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Results for "

Diabetes,Experimental autoimmune encephalomyelitis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (3) Acetyl-CoA synthetase (1) ADC Linker (2) ADC Payload (2) Adenosine Receptor (2) Adrenergic Receptor (2) AIM2 (2) Akt (7) ALCAM/CD166 (1) Aldehyde Dehydrogenase (ALDH) (1) Amino Acid Decarboxylase (2) Aminopeptidase (7) AMPK (1) Amyloid-β (5) Angiotensin-converting Enzyme (ACE) (4) Antibiotic (4) Antifolate (4) AP-1 (1) Apoptosis (26) Aquaporin (4) Arenavirus (2) Arginase (1) Arrestin (4) Aryl Hydrocarbon Receptor (1) ASK1 (1) Atg8/LC3 (1) Autophagy (13) Bacterial (8) Bcl-2 Family (1) BCL6 (2) Bcr-Abl (1) Beclin1 (1) Biochemical Assay Reagents (13) BMX Kinase (1) Btk (27) c-Fms (4) C-type Lectin-like Receptors (CTLRs) (1) Calcineurin (1) Calcium Channel (9) Cannabinoid Receptor (1) Carbonic Anhydrase (2) Caspase (5) Cathepsin (2) CCR (17) CD1 (1) CD19 (2) CD20 (5) CD22 (1) CD28 (4) CD3 (1) CD73 (1) CD74 (1) CDK (3) Chemerin Receptor (1) CHIKV (5) Cholecystokinin Receptor (1) Cholinesterase (ChE) (2) Complement System (8) COX (2) CRAC Channel (1) CTLA-4 (2) CXCR (12) Cyclic GMP-AMP Synthase (7) Cytochrome P450 (3) DAPK (1) Deubiquitinase (3) DGK (2) Dihydroorotate Dehydrogenase (2) DNA Alkylator/Crosslinker (2) DNA/RNA Synthesis (4) DOCK (2) Dopamine Receptor (2) Drug Derivative (7) Drug Intermediate (4) Drug Isomer (1) Drug Metabolite (3) Drug-Linker Conjugates for ADC (3) E1/E2/E3 Enzyme (1) EAAT (1) EBI2/GPR183 (2) EBV (2) Endogenous Metabolite (20) Enterovirus (1) Environmental Pollutants (1) Epigenetic Reader Domain (7) ERK (8) Estrogen Receptor/ERR (3) Eukaryotic Initiation Factor (eIF) (1) FAAH (1) FABP (1) Fc Receptor (FcR) (10) FLT3 (2) FOXO (1) Fungal (1) FXR (2) G Protein-coupled Receptor Kinase (GRK) (2) GCGR (1) Glucocorticoid Receptor (9) GLUT (1) Glutaminase (4) Glycosyltransferase (1) GPR84 (1) GSK-3 (1) HCV Protease (1) HDAC (2) Histamine Receptor (11) Histone Acetyltransferase (2) Histone Methyltransferase (4) HIV (1) HSV (1) IFNAR (21) iGluR (1) IKK (5) IMPDH (1) Indoleamine 2,3-Dioxygenase (IDO) (3) Influenza Virus (11) Insulin Receptor (2) Integrin (9) Interleukin Related (85) IRAK (15) IRE1 (2) Isotope-Labeled Compounds (15) Itk (3) JAK (54) JNK (6) Keap1-Nrf2 (2) LDLR (1) Ligands for Target Protein for PROTAC (1) Lipocalin Family (2) Liposome (4) Lipoxygenase (2) LPL Receptor (37) LRRK2 (2) LYTACs (1) MAGL (2) MALT1 (2) MAP3K (2) MAPKAPK2 (MK2) (1) Mas-related G-protein-coupled Receptor (MRGPR) (4) MEK (3) Melatonin Receptor (2) METTL3 (2) MHC (8) Mitochondrial Metabolism (4) MMP (5) Molecular Glues (7) Monoamine Oxidase (1) mRNA (3) mTOR (2) Myosin (1) Na+/K+ ATPase (5) nAChR (2) NAMPT (1) Necroptosis (2) NEKs (2) NF-κB (25) NO Synthase (3) NOD-like Receptor (NLR) (6) Notch (5) Nuclear Factor of activated T Cells (NFAT) (3) Nuclear Hormone Receptor 4A/NR4A (1) Opioid Receptor (1) Orexin Receptor (OX Receptor) (1) Organoid (1) P-glycoprotein (2) p38 MAPK (18) Parasite (8) PARP (1) PD-1/PD-L1 (7) PDHK (2) Peptide-Drug Conjugates (PDCs) (1) Phosphatase (6) Phosphodiesterase (PDE) (8) Phospholipase (3) Phosphorylase (2) PI3K (15) PIKfyve (2) Pim (1) PKC (8) Potassium Channel (15) PPAR (1) Prostaglandin Receptor (2) PROTACs (12) Protease Activated Receptor (PAR) (1) Proteasome (7) Protein Arginine Deiminase (8) Pyk2 (1) Pyroptosis (1) Pyruvate Kinase (1) Radionuclide-Drug Conjugates (RDCs) (1) Raf (1) Ras (2) Reactive Oxygen Species (ROS) (5) Reference Standards (29) RET (1) REV-ERB (3) RIP kinase (6) ROCK (3) ROR (22) Salt-inducible Kinase (SIK) (1) SARS-CoV (7) Ser/Thr Protease (3) SHP1 (1) SHP2 (1) SLC39 (Zinc Transporter) (1) Smo (1) Src (5) STAT (16) STING (20) Succinate Receptor 1 (1) Syk (3) TAM Receptor (4) Tau Protein (1) TGF-beta/Smad (1) TGF-β Receptor (2) Thyroid Hormone Receptor (1) Tim3 (1) TNF Receptor (46) Toll-like Receptor (TLR) (20) Transmembrane Glycoprotein (13) Trk Receptor (1) TRP Channel (6) Tyrosinase (5) VD/VDR (4) VEGFR (1) Wnt (1) γ-secretase (2)
By Research Areas:	Cancer (220) Cardiovascular Disease (44) Endocrinology (11) Infection (48) Inflammation/Immunology (701) Metabolic Disease (47) Neurological Disease (91)
Click Chemistry:	Azide (2) Alkynes (3)
Oligonucleotides:	Aptamers (1) CpG ODNs (2) mRNA (3) Cationic Lipids (3) Adjuvant (3) Antisense Oligonucleotides (2) Cholesterol (1) Interleukin & Receptors (3)

754

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-153808

Complete Freund's adjuvant (CFA) Maximum Cited Publications 15 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
Complete Freund's adjuvant (CFA) is an immunoadjuvant emulsified with antigen by its discoverer Jules T. Freund to enhance an animal's immune response to an antigen. Complete Freund's adjuvant (CFA) is also an inducer of the Th1 immune response and a ligand of TLRs. Complete Freund's adjuvant (CFA) contains heat-killed inactive tuberculosis bacilli and consists of a paraffin oil-in-water emulsion. Complete Freund's adjuvant (CFA) stimulates a strong and durable immune response and can be used to induce persistent inflammatory pain models in mice, experimental autoimmune myocarditis (EAM) models, and more. Incomplete Freund's adjuvant (IFA) (HY-153808A) is another type of Freund's Adjuvant that stimulates a weaker immune response .

HY-A0124A

Sapropterin dihydrochloride 2 Publications Verification (6R)-BH4 dihydrochloride; (6R)-Tetrahydro-L-biopterin dihydrochloride	Endogenous Metabolite	Infection Metabolic Disease Inflammation/Immunology
Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) dihydrochloride is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin dihydrochloride can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin dihydrochloride can aggravate experimental autoimmune encephalomyelitis (EAE) .

HY-P3719

MOG(35-55) amide, mouse, rat 1 Publications Verification	CCR	Inflammation/Immunology
MOG (35-55) amide, mouse, rat the terminal amidation form of the 35-55 fragment of the myelin oligodendrocyte glycoprotein (MOG) immunogenic peptide (MOG (35-55) (HY-P1240)). MOG(35-55) amide, mouse, rat can be used for experimental autoimmune encephalomyelitis (EAE) modeling .

HY-B1462

Chlorzoxazone 3 Publications Verification	Cytochrome P450 Potassium Channel FOXO Amyloid-β	Neurological Disease Inflammation/Immunology
Chlorzoxazone is a SK-type potassium channel activator. Chlorzoxazone modulates FOXO3 phosphorylation and Aβ. Chlorzoxazone enhances immunosuppression, attenuates vasoconstriction, attenuates cognitive deficits, and improves experimental autoimmune encephalomyelitis .

HY-N2279

Kurarinone 5 Publications Verification	Eukaryotic Initiation Factor (eIF)	Inflammation/Immunology Cancer
Kurarinone is an orally active flavonoid isolated from matrine that inhibits the pathogenesis of experimental autoimmune encephalomyelitis by inhibiting cell differentiation of Th1 and Th17. Kurarinone has antitumor and anti-inflammatory activity .

HY-168625

VAV1 degrader-3	Molecular Glues	Inflammation/Immunology
VAV1 degrader-3 (Example 185) is an orally active VAV1 molecular glue degrader (DC₅₀: 7 nM). VAV1 degrader-3 reduces immune cell activation, immune cell proliferation and the production of various cytokines. VAV1 degrader-3 can be used for research of inflammatory or autoimmune disorder. VAV1 degrader-3 inhibits disease progression in experimntal autoimmune encephalomyelitis (EAE) mouse model, Collagen-induced arthritis (CIA) mouse model, etc. .

HY-101254

Luzindole 15+ Cited Publications N-0774	Melatonin Receptor	Neurological Disease
Luzindole (N-0774) is a selective melatonin receptor antagonist. Luzindole preferentially targets MT2 (Mel_1b) over MT1 (Mel_1a) with K_i values of 10.2 and 158 nM for human MT2 and MT1, respectively. Luzindole suppresses experimental autoimmune encephalomyelitis (EAE), and exerts antidepressant-like activity .

HY-B0157

Ketotifen 3 Publications Verification HC 20-511	Endogenous Metabolite Histamine Receptor SARS-CoV Influenza Virus	Infection Inflammation/Immunology Endocrinology Cancer
Ketotifen (HC 20-511) is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

HY-17606

Cenerimod ACT-334441	LPL Receptor	Inflammation/Immunology
Cenerimod (ACT-334441) is a potent, selective and orally active S1P1 receptor modulator, with an EC₅₀ of 1 nM. Cenerimod shows more than 36 fold selctivity for hS1P1 over hS1P2, hS1P3, hS1P4, and hS1P5 receptor subtypes (EC₅₀s=>10000, 228, 2134, and 36 nM, respectively). Cenerimod can attenuate murine experimental autoimmune encephalomyelitis (EAE) and murine sclerodermatous .

HY-B0157A

Ketotifen fumarate 3 Publications Verification HC 20511 fumarate	Histamine Receptor Endogenous Metabolite SARS-CoV Influenza Virus	Inflammation/Immunology Endocrinology Cancer
Ketotifen (HC 20-511) fumarate is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen fumarate can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen fumarate also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen fumarate can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

HY-Y0344J

Sodium chloride, for molecular biology 3 Publications Verification Halite, for molecular biology	Biochemical Assay Reagents Na+/K+ ATPase Interleukin Related	Inflammation/Immunology Cancer
Sodium chloride is an orally active salt. Sodium chloride induces the expression of ATP1A1. Sodium chloride induces the pro-inflammatory cytokines IL-2, TNFα, IL-9 and several chemokines. Sodium chloride enhances the anti-tumor activities of Digoxin (HY-B1049) against small cell lung cancer. Sodium chloride drives autoimmune disease by the induction of pathogenic Th17 cells .

HY-P10936A

AQP4 (201-220) TFA	Aquaporin	Neurological Disease Inflammation/Immunology
AQP4 (201-220) TFA is an encephalitogenic epitope of AQP-4. AQP4 (201-220) TFA can induce experimental autoimmune encephalomyelitis (EAE) (characterized by midline lesions in the brain, retinal pathology, and lesions at the grey matter/white matter border zone in the spinal cord). AQP-4 is a target antigen in neuromyelitis optica .

HY-N8441

Neriifolin 17β-Neriifolin	Atg8/LC3 Na+/K+ ATPase Apoptosis Beclin1	Cardiovascular Disease Inflammation/Immunology Cancer
Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na ⁺, K ⁺-ATPase. Neriifolin can target beclin 1, inhibits the formation of LC3-associated phagosomes and ameliorates experimental autoimmune encephalomyelitis (EAE) development. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells ^[2.

HY-P990155

Anti-Mouse TIGIT Antibody (1G9)	Transmembrane Glycoprotein	Others
Anti-Mouse TIGIT Antibody (1G9) is a mouse-derived agonistic TIGIT IgG1 κ type antibody. Anti-Mouse TIGIT Antibody (1G9) blocks CD155 binding to TIGIT. Anti-Mouse TIGIT Antibody (1G9) shows potent anti-infection and anti-immune effects in septic and experimental autoimmune encephalomyelitis .

HY-109520

Glatiramer acetate 2 Publications Verification	MHC	Inflammation/Immunology Cancer
Glatiramer acetate, a synthetic analogue of myelin basic protein and an immunomodulating agent, inhibits Experimental autoimmune encephalomyelitis (EAE), and can be used for the research of multiple sclerosis. Glatiramer acetate exhibits strong and promiscuous binding to MHC molecules and consequent competition with various myelin antigens for their presentation to T cells. A further aspect of its action is potent induction of specific suppressor cells of the T helper 2 (Th2) type that migrate to the brain and lead to in situ bystander suppression .

HY-P1587

IRBP (1-20), human	MHC	Inflammation/Immunology
IRBP (1-20), human contains a major epitope for the H-2 ^b haplotype. IRBP (1-20), human induces experimental autoimmune uveoretinitis (EAU) in H-2 ^b mice .

HY-18166

NIBR0213	LPL Receptor	Inflammation/Immunology
NIBR-0213 is a potent, orally active and selective S1P1 antagonist with efficacy in experimental autoimmune encephalomyelitis. NIBR-0213 displays potent and comparable potency on human and rat S1P1 (IC₅₀ of 2.0 nM and 2.3 nM, respectively) in GTPγ ³⁵S assays .

HY-108039

Bezisterim HE 3286; NE-3107	NF-κB	Neurological Disease Metabolic Disease Inflammation/Immunology
Bezisterim (HE 3286; NE-3107) is a synthetic derivative of a natural anti-inflammatory steroid, β-AET. Bezisterim is an orally active partial NF-κB inhibitor. HE3286 reduces proinflammatory signals, including IL-6 and matrix metallopeptidase 3. Bezisterim freely penetrates the blood brain barrier in mice. Bezisterim can be used for the research of the ulcerative colitis, arthritis, experimental autoimmune encephalomyelitis . Bezisterim is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-148103

SR12418	REV-ERB	Inflammation/Immunology
SR12418 is a REV-ERB-specific synthetic ligand with IC₅₀s of 68 nM and 119 nM for REV-ERBα and REV-ERBβ, respectively. SR12418 can be used in experimental autoimmune encephalomyelitis (EAE) and colitis research .

HY-117213

Ex26 S1P1-IN-Ex26	LPL Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology
Ex26 (S1P1-IN-Ex26) is a potent and selective sphingosine 1-phosphate receptor 1 (S1P₁) antagonist (IC₅₀=0.93 nM). Ex26 shows >3,000-fold selectivity for S1P₁ over other Sphingosine 1-phosphate receptors. Ex26 can be used in experimental autoimmune encephalomyelitis reseach .

HY-126328

PKC-theta inhibitor 1	PKC Interleukin Related	Inflammation/Immunology
PKC-theta inhibitor 1 is an orally active and selective ATP-competitive inhibitor of Protein Kinase Cθ (PKCθ), with a K_i value of 6 nM. PKC-theta inhibitor 1 inhibits T-cell-mediated inflammatory responses by suppressing the release of proinflammatory cytokines (IL-2 IC₅₀ = 0.21 μM in anti-CD3/CD28-stimulated PBMCs; IL-17 IC₅₀ = 1 μM in CD3/CD28-stimulated Th17 cells) PKC-theta inhibitor 1 significantly reduces symptoms in mice with ongoing experimental autoimmune encephalomyelitis (EAE). PKC-theta inhibitor 1 can be used for the study of T-cell-mediated inflammatory diseases such as multiple sclerosis .

HY-W010144

Phenidone	COX Lipoxygenase	Cardiovascular Disease Inflammation/Immunology
Phenidone, an orally active dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), ameliorates rat paralysis in experimental autoimmune encephalomyelitis. Phenidone is a potent hypotensive agent in the spontaneously hypertensive rat . Phenidone is used as a photographic developer .

HY-176566

H-151 Alkyne	STING	Inflammation/Immunology
H-151 Alkyne (Compound H-151-AL) is a selective STING (Stimulator of interferon genes) inhibitor. H-151 Alkyne is promising for research of autoimmune diseases such as systemic lupus erythematosus, scleroderma, and autoinflammatory diseases .

HY-103333

Arvanil N-Vanillylarachidonamide	TRP Channel Cannabinoid Receptor CD74 Akt Orexin Receptor (OX Receptor)	Neurological Disease Inflammation/Immunology
Arvanil (N-Vanillylarachidonamide) is a mixed agonist of CB1 and TRPV1 receptors. Arvanil downregulates CD25, HLA-DR, CD134/OX40, blocks G1/S phase transition, and induces phosphorylation of Akt. Arvanil does not induce apoptosis in cells. Arvanil inhibits lymphocyte activation and ameliorates autoimmune encephalomyelitis. Arvanil can be used in research related to Huntington's disease, vomiting, and multiple sclerosis .

HY-153245

JNJ-64264681	Btk	Inflammation/Immunology Cancer
JNJ-64264681 is a potent, orally active, selective and irreversible covalent BTK inhibitor. JNJ-64264681 exhibits good pharmacokinetic characteristics and can be used for cancer and autoimmune diseases research .

HY-139203

IL-17 modulator 3	Interleukin Related	Inflammation/Immunology Cancer
IL-17 modulator 3 is an IL-17 modulator (US20200247785A1). IL-17 modulator 3 can be used for the research of inflammation, cancer and autoimmune diseases .

HY-P10936

AQP4 (201-220)	Aquaporin	Neurological Disease Inflammation/Immunology
AQP4 (201-220) is an encephalitogenic epitope of AQP-4. AQP4 (201-220) can induce experimental autoimmune encephalomyelitis (EAE) (characterized by midline lesions in the brain, retinal pathology, and lesions at the grey matter/white matter border zone in the spinal cord). AQP-4 is a target antigen in neuromyelitis optica .

HY-158417

KSI-6666	LPL Receptor	Inflammation/Immunology
KSI-6666 is an orally active, competitive antagonist for sphingosine 1-phosphate receptor 1 (S1PR1), with an IC₅₀ of 6.4 nM. KSI-6666 exhibits anti-inflammatory efficacy in autoimmune encephalomyelitis model and T cell transfer colitis model .

HY-A0124

Sapropterin (6R)-BH4; (6R)-Tetrahydro-L-biopterin	Endogenous Metabolite	Infection Metabolic Disease Inflammation/Immunology
Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin can aggravate experimental autoimmune encephalomyelitis (EAE) .

HY-B1084

Cinoctramide	Drug Intermediate	Others
Cinoctramide is an intermediate of pharmaceutical synthesis. Cinoctramide can be used for the research of autoimmune diseases .

HY-119245

Udifitimod BMS-986166	LPL Receptor	Inflammation/Immunology
Udifitimod (BMS-986166) is a potent, selective and orally active S1P1R modulator. Udifitimod has the potential for the research of autoimmune diseases .

HY-46225

DEX-maleimide	Drug Intermediate	Inflammation/Immunology
DEX-maleimide is a coupling agent that can be used to synthesize conjugates containing single-domain antibodies (VHH) conjugated with antigens and anti-inflammatory agents. DEX-maleimide can be used for research on autoimmune diseases .

HY-157807

Prostaglandin E2-biotin	Nuclear Hormone Receptor 4A/NR4A	Inflammation/Immunology Cancer
Prostaglandin E2-biotin is a prostaglandin analog. Prostaglandin E2-biotin can be used for research of Nurr1-related disease, such as cancer and autoimmune disease .

HY-154956

PIKfyve-IN-2	PIKfyve	Inflammation/Immunology Cancer
PIKfyve-IN-2 is a potent PIKfyve kinase inhibitor and can be used for cancers, autoimmune disorders research .

HY-142042

3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles	MEK TGF-beta/Smad	Neurological Disease Inflammation/Immunology Cancer
3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles is an inhibitor for bone morphogenetic protein 2 (BMP2) with an IC₅₀ of 2.2 μM. 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles is inhibitor for mitogen-activated protein kinase 1 (MEK1). 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles exhibits anti-inflammatory and neuroprotective activity in EAE mouse model .

HY-111021

ASP-4058 1 Publications Verification	LPL Receptor	Inflammation/Immunology
ASP-4058 is a next-generation, selective and oral bioactive agonist for Sphingosine 1-Phosphate receptors 1 and 5 (S1P₁ and S1P₅), ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile .

HY-115566

S1PL-IN-1	LPL Receptor Smo	Inflammation/Immunology
S1PL-IN-31 (compound ) is an oral active sphingosine-1-phosphate (S1P) lyase inhibitor with the IC₅₀ of 210 nM. S1PL-IN-31 is Smoothened receptor antagonist with the IC₅₀ of 440 nM. S1PL-IN-31 can be used for study of experimental autoimmune encephalomyelitis .

HY-P990808

Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1)	Interleukin Related	Infection Metabolic Disease Inflammation/Immunology Cancer
Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1) is a rat-derived IgG2b κ type antibody inhibito, targeting to mouse CD122/IL-2Rβ. Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1) can block IL-2 and IL-15. Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1) can deplete natural killer (NK) cells and NKT cells. Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1) can be used for the researches of cancer, infection, inflammation, immunology and metabolic disease, such as melanoma, experimental autoimmune encephalomyelitis (EAE) and diabetes .

HY-N11451

Lacto-N-fucopentaose III LNFP-III	Arginase Aldehyde Dehydrogenase (ALDH) Indoleamine 2,3-Dioxygenase (IDO)	Inflammation/Immunology
Lacto-N-fucopentaose III (LNFP-III) is an immune modulator. Lacto-N-fucopentaose III reduces the severity of experimental autoimmune encephalomyelitis (EAE) and CNS inflammation .

HY-N11286

Tridocosahexaenoylglycerol TG-DHA; Meganol D	Others	Neurological Disease Metabolic Disease Inflammation/Immunology
Tridocosahexaenoylglycerol (TG-DHA) is an orally active dietary supplement that improves autoimmune encephalomyelitis in mice. Tridocosahexaenoylglycerol shows beneficial effects on neurodegenerative diseases and also improves macular function in diabetic retinopathy. Tridocosahexaenoylglycerol can be used for research on neurological diseases, inflammatory immune diseases, and metabolic diseases .

HY-170409

BNN27	Trk Receptor Apoptosis	Neurological Disease Inflammation/Immunology
BNN27 is the agonist for TrkA receptor and p75NTR receptor, that exhibits neurotrophic and anti-apoptotic effects. BNN27 increases the levels of glutamate, GABA, and glutamine in the rat hippocampus and prefrontal cortex, improves glutamate turnover. BNN27 exhibits neuroprotective efficacy in mouse amyotrophic lateral sclerosis (ALS) model, exhibits anti-inflammatory efficacy in experimental autoimmune encephalomyelitis (EAE) model, exhibits retinal protective efficacy in rat diabete models. BNN27 is blood-brain barrier penetrable .

HY-P1409A

ADWX 1 TFA 1 Publications Verification	Potassium Channel	Inflammation/Immunology
ADWX 1 TFA is a new peptide inhibitor that is potent and selective for Kv1.3 with an IC₅₀ value of 1.89 pM. ADWX 1 inhibits Kv1.3 channel activity specifically to inhibit both the initial calcium signaling and NF-κB activation. ADWX 1 TFA ameliorates the disease in rats of experimental autoimmune encephalomyelitis (EAE) models. ADWX 1 TFA can be used to study T cell-mediated autoimmune diseases .

HY-134919

CU-76	Cyclic GMP-AMP Synthase	Inflammation/Immunology
CU-76 is an inhibitor for human cyclic GMP-AMP synthase (hcGAS) with an IC₅₀ of 0.24 μM. CU-76 selectively inhibits the DNA pathway in human cells, and can be used in autoimmune research .

HY-151805

RGT-068A	MALT1	Inflammation/Immunology
RGT-068A is a MALT1 inhibitor with oral bioavailability. RGT-068A inhibits MALT1 activity. RGT-068A can be used for the research of autoimmune diseases .

HY-P5966

Myelin Oligodendrocyte Glycoprotein (40-54), Rat, Mouse MOG (40-54)	MHC	Inflammation/Immunology
Myelin Oligodendrocyte Glycoprotein (40-54), Rat, Mouse (MOG (40-54)) is a CD8-related self-antigenic epitope of the myelin oligodendrocyte glycoprotein (MOG) protein and is presented in association with H-2Db .

HY-P991682

Emzotamig	TNF Receptor	Inflammation/Immunology
Emzotamig is a monoclonal antibody inhibitor targeting tumor necrosis factor (TNF). Emzotamig is promising for research of autoimmune diseases associated with TNF overexpression, such as rheumatoid arthritis and ankylosing spondylitis .

HY-P991658

Gerilimzumab ARGX-109; GB224; RYI-008	Interleukin Related	Inflammation/Immunology
Gerilimzumab (GB224) is a humanized monoclonal antibody inhibitor targeting interleukin-6 (IL-6). Gerilimzumab is promising for research of autoimmune diseases such as rheumatoid arthritis .

HY-158374

BIO-8169	IRAK	Inflammation/Immunology
BIO-8169 is a selective inhibitor for interleukin receptor-associated kinase 4 (IRAK 4), with an IC₅₀ of 0.23 nM. BIO-8169 exhibits good pharmacokinetic character, reduces the production of pro-inflammatory cytokines, and attenuates the autoimmune encephalomyelitis in EAE mice model. BIO-8169 exhibits good blood brain penetrant with a rat Kpu,u of 0.7 .

HY-P11553

ECL1i	CCR	Inflammation/Immunology
ECL1i is an allosteric, selective CCR2 inhibitor. ECL1i specifically inhibits CCL2-/CCR2-mediated chemotaxis. ECL1i interferes with CCR2-positive cell recruitment and attenuates disease progression in experimental autoimmune encephalomyelitis .

HY-P3248

J5 peptide Myelin basic protein (85-99) antagonist	Biochemical Assay Reagents	Inflammation/Immunology
J5 peptide is an MBP inhibitor that competitively inhibits the binding of MBP_85-99 to HLA-DR2. J5 peptide alleviates PLP_139-151/MBP_85-99-induced experimental autoimmune encephalomyelitis (EAE) in mice. J5 peptide can be used in research on inflammatory and immune diseases .

Cat. No.	상품명

HY-L156

Autoimmune Disease Compound Library

958 compounds

Autoimmune disease is a pathological disease characterized by inflammatory disorders targeting autoantigens. The routine treatment of autoimmune diseases suppresses general immune function to regulate uncontrolled inflammation. The current targeted immunotherapy suppresses the main pro-inflammatory signaling pathways by blocking inflammatory cytokines, cell surface molecules, and intracellular kinases. As key participants in innate immunity, macrophages and dendritic cells (DCs) are crucial for Ag presentation and pro-inflammatory cytokine production, such as TNF and IL-1 β、 IL-6, IL-23, B cell activating factor (BAFF), and the proliferation-inducing ligand (APRIL, also known as TNFSF13A).

MCE designs a unique collection of 958 autoimmune disease-related compounds, covering multiple targets and subtypes, such as TNF Receptor, IFNAR, JAK, Btk, TLR, IL-6, IL-17, IL-23, etc. It is a useful tool for screening autoimmune disease drugs.

HY-L164

Serine/Threonine Kinase Inhibitor Library

2,162 compounds

Protein serine/threonine kinases (PSKs) are protein kinases that use ATP as a high-energy donor molecule to transfer phosphate groups to serine/threonine residues of target protein. As an important signal transduction regulator, serine/threonine kinases can affect the function of target proteins by disrupting enzyme activity or binding of target proteins to other proteins. Serine/threonine kinases are involved in the regulation of immune response, cell proliferation, differentiation, apoptosis and other physiological processes. Serine/threonine kinase inhibitors are an important class of compounds that have been widely studied in cancer, chronic inflammation, autoimmune diseases, aging and other diseases.

MCE designs a unique collection of 2,162 serine/threonine kinase inhibitors, mainly targeting the receptor PKA, Akt, PKC, MAPK/ERK, etc, which is an effective tool for development and research of anti-cancer, anti-chronic inflammatory diseases, anti-autoimmune diseases and anti-aging compounds.

HY-L161

Cytokine Inhibitors Library

1,332 compounds

Cytokines are a kind of low molecular soluble proteins synthesized and secreted by immunogen, mitogen or other factors. They have functions of regulating innate and adaptive immune responses, promoting hematopoiesis, stimulating cell activation, proliferation and differentiation. The process of releasing a large number of cytokines is also called “Cytokine storm”, which can cause damage to many tissues and organs in the body. Cytokine is involved in the pathogenesis of many human diseases, including cancer, diabetes, chronic inflammatory diseases and so on. Cytokine inhibitors are a class of essential compounds that act by directly inhibiting the synthesis and release of cytokine or blocking the binding of cytokine to their receptors. Cytokine inhibitors are important compounds for the study of tumor and autoimmune diseases.

MCE designs a unique collection of 1,332 cytokine inhibitors, mainly targeting the receptor interleukin (IL), colony-stimulating factor (CSF), interferon (IFN), tumor necrosis factor (TNF), growth factor (GF) and chemokine, which is an effective tool for development and research of anti-cancer, anti-chronic inflammatory diseases and anti-autoimmune diseases compounds.

HY-L210

Anti-Rheumatic Arthritis Compound Library

1,883 compounds

Rheumatoid Arthritis (RA) is a autoimmune disease characterized by persistent joint inflammation. The pathology of RA includes immune cell infiltration, synovial lining proliferation, pannus formation, and the destruction of joint cartilage and bone, which is highly disabling. Due to long-term chronic inflammation, RA not only severely affects the quality of life of patients but can also damage multiple organs, leading to lung diseases, cardiovascular diseases, and malignant tumors. The pathogenesis of RA is complex, involving genetic, environmental, and immune factors. With the advancement of high-throughput screening technology, screening for compounds targeting JAK, CCR, MEK, MMP targets may contribute to the development of more effective drugs against Rheumatoid Arthritis (RA).

MCE has collected 1,883 small molecule compounds with definite or potential anti-rheumatoid arthritis activity. This library is of significant value for researching the anti-RA drugs.

HY-L024

Histone Modification Research Compound Library

904 compounds

A histone modification, a covalent post-translational modification (PTM) to histone proteins, includes methylation, phosphorylation, acetylation, ubiquitylation, and sumoylation, etc. In general, histone modifications are catalyzed by specific enzymes that act predominantly at the histone N-terminal tails involving amino acids such as lysine or arginine, as well as serine, threonine, tyrosine, etc. The PTMs made to histones can impact gene expression by altering chromatin structure or recruiting histone modifiers. Histone modifications act in diverse biological processes such as transcriptional activation/inactivation, chromosome packaging, and DNA damage/repair. Deregulation of histone modification contributes to many diseases, including cancer and autoimmune diseases.

MCE owns a unique collection of 904 bioactive compounds targeting Epigenetic Reader Domain, HDAC, Histone Acetyltransferase, Histone Demethylase, Histone Methyltransferase, Sirtuin, etc. Histone Modification Research Compound Library is a useful tool for histone modification research and drug screening.

HY-L007

Immunology/Inflammation Compound Library

7,846 compounds

The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, and distinguish them from the organism's own healthy tissue. Inflammation is also the body's attempt at self-protection to remove harmful stimuli and begin the healing process. It’s part of the body's immune response. The immune system recognizes damaged cells, irritants, and pathogens, and inflammation begins the healing process. Inflammatory abnormalities are a large group of disorders that underlie a vast variety of human diseases. The immune system is often involved with inflammatory disorders, demonstrated in both allergic reactions and some myopathies, with many immune system disorders resulting in abnormal inflammation.

MCE designs a unique collection of 7,846 compounds that are useful tool for Immunology/Inflammation research or autoimmune inflammatory diseases drug discovery.

HY-L175

Inflammasomes related Compound Library

163 compounds

Inflammasomes are classic pattern recognition receptors for natural immune responses. Inflammasomes are polymeric protein complexes that regulate inflammatory responses and pyrolytic cell death, thereby exerting the host's defense against microorganisms. Inflammasomes sensors are associated with adapter proteins, activating inflammatory caspase-1, releasing inflammatory cytokines and inducing cell death, endowing the host with defense against pathogens. NLRP1, NLRP3, NLRC4, AIM2, and pyrin are considered typical inflammasomes because they convert cysteine asparaginase-1 into catalytically active capsaicin-1. In addition to infectious diseases, the importance of inflammasomes is also related to various clinical diseases, such as autoimmune diseases, neurodegeneration and metabolic disorders, and the development of cancer. Therefore, it is necessary to strictly regulate the activation and function of inflammasomes to avoid accidental host tissue damage while inducing pathogens to kill the inflammatory response.

MCE designs a unique collection of 163 inflammasomes related compounds. It is a good tool to be used for research on Inflammation, cancer and other diseases.

HY-L237

Pattern Recognition Receptors Library

313 compounds

Pattern Recognition Receptors (PRRs) are a crucial class of protein molecules expressed in cells of the innate immune system. The core function of Pattern Recognition Receptors is to recognize Pathogen-Associated Molecular Patterns (PAMPs) and Damage-Associated Molecular Patterns (DAMPs). Upon recognizing and binding to PAMPs or DAMPs, PRRs rapidly initiate intracellular signaling pathways (such as the NF-κB, IRF, and inflammasome pathways). This triggers the production of inflammatory factors, chemokines, and type I interferons, thereby initiating inflammatory responses to eliminate pathogens or repair damage. PRRs represent the body's first line of defense against infection, and the rapidity and broad specificity of their response are crucial for host survival. However, aberrant activation of PRR signaling is also a cause of many chronic inflammatory diseases, autoimmune disorders, and neurodegenerative diseases. Therefore, precisely regulating PRR activity has become a key therapeutic strategy for these conditions.

MCE has cataloged 313 inhibitors targeting key PRRs, such as NLRs, TLRs, C-type Lectin Receptors (CLRs), and cGAS, to support drug discovery efforts for chronic inflammatory diseases.

HY-L934

CRBN Ligand Library

125 compounds

CRBN, namely cereblon, is the substrate recognition subunit of the E3 ubiquitin ligase complex in the ubiquitin-proteasome system. A CRBN ligand library refers to a collection of numerous fragments that can specifically bind to the CRBN protein.

These ligands are mostly designed based on validated CRBN-binding warheads and modified through AI-driven molecular generation optimization systems. They not only include classic lenalidomide-derived structures but also cover novel non-lenalidomide scaffolds. After drug-likeness filtering, these ligands exhibit structural diversity and favorable druggable properties. They can be further optimized and modified to facilitate the development of novel molecular glue degraders, accelerate the discovery of molecular glues that induce interactions between CRBN and new substrate proteins, and enable the exploration of novel CRBN substrates for identifying previously unknown CRBN-binding proteins.

MCE compiles 125 fragments that can specifically bind to the CRBN protein, with molecular weights ranging from 200 to 500. Compounds developed based on the library ligands target multiple disease targets such as cancer and autoimmune diseases, further advancing the development of Molecular Glues and PROTACs therapeutic agents.

HY-L014

NF-κB Signaling Compound Library

1,670 compounds

Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB. These proteins function as dimeric transcription factors that regulate the expression of genes and influence a broad range of biological processes including innate and adaptive immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis. NF-κB plays a key role in regulating the immune response to infection. In addition, activation of the NF-κB pathway is involved in the pathogenesis of chronic inflammatory diseases, such as asthma, rheumatoid arthritis, and inflammatory bowel disease. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development.

MCE owns a unique collection of 1,670 small molecule compounds that can be used in the research of NF-κB signaling pathway or high throughput screening (HTS) related drug discovery.

Cat. No.	상품명	Type

HY-Y0344D

Sodium chloride, for cell culture

3 Publications Verification

Halite, for cell culture

Biochemical Assay Reagents

Sodium chloride, for cell culture is an orally active salt. Sodium chloride, for cell culture induces the expression of ATP1A1. Sodium chloride, for cell culture induces the pro-inflammatory cytokines IL-2, TNFα, IL-9 and several chemokines. Sodium chloride, for cell culture enhances the anti-tumor activities of Digoxin (HY-B1049) against small cell lung cancer. Sodium chloride, for cell culture drives autoimmune disease by the induction of pathogenic Th17 cells .

HY-Y0344J

Sodium chloride, for molecular biology

3 Publications Verification

Halite, for molecular biology

Biochemical Assay Reagents

Sodium chloride is an orally active salt. Sodium chloride induces the expression of ATP1A1. Sodium chloride induces the pro-inflammatory cytokines IL-2, TNFα, IL-9 and several chemokines. Sodium chloride enhances the anti-tumor activities of Digoxin (HY-B1049) against small cell lung cancer. Sodium chloride drives autoimmune disease by the induction of pathogenic Th17 cells .

HY-14519B

Methotrexate hydrate Maximum Cited Publications 76 Publications Verification Amethopterin hydrate; CL14377 hydrate; WR19039 hydrate	Biochemical Assay Reagents
Methotrexate hydrate is a substance that affects cell growth and division. It is commonly used to fight certain diseases, especially cancer and autoimmune diseases. It works by inhibiting the process by which cells synthesize DNA.

HY-Y0344I

Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al

3 Publications Verification

Halite, meets analytical specification of Ph. Eur. BP USP

Biochemical Assay Reagents

Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al, an inorganic salt is an orally active salt. Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al, an inorganic salt induces the expression of ATP1A1. Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al, an inorganic salt induces the pro-inflammatory cytokines IL-2, TNFα, IL-9 and several chemokines. Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al, an inorganic salt enhances the anti-tumor activities of Digoxin (HY-B1049) against small cell lung cancer. Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al, an inorganic salt drives autoimmune disease by the induction of pathogenic Th17 cells .

HY-125139

omega-3 Arachidonic acid ethyl ester, in ethanol, 98%

ω-3 Arachidonic acid ethyl ester, in ethanol, 98%; (all-Z)-8,11,14,17-Eicosatetraenoic acid ethyl ester, in ethanol, 98%

Biochemical Assay Reagents

omega-3 Arachidonic acid ethyl ester, in ethanol, 98% is a rare polyunsaturated fatty acid found in very small amounts in dietary sources. Omega-3 fatty acids are known to be essential for the growth and development of infants, and they protect against heart disease, blood clots, high blood pressure, and inflammatory and autoimmune diseases. In human platelet membranes, omega-3 arachidonic acid inhibits arachidonyl-CoA synthetase with a Ki of 14 μM. It also inhibits arachidonoyl-CoA synthetase in calf brain extract with an IC50 of approximately 5 μM. Omega-3 ethyl arachidonate is the more lipophilic form of the free acid.

HY-W355779

Gliadins Tyrosylprolylglutaminylprolylglutamine	Biochemical Assay Reagents
Gliadins (Tyrosylprolylglutaminylprolylglutamine) comprise a family of glutamine- and proline-rich monomeric proteins that plays an role in autoimmune disease, such as celiac disease .

HY-Y0344H

Sodium chloride, United States Pharmacopeia (USP) Reference Standard

Halite (Pharmaceutical primary standard, USP)

Biochemical Assay Reagents

Sodium chloride, United States Pharmacopeia (USP) Reference Standard is an orally active salt. Sodium chloride, United States Pharmacopeia (USP) Reference Standard induces the expression of ATP1A1. Sodium chloride, for cell culture induces the pro-inflammatory cytokines IL-2, TNFα, IL-9 and several chemokines. Sodium chloride, United States Pharmacopeia (USP) Reference Standard enhances the anti-tumor activities of Digoxin (HY-B1049) against small cell lung cancer. Sodium chloride, United States Pharmacopeia (USP) Reference Standard drives autoimmune disease by the induction of pathogenic Th17 cells .

HY-W145695

Chitoheptaose

Biochemical Assay Reagents

Chitoheptaose is an orally active chitooligosaccharide (degree of polymerization = 7). Chitoheptaose can be extracted from the exoskeletons of crustaceans, such as the shells of crabs, shrimps and lobsters. Chitoheptaose reduces pro-inflammatory cytokines while increasing the levels of anti-inflammatory cytokines (decreasing the levels of pro-inflammatory cytokines IL-1β, IL-17A and IFN-γ, and increasing the level of the anti-inflammatory cytokine IL-10). Chitoheptaose possesses antioxidant, anti-inflammatory and anti-Apoptotic activities. Chitoheptaose improves cardiac parameters, alleviates myocarditis injury, and exerts cardioprotective effects in a rat model of myocarditis. Chitoheptaose can be used in studies related to myocarditis .

HY-120978

Omega-3 arachidonic acid methyl ester

ω-3 Arachidonic acid methyl ester; (all-Z)-8,11,14,17-Eicosatetraenoic acid methyl ester

Biochemical Assay Reagents

omega-3 Arachidonic Acid methyl ester, mainly docosahexaenoic acid, eicosapentaenoic acid and α-Linoleic acid, represented by linoleic acid, is an essential dietary nutrient required for normal growth and development.Omega-3Methyl arachidonic acid is a rare fatty acid Omega-3Neutral fat-soluble form of arachidonic acid. Omega-3Fatty acids, as a group, were associated with reduced inflammation and autoimmune activity, as well as reduced thrombosis and platelet activation.

Cat. No.	상품명	Category	Target	Chemical Structure

HY-A0124A

Sapropterin dihydrochloride 2 Publications Verification (6R)-BH4 dihydrochloride; (6R)-Tetrahydro-L-biopterin dihydrochloride	Cardiovascular Disease Classification of Application Fields Disease Research Fields	Endogenous Metabolite
Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) dihydrochloride is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin dihydrochloride can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin dihydrochloride can aggravate experimental autoimmune encephalomyelitis (EAE) .

HY-N10574

Queuine 1 Publications Verification	Alkaloids Microorganisms Pyrrole Alkaloids Source Classification	Bacterial
Queuine is a selective substrate for tRNA guanine transglycosylase (TGT) and can be incorporated into eukaryotic tRNA. Queuine promotes tRNA modification, affecting mitochondrial function and Warburg metabolic phenotype. If Queuine is deficient, aerobic glycolysis can be enhanced, oxidative phosphorylation can be inhibited, and Warburg metabolism can be promoted, accompanied by increased ammonia and lactate production and increased lactate dehydrogenase activity. Queuine can be used for autoimmune diseases (such as experimental models of multiple sclerosis) and cancer metabolic regulation, and its deficiency is associated with low tRNA modification in tumor cells .

HY-N2279

Kurarinone 5 Publications Verification	Flavonoids Classification of Application Fields Leguminosae Flavonones Phenols Polyphenols Sophora flavescens Aiton Plants Inflammation/Immunology Disease Research Fields Source Classification	Eukaryotic Initiation Factor (eIF)
Kurarinone is an orally active flavonoid isolated from matrine that inhibits the pathogenesis of experimental autoimmune encephalomyelitis by inhibiting cell differentiation of Th1 and Th17. Kurarinone has antitumor and anti-inflammatory activity .

HY-B0157

Ketotifen 3 Publications Verification HC 20-511	Infection Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Endocrinology Source Classification	Endogenous Metabolite Histamine Receptor SARS-CoV Influenza Virus
Ketotifen (HC 20-511) is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

HY-32343

Secalciferol Maximum Cited Publications 6 Publications Verification (24R)-24,25-Dihydroxyvitamin D3	Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids Source Classification	Endogenous Metabolite VD/VDR
Secalciferol ((24R)-24,25-Dihydroxyvitamin D3) is the major active metabolite of Vitamin D. Secalciferol activates vitamin D receptor (VDR) with an EC₅₀ value of 150 nM. Secalciferol is involved in a wide range of biological functions such as calcium homeostasis, cellular differentiation and proliferation processes, as well as other functions related to the immune system, which is promising for research of rickets, osteomalacia, hypercalcemia and autoimmune disorders .

HY-N2335

Coumestrol Maximum Cited Publications 6 Publications Verification	Classification of Application Fields Leguminosae Glycine max (L.) merr Coumarins Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Source Classification Cancer	Estrogen Receptor/ERR
Coumestrol, a phytoestrogen present in soybean products, exhibits activities against cancers, neurological disorders, and autoimmune diseases. It suppresses proliferation of ES2 cells with an IC₅₀ of 50 μM.

HY-B0157A

Ketotifen fumarate 3 Publications Verification HC 20511 fumarate	Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Histamine Receptor Endogenous Metabolite SARS-CoV Influenza Virus
Ketotifen (HC 20-511) fumarate is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen fumarate can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen fumarate also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen fumarate can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

HY-N1363

Royal Jelly acid Maximum Cited Publications 6 Publications Verification (E)-Queen Bee Acid; (E)-10-Hydroxy-2-decenoic acid	Animals Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite NO Synthase NF-κB Parasite IFNAR
Royal Jelly Acid ((E)-Queen Bee Acid) is a major fatty acid found in royal jelly with oral bioavailability, exhibiting anti-inflammatory, anticancer, antimalarial, antiprotozoal, and neuroregulatory activities. Royal Jelly Acid can be used for research in various fields, including cancer, infections, immune inflammation, and neurological diseases .

HY-113037C

Farnesyl pyrophosphate ammonium Farnesyl diphosphate ammonium	Natural Products Neurological Disease Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	TRP Channel Endogenous Metabolite Calcium Channel
Farnesyl pyrophosphate (Farnesyl diphosphate) ammonium is a metabolic intermediate in the mevalonate (MVA) pathway. It is a TRP channel (TRPM2) agonist that triggers Ca2+ influx and cell death. Farnesyl pyrophosphate ammonium is a key branch substrate for cholesterol synthesis, ubiquinone synthesis, protein farnesylation, and geranylgeranyl pyrophosphate (GGPP) synthesis. Farnesyl pyrophosphate ammonium is used in research on cerebral ischemia, neurodegenerative diseases, pancreatic cancer, inflammation, and autoimmune diseases .

HY-P1680

Astin C Asterin	Natural Products Plants Compositae Erythrina latissima E. Mey. Source Classification	STING HSV
Astin C (Asterin) is a cyclopeptide that can be extracted from Aster tataricus. Astin C has anti-inflammatory and anti-cancer activities. Astin C can specifically inhibit the cGAS-STING signaling pathway, block the recruitment of IRF3 to the STING signalosome, and thus inhibit the innate inflammatory response. Astin C can be used in the research of autoimmune diseases and cancers .

HY-N8441

Neriifolin 17β-Neriifolin	Apocynaceae Classification of Application Fields Cardiacglycosides Cerbera manghas Linn. Plants Inflammation/Immunology Disease Research Fields Steroids Source Classification	Atg8/LC3 Na+/K+ ATPase Apoptosis Beclin1
Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na ⁺, K ⁺-ATPase. Neriifolin can target beclin 1, inhibits the formation of LC3-associated phagosomes and ameliorates experimental autoimmune encephalomyelitis (EAE) development. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells ^[2.

HY-N2303

Eriocalyxin B 3 Publications Verification	Natural Products Classification of Application Fields Labiatae Senna sophera (L.) Roxb. Plants Inflammation/Immunology Disease Research Fields Source Classification	Apoptosis NF-κB Autophagy Reactive Oxygen Species (ROS) CDK PPAR FABP Akt mTOR
Eriocalyxin B is a diterpenoid compound that can be isolated from Chinese herb Isodon eriocalyx. Eriocalyxin B exhibits multiple activities, such as anti-cancer, anti-inflammatory, and inhibition of adipogenesis. Eriocalyxin B is capable of inducing apoptosis and autophagy in tumor cells. Eriocalyxin B can be used in the research of cancers, autoimmune diseases, and other conditions .

HY-N0204

Pulchinenoside A Anemoside A3	Triterpenes Structural Classification Classification of Application Fields Terpenoids Ranunculaceae Other Diseases Plants Disease Research Fields Pulsatilla chinensis (Bunge) Regel Source Classification	NF-κB p38 MAPK
Pulchinenoside A (Anemoside A3) is an orally active triterpenoid glycoside found in the root of Pulsatilla chinensis. Pulchinenoside A has amti-inflammation, antitumor, antidepressant, immunoregulatory and neuroprotective efrects. Pulchinenoside A activates NF-κB/MAPK signaling pathway. Pulchinenoside A can induce relaxing effect in rat renal arteries. Pulchinenoside A can be used for the researches of experimental autoimmune encephalomyelitis, breast cancer, depression and renovascular hypertension .

HY-N3103

p-Coumaric Acid Ethyl Ester Ethyl (E)-p-hydroxycinnamate; Ethyl trans-4-hydroxycinnamate	Monophenols other families Classification of Application Fields Simple Phenylpropanols Phenols Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields Source Classification	Tyrosinase
p-Coumaric Acid Ethyl Ester (Ethyl (E)-p-hydroxycinnamate; Ethyl trans-4-hydroxycinnamate) is a non-competitive, reversible inhibitor of tyrosinase (IC₅₀=4.89 μg/mL, K_i=1.83 μg/mL), which can quench the intrinsic fluorescence of the enzyme. p-Coumaric Acid Ethyl Ester changes the binding affinity of L-tyrosine by inducing conformational changes in the catalytic domain of tyrosinase, and does not bind to the copper ion of the enzyme. p-Coumaric Acid Ethyl Ester is used in the development of medicines, cosmetics and fruit preservation products using pollen .

HY-N10574A

Queuine dihydrochloride 1 Publications Verification	Alkaloids Microorganisms Pyrrole Alkaloids Source Classification	Others
Queuine dihydrochloride is a selective substrate for tRNA guanine transglycosylase (TGT) and can be incorporated into eukaryotic tRNA. Queuine dihydrochloride promotes tRNA modification, affecting mitochondrial function and Warburg metabolic phenotype. If Queuine dihydrochloride is deficient, aerobic glycolysis can be enhanced, oxidative phosphorylation can be inhibited, and Warburg metabolism can be promoted, accompanied by increased ammonia and lactate production and increased lactate dehydrogenase activity. Queuine dihydrochloride can be used for autoimmune diseases (such as experimental models of multiple sclerosis) and cancer metabolic regulation, and its deficiency is associated with low tRNA modification in tumor cells .

HY-N11451

Lacto-N-fucopentaose III LNFP-III	Polysaccharides Animals Saccharides Source Classification	Arginase Aldehyde Dehydrogenase (ALDH) Indoleamine 2,3-Dioxygenase (IDO)
Lacto-N-fucopentaose III (LNFP-III) is an immune modulator. Lacto-N-fucopentaose III reduces the severity of experimental autoimmune encephalomyelitis (EAE) and CNS inflammation .

HY-N10520

Pectic acid Methyl protopectin; Polygalacturonic acid	Natural Products Classification of Application Fields Rutaceae Plants Endogenous metabolite Citrus reticulata Blanco Human Gut Microbiota Metabolites Polysaccharides Microorganisms Inflammation/Immunology Disease Research Fields Saccharides Cancer Source Classification	Apoptosis Necroptosis Endogenous Metabolite
Pectic acid (Methyl protopectin), a polygalacturonic acid, induces cell apoptosis and necrosis in pituitary tumor cells. Pectic acid can be used in the research of cancers and autoimmune disease .

HY-N11286

Tridocosahexaenoylglycerol TG-DHA; Meganol D	Structural Classification Animals Lipid Source Classification	Others
Tridocosahexaenoylglycerol (TG-DHA) is an orally active dietary supplement that improves autoimmune encephalomyelitis in mice. Tridocosahexaenoylglycerol shows beneficial effects on neurodegenerative diseases and also improves macular function in diabetic retinopathy. Tridocosahexaenoylglycerol can be used for research on neurological diseases, inflammatory immune diseases, and metabolic diseases .

HY-N2335R

Coumestrol (Standard)	Structural Classification Leguminosae Glycine max (L.) merr Coumarins Phenols Polyphenols Phenylpropanoids Plants Source Classification	Reference Standards Estrogen Receptor/ERR
Coumestrol (Standard) is the analytical standard of Coumestrol. This product is intended for research and analytical applications. Coumestrol, a phytoestrogen present in soybean products, exhibits activities against cancers, neurological disorders, and autoimmune diseases. It suppresses proliferation of ES2 cells with an IC50 of 50 μM.

HY-B0157AR

Ketotifen fumarate (Standard) HC 20511 fumarate (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Histamine Receptor Endogenous Metabolite SARS-CoV Influenza Virus
Ketotifen (fumarate) (Standard) is the analytical standard of Ketotifen (fumarate). This product is intended for research and analytical applications. Ketotifen (HC 20-511) fumarate is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen fumarate can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen fumarate also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen fumarate can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

HY-N10768

1-Dehydro-[10]-gingerdione	Monophenols Phenols Plants Source Classification Zingiberaceae	IKK NF-κB
1-Dehydro-[10]-gingerdione directly inhibits IKKβ activity by targeting the activation loop of IKKβ, thus disrupting IKKβ-catalysed IκBα phosphorylation in macrophages stimulated with agonists. 1-Dehydro-[10]-gingerdione inhibits LPS (HY-D1056)-induced NF-κB transcriptional activity. 1-Dehydro-[10]-gingerdione has the potential for NF-κB-associated inflammation and autoimmune disorders research .

HY-B0157R

Ketotifen (Standard) HC 20-511 (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Histamine Receptor SARS-CoV Influenza Virus
Ketotifen (Standard) is the analytical standard of Ketotifen. This product is intended for research and analytical applications. Ketotifen (HC 20-511) is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

HY-N12108

Forphenicine	Microorganisms Ketones, Aldehydes, Acids Phenols Source Classification	Phosphatase
Forphenicine is a bacterial metabolite that is found in S. fulvoviridis and an inhibitor of alkaline phosphatase. Forphenicine inhibits the growth of HL-60 leukemia cells at 10 µM. Forphenicine also increases survival in a guinea pig model of experimental autoimmune encephalomyelitis (EAE) .

HY-13764A

dl-Tetrandrine	Alkaloids Stephania japonica var. discolor (Blume) Forman Plants Menispermaceae Alkaloid Dimers Source Classification	Calcium Channel
dl-Tetrandrine is an orally active and brain-penetrant calcium channel blocker that inhibits voltage-dependent calcium channels. dl-Tetrandrine selectively blocks Ca ²⁺ influx with an IC₅₀ value of approximately 1-10 μM. dl-Tetrandrine exerts anti-inflammatory, immunosuppressive, and anti-arrhythmic activities by inhibiting intracellular calcium overload, and can reverse multidrug resistance in tumor cells. dl-Tetrandrine is promising for research of autoimmune diseases (such as rheumatoid arthritis), cardiovascular diseases, and tumor drug resistance reversal .

HY-N3103R

p-Coumaric Acid Ethyl Ester (Standard) Ethyl (E)-p-hydroxycinnamate (Standard); Ethyl trans-4-hydroxycinnamate (Standard)	Structural Classification Monophenols other families Simple Phenylpropanols Phenols Phenylpropanoids Plants Source Classification	Reference Standards Drug Metabolite
Benazeprilat (Standard) is the analytical standard of Benazeprilat. This product is intended for research and analytical applications. Benazeprilat is an orally active and the active metabolite of benazepril, a carboxyl-containing ACE inhibitor with antihypertensive activity. Benazepril is a well-established antihypertensive agent, both in monoresearch and in combination with other classes of drugs including thiazide diuretics and calcium channel blockers. Benazepril is a first-line research in reducing various pathologies associated with CV risk and secondary end-organ damage .

HY-114341

Kaempferol 5-glucoside Kaempferol 5-O-β-D-glucopyranoside	Structural Classification Flavonols Flavonoids Plants Indigofera aspalathoides Vahl ex DC. Fabaceae Source Classification	Others
Kaempferol 5-glucoside (Kaempferol 5-O-β-D-glucopyranoside) is an orally active flavonol glycoside and immunomodulator. Kaempferol 5-glucoside is isolated from the aerial parts of Indigofera aspalathoides Vahl ex DC. Kaempferol 5-glucoside enhances delayed-type hypersensitivity in rats. Kaempferol 5-glucoside increases humoral antibody titers. Kaempferol 5-glucoside is used for the research of autoimmune diseases .

HY-N14737

Dunaimycin A1	Natural Products Microorganisms Source Classification	Fungal
Dunaimycin A1 is a 24-membered macrolide compound with immunosuppressive activity and antifungal activity against Aspergillus niger. Dunaimycin A1 is promising for research of autoimmune diseases .

Cat. No.	Compare	상품명	Species	Source	Image

HY-P72180

	ELAVL4 Protein, Human (His-SUMO, Myc) ELAV embryonic lethal abnormal vision Drosophila; like 4; ELAV L4; ELAV like 4; ELAV like protein 4; ELAV-like protein 4; ELAV4_HUMAN; Elavl4; Embryonic lethal abnormal vision Drosophila homolog of like 4; Hu antigen D; Hu-antigen D; HuD; Paraneoplastic encephalomyelitis antigen HuD; PNEM	Human	E. coli
	ELAVL4 protein is a broad RNA-binding factor that post-transcriptionally regulates mRNAs such as GAP43, VEGF, FOS, CDKN1A, and ACHE, stabilizing and protecting them from decay by binding to ARE sequences. It reduces mRNA deadenylation and enhances mRNA binding affinity by interacting with the Poly(A) tail. ELAVL4 Protein, Human (His-SUMO) is the recombinant human-derived ELAVL4 protein, expressed by E. coli , with N-10*His, N-SUMO, C-Myc labeled tag.

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Cat. No.	상품명	Chemical Structure

HY-50856S

Deuruxolitinib
Deuruxolitinib, a deuterated Ruxolitinib (HY-50856), is an orally active JAK1 and JAK2 inhibitor. Deuruxolitinib demonstrates significant hair regrowth effects. Deuruxolitinib can be used for the research of alopecia areata .

HY-W727879

Upadacitinib-15N,d2

1 Publications Verification

Upadacitinib- ¹⁵N,d₂ (ABT-494- ¹⁵N,d₂) is the deuterium-labeled Upadacitinib (HY-19569). Upadacitinib- ¹⁵N,d₂ (ABT-494) is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC₅₀=43 nM). Upadacitinib- ¹⁵N,d₂ (ABT-494) displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib- ¹⁵N,d₂ (ABT-494) can be used for several autoimmune disorders research .

HY-117433S

4-Hydroperoxy Cyclophosphamide-d4

4-Hydroperoxy Cyclophosphamide-d₄ is the deuterium labeled 4-Hydroperoxy cyclophosphamide. 4-Hydroperoxy cyclophosphamide is the active metabolite form of the proagent Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide has the potential for lymphomas and autoimmune disorders .

HY-113037CS

Farnesyl pyrophosphate-d2 triammonium

Farnesyl pyrophosphate-d₂ (Farnesyl diphosphate-d₂) triammonium is a deuterium labeled Farnesyl pyrophosphate triammonium (HY-113037C). Farnesyl pyrophosphate ammonium is a metabolic intermediate in the mevalonate (MVA) pathway. It is a TRP channel (TRPM2) agonist that triggers Ca2+ influx and cell death. Farnesyl pyrophosphate ammonium is a key branch substrate for cholesterol synthesis, ubiquinone synthesis, protein farnesylation, and geranylgeranyl pyrophosphate (GGPP) synthesis. Farnesyl pyrophosphate ammonium is used in research on cerebral ischemia, neurodegenerative diseases, pancreatic cancer, inflammation, and autoimmune diseases.

HY-19569S1

Upadacitinib-d5

Upadacitinib-d₅ (ABT-494-d₅) is the deuterium labeled Upadacitinib (HY-19569). Upadacitinib (ABT-494) is a potent, orally active and selective JAK1 inhibitor (IC₅₀ = 43 nM). Upadacitinib (ABT-494) displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib (ABT-494) can be used for several autoimmune disorders research .

HY-177130S

Socrodeucitinib

Socrodeucitinib (Compound Example 58) is an orally active and selective tyrosine kinase 2 (TYK2) inhibitor with an IC₅₀ value of 1.41 nM. Socrodeucitinib exerts anti-inflammatory activity by inhibiting TYK2-mediated cytokine signaling pathways and reducing the secretion of inflammatory factors. Socrodeucitinib is promising for research of autoimmune diseases such as psoriasis and inflammatory diseases .

HY-144031S

Tyk2-IN-8
Tyk2-IN-8 (compound 3) is a selective Tyk-2 inhibitor with an IC₅₀ of 5.7 nM for TYK2-JH2. Tyk2-IN-8 inhibits JAK1-JH1 with IC₅₀ of 3.0 nM. Tyk2-IN-8 can be used for the research of autoimmune disease .

HY-175310S

Voderdeucitinib
Voderdeucitinib (Compoudn I) is a TYK2 inhibitor with an anti-inflammatory activity. Voderdeucitinib can be used for inflammatory and autoimmune disease research, such as rheumatoid arthritis (RA), multiple sclerosis and intestinal bowel disease (IBD) .

HY-113037AS

Farnesyl pyrophosphate-d6

Farnesyl pyrophosphate-d₆ (Farnesyl diphosphate-d₆) is a deuterium labeled Farnesyl pyrophosphate (HY-113037B). Farnesyl pyrophosphate is a metabolic intermediate in the mevalonate (MVA) pathway. It is a TRP channel (TRPM2) agonist that triggers Ca2+ influx and cell death. Farnesyl pyrophosphate is a key branch substrate for cholesterol synthesis, ubiquinone synthesis, protein farnesylation, and geranylgeranyl pyrophosphate (GGPP) synthesis. Farnesyl pyrophosphate is used in research on cerebral ischemia, neurodegenerative diseases, pancreatic cancer, inflammation, and autoimmune diseases.

HY-B0352S3

Mirtazapine-d4 hydrochloride
Mirtazapine-d₄ hydrochloride is deuterated labeled Mirtazapine (HY-B0352). Mirtazapine (Org3770) is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. Mirtazapine is also a 5-HT₂, 5-HT₃, histamine H1 receptor and α2-adrenoceptor antagonist with pK_i values of 8.05, 8.1, 9.3 and 6.95, respectively .

HY-163314S

Tyk2-IN-18-d3
Tyk2-IN-18-d3 (Compound 18) is a Tyk2 inhibitor with an IC₅₀ value of < 30 nM for both IL-23 and IFNα. Tyk2-IN-18-d3 can be used for research on autoimmune diseases .

HY-163312S

Tyk2-IN-18-d5
Tyk2-IN-18-d5 (Compound 13) is the deuterated TYK2 inhibitor, targeting to JH2 domain. Tyk2-IN-18-d5 can be used for the research of inflammatory and autoimmune diseases .

HY-B0157S1

Ketotifen-d3

Ketotifen-d₃ (HC 20-511-d₃) is deuterium labeled Ketotifen. Ketotifen (HC 20-511) is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

HY-153951S

BTK-IN-26
BTK-IN-26 (compound 18) is a potent inhibitor of Bruton's tyrosine kinase (BTK) and its C481 mutant, with IC₅₀ values of 0.7 and 0.8 nM for BTK and BTK C481S, respectively. BTK-IN-26 can be used for cancer and autoimmune diseases research .

HY-135810S

Cletoquine-d4

Cletoquine-d₄ is deuterium labeled Cletoquine. Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment .

HY-135810S1

Cletoquine-d4-1

Cletoquine-d₄-1 is the deuterium labeled Cletoquine. Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment .

HY-10405S

Pamapimod-d4

Pamapimod-d₄ (Ro4402257-d₄) is the deuterium labeled Pamapimod. Pamapimod (Ro4402257) is a potent, selective and orally active p38 MAPK inhibitor with IC₅₀s of 14 nM and 480 nM and Kis of 1.3 nM and 120 nM for p38α and p38β, respectively. Pamapimod has no activity against p38δ or p38γ isoforms. Pamapimod has the potential for rheumatoid arthritis and other autoimmune diseases treatment .

HY-W777442

Cletoquine-d4 Oxalate

Cletoquine-d₄ Oxalate is the deuterium labeled Cletoquine (oxalate) (HY-135810A). Cletoquine oxalate (Desethylhydroxychloroquine oxalate) is a major active metabolite of Hydroxychloroquine. Cletoquine oxalate is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine oxalate is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine oxalate has antimalarial effects and has the potential for autoimmune diseases treatment .

HY-B1451S

Imidapril-d3 hydrochloride

Imidapril-d₃ hydrochloride (TA-6366-d₃) is the deuterium labeled Imidapril hydrochloride. Imidapril hydrochloride (TA-6366) is an orally active dual inhibitor of angiotensin-converting enzyme (ACE) and MMP-9. Imidapril hydrochloride inhibits lipopolysaccharide-induced phosphorylation of c-Jun, MKK4 and JNK in monocytes, and downregulates the production of specific inflammatory factors such as TNF-α and IP-10, thereby exerting anti-inflammatory activity. Imidapril hydrochloride also effectively ameliorates mesangial expansion and reduces urinary albumin excretion by inhibiting angiotensin AngII production, lowering glomerular pressure and oxidative stress, thus delaying disease progression. Imidapril hydrochloride can also directly bind to the active site of MMP-9 to inhibit gelatinase activity, and suppress the enlargement of cerebral aneurysms without altering systemic blood pressure. Imidapril hydrochloride is widely applicable to related studies on autoimmune glomerulonephritis, diabetic nephropathy, cerebral aneurysms and other conditions .

HY-B1139S

Tolperisone-d10 hydrochloride

Tolperisone-d₁₀ (hydrochloride) is the deuterium labeled Tolperisone hydrochloride. Tolperisone hydrochloride is a centrally acting muscle relaxant, is indicated for use in the treatment of pathologically increased tone of the cross-striated muscle caused by neurological diseases (damage of the pyramidal tract, multiple sclerosis, myelopathy, encephalomyelitis) and of spastic paralysis and other encephalopathies manifested with muscular dystonia.

HY-23127S

Decyltriphenylphosphonium-d5 bromide
Decyltriphenylphosphonium-d₅ bromide is the deuterium labeled Decyltriphenylphosphonium bromide (HY-23127). Decyltriphenylphosphonium bromide is a mitochondrial antioxidant with oral activity. Decyltriphenylphosphonium bromide can be used in the research of autoimmune arthritis .

HY-166594S

Deucravacitinib-13C,d3

Deucravacitinib- ¹³C,d₃ is the ¹³C- and deuterium labeled Deucravacitinib. Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of autoimmune diseases, which selectively binds to TYK2 pseudokinase (JH2) domain (IC₅₀=1.0 nM) and blocks receptor-mediated Tyk2 activation by stabilizing the regulatory JH2 domain. Deucravacitinib inhibits IL-12/23 and type I IFN pathways. Deucravacitinib, the FDA's world first de novo deuterium, is available for study in moderate to severe plaque psoriasis .

Cat. No.	상품명		Classification

HY-108039

Bezisterim HE 3286; NE-3107		Alkynes
Bezisterim (HE 3286; NE-3107) is a synthetic derivative of a natural anti-inflammatory steroid, β-AET. Bezisterim is an orally active partial NF-κB inhibitor. HE3286 reduces proinflammatory signals, including IL-6 and matrix metallopeptidase 3. Bezisterim freely penetrates the blood brain barrier in mice. Bezisterim can be used for the research of the ulcerative colitis, arthritis, experimental autoimmune encephalomyelitis . Bezisterim is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-176566

H-151 Alkyne		Alkynes
H-151 Alkyne (Compound H-151-AL) is a selective STING (Stimulator of interferon genes) inhibitor. H-151 Alkyne is promising for research of autoimmune diseases such as systemic lupus erythematosus, scleroderma, and autoinflammatory diseases .

HY-148908

TNF-α-IN-8		Azide
TNF-α-IN-8 (compound I-42) is a TNF-α inhibitor. TNF-α-IN-8 is an isoindole-imide compound. TNF-α-IN-8 can be used for the research of cancer, heart disease, osteoporosis, inflammatory, allergic and autoimmune diseases . TNF-α-IN-8 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-112946

LU-001i		Azide
LU-001i is a highly specific proteasome β1i (LMP2) inhibitor. LU-001i alone has no significant immunomodulatory effect, but when combined with the LMP7 inhibitor (PRN1126), it can exert anti-inflammatory and immunomodulatory effects. LU-001i can be used for the study of autoimmune diseases .

HY-125387

TOP1210		Alkynes
TOP1210 is a narrow-spectrum tyrosine kinase inhibitor with potent inhibitory activity against P38α, Src, and Syk kinases. TOP1210 effectively reduced proinflammatory cytokines released by peripheral blood monocytes, primary macrophages, HT29 cells, inflammatory cells in ulcerative colitis (UC) biopsies, and myofibroblasts isolated from inflamed colonic UC mucosa. TOP1210 showed significant anti-inflammatory effects in cell experiments and UC biopsies, superior to some selective kinase inhibitors. The multi-kinase inhibition of TOP1210 provides the possibility of obtaining a wider range of therapeutic effects, especially in the regulation of autoimmune responses .

Cat. No.	상품명		Classification

HY-153808

Complete Freund's adjuvant (CFA) Maximum Cited Publications 15 Publications Verification		Adjuvant
Complete Freund's adjuvant (CFA) is an immunoadjuvant emulsified with antigen by its discoverer Jules T. Freund to enhance an animal's immune response to an antigen. Complete Freund's adjuvant (CFA) is also an inducer of the Th1 immune response and a ligand of TLRs. Complete Freund's adjuvant (CFA) contains heat-killed inactive tuberculosis bacilli and consists of a paraffin oil-in-water emulsion. Complete Freund's adjuvant (CFA) stimulates a strong and durable immune response and can be used to induce persistent inflammatory pain models in mice, experimental autoimmune myocarditis (EAM) models, and more. Incomplete Freund's adjuvant (IFA) (HY-153808A) is another type of Freund's Adjuvant that stimulates a weaker immune response .

HY-153808A

Incomplete Freund's adjuvant (IFA) 4 Publications Verification		Adjuvant
Incomplete Freund's adjuvant (IFA) (Montanide ISA-51) is an immunoadjuvant emulsified with antigen by its discoverer Jules T. Freund. Incomplete Freund's adjuvant (IFA) does not contain inactivated tuberculosis bacilli and consists of petroleum jelly containing lanolin. Incomplete Freund's adjuvant (IFA) induces high antibody titers and long-lasting effector T cell responses with no long-term effects on collagen disease, tumors, or death. Complete Freund's adjuvant (CFA) (HY-153808) is another type of Freund's Adjuvant that stimulates a stronger immune response .

HY-150751

ODN TTAGGG 3 Publications Verification ODN A151		CpG ODNs
ODN TTAGGG (ODN A151), an inhibitory oligonucleotide (ODN), is a TLR9, AIM2, and cGAS antagonist. ODN TTAGGG inhibits AIM2 inflammasome activation and cGAS activation through competition with DNA. ODN TTAGGG blocks AIM2-mediated Pyroptosis and inhibits IL-18 production. ODN TTAGGG has immunosuppressive effects and can be used in research on related autoimmune diseases such as lupus erythematosus . ODN TTAGGG sequence: 5'-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-3'.

HY-153808B

Complete Freund's adjuvant (CFA, 1 mg/ml)		Adjuvant
Complete Freund's adjuvant (CFA, 1 mg/ml) is an immunoadjuvant emulsified with antigen that can enhance an animal's immune response to an antigen. Complete Freund's adjuvant (CFA, 1 mg/ml) is also an inducer of the Th1 immune response and a ligand of TLRs. Complete Freund's adjuvant (CFA, 1 mg/ml) contains heat-killed inactive tuberculosis bacilli and consists of a paraffin oil-in-water emulsion. Complete Freund's adjuvant (CFA, 1 mg/ml) stimulates a strong and durable immune response and can be used to induce rheumatoid arthritis in rats, and more .

HY-150751C

ODN TTAGGG sodium 3 Publications Verification ODN A151 sodium		CpG ODNs
ODN TTAGGG sodium, inhibitory oligonucleotide (ODN), is a TLR9, AIM2 and cGAS antagonist. ODN TTAGGG sodium is immunosuppressive and inhibits AIM2 inflammasome activation, as well as cGAS activation, by competing with DNA. ODN TTAGGG sodium can be used in the study of lupus erythematosus and other related autoimmune diseases. ODN TTAGGG sequence: 5'-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-3' .

HY-154974

LNP Lipid-8		Cationic Lipids
LNP Lipid-8 (11-A-M) is an ionizable single-tail multi-head lipid that can be used as a lipid nanoparticle (LNP) to deliver siRNA to T cells without targeting ligands. LNP Lipid-8 is more selective for T cells than other cell types such as hepatocytes. LNP Lipid-8 selectively delivers siRNA/sgRNA to T cells (especially CD8+ T cells) through endogenous lipid transport pathways, and can enter cells and release RNA through endocytosis to achieve gene silencing. LNP Lipid-8 loaded with GFP siRNA (siGFP) significantly led to GFP gene silencing in mouse models. LNP Lipid-8 showed good efficacy and safety in both cells and animals, without obvious liver targeting and toxicity. LNP Lipid-8 can be used for RNA delivery research in the fields of tumor immunotherapy and T cell-mediated autoimmune diseases .

HY-W409806

Cholesterylamine		Cholesterol
Cholesterylamine is a cationic lipid. Cholesterylamine can be added to the PLGA to prepare PLGA particle having surface charge. Cholesterylamine can be used for drug delivery. Cholesterylamine can be used for autoimmune diseases and allergy research .

HY-148412

Monarsen EN101; ODN 7040; BL 7040		Antisense Oligonucleotides
Monarsen (EN101) is a synthetic 20-base antisense oligodeoxynucleotide directed against the human AChE gene. Monarsen is used in the study of Autoimmune myasthenia gravis (MG), a neuromuscular disorder caused by autoantibodies directed against the acetylcholine receptor (AChR).

HY-160577

DOG-IM4		Cationic Lipids
DOG-IM4 can be used to synthesize nanoparticles to deliver antigen-encoding nucleic acids. It could be used to try to target autoimmune diseases, rare blood or metabolic diseases, allergies, cancer or infectious diseases .

HY-171984

514O6,10		Cationic Lipids
514O6,10 is an ionizable lipidoid containing a branched-tail. 514O6,10 can be used to synthesize lipid nanoparticles (LNPs) for delivering mRNA to natural killer and dendritic cells within the lung. 514O6,10 can be used for the RNA therapies for lung diseases associated with immune cell dysregulation, including cancer, viral infections, and autoimmune disorders research .

HY-148412A

Monarsen sodium EN101 sodium; ODN 7040 sodium; BL 7040 sodium		Antisense Oligonucleotides
Monarsen sodium is a synthetic 20-base antisense oligodeoxynucleotide directed against the human AChE gene. Monarsen sodium is used in the study of Autoimmune myasthenia gravis (MG), a neuromuscular disorder caused by autoantibodies directed against the acetylcholine receptor (AChR).

HY-174633

Human IL17A mRNA		mRNA Interleukin & Receptors
Human IL17A mRNA encodes the human interleukin 17A (IL17A) protein, a member of the IL-17 receptor family. IL17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer.

HY-174632

Human IL17RA mRNA		mRNA Interleukin & Receptors
Human IL17RA mRNA encodes the human interleukin 17 receptor subunit alpha (IL17RA) protein, a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis.

HY-174600

Human IL6 mRNA		mRNA Interleukin & Receptors
Human IL6 mRNA encodes the human interleukin 6 (IL6) protein, a cytokine that functions in inflammation and the maturation of B cells. IL6 has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis.

HY-177814

LJM-3064 sodium		Aptamers
LJM-3064 sodium is a guanosine-rich 40-mer DNA aptamer that targets myelin. LJM-3064 mediates remyelination in the Theiler's murine encephalomyelitis virus mouse model of multiple sclerosis.

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