58 Results for "

CD3ε

" in MedChemExpress (MCE) Product Catalog:
Products (58)

58 Results for "CD3ε" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-P80598
Synonyms: CD3E; T3E; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e

Host:  

Rabbit

Application:  

WB, IHC-P, IP

Reactivity:  

Human

loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P86804
Synonyms: 4930549J05Rik antibody; A430104F18Rik antibody; AW552088 antibody; CD247 antibody; CD3 antibody; CD3 delta antibody; CD3 epsilon antibody; CD3 eta antibody; CD3 gamma antibody; CD3 zeta antibody; CD3H antibody; CD3Q antibody; CD3Z antibody; CD3zeta antibody; Ctg3 antibody; FLJ17620 antibody; FLJ17664 antibody; FLJ18683 antibody; FLJ79544 antibody FLJ94613 antibody; IMD19 antibody; Leu-4 antibody; MGC138597 antibody; OKT3, delta chain antibody; OTTHUMP00000032544 antibody; T cell receptor antibody; T3 antibody; T3d antibody; T3e antibody; T3g antibody; T3z antibody; TCRE antibody; TCRk antibody; Tcrz antibody; TCRzeta antibody

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF, IP, IF-Tissue, mIHC

Reactivity:  

Human

loading...
    loading...
Cat. No.: HY-P990688
CAS No.: 2559056-68-5
Synonyms: AMG-509

Target:  

CD3

Research Areas:  

Cancer

Xaluritamig (AMG-509) is a bispecific T cell engager and cytolytic agent with a Kd of 27.6 nM for human CD3ε. Xaluritamig binds to CD3ε via an anti-CD3 single-chain variable fragment (scFv) domain, and to STEAP1 via a bispecific anti-STEAP1 antigen-binding fragment (Fab) domain, thereby recruiting and activating T cells and forming a bridge between T cells and STEAP1-expressing cancer cells. Xaluritamig induces T cell-mediated redirected cytotoxicity, tumor cell lysis, cytokine release, CD8 + T cell activation and expansion, as well as tumor stasis or regression. Xaluritamig contains an Fc domain with no effector function, which prolongs serum half-life, exhibits only minimal activity against cells with low STEAP1 expression and normal cells, and shows extremely low target-related off-tumor toxicity in cynomolgus monkeys. Xaluritamig is used in STEAP1×CD3 XmAb 2+1 immunotherapy and in research on metastatic castration-resistant prostate cancer and Ewing sarcoma [3].
loading...
    loading...
Cat. No.: HY-P990802

Target:  

CD3

Anti-Mouse CD3ε Antibody (145-2C11) is an orally active anti-mouse CD3ε IgG1 monoclonal antibody. Anti-Mouse CD3ε Antibody (145-2C11) can improve the function of regulatory T cells (Tregs). Anti-Mouse CD3ε Antibody (145-2C11) relieves inflammatory response by inhibiting the production of pro-inflammatory cytokines and increasing the secretion of anti-inflammatory factors. Anti-Mouse CD3ε Antibody (145-2C11) can be used for researches on metabolic and immune system conditions such as diabetes and lupus. The recommend isotype control of Anti-Mouse CD3ε Antibody (145-2C11): Armenian hamster IgG, Isotype Control (HY-P990305) .
loading...
    loading...
Cat. No.: HY-P991155
CAS No.: 2988886-91-3
Synonyms: JNJ-79635322; JNJ-5322

Target:  

CD3 TNF Receptor

Research Areas:  

Cancer

Ramantamig (JNJ-79635322) is a humanized monoclonal antibody targeting human CD3ε, GPRC5D, and TNFRSF17 (BCMA). Ramantamig binds to BCMA and GPRC5D on multiple myeloma cells, binds to CD3ε on T cells, forms immunological synapses, and enables T-cell-mediated cytotoxicity. Ramantamig activates T cells concomitantly with inducing myeloma cell cytotoxicity, with no nonspecific T-cell activation in the absence of target myeloma cells. Ramantamig carries mutations to reduce interaction with Fc receptors and disrupt protein A binding of monomeric and homodimerized chains. Ramantamig can be used for the research of multiple myeloma .
loading...
    loading...
Cat. No.: HY-P990272

Target:  

CD3

Research Areas:  

Inflammation/Immunology

Anti-Mouse CD3ε Antibody (KT3) is a rat-derived IgG2a type antibody inhibitor, targeting to mouse CD3ε. Anti-Mouse CD3ε Antibody (KT3) increases thymocytes proliferation. Anti-Mouse CD3ε Antibody (KT3) can be used for the research of immunology [3].
loading...
    loading...
Cat. No.: HY-P991088

Target:  

CD3

Research Areas:  

Cancer

HPN536 is a trispecific, T-cell-activating protein-based construct, which binds to mesothelin-expressing tumor cells, CD3ε on T cells, and to serum albumin. HPN536 specifically redirects T cells for potent redirected lysis of mesothelin-expressing cancer cells with concomitant T-cell activation .
loading...
    loading...
Cat. No.: HY-P991122
CAS No.: 3037124-22-1
Synonyms: ONO-4685

Target:  

PD-1/PD-L1 CD3

Research Areas:  

Inflammation/Immunology Cancer

Besufetamig is a bispecific antibody targeting programmed cell death 1 (PD-1) and CD3ε chain. Besufetamig modulates the activity of immune cells, exerting immunosuppressive and antineoplastic activities. Besufetamig is promising for research of cancers .
loading...
    loading...
Cat. No.: HY-P991163
CAS No.: 2969220-04-8

Target:  

CD3 Claudin

Research Areas:  

Cancer

Tixentamig is a bispecific monoclonal antibody targeting human CD3 ε and CLDN18 (claudin 18). Tixentamig is promising for research of cancers .
loading...
    loading...
Cat. No.: HY-180888
CAS No.: 1356734-45-6
Target:  

Src CD3

Research Areas:  

Inflammation/Immunology

Lck-IN-5 (example C10) is a potent and selective lymphocyte-specific protein tyrosine kinase (LCK) inhibitor. Lck-IN-5 selectively disrupts the interaction between the SH3 domain of LCK and the RK motif of CD3ε, thereby impairing LCK recruitment to the TCR. Lck-IN-5 modulates the activity of CD3ε-containing CAR and TRuC T cells, attenuating cytokine production and promoting a central-memory-like phenotype associated with enhanced persistence. Lck-IN-5 can be used for autoimmune diseases and graft-versus-host disease research .
loading...
    loading...
Cat. No.: HY-P991842

Target:  

CD3

Research Areas:  

Inflammation/Immunology

Anti-CD3 Antibody (UCHT-1) reacts with human CD3ε. Anti-CD3 Antibody (UCHT-1) can be used for the study of graft-versus-host disease (GVHD). Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
loading...
    loading...
Cat. No.: HY-P992061

Target:  

CD3 Calcium Channel

Research Areas:  

Inflammation/Immunology

Anti-Mouse CD3E Antibody (500A2) is an antibody targeting mouse CD3ε, which specifically binds to the region on CD3ε adjacent to the T cell receptor binding site. Anti-Mouse CD3E Antibody (500A2) triggers functional signal transduction in immature T cells and activates naive T cells. When cross-linked, Anti-Mouse CD3E Antibody (500A2) induces a rapid, robust and transient increase in cytoplasmic calcium concentration, acting as a potent calcium flux inducer. Anti-Mouse CD3E Antibody (500A2) is suitable for multiple experimental techniques such as flow cytometry, immunoprecipitation and EMARS reactions. It can be used to detect CD3E expression on thymocytes, mature T lymphocytes and NK-T cells from different mouse strains, or to identify membrane cluster components of the TCR complex, and shows no cross-reactivity with rat leukocytes [3].
loading...
    loading...
Cat. No.: HY-P78874
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FLJ18683; T3E; TCRE; CD3E; CD3-epsilon
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-P78269
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: CD3e; CD3E; T3E; FLJ18683; TCRE; CD3-epsilon; IMD18
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-P86568
Synonyms: T-cell surface glycoprotein CD3 epsilon chain; T-cell surface antigen T3/Leu-4 epsilon chain; CD antigen CD3e;

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF, IP, ELISA

Reactivity:  

Human, Mouse, Rat

loading...
    loading...
Cat. No.: HY-P77607
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: CD3e; CD3E; T3E; FLJ18683; TCRE; CD3-epsilon; IMD18
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-P78089
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: CD3e; CD3E; T3E; FLJ18683; TCRE; CD3-epsilon; IMD18
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-P77608
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: CD3e; CD3E; T3E; FLJ18683; TCRE; CD3-epsilon; IMD18
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-P72899
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: T-cell surface glycoprotein CD3 epsilon chain; CD3E; T3E; CD3 epsilon
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-P83994
Synonyms: T3E; TCRE; FLJ18683; CD3E

Host:  

Mouse

Application:  

WB, FC, ELISA

Reactivity:  

Human

loading...
    loading...