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Results for "

DAP12

" in MedChemExpress (MCE) Product Catalog:

By Targets:	c-Fms (1) Interleukin Related (1) Liposome (1) Small Interfering RNA (siRNA) (2) Syk (1) TNF Receptor (1) TREM receptor (4)
By Research Areas:	Cancer (2) Inflammation/Immunology (2) Neurological Disease (4)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Cationic Lipids (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P991220

AL002	TREM receptor	Neurological Disease
AL002 is a humanized monoclonal IgG1 antibody and a blood-brain barrier-permeable TREM2 modulator. AL002 binds to TREM2 on the surface of microglia, promotes TREM2 clustering and the formation of the *TREM2*-DAP12 complex, activates the TREM2 signaling pathway and PI3K cascade, and induces TREM2 internalization and degradation. AL002 is applicable to research related to Alzheimer's disease .

HY-175510

TREM2 agonist-5	TREM receptor	Neurological Disease
TREM2 agonist-5 is the microglial lipid-sensing receptor (TREM2) agonist with a K_d of 71.36 μM. TREM2 agonist-5 is a racemic structural analog of the TREM2 agonist VG-3927 and exhibits superior microglial phagocytosis and activates TREM2 signaling in HEK293-hTREM2/DAP12 cells. TREM2 agonist-5 displays a superior in vitro pharmacokinetic profile to VG-3927. TREM2 agonist-5 can used for the study of Alzheimer’s disease .

HY-P10086

TREM-1 inhibitory peptide GF9 1 Publications Verification Human TREM-1(213-221)	TREM receptor TNF Receptor Interleukin Related c-Fms	Neurological Disease Inflammation/Immunology Cancer
TREM-1 inhibitory peptide GF9 (Human TREM-1 (213-221)) is a TREM-1 inhibitor. TREM-1 inhibitory peptide GF9 blocks the TREM-1 signaling pathway via a ligand-independent mechanism, spontaneously inserts into the cell membrane to dissociate TREM-1 from *DAP-12, and functions through the Signaling Chain Homooligomerization (SCHOOL) model. TREM-1 inhibitory peptide GF9 reduces the levels of TNFα, IL-1β, IL-6, and M-CSF*. TREM-1 inhibitory peptide GF9 inhibits tumor growth, prolongs the survival of mice with pancreatic cancer models, ameliorates collagen-induced arthritis, and exerts protective effects on bone and cartilage simultaneously. TREM-1 inhibitory peptide GF9 can be used in research related to arthritis, pancreatic cancer, retinopathy, alcoholic liver disease, and liver cancer .

HY-174369

TREM2 agonist-3	TREM receptor Syk	Neurological Disease
TREM2 agonist-3 (Compound 4i) is a TREM2 agonist with a K_D value of 19.0 µM. The K_D value of TREM2 agonist-3 for TREM1 is 39.8 µM. TREM2 agonist-3 induces an increase in phosphorylated SYK levels. TREM2 agonist-3 can be used in the research of neurodegenerative diseases and other diseases associated with TREM2 dysfunction .

HY-144020

14:0 DAP	Liposome	Others
14:0 DAP (1,2-dimyristoyl-3-dimethylammonium-propane ) is a cationic lipid that can be used for drug delivery .

HY-RS15309

TYROBP Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TYROBP Human Pre-designed siRNA Set A contains three designed siRNAs for TYROBP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TYROBP Human Pre-designed siRNA Set A TYROBP Human Pre-designed siRNA Set A

HY-RS21215

Tyrobp Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tyrobp Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tyrobp gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tyrobp Mouse Pre-designed siRNA Set A Tyrobp Mouse Pre-designed siRNA Set A

Cat. No.	Product Name	Type

HY-144020

14:0 DAP	Biochemical Assay Reagents
14:0 DAP (1,2-dimyristoyl-3-dimethylammonium-propane ) is a cationic lipid that can be used for drug delivery .

Cat. No.	Product Name	Target	Research Area

HY-P10086

TREM-1 inhibitory peptide GF9 1 Publications Verification Human TREM-1(213-221)	TREM receptor TNF Receptor Interleukin Related c-Fms	Neurological Disease Inflammation/Immunology Cancer
TREM-1 inhibitory peptide GF9 (Human TREM-1 (213-221)) is a TREM-1 inhibitor. TREM-1 inhibitory peptide GF9 blocks the TREM-1 signaling pathway via a ligand-independent mechanism, spontaneously inserts into the cell membrane to dissociate TREM-1 from *DAP-12, and functions through the Signaling Chain Homooligomerization (SCHOOL) model. TREM-1 inhibitory peptide GF9 reduces the levels of TNFα, IL-1β, IL-6, and M-CSF*. TREM-1 inhibitory peptide GF9 inhibits tumor growth, prolongs the survival of mice with pancreatic cancer models, ameliorates collagen-induced arthritis, and exerts protective effects on bone and cartilage simultaneously. TREM-1 inhibitory peptide GF9 can be used in research related to arthritis, pancreatic cancer, retinopathy, alcoholic liver disease, and liver cancer .

HY-P10087

Mouse TREM-1 SCHOOL peptide Mouse TREM-1(213–221), GF9	Peptides	Inflammation/Immunology Cancer
Mouse TREM-1 SCHOOL peptide (Mouse TREM-1(213-221), GF9) targets the interaction between TREM-1 and its signaling partner DAP-12, specifically silencing the TREM-1 signaling pathway, regulate the production of TREM-1-mediated pro-inflammatory cytokines in vivo and in vitro. Mouse TREM-1 SCHOOL peptide has anti-tumor effects. Mouse TREM-1 SCHOOL peptide can reduce the formation of vitreoretinal neovascularization .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991220

AL002	TREM receptor	Neurological Disease
AL002 is a humanized monoclonal IgG1 antibody and a blood-brain barrier-permeable TREM2 modulator. AL002 binds to TREM2 on the surface of microglia, promotes TREM2 clustering and the formation of the *TREM2*-DAP12 complex, activates the TREM2 signaling pathway and PI3K cascade, and induces TREM2 internalization and degradation. AL002 is applicable to research related to Alzheimer's disease .

Species:	Human (2) Mouse (2)
Tag:	His (2) Strep (1) Avi (1) Fc (2)
Source:	HEK293 (4)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P77632

	CLEC5A/MDL-1 Protein, Human (HEK293, Fc) MDL-1; CLECSF5; MDL1; CLEC5A; DAP12-associating lectin 1	Human	HEK293
	The CLEC5A/MDL-1 protein positively regulates osteoclastogenesis and regulates inflammatory responses. It acts as a critical macrophage receptor for dengue virus serotypes 1-4, triggering signaling through TYROBP phosphorylation. This interaction stimulates the release of pro-inflammatory cytokines without viral entry. CLEC5A/MDL-1 Protein, Human (HEK293, Fc) is the recombinant human-derived CLEC5A/MDL-1 protein, expressed by HEK293 , with N-hFc labeled tag.

HY-P77906

	CLEC5A/MDL-1 Protein, Mouse (HEK293, Fc) MDL-1; CLECSF5; MDL1; CLEC5A; DAP12-associating lectin 1	Mouse	HEK293
	CLEC5A/MDL-1 Protein positively regulates osteoclastogenesis and acts as a cell surface receptor signaling via TYROBP. Its expression relies on the TYROBP interaction and it plays a role in regulating inflammatory responses. CLEC5A/TYROBP/HCST complex formation highlights its intricate involvement in immune and inflammatory processes. CLEC5A/MDL-1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CLEC5A/MDL-1 protein, expressed by HEK293 , with N-hFc labeled tag.

HY-P704543

	CLEC5A/MDL-1 Protein, Human (HEK293, His) MDL-1; CLECSF5; MDL1; CLEC5A; DAP12-associating lectin 1	Human	HEK293
	The CLEC5A/MDL-1 protein positively regulates osteoclastogenesis and regulates inflammatory responses. It acts as a critical macrophage receptor for dengue virus serotypes 1-4, triggering signaling through TYROBP phosphorylation. This interaction stimulates the release of pro-inflammatory cytokines without viral entry. CLEC5A/MDL-1 Protein, Human (HEK293, His) is the recombinant human-derived CLEC5A/MDL-1 protein, expressed by HEK293, with N-His labeled tag.

HY-P703963

	CLEC5A/MDL-1 Protein, Mouse (Biotinylated, HEK293, His, Avi) MDL-1; CLECSF5; MDL1; CLEC5A; DAP12-associating lectin 1	Mouse	HEK293
	CLEC5A/MDL-1 Protein positively regulates osteoclastogenesis and acts as a cell surface receptor signaling via TYROBP. Its expression relies on the TYROBP interaction and it plays a role in regulating inflammatory responses. CLEC5A/TYROBP/HCST complex formation highlights its intricate involvement in immune and inflammatory processes. CLEC5A/MDL-1 Protein, Mouse (Biotinylated, HEK293, His, Avi) is the recombinant mouse-derived CLEC5A/MDL-1 protein, expressed by HEK293, with N-Avi and N-His labeled tag.

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HY-P81906

	DAP12 Antibody (YA1651) DAP12; KARAP; PLOSL; TYROBP	WB, IHC-P, ICC/IF, FC	Human
	DAP12 Antibody (YA1651) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DAP12.

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Cat. No.	Product Name		Classification

HY-144020

14:0 DAP		Cationic Lipids
14:0 DAP (1,2-dimyristoyl-3-dimethylammonium-propane ) is a cationic lipid that can be used for drug delivery .

HY-RS15309

TYROBP Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TYROBP Human Pre-designed siRNA Set A contains three designed siRNAs for TYROBP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS21215

Tyrobp Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Tyrobp Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tyrobp gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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