63 Results for "

CRF2

" in MedChemExpress (MCE) Product Catalog:
Products (63)

63 Results for "CRF2" in MCE Product Catalog:

4
4 Cited Publications
Cat. No.: HY-P1107
CAS No.: 220673-95-0
Synonyms: aSvg-30
Target:  

CRFR

Research Areas:  

Neurological Disease

Antisauvagine-30 (aSvg-30) is a potent, competitive and selective CRF2 receptor antagonist with Kd values of 1.4 nM and 153.6 nM for mouse CRF and rat CRF1 receptors, respectively .
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4
4 Cited Publications
Cat. No.: HY-P1107A
Synonyms: aSvg-30 TFA
Target:  

CRFR

Research Areas:  

Neurological Disease

Antisauvagine-30 TFA (aSvg-30 TFA) is a potent, highly selective and competitive CRF2 receptor peptidic antagonist. Antisauvagine-30 TFA exhibits a Kd of 1.4 nM and 150 nM for mCRFR2β and CRFR1, respectively [2] .
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1
1 Cited Publications
Cat. No.: HY-P1108
CAS No.: 681260-70-8
Target:  

CRFR

Astressin 2B is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist (rCRFR2, IC50=0.57 nM). Astressin 2B blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats. Astressin 2B reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion and upregulation of inflammatory mediators. Astressin 2B also blocks the anxiogenic effect of Urocortin 2 and attenuates stress-induced anxiety-related behaviors. In the Clostridioides difficile toxin A (C. difficile toxin A)-mediated enteritis model, Astressin 2B mimics the phenotype of CRFR2-deficient mice, significantly exacerbating intestinal epithelial damage, edema, neutrophil migration and the expression of multiple proinflammatory cytokines. Astressin 2B is an important tool molecule for investigating the intestinal protective mechanisms of CRFR2 [2] .
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1
1 Cited Publications
Cat. No.: HY-P73153
Purity:  ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: Interleukin-10 receptor subunit beta; IL-10RB; CRF2-4; IL-10R2; CDw210b
Species:  
Source:  
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1
1 Cited Publications
Cat. No.: HY-P77969
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: IL-22R-alpha-1; IL-22RA1; CRF2-9; IL22R; IL22R1; IL-TIF-R1; zcytoR11
Species:  
Source:  
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Cat. No.: HY-P2847
CAS No.: 330648-32-3
Target:  

CRFR

Research Areas:  

Metabolic Disease Endocrinology

Urocortin II, mouse is a potent and selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor with Ki values of 0.66 nM and ﹥100 nM for CRFR2 and CRFR1, respectively. Urocortin II, mouse activates CRF2 receptors in a cAMP/PKA- and Ca 2+/CaMKII-dependent manner.Urocortin II, mouse is expressed in discrete areas of the central nervous system, and activates central neurons involved in the processing of visceral sensory information, and in modulating autonomic outflow [2] .
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Cat. No.: HY-P1752
CAS No.: 351999-18-3
Research Areas:  

Metabolic Disease

Urocortin II, human is a selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor. Urocortin II, human has an effect of promoting satiet and neuroprotective effect. Urocortin II, human also has bactericidal, antiparasitic and pro-inflammation activity. Urocortin II, human can activate NF-κB pathway and ERK1/2 MAP kinase. Urocortin II, human can reduce pulmonary arterial hypertension and shows cardiac protection effect. Urocortin II, human can be used for the researches of infection, inflammation, metabolic, neurological and cardiovascular disease [2] .
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Cat. No.: HY-14875
CAS No.: 885220-61-1
Purity:  99.93%
Synonyms: GSK561679
Target:  

CRFR

Research Areas:  

Neurological Disease Endocrinology

Verucerfont is a corticotropin-releasing factor receptor 1 (CRF1) antagonist with IC50s of ~6.1, >1000 and >1000?nM for CRF1, CRF2, and CRF-BP, respectively.
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Cat. No.: HY-12129
CAS No.: 257639-98-8
Purity:  99.7%
Target:  

CFTR

Research Areas:  

Neurological Disease

CP 154526 hydrochloride is a potent, brain-penetrant and selective corticotropin-releasing factor receptor 1 (CRF1) antagonist with a Ki of 2.7 nM. CP 154526 hydrochloride shows selective for CRF1 over CRF2 (Ki = >10 μM). CP 154526 hydrochloride has anxiolytic activities [2].
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Cat. No.: HY-P1294
CAS No.: 90880-23-2
Target:  

CRFR

Research Areas:  

Neurological Disease

α-Helical CRF(9-41) is a competitive CRF2 receptor antagonist with KB of ~100 nM. α-Helical CRF(9-41) is also a partial agonist of CRF1 receptor with an EC50 of 140 nM [2].
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Cat. No.: HY-P1294A
Target:  

CRFR

Research Areas:  

Neurological Disease

α-Helical CRF(9-41) TFA is a competitive CRF2 receptor antagonist with KB of ~100 nM. α-Helical CRF(9-41) TFA is also a partial agonist of CRF1 receptor with an EC50 of 140 nM [2].
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Cat. No.: HY-P1106A
Target:  

CFTR

Research Areas:  

Cardiovascular Disease

K41498 TFA is a highly selective CRF 2 receptor antagonist, with a Ki of 0.66 nM for human CRF2α receptor and a Ki of 0.62 nM for human CRF2β receptor. K41498 TFA inhibits cAMP accumulation in cells expressing CRF2. K41498 TFA antagonizes the hypotensive response induced by systemic administration of urocortin in conscious rats. K41498 TFA undergoes radioiodination without loss of activity and serves for autoradiographic studies of native CRF2 receptors in rat brain and peripheral tissues [2].
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Cat. No.: HY-P1752B
Research Areas:  

Metabolic Disease

Urocortin II, human acetate is a selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor. Urocortin II, human acetate has an effect of promoting satiet and neuroprotective effect. Urocortin II, human acetate also has bactericidal, antiparasitic and pro-inflammation activity. Urocortin II, human acetate can activate NF-κB pathway and ERK1/2 MAP kinase. Urocortin II, human acetate can reduce pulmonary arterial hypertension and shows cardiac protection effect. Urocortin II, human acetate can be used for the researches of infection, inflammation, metabolic, neurological and cardiovascular disease [2] .
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Cat. No.: HY-P1106
CAS No.: 434938-41-7
Target:  

CRFR

Research Areas:  

Cardiovascular Disease

K41498 is a highly selective CRF 2 receptor antagonist, with a Ki of 0.66 nM for human CRF2α receptor and a Ki of 0.62 nM for human CRF2β receptor. K41498 inhibits cAMP accumulation in cells expressing CRF2. K41498 antagonizes the hypotensive response induced by systemic administration of urocortin in conscious rats. K41498 undergoes radioiodination without loss of activity and serves for autoradiographic studies of native CRF2 receptors in rat brain and peripheral tissues [2].
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Cat. No.: HY-P1296
CAS No.: 171543-83-2
Synonyms: Urocortin (Rattus norvegicus); Rat urocortin
Target:  

CRFR

Research Areas:  

Neurological Disease Endocrinology

Urocortin, rat (Urocortin (Rattus norvegicus)) is a neuropeptide and a potent endogenous CRFR agonist with Kis of 13 nM, 1.5 nM, and 0.97 nM for human CRF1, rat CRF and mouse CRF, respectively [2].
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Cat. No.: HY-12130
CAS No.: 157286-86-7
Target:  

CRFR

Research Areas:  

Neurological Disease

CP 154526 is a potent, brain-penetrant and selective corticotropin-releasing factor receptor 1 (CRF1) antagonist with a Ki of 2.7 nM. CP 154526 shows selective for CRF1 over CRF2 (Ki = >10 μM). CP 154526 has anxiolytic activities [2].
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Cat. No.: HY-103378
CAS No.: 603151-83-3
Target:  

CRFR

Research Areas:  

Neurological Disease

NBI 35965 methanesulfonate is a selective, orally active and brain-penetrant corticotropin-releasing factor receptor 1 (CRF1) antagonist with a Ki value of 4 nM and a pKi value of 8.5. NBI 35965 methanesulfonate does not inhibit CRF2. NBI 35965 methanesulfonate reduces CRF or stress-induced adrenocorticotropic hormone (ACTH) production in vivo with pIC50 values of 7.1 and 6.9, respectively. NBI 35965 methanesulfonate shows anxiolytic effects [2].
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Cat. No.: HY-P1542
CAS No.: 83930-33-0
Synonyms: Catostomus urotensin I
Target:  

CRFR

Urotensin I (Catostomus urotensin I), a CRF-like neuropeptide, acts as an agonist of CRF receptor with pEC50s of 11.46, 9.36 and 9.85 for human CRF1, human CRF2 and rat CRF receptors in CHO cells, and Kis of 0.4, 1.8, and 5.7 nM for hCRF1, rCRF and mCRF receptors, respectively [2].
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Cat. No.: HY-14128
CAS No.: 268545-87-5
Synonyms: SB-723620
Target:  

CRFR

Research Areas:  

Neurological Disease

NBI-34041 (SB-723620) is a selective and orally active nonpeptide CRF1 receptor antagonist with an IC50 of 58.9 nM and a Ki of 4.0 nM for human CRF1 receptor. NBI-34041 has no inhibitory effect on the CRF2 receptor. NBI-34041 can be used for depression and anxiety disorders research.
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Cat. No.: HY-P1542B
Synonyms: Catostomus urotensin I TFA
Target:  

CRFR

Urotensin I (Catostomus urotensin I) TFA, a CRF-like neuropeptide, acts as an agonist of CRF receptor with pEC50s of 11.46, 9.36 and 9.85 for human CRF1, human CRF2 and rat CRF receptors in CHO cells, and Kis of 0.4, 1.8, and 5.7 nM for hCRF1, rCRF and mCRF receptors, respectively [2].
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