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Defensive

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Bacterial (1) Biochemical Assay Reagents (1) Calcium Channel (2) CRFR (3) Dengue Virus (1) Drug Isomer (1) Endogenous Metabolite (2) Histamine Receptor (1) HIV (1) Insecticide (1) Phytohormone (1) Reference Standards (2) Sex Pheromone (1)
By Research Areas:	Cancer (1) Endocrinology (2) Infection (3) Inflammation/Immunology (4) Metabolic Disease (1) Neurological Disease (3)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0758

Troxipide	Calcium Channel	Inflammation/Immunology
Troxipide is an orally active defensive factor-enhancing therapeutic agent for gastritis and gastric ulcer (GU). Troxipide is a non-antisecretory gastro protective agent with antiulcer, anti-inflammatory and mucus-secreting properties .

HY-14127

R121919 5+ Cited Publications NBI30775	CRFR	Neurological Disease Endocrinology
R121919 (NBI30775) is a potent and selective CRF1R antagonist with a K_i of 2 to 5 nM. R121919 has antidepressant and anxiolytic effects. R121919 alleviates defensive withdrawal in rats .

HY-P0279

Systemin	Endogenous Metabolite	Others
Systemin, an 18-amino acid polypeptide, has been isolated from tomato leaves that is a powerful inducer of over 15 defensive genes.

HY-133620

7-Oxodehydroabietic acid	Insecticide	Infection
7-Oxodehydroabietic acid is a diterpene resin acid isolated from the roots of the pine Pinus densiflora. 7-Oxodehydroabietic acid play a defensive role against herbivorous insects via insect endocrine-disrupting activity .

HY-P10400

AtPep1	Phytohormone	Inflammation/Immunology
AtPep1 is a plant elicitor peptide. AtPep1 activates transcription of the defensive gene defensin (PDF1.2) and activates the synthesis of H₂O₂, which are components of the innate immune response against pathogens. AtPep1 can be isolated from extracts of Arabidopsis leaves .

HY-W698586

(R)-Lotaustralin	Drug Isomer	Others
(R)-Lotaustralin is a cyanogenic compound derived from Manihot Utilissima, playing a role in the plant's biological defense mechanism. When plant tissue is damaged, (R)-Lotaustralin is hydrolyzed by enzymes such as linamarase, releasing cyanide and thereby exerting a toxic defensive effect .

HY-N16472

Echiumine N-oxide	Endogenous Metabolite	Others
Echiumine N-oxide, a pyrrolizidine alkaloid related N-oxides (PANOs), is a plant secondary metabolite. Echiumine N-oxide can be isolated from Echium plantagineum. Echiumine N-oxide acts as a defensive role in plants, prevent plants from tissue death .

HY-B0758R

Troxipide (Standard)	Calcium Channel Reference Standards	Inflammation/Immunology
Troxipide (Standard) is the analytical standard of Troxipide. This product is intended for research and analytical applications. Troxipide is an orally active defensive factor-enhancing therapeutic agent for gastritis and gastric ulcer (GU). Troxipide is a non-antisecretory gastro protective agent with antiulcer, anti-inflammatory and mucus-secreting properties .

HY-115645

R121919 hydrochloride NBI30775 hydrochloride	CRFR	Neurological Disease Metabolic Disease
R121919 (NBI30775) hydrochloride is a potent and selective CRF1R antagonist with a K_i of 2 to 5 nM. R121919 hydrochloride has antidepressant and anxiolytic effects. R121919 hydrochloride alleviates defensive withdrawal in rats .

HY-114735

Mandelonitrile benzoate	Antibiotic	Infection
Mandelonitrile benzoate is a defensive secretion of millipedes that releases other chemicals during the cyanidation process in addition to hydrocyanic acid (HCN) and benzaldehyde. Several families of millipedes, including Polydesmidae, Paradoxosomatidae, and Euryuridae, have been shown to secrete phenols and guaiaeol, with one Paradoxosomatid also producing ethylbenzoic acid and benzoic acid. In addition, members of the Xystodesmidae family commonly produce three compounds: benzoic acid, mandelonitrile benzoate, and benzoyl cyanide. Benzoyl cyanide has not been previously discovered as a natural product. These additional natural products are discussed as defensive antipredator and antibiotic agents. Benzoyl cyanide appears to have anesthetic properties for some predators. The study provides a preliminary chemotaxonomic basis for distinguishing various taxonomic groups of millipedes.

HY-14127R

R121919 (Standard) NBI30775 (Standard)	CRFR Reference Standards	Neurological Disease Endocrinology
R121919 (Standard) is the analytical standard of R121919. This product is intended for research and analytical applications. R121919 (NBI30775) is a potent and selective CRF1R antagonist with a Ki of 2 to 5 nM. R121919 has antidepressant and anxiolytic effects. R121919 alleviates defensive withdrawal in rats .

HY-B0377G

Famotidine (GMP) MK-208 (GMP)	Histamine Receptor	Inflammation/Immunology Cancer
Famotidine GMP (MK-208 GMP) is Famotidine (HY-B0377) produced in GMP guideline. Famotidine GMP is a competitive histamine H2-receptor antagonist, inhibits gastric secretion, activates the gastric mucosal defensive mechanisms. Famotidine GMP ameliorates peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD/GORD) in rats model .

HY-E71103

(R)-Mandelonitrile oxidase	Biochemical Assay Reagents	Others
(R)-Mandelonitrile oxidase (EC 1.1.3.49) , characterized from the millipede Chamberlinius hualienensis, is segregated from its substrate, which is contained in special sacs. The sacs are ruptured during defensive behavior, allowing the enzyme and substrate to mix in special reaction chambers leading to production of the defensive chemical benzoyl cyanide.

HY-W995298

3-Methyltridecane	Sex Pheromone	Others
3-Methyltridecane is a secretion of metathoracic scent gland in Tessaratoma papillosa. 3-Methyltridecane has volatility. 3-Methyltridecane may serve as defensive allogens, alarm pheromones, and aggregation pheromones .

HY-182588

Circulin B	Bacterial HIV Dengue Virus	Infection
Circulin B is a macrocyclic plant cyclopeptide. Circulin B functions as a plant defense peptide and exhibits antibacterial and anti-HIV activities. Circulin B has high binding affinity for the envelope protein of dengue virus, showing potential anti-dengue virus activity. Circulin B can be used in studies related to dengue virus infection, human immunodeficiency virus infection and microbial infection .

Cat. No.	Product Name

HY-L059

Pyroptosis Compound Library	1,885 compounds
Programmed cell death pathways, including apoptosis, pyroptosis and necroptosis, are regulated by unique sets of host proteins that coordinate a variety of biological outcomes. Pyroptosis is a highly inflammatory form of programmed cell death that occurs most frequently upon infection with intracellular pathogens and is likely to form part of the antimicrobial response. This process promotes the rapid clearance of various bacterial, viral, fungal and protozoan infections by removing intracellular replication niches and enhancing the host's defensive responses. Pyroptosis has been widely studied in inflammatory and infection disease models. Recently, there are growing evidences that pyroptosis also plays an important role in the development of cancer, cardiovascular diseases and Metabolic disorder, etc. MCE designs a unique collection of 1,885 pyroptosis-related compounds mainly focusing on the key targets in the pyroptosis signaling pathway and can be used in the research of pyroptosis signal pathway and related diseases.

Pyroptosis Compound Library

1,885 compounds

Programmed cell death pathways, including apoptosis, pyroptosis and necroptosis, are regulated by unique sets of host proteins that coordinate a variety of biological outcomes. Pyroptosis is a highly inflammatory form of programmed cell death that occurs most frequently upon infection with intracellular pathogens and is likely to form part of the antimicrobial response. This process promotes the rapid clearance of various bacterial, viral, fungal and protozoan infections by removing intracellular replication niches and enhancing the host's defensive responses. Pyroptosis has been widely studied in inflammatory and infection disease models. Recently, there are growing evidences that pyroptosis also plays an important role in the development of cancer, cardiovascular diseases and Metabolic disorder, etc.

MCE designs a unique collection of 1,885 pyroptosis-related compounds mainly focusing on the key targets in the pyroptosis signaling pathway and can be used in the research of pyroptosis signal pathway and related diseases.

Famotidine (GMP) MK-208 (GMP)	Fluorescent Dye
Famotidine GMP (MK-208 GMP) is Famotidine (HY-B0377) produced in GMP guideline. Famotidine GMP is a competitive histamine H2-receptor antagonist, inhibits gastric secretion, activates the gastric mucosal defensive mechanisms. Famotidine GMP ameliorates peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD/GORD) in rats model .

Famotidine (GMP) MK-208 (GMP)	Biochemical Assay Reagents
Famotidine GMP (MK-208 GMP) is Famotidine (HY-B0377) produced in GMP guideline. Famotidine GMP is a competitive histamine H2-receptor antagonist, inhibits gastric secretion, activates the gastric mucosal defensive mechanisms. Famotidine GMP ameliorates peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD/GORD) in rats model .

Cat. No.	Product Name	Target	Research Area

HY-P0279

Systemin	Endogenous Metabolite	Others
Systemin, an 18-amino acid polypeptide, has been isolated from tomato leaves that is a powerful inducer of over 15 defensive genes.

HY-P10400

AtPep1	Phytohormone	Inflammation/Immunology
AtPep1 is a plant elicitor peptide. AtPep1 activates transcription of the defensive gene defensin (PDF1.2) and activates the synthesis of H₂O₂, which are components of the innate immune response against pathogens. AtPep1 can be isolated from extracts of Arabidopsis leaves .

Systemin	Natural Products other families Classification of Application Fields Other Diseases Solanum lycopersicum L. Solanaceae Plants Disease Research Fields Source Classification	Endogenous Metabolite
Systemin, an 18-amino acid polypeptide, has been isolated from tomato leaves that is a powerful inducer of over 15 defensive genes.

Echiumine N-oxide	Structural Classification Alkaloids Echium plantagineum L. Other Alkaloids Plants Boraginaceae Source Classification	Endogenous Metabolite
Echiumine N-oxide, a pyrrolizidine alkaloid related N-oxides (PANOs), is a plant secondary metabolite. Echiumine N-oxide can be isolated from Echium plantagineum. Echiumine N-oxide acts as a defensive role in plants, prevent plants from tissue death .

3-Methyltridecane	Structural Classification Natural Products Animals Source Classification	Sex Pheromone
3-Methyltridecane is a secretion of metathoracic scent gland in Tessaratoma papillosa. 3-Methyltridecane has volatility. 3-Methyltridecane may serve as defensive allogens, alarm pheromones, and aggregation pheromones .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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