293
	The Cadherin-1/CD324 protein is a calcium-dependent receptor on myeloid cells that binds to carbohydrates on neutrophils and monocytes. It promotes interactions between activated endothelial cells or platelets and leukocytes. Cadherin-1/CD324 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Cadherin-1/CD324 protein, expressed by HEK293 , with C-His labeled tag.

HY-P703980

	Cadherin-1/CD324 Protein, Human (Biotinylated, HEK293, His, Avi) Cadherin-1; Cadherin1; E-Cadherin; E Cadherin; Epithelial cadherin; CDH1; CD324; Arc-1; CAD1; ECAD; E-CAD; LCAM; UVO; L-CAM	Human	HEK293
	The Cadherin-1/CD324 protein is a calcium-dependent cell adhesion protein that interacts with homology in junctional cells to facilitate cell type sorting. CDH1 is involved in regulating intercellular adhesion, mobility, and epithelial cell proliferation. Cadherin-1/CD324 Protein, Human (Biotinylated, HEK293, His, Avi) is the recombinant human-derived Cadherin-1/CD324 protein, expressed by HEK293, with C-Avi and C-His labeled tag.

HY-P701373

	CDK8-CCNC-MED12 Complex Protein, Human (Active, sf9, GST, FLAG, His) 1 Publications Verification CDK8; CCNC; MED12; Cyclin-dependent kinase 8; Cell division protein kinase 8; Mediator complex subunit CDK8; Mediator of RNA polymerase II transcription subunit CDK8; Protein kinase K35; Cyclin-C; SRB11 homolog; hSRB11; Mediator of RNA polymerase II transcription subunit 12; Activator-recruited cofactor 240 kDa component; Arc240; CAG repeat protein 45; Mediator complex subunit 12; OPA-containing protein; Thyroid hormone receptor-associated protein complex 230 kDa component; Trap230; Trinucleotide repeat-containing gene 11 protein	Human	Sf9 insect cells
	The CDK8-CCNC-MED12 protein is an important component of the mediator complex, acting as a bridge for gene transcription regulation, transmitting information from gene-specific regulatory factors to RNA polymerase II. It is recruited to the promoter, assembles a preinitiation complex, and promotes transcription. CDK8-CCNC-MED12 Protein, Human (sf9, GST, FLAG, His) is the recombinant human-derived CDK8-CCNC-MED12 protein, expressed by sf9 insect cells , with N-6*His, N-Flag, N-GST labeled tag.

HY-P701363

	CDK19-CCNC-MED12 Protein, Human (sf9) CDK19; CCNC; MED12; Cyclin-dependent kinase 19; CDC2-related protein kinase 6; Cell division cycle 2-like protein kinase 6; Cell division protein kinase 19; Cyclin-dependent kinase 11; Death-preventing kinase; Cyclin-C; SRB11 homolog; hSRB11; Mediator of RNA polymerase II transcription subunit 12; Activator-recruited cofactor 240 kDa component; Arc240; CAG repeat protein 45; Mediator complex subunit 12; OPA-containing protein; Thyroid hormone receptor-associated protein complex 230 kDa component; Trap230; Trinucleotide repeat-containing gene 11 protein	Human	Sf9 insect cells
	CDK19 plays a key role in cellular homeostasis and developmental programming. CDK19 can interact with p53 to inhibit p53-mediated transcription of p21, and regulates the proliferation of hematopoietic stem cells and acute myeloid leukemia cells. Besides, CDK19 is the paralog of CDK8. CDK8 and CDK19 can cooperate with each other in stimulating NFκB-induced transcription and Dengue virus replication. CDK19-CCNC-MED12 Protein, Human (sf9) is the recombinant human-derived CDK19-CCNC-MED12 protein, expressed by sf9 insect cells , with tag free. ,

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Cat. No.	Product Name	Chemical Structure

HY-78542S

Deshydroxyethoxy Ticagrelor-d7
Deshydroxyethoxy Ticagrelor-d₇ is deuterium labeled AR-C 124910XX.

HY-10064S1

Ticagrelor-d4
Ticagrelor-d₄ (AZD6140-d₄) is deuterium labeled Ticagrelor. Ticagrelor (AZD6140) is a reversible oral P2Y12 receptor antagonist for the treatment of platelet aggregation.

HY-B0678S

Metaxalone-d3

Metaxalone-d₃ is the deuterium labeled Metaxalone. Metaxalone (AHR438; NSC170959) is an FDA-approved muscle relaxant. Metaxalone acts mainly on the central nervous system and achieves muscle relaxation by inhibiting polysynaptic reflex arcs. In addition, Metaxalone is an inhibitor of MAO-A, which has anti-inflammatory and antioxidant effects. Metaxalone inhibits IL-1β-induced inflammatory phenotype, modulates NF-κB and other related signaling pathways, and decreases MAO-A expression and activity in IL-1β-treated microglia .

HY-B0678S1

Metaxalone-d6

Metaxalone-d₆ is deuterium labeled Metaxalone. Metaxalone (AHR438; NSC170959) is an FDA-approved muscle relaxant. Metaxalone acts mainly on the central nervous system and achieves muscle relaxation by inhibiting polysynaptic reflex arcs. In addition, Metaxalone is an inhibitor of MAO-A, which has anti-inflammatory and antioxidant effects. Metaxalone inhibits IL-1β-induced inflammatory phenotype, modulates NF-κB and other related signaling pathways, and decreases MAO-A expression and activity in IL-1β-treated microglia .

Host:	Mouse (5) Rabbit (6)
Reactivity:	Human (11) Rat (6) Mouse (8) Monkey (2)
Application:	IHC-P (9) ICC/IF (4) IP (4) IHC-F (2) WB (9) FC (2) ELISA (3)
Isotype:	IgG (6) IgG1 (5)
Conjugation:	Non-conjugated (11) Biotin (1)
Clonality:	Monoclonal (7) Recombinant (4)
Modification:	Unmodified (7)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82109

	*p16 ARC* Antibody (YA1854)** p16 Arc; ARPC5; Arc16; Arp2/3 protein complex subunit p16	WB, IHC-P, IP	Human, Mouse, Rat
	p16 ARC Antibody (YA1854) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p16 ARC.

HY-P82109A

	*p16 ARC* Antibody (YA1854)(PBS only)** p16 Arc; ARPC5; Arc16; Arp2/3 protein complex subunit p16	WB, IHC-P, IP	Human, Mouse, Rat
	p16 ARC Antibody (YA1854) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p16 ARC.

HY-P82407

	ARPC2 Antibody (YA2152) Arc34; PRO2446; p34-Arc; PNAS-139	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	ARPC2 Antibody (YA2152) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ARPC2.

HY-P82407A

	ARPC2 Antibody (YA2152)(PBS only) Arc34; PRO2446; p34-Arc; PNAS-139	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	ARPC2 Antibody (YA2152) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ARPC2.

HY-P84078

	E-Cadherin Antibody (YA3775) UVO; CDHE; ECAD; LCAM; Arc-1; CD324; CDH1; E-cadherin; E cadherin	WB, IHC-P, FC, ELISA	Human, Mouse, Monkey
	E-Cadherin Antibody (YA3775) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to E-Cadherin.

HY-P88965

	MED15 Antibody (YA8649) Arc105; CAG7A; CTG7A; PCQAP; TIG-1; TIG1; TNRC7	IHC-P	Human
	MED15 Antibody (YA8649) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MED15.

HY-P84078A

	E-Cadherin Antibody (YA3775)(PBS only) UVO; CDHE; ECAD; LCAM; Arc-1; CD324; CDH1; E-cadherin; E cadherin	WB, IHC-P, FC, ELISA	Human, Mouse, Monkey
	E-Cadherin Antibody (YA3775) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to E-Cadherin.

HY-P88965A

	MED15 Antibody (YA8649)(PBS only) Arc105; CAG7A; CTG7A; PCQAP; TIG-1; TIG1; TNRC7	IHC-P	Human
	MED15 Antibody (YA8649) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MED15.

HY-P86959

	MED12 Antibody (YA6652) Activator recruited cofactor 240 kDa component antibody; Activator-recruited cofactor 240 kDa component antibody; Arc240 antibody; CAG repeat protein 45 antibody; CAGH45 antibody; HOPA antibody; KIAA0192 antibody; MED12 antibody; MED12_HUMAN antibody; Mediator complex subunit 12 antibody; Activator recruited cofactor 240 kDa component antibody; Activator-recruited cofactor 240 kDa component antibody; Arc240 antibody; CAG repeat protein 45 antibody; CAGH45 antibody; HOPA antibody; KIAA0192 antibody	WB	Human, Mouse, Rat
	MED12 Antibody (YA6652) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MED12.

HY-P86960

	MED4 Antibody (YA6653) Activator-recruited cofactor 36 kDa component antibody; Arc36 antibody; DRIP36 antibody; FLJ10956 antibody; HSPC126 antibody; med4 antibody; MED4_HUMAN antibody; Mediator complex subunit 4 antibody; Mediator of RNA polymerase II transcription subunit 4 antibody; Mediator of RNA polymerase II transcription, subunit 4 homolog antibody; Activator-recruited cofactor 36 kDa component antibody; Arc36 antibody; DRIP36 antibody; FLJ10956 antibody; HSPC126 antibody; med4 antibody; MED4_HUMAN antibody; Mediator complex subunit 4 antibody; Mediator of RNA polymerase II transcription subunit 4 antibody; Mediator of RNA polymerase II transcription, subunit 4 homolog antibody; OTTHUMP00000018390 antibody; OTTHUMP00000018391 antibody; OTTHUMP00000018392 antibody; RP11-90M2.2 antibody; TRAP/SMCC/PC2 subunit p36 subunit antibody; TRAP36 antibody; VDR; IP : antibody; Vitamin D3 receptor-interacting protein complex 36 kDa component antibody;	WB, ICC/IF, IHC-P	Human, Mouse, Rat
	MED4 Antibody (YA6653) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MED4.

HY-P85872

	MED1 Antibody (YA5564) Mediator of RNA polymerase II transcription subunit 1; Activator-recruited cofactor 205 kDa component; Arc205; Mediator complex subunit 1; Peroxisome proliferator-activated receptor-binding protein; PBP; PPAR-binding protein; Thyroid hormone receptor-associated protein complex 220 kDa component; Trap220; Thyroid receptor-interacting protein 2; TR-interacting protein 2; TRIP-2; Vitamin D receptor-interacting protein complex component DRIP205;	WB, ICC/IF, ELISA	Human
	MED1 Antibody (YA5564) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MED1.

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Cat. No.	Product Name		Classification

HY-147080

Avacincaptad pegol sodium Arc1905		Aptamers
Avacincaptad pegol (ARC1905) sodium is a 40KDa PEG-conjugated aptamer. Avacincaptad pegol sodium targets complement factor 5 (C5), inhibits the cleavage of C5 into C5a and C5b, limits inflammatory stimulation and complement membrane attack complex (MAC), and is used to study age-related macular degeneration (AMD). Avacincaptad pegol sodium limits irregular cell apoptosis by targeting downstream factors in the complement cascade while preserving the early steps of the complement system .

HY-148826

Rovunaptabin Arc 183; BC 007		Aptamers
Rovunaptabin (ARC 183) is an aptamer, a single-stranded DNA molecule composed of 15 deoxynucleotides. It acts as a broad-spectrum neutralizer of pathogenic G-protein-coupled receptor autoantibodies. Rovunaptabin can be used in research related to cardiomyopathy and pulmonary hypertension .

HY-153492A

Olpasiran sodium AMG 890 sodium; Arc-LPA sodium		siRNAs siRNA drugs
Olpasiran (AMG 890, ARC-LPA) sodium is an N-acetyl galactosamine (GalNAc)-conjugated, hepatocyte-targeted siRNA. Olpasiran sodium directly inhibits LPA messenger RNA translation in hepatocytes and potently reduce Lp(a) concentration. Olpasiran sodium can be used for the research of cardiovascular disease, such as atherosclerosis .

HY-153480A

ARC19499 sodium 1 Publications Verification BAX499 sodium		Aptamers
ARC19499 sodium is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 sodium blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 sodium corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.

HY-177800

ARC5690 sodium		Aptamers
ARC5690 sodium is an anti-mouse P-selectin aptamer. ARC5690 bound to recombinant mouse P-selectin with a KD of approximately 15pM in vitro. ARC5690 showed a significant anti-inflammatory effect

HY-153480

ARC19499 BAX499		Aptamers
ARC19499 is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.

HY-147079

Egaptivon pegol Arc 1779		Aptamers
Egaptivon pegol (ARC1779) is an aptamer, which blocks binding of the von Willebrand Factor (VWF) to platelet GPIb receptors. Egaptivon pegol has anti-thrombotic efficacy.

HY-147079A

Egaptivon pegol sodium Arc 1779 sodium		Aptamers
Egaptivon pegol sodium is an aptamer, which blocks binding of the von Willebrand Factor (VWF) to platelet GPIb receptors. Egaptivon pegol sodium has anti-thrombotic efficacy.

HY-153098

ARC186		Aptamers
ARC186 (sodium) is an unconjugated 40KDa PEG aptamer with a sequence identical to HY-147080 Avacincaptad pegol (ARC1905) sodium. ARC1905 is highly potent complement inhibitors that function by blocking the convertase-catalyzed activation of C5.

HY-153785

*NH2-C6-ARC186 sodium*		Aptamers
NH2-C6-ARC186 sodium is a modified ARC186 (HY-153098) with NH₂-C₆ that can be coupled to other peptides or molecules. ARC186 is a aptamer and a highly potent complement inhibitor that function by blocking the convertase-catalyzed activation of C5 .

HY-RS00890

ARC Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
ARC Human Pre-designed siRNA Set A contains three designed siRNAs for ARC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS18487

Nol3 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Nol3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nol3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS09414

NOL3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
NOL3 Human Pre-designed siRNA Set A contains three designed siRNAs for NOL3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-153480D

*FAM labled ARC19499 sodium*		Aptamers
FAM labled ARC19499 sodiumis a FAM labled ARC19499 sodium.

HY-153480E

*Cy3 labled ARC19499 sodium*		Aptamers
Cy3 labled ARC19499 sodium is a Cy3 labled ARC19499 sodium.

HY-153480C

ARC19499 sodium scrambled negative control		Aptamers
ARC19499 sodium scrambled negative control is the sequence scrambled negative control of ARC19499 sodium.

HY-RS17064

Arc Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Arc Mouse Pre-designed siRNA Set A contains three designed siRNAs for Arc gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23508

Arc Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Arc Rat Pre-designed siRNA Set A contains three designed siRNAs for Arc gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-148826A

Rovunaptabin sodium Arc 183 sodium; BC 007 sodium		Aptamers
Rovunaptabin sodium (ARC 183 sodium) is a DNA aptamer, which is a single-stranded DNA molecule consisting of 15 deoxynucleotides that forms well-defined three-dimensional configuration, allowing it to bind to thrombin with high affinity and specificity.

HY-RS24969

Nol3 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Nol3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nol3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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