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Results for "

CEACAM6

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

5

Inhibitory Antibodies

11

Recombinant Proteins

3

Antibodies

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P99051
    Tinurilimab
    2 Publications Verification

    BAY 1834942

    		 Transmembrane Glycoprotein Inflammation/Immunology Cancer
    Tinurilimab (Bay 1834942) is an anti-CEACAM6 (carcinoembryonic antigen-related cell adhesion molecule 6) humanized IgG2 monoclonal antibody. CEACAM6 is an immune checkpoint regulator suppressing the activity of effector T-cells against tumors. Tinurilimab shows an increased tumor cell killing effect in the tumor-cell/T-cell co-culture system .
    Tinurilimab
  • HY-164899
    2A3

    2-aminopyridine-3-carboxylic acid imidazolide

    		 Transmembrane Glycoprotein Cancer
    2A3 (2-aminopyridine-3-carboxylic acid imidazolide) is a T cell activator that specifically binds to CEACAM6 and CEACAM5. 2A3 exhibits enzymatic activity that catalyzes the glucuronidation of specific substrates (e.g., 1-naphthol), and possesses significant cytotoxic activity. When integrated into CAR T cells or used alone, 2A3 acts by inducing cytokine release, degranulation, and direct cytotoxicity. 2A3 kills pancreatic and breast cancer cells with high target antigen expression in vitro, and significantly inhibits the growth of pancreatic cancer xenografts in vivo. 2A3 broadly targets malignant tumors with overexpressed CEACAM5, CEACAM6, or co-expressed both, and shows high expression mainly in tissues such as the liver and colon. 2A3 serves as an important research tool for the immunotherapy of pancreatic and breast cancer . 2A3 is a novel SHAPE reagent, which can be used for the analysis of RNA structure both in vitro and in vivo . 2A3 is an electrophilic chemical probe that acylates the 2'-OH in the RNA backbone. 2A3 can be used for RNA SHAPE-MaP experiments and is capable of analyzing the RNA secondary structures at single nucleotide resolution.
    2A3
  • HY-RS24916
    Ceacam6 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Ceacam6 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ceacam6 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Ceacam6 Rat Pre-designed siRNA Set A
    Ceacam6 Rat Pre-designed siRNA Set A
  • HY-RS02442
    CEACAM6 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    CEACAM6 Human Pre-designed siRNA Set A contains three designed siRNAs for CEACAM6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CEACAM6 Human Pre-designed siRNA Set A
    CEACAM6 Human Pre-designed siRNA Set A
  • HY-P992344
    DNP002

    		Transmembrane Glycoprotein Cancer
    DNP002 is a humanized IgG1 monoclonal antibody targeting tumor-associated CEACAM6. DNP002 binds to CEACAM1, CEACAM5 and CEACAM6, and exhibits antibody-dependent cellular cytotoxicity against tumor cells overexpressing these targets. DNP002 binds to CEACAM6 on the surface of tumor-associated neutrophils (including MDSCs) to reverse the immunosuppressive effect in the tumor microenvironment. DNP002 shows anti-tumor activity in advanced solid tumors. DNP002 can be used for the research of advanced solid tumors. The recommended isotype control is human IgG1 kappa (HY-P99001) .
    DNP002
  • HY-P992350
    EBC-129 Antibody

    		ADC Antibody Transmembrane Glycoprotein Cancer
    EBC-129 Antibody is a specific antibody for the synthetic antibody-drug conjugate (ADC) EBC-129, which specifically targets CEACAM5 and CEACAM6 glycosylated at N256. EBC-129 Antibody can be used for the research of pancreatic ductal adenocarcinoma .
    EBC-129 Antibody
  • HY-P990854
    Anti-CEACAM1/3/5/6/8 Antibody (6G5j)

    		Transmembrane Glycoprotein Cancer
    Anti-CEACAM1/3/5/6/8 Antibody (6G5j) is a kind of mouse IgG1 κ chimeric antibody, targeting to human CEACAM1/3/5/6/8. Anti-CEACAM1/3/5/6/8 Antibody (6G5j) reacts with an antigen epitope shared by human carcinoembryonic antigen-related cell adhesion molecule (CEACAM) 1, 3, 5, 6, and 8. Anti-CEACAM1/3/5/6/8 Antibody (6G5j) can be used for the detections of western blot, ELISA, immunofluorescence immunohistochemistry and flow cytometry in cancer .
    Anti-CEACAM1/3/5/6/8 Antibody (6G5j)

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