14 Results for "

DAP12

" in MedChemExpress (MCE) Product Catalog:
Products (14)

14 Results for "DAP12" in MCE Product Catalog:

1
1 Cited Publications
Art. -Nr.: HY-P10086
CAS. Nr.: 1289375-12-7
Synonyms: Human TREM-1(213-221)
TREM-1 inhibitory peptide GF9 (Human TREM-1 (213-221)) is a TREM-1 inhibitor. TREM-1 inhibitory peptide GF9 blocks the TREM-1 signaling pathway via a ligand-independent mechanism, spontaneously inserts into the cell membrane to dissociate TREM-1 from DAP-12, and functions through the Signaling Chain Homooligomerization (SCHOOL) model. TREM-1 inhibitory peptide GF9 reduces the levels of TNFα, IL-1β, IL-6, and M-CSF. TREM-1 inhibitory peptide GF9 inhibits tumor growth, prolongs the survival of mice with pancreatic cancer models, ameliorates collagen-induced arthritis, and exerts protective effects on bone and cartilage simultaneously. TREM-1 inhibitory peptide GF9 can be used in research related to arthritis, pancreatic cancer, retinopathy, alcoholic liver disease, and liver cancer .
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Art. -Nr.: HY-P991220

Target:  

TREM receptor

Forschungsgebiete:  

Neurological Disease

AL002 is a humanized monoclonal IgG1 antibody and a blood-brain barrier-permeable TREM2 modulator. AL002 binds to TREM2 on the surface of microglia, promotes TREM2 clustering and the formation of the TREM2-DAP12 complex, activates the TREM2 signaling pathway and PI3K cascade, and induces TREM2 internalization and degradation. AL002 is applicable to research related to Alzheimer's disease .
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Art. -Nr.: HY-175510
CAS. Nr.: 3114105-24-4
Target:  

TREM receptor

Forschungsgebiete:  

Neurological Disease

TREM2 agonist-5 is the microglial lipid-sensing receptor (TREM2) agonist with a Kd of 71.36 μM. TREM2 agonist-5 is a racemic structural analog of the TREM2 agonist VG-3927 and exhibits superior microglial phagocytosis and activates TREM2 signaling in HEK293-hTREM2/DAP12 cells. TREM2 agonist-5 displays a superior in vitro pharmacokinetic profile to VG-3927. TREM2 agonist-5 can used for the study of Alzheimer’s disease .
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Art. -Nr.: HY-174369
Target:  

TREM receptor Syk

Forschungsgebiete:  

Neurological Disease

TREM2 agonist-3 (Compound 4i) is a TREM2 agonist with a KD value of 19.0 µM. The KD value of TREM2 agonist-3 for TREM1 is 39.8 µM. TREM2 agonist-3 induces an increase in phosphorylated SYK levels. TREM2 agonist-3 can be used in the research of neurodegenerative diseases and other diseases associated with TREM2 dysfunction .
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Art. -Nr.: HY-P10087
CAS. Nr.: 1292755-24-8
Synonyms: Mouse TREM-1(213–221), GF9
Target:  

Peptides

Forschungsgebiete:  

Inflammation/Immunology Cancer

Mouse TREM-1 SCHOOL peptide (Mouse TREM-1(213-221), GF9) targets the interaction between TREM-1 and its signaling partner DAP-12, specifically silencing the TREM-1 signaling pathway, regulate the production of TREM-1-mediated pro-inflammatory cytokines in vivo and in vitro. Mouse TREM-1 SCHOOL peptide has anti-tumor effects. Mouse TREM-1 SCHOOL peptide can reduce the formation of vitreoretinal neovascularization .
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Art. -Nr.: HY-P81906
Synonyms: DAP12; KARAP; PLOSL; TYROBP

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF, FC

Reactivity:  

Human

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Art. -Nr.: HY-144020
CAS. Nr.: 72719-84-7
14:0 DAP (1,2-dimyristoyl-3-dimethylammonium-propane ) is a cationic lipid that can be used for drug delivery .
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Art. -Nr.: HY-RS15309
Forschungsgebiete:  

Others

TYROBP Human Pre-designed siRNA Set A contains three designed siRNAs for TYROBP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Art. -Nr.: HY-RS21215
Forschungsgebiete:  

Others

Tyrobp Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tyrobp gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Art. -Nr.: HY-P77632
Reinheit:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: MDL-1; CLECSF5; MDL1; CLEC5A; DAP12-associating lectin 1
Species:  
Source:  
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Art. -Nr.: HY-P77906
Reinheit:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: MDL-1; CLECSF5; MDL1; CLEC5A; DAP12-associating lectin 1
Species:  
Source:  
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Art. -Nr.: HY-P704543
Reinheit:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MDL-1; CLECSF5; MDL1; CLEC5A; DAP12-associating lectin 1
Species:  
Source:  
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Art. -Nr.: HY-P703963
Reinheit:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: MDL-1; CLECSF5; MDL1; CLEC5A; DAP12-associating lectin 1
Species:  
Source:  
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Art. -Nr.: HY-P992516

Target:  

TREM receptor

Forschungsgebiete:  

Neurological Disease

DNL-919 ATV is a brain-penetrant TREM2 agonist. DNL-919 ATV induces responsive microglial cell state changes and modulates microglial biomarkers. DNL-919 ATV can be used for the research of Alzheimer's disease .
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