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Cleaved-Parp1

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By Targets:	Akt (1) Androgen Receptor (1) Apoptosis (6) Bcl-2 Family (1) Caspase (3) GSK-3 (1) MDM-2/p53 (2) Microtubule/Tubulin (1) MMP (1) mTOR (1) OGT (1) PARP (3) PROTACs (1) Reactive Oxygen Species (ROS) (2) Thymidylate Synthase (1) YTHDF (1)
By Research Areas:	Cancer (6) Inflammation/Immunology (1)

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Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N3677

Dammarenediol II	OGT Akt mTOR GSK-3 Reactive Oxygen Species (ROS) Apoptosis PARP MDM-2/p53	Inflammation/Immunology Cancer
Dammarenediol II is a ginsenoside precursor . Dammarenediol II reduces the activity of O-GlcNAc transferase (OGT) and downregulates the global O-GlcNAcylation level. Dammarenediol II inhibits the phosphorylation of Akt, mTOR and GSK3β. Dammarenediol II inhibits human carboxylesterase activity, VEGF-induced ROS production, stress fiber formation and vascular endothelial cadherin disruption. Dammarenediol II promotes cell apoptosis (apoptosis), increases the levels of cleaved PARP1 and p53, and inhibits retinal microvascular leakage. Dammarenediol II can be used in studies related to liver cancer and diabetic retinopathy ^[1] .

HY-176848

SKLB-Y13	YTHDF Apoptosis MMP Caspase	Cancer
SKLB-Y13 is a selective *YTHDF1* inhibitor with an IC₅₀ of 0.76 μM and a K_D of 5.097 μM. SKLB-Y13 binds to the Tyr397 and Trp470 residues in the m ⁶A-binding pocket of *YTHDF1, disrupting the interaction between YTHDF1* and m ⁶A-modified mRNA. SKLB-Y13 inhibits cancer cell proliferation and promotes apoptosis. SKLB-Y13 is applicable to breast cancer-related research ^[1].

HY-176128

BWA-6047	PROTACs Androgen Receptor Apoptosis PARP Caspase	Cancer
BWA-6047 is an oral active PROTAC degrader targeting AR/AR-V7 and *GSPT1* with DC₅₀ values of 3.7, 3.0 and 1.2 nM in 22Rv1 cells. BWA-6047 suppresses the expression of AR downstream target genes and and transcriptional activity. BWA-6047 inhibits cancer cells proliferation, causes G1 phase cell cycle arrest and induces apoptosis. BWA-6047 increases cleaved-PARP-1 and cleaved-caspase-3 levels. BWA-6047 reduces growth of LNCaP xenograft tumors in mice models without obvious toxicity. BWA-6047 can be used for the research of prostate cancer ^[1].

HY-146817

Tubulin polymerization-IN-11	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-11 is a potent tubulin polymerization inhibitor with an IC₅₀ value of 3.4 μM. Tubulin polymerization-IN-11 shows antiproliferative activity. Tubulin polymerization-IN-11 induces Apoptosis and cell cycle arrest at G2/M phase. Tubulin polymerization-IN-11 decreases the expression of cyclin B1, p-cdc2, and Bcl-2 protein levels and increases the expression of cleaved PARP .

HY-168877

FMP	MDM-2/p53 Reactive Oxygen Species (ROS) Apoptosis Caspase PARP Bcl-2 Family	Cancer
FMP is a Platinum(IV) complexe. FMP significantly upregulates the expression of γ-H2AX and p53. FMP increases the production of ROS. FMP markedly upregulates the expressions of Apoptosis-related proteins (*DR5, Fas, caspase-8, Cyt-c, caspase-3, cleaved-PARP1, Bax*). FMP shows antiproliferative activity against breast cancer ^[1].

HY-N14161

Diazaquinomycin A	Thymidylate Synthase Apoptosis	Cancer
Diazaquinomycin A (DAQA), a diaza-anthracene antibiotic, is a thymidylate synthase inhibitor. Diazaquinomycin A (DAQA) induces DNA damage, cell cycle arrest, and apoptosis through cleaved-PARP .

Dammarenediol II	Triterpenes Structural Classification other families Boswellia freerana Terpenoids Plants Source Classification	OGT Akt mTOR GSK-3 Reactive Oxygen Species (ROS) Apoptosis PARP MDM-2/p53
Dammarenediol II is a ginsenoside precursor . Dammarenediol II reduces the activity of O-GlcNAc transferase (OGT) and downregulates the global O-GlcNAcylation level. Dammarenediol II inhibits the phosphorylation of Akt, mTOR and GSK3β. Dammarenediol II inhibits human carboxylesterase activity, VEGF-induced ROS production, stress fiber formation and vascular endothelial cadherin disruption. Dammarenediol II promotes cell apoptosis (apoptosis), increases the levels of cleaved PARP1 and p53, and inhibits retinal microvascular leakage. Dammarenediol II can be used in studies related to liver cancer and diabetic retinopathy ^[1] .

Diazaquinomycin A	Microorganisms Antibiotics Other Antibiotics Source Classification	Thymidylate Synthase Apoptosis
Diazaquinomycin A (DAQA), a diaza-anthracene antibiotic, is a thymidylate synthase inhibitor. Diazaquinomycin A (DAQA) induces DNA damage, cell cycle arrest, and apoptosis through cleaved-PARP .

Host:	Rabbit (4)
Reactivity:	Human (4) Rat (1) Mouse (1)
Application:	IHC-P (1) ICC/IF (2) IP (1) WB (4) FC (1) ELISA (1)
Isotype:	IgG,Kappa (1) IgG (3)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (3) Recombinant (3)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80448

	Cleaved-PARP1 Antibody (YA500) 3 Publications Verification	WB, ICC/IF, IP, FC	Human
	Cleaved-PARP1 Antibody (YA500) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cleaved-PARP1.

HY-P87903

	Cleaved PARP1 Antibody (YA7588)	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	Cleaved PARP1 Antibody (YA7588) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to Cleaved PARP1.

HY-P80625

	Cleaved-PARP1 Antibody (YA498) Parp1; ADPRT; PPOL; Poly [ADP-ribose] polymerase 1; Parp-1; ADP-ribosyltransferase diphtheria toxin-like 1; ARTD1; NAD(+) ADP-ribosyltransferase 1; ADPRT 1; Poly[ADP-ribose] synthase 1	WB	Human
	Cleaved-PARP1 Antibody (YA498) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cleaved-PARP1.

HY-P80625A

	Cleaved-PARP1 Antibody (YA498)(PBS only) Parp1; ADPRT; PPOL; Poly [ADP-ribose] polymerase 1; Parp-1; ADP-ribosyltransferase diphtheria toxin-like 1; ARTD1; NAD(+) ADP-ribosyltransferase 1; ADPRT 1; Poly[ADP-ribose] synthase 1	WB	Human
	Cleaved-PARP1 Antibody (YA498) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cleaved-PARP1.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Cleaved-Parp1

Inhibitors & Agonists

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Antibodies

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