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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
Curcuminoid
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "Curcuminoid" in MCE Product Catalog:
2
Cat. No.: HY-N0007A
CAS No.: 24939-16-0
Synonyms: Curcumin III; Didemethoxycurcumin
Cat. No.: HY-N0007AR
CAS No.: 24939-16-0
Synonyms: Curcumin III (Standard); Didemethoxycurcumin (Standard)
Cat. No.: HY-N0006A
CAS No.: 24939-17-1
Synonyms: p-Hydroxycinnamoyl-feruloylmethane
Target:
Cat. No.: HY-N0006S1
Synonyms: Curcumin II-d4; Desmethoxycurcumin-d4; Monodemethoxycurcumin-d4
Cat. No.: HY-N0893R
CAS No.: 36062-04-1
Synonyms: HZIV 81-2 (Standard)
Cat. No.: HY-N7275
CAS No.: 824951-60-2
Category:
Natural Products Plants Curcuma longa Disease Research Fields Inflammation/Immunology Zingiberaceae
Target:
RL71 is a curcuminoid anticancer agent that exhibits potent cytotoxicity against a variety of ER-negative breast cancer cells. RL71 (1 μM) induces cell cycle arrest in the G2/M phase and induces apoptosis in SKBr3 cells. RL7 also decreases HER2/neu phosphorylation and increases p27. RL71 also significantly reduced the phosphorylation of Akt and transiently increased the stress kinases JNK1/2 and p38 MAPK. Furthermore, RL71 exhibited anti-angiogenic potential in vitro, inhibiting the migration of HUVEC cells and the ability of these cells to form tubular networks .
Cat. No.: HY-178380
Target:
HDAC Reactive Oxygen Species (ROS) Apoptosis Necroptosis Biochemical Assay Reagents Caspase Bcl-2 Family
Research Areas:
HDAC8-IN-14, a curcuminoid derivative, is a selective HDAC8 inhibitor with a Ki of 9 nM. HDAC8-IN-14 induces the production of reactive oxygen species (ROS), disrupts mitochondrial membrane potential, and promotes apoptosis. HDAC8-IN-14 can significantly promote the accumulation of cells in the sub-G0/G1 phase, consistent with apoptotic or necrotic cell death. HDAC8-IN-14 induces upregulation of cytochrome c, cleaved caspase-3, and the pro-apoptotic protein Bak while leaving the anti-apoptotic Bcl-2 levels unaltered. HDAC8-IN-14 can be used for the study of leukemia .
Cat. No.: HY-N0007S
CAS No.: 2470233-08-8
Synonyms: Curcumin III-d8; Didemethoxycurcumin-d8
Cat. No.: HY-150791
CAS No.: 950665-12-0
Research Areas:
FLDP-5 is a blood-brain barrier (BBB) penetrant curcuminoid analogues. FLDP-5 can induce production of ROS (Reactive Oxygen Species), DNA damage and cell cycle S phase arrest. FLDP-5 exhibits highly potent tumour-suppressive effects with anti-proliferative and anti-migratory activities on LN-18 cells .
Cat. No.: HY-W030796AR
CAS No.: 150436-68-3
Target:
Research Areas:
Bisdemethoxycucurmin (Standard) is the analytical standard of Bisdemethoxycucurmin. This product is intended for research and analytical applications. Bisdemethoxycucurmin (Curcumin III), a curcuminoid, has antioxidant and antiinflammatory activities .
Cat. No.: HY-N0893S
CAS No.: 1794898-13-7
Synonyms: HZIV 81-2 d6
Cat. No.: HY-N0006S
CAS No.: 2470243-19-5
Synonyms: Curcumin II-d7; Desmethoxycurcumin-d7; Monodemethoxycurcumin-d7
Cat. No.: HY-121605S
Cat. No.: HY-184665
CAS No.: 1638811-35-4
Target:
Research Areas:
Dedimethyl MitoCur-1 is a mitochondria-targeted curcuminoid derived from MitoCur-1 (HY-150228) with anticancer activity. MitoCur-1 induces massive reactive oxygen species production in cancer cells, reduces mitochondrial membrane potential, and triggers cell cycle arrest and apoptosis. Meanwhile, MitoCur-1 inhibits the phosphorylation of Akt and STAT3, enhances ERK phosphorylation, and upregulates the expression of the pro-apoptotic protein BNIP3. Dedimethyl MitoCur-1 can be used in research related to breast cancer, cervical cancer, prostate cancer, and neuroblastoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
