Search Result

Isoforms Recommended:	DNMT1

Results for "

Dnmt1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Payload (1) Adrenergic Receptor (1) Apoptosis (15) Autophagy (5) Bcl-2 Family (1) c-Myc (1) Caspase (4) Deubiquitinase (2) DNA Methyltransferase (37) DNA/RNA Synthesis (2) E1/E2/E3 Enzyme (1) Ferroptosis (2) Glutathione Peroxidase (2) HDAC (2) Heme Oxygenase (HO) (2) HIF/HIF Prolyl-Hydroxylase (1) Histone Demethylase (1) Histone Methyltransferase (5) Indoleamine 2,3-Dioxygenase (IDO) (2) Isotope-Labeled Compounds (1) Keap1-Nrf2 (4) MDM-2/p53 (3) METTL3 (1) Mitochondrial Metabolism (1) Molecular Glues (1) Nucleoside Antimetabolite/Analog (1) Potassium Channel (5) Reactive Oxygen Species (ROS) (2) Reference Standards (6) Small Interfering RNA (siRNA) (3) STAT (1) TGF-β Receptor (2) Virus Protease (2)
By Research Areas:	Cancer (47) Cardiovascular Disease (4) Endocrinology (1) Infection (2) Inflammation/Immunology (3) Metabolic Disease (4) Neurological Disease (3)
Oligonucleotides:	Aptamers (1) Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-135146

GSK-3484862 20+ Cited Publications	DNA Methyltransferase	Cancer
GSK-3484862 is a non-covalent inhibitor for DNA methyltransferase (Dnmt1). GSK-3484862 induces DNA hypomethylation to against cancer. GSK-3484862 mediates dramatic demethylation in murine embryonic stem cells with minimal non-specific toxicity ^[1] .

HY-139664

GSK-3685032 10+ Cited Publications	DNA Methyltransferase	Cancer
GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible *DNMT1*-selective inhibitor, with an IC₅₀ of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition ^[1].

HY-112288

C188-9 Maximum Cited Publications 32 Publications Verification TTI-101	STAT Apoptosis DNA Methyltransferase	Metabolic Disease Inflammation/Immunology Cancer
C188-9 (TTI-101) is a STAT3 inhibitor with a K_d value of 4.7 nM. C188-9 targets the SH2 domain of STAT3, blocks the processes of STAT3 ligand binding, receptor recruitment, homodimerization and phosphorylation, and regulates STAT3-mediated genes associated with tumorigenesis and radioresistance. C188-9 regulates STAT1-mediated genes related to radioresistance and reduces the activation level of STAT1. C188-9 downregulates the expression of *DNMT1, enhances DAC-induced demethylation and re-expression of RASSF1A, and simultaneously potentiates the anti-tumor effect of DAC on pancreatic cancer cells. C188-9 inhibits both anchorage-dependent and anchorage-independent growth of cancer cells, induces Apoptosis*, blocks the growth of tumor xenografts, and suppresses muscle atrophy. C188-9 maintains muscle mass, increases body weight and improves grip strength in tumor-bearing mice. C188-9 can be used in research related to head and neck squamous cell carcinoma, pancreatic cancer, sepsis-related skeletal muscle wasting, non-small cell lung cancer, acute myeloid leukemia and cancer cachexia ^[1] .

HY-17389

Genipin Maximum Cited Publications 22 Publications Verification (+)-Genipin	Autophagy	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Genipin ((+)-Genipin) is a natural crosslinking reagent derived from Gardenia jasminoides Ellis fruits. Genipin inhibits UCP2 (uncoupling protein 2) in cells. Genipin has a variety of bioactivities, including modulation on proteins, antitumor, anti-inflammation, immunosuppression, antithrombosis, and protection of hippocampal neurons. Genipin also can be used for type 2 diabetes research ^[1] .

HY-B2230

Hinokitiol 5+ Cited Publications β-Thujaplicin	Keap1-Nrf2 DNA Methyltransferase Virus Protease	Infection Cancer
Hinokitiol is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases *DNMT1* and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities.

HY-13962

SGI-1027 15+ Cited Publications	DNA Methyltransferase Apoptosis	Cancer
SGI-1027 is a DNA methyltransferase (DNMT) inhibitor, with IC₅₀s of 7.5 μM, 8 μM, and 12.5 μM for DNMT3B, DNMT3A, and DNMT1 with poly(dI-dC) as substrate.

HY-103236

NSC232003 5 Publications Verification	E1/E2/E3 Enzyme	Cancer
NSC232003 is a highly potent and cell-permeable *UHRF1* inhibitor, which inhibits DNA methylation in vitro and disrupts DNMT1/UHRF1 interactions at a cellular level.

HY-B2194

γ-Oryzanol 5+ Cited Publications	DNA Methyltransferase	Metabolic Disease Cancer
γ-Oryzanol is a potent DNA methyltransferases (DNMTs) inhibitor in the striatum of mice. γ-Oryzanol significantly inhibits the activities of *DNMT1* (IC₅₀=3.2 μM), *DNMT3a* (IC₅₀=22.3 μM).

HY-101925

CM-272 3 Publications Verification	Histone Methyltransferase DNA Methyltransferase Apoptosis	Cancer
CM-272 is a first-in-class, potent, selective, substrate-competitive and reversible dual G9a/DNA methyltransferases (DNMTs) inhibitor with antitumor activities. CM-272 inhibits G9a, *DNMT1, DNMT3A, DNMT3B* and GLP with IC₅₀s of 8 nM, 382 nM, 85 nM, 1200 nM and 2 nM, respectively. CM-272 inhibits cell proliferation and promotes apoptosis, inducing IFN-stimulated genes and immunogenic cell death ^[1].

HY-N0353

Curdione 2 Publications Verification (+)-Curdione	Ferroptosis Apoptosis Reactive Oxygen Species (ROS) Autophagy Glutathione Peroxidase Keap1-Nrf2 Heme Oxygenase (HO) TGF-β Receptor Indoleamine 2,3-Dioxygenase (IDO)	Cardiovascular Disease Neurological Disease Cancer
Curdione ((+)-Curdione) is an orally active sesquiterpenoid. Curdione inhibits platelet aggregation. Curdione induces ferroptosis in colorectal cancer via m6A methylation mediated by METTL14 and YTHDF2. Curdione inhibits ferroptosis in Isoproterenol (HY-B0468)-induced myocardial infarction by regulating the Keap1/Trx1/GPX4 signaling pathway, suppressing oxidative stress (ROS) and apoptosis. Curdione ameliorates Doxorubicin (HY-15142)-induced cardiotoxicity by inhibiting oxidative stress (ROS) and activating the *Nrf2/HO-1* pathway. Curdione ameliorates sepsis-induced lung injury by inhibiting platelet-mediated neutrophil extracellular trap formation. Curdione ameliorates Bleomycin (HY-17565A)-induced pulmonary fibrosis by inhibiting TGF-β-induced fibroblast-to-myofibroblast differentiation. Curdione exhibits neuroprotective effects against focal cerebral ischemia-reperfusion injury in rats. Curdione exerts antiproliferative effects against human uterine leiomyosarcoma by targeting *IDO1. Curdione protects vascular endothelial cells and atherosclerosis by regulating DNMT1-mediated* ERBB4 promoter methylation. Curdione inhibits inducible prostaglandin E2 production (IC₅₀ = 1.1 μM) and cyclooxygenase 2 expression ^[1] .

HY-A0084A

Procainamide 5+ Cited Publications Procaine amide; SP 100	DNA Methyltransferase Potassium Channel	Cardiovascular Disease Cancer
Procainamide (Procaine amide) is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1), which reactivates the expression of tumor suppressor factors by demethylating tumor suppressor genes. Procainamide induces vacuolization in various cell types and reduces cell proliferation and migration. Procainamide relaxes airway smooth muscle by activating potassium channels. Procainamide can be used in cancer and arrhythmia research ^[1] .

HY-A0084

Procainamide hydrochloride 5+ Cited Publications Procaine amide hydrochloride; SP 100 hydrochloride	DNA Methyltransferase Potassium Channel	Cancer
Procainamide hydrochloride (Procaine amide hydrochloride) is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1), which reactivates the expression of tumor suppressor factors by demethylating tumor suppressor genes. Procainamide hydrochloride induces vacuolization in various cell types and reduces cell proliferation and migration. Procainamide hydrochloride relaxes airway smooth muscle by activating potassium channels. Procainamide hydrochloride can be used in cancer and arrhythmia research ^[1] .

HY-15228

RX-3117 2 Publications Verification TV-1360; Fluorocyclopentenylcytosine	Nucleoside Antimetabolite/Analog Apoptosis	Cancer
RX-3117 (TV-1360) is a potent and orally active anticancer and antimetaboliteagent. RX-3117 inhibits DNA methyltransferase 1 (DNMT1). RX-3117 shows antiproliferative and anti-tumour activity. RX-3117 induces cell cycle arrest at S phase and apoptosis ^[1] .

HY-12746

DC-05 1 Publications Verification	DNA Methyltransferase	Cancer
DC-05 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC₅₀ and a K_d of 10.3 μM and 1.09 μM, respectively.

HY-15647

BRD9539 1 Publications Verification	Histone Methyltransferase	Cancer
BRD9539 is a histone methyltransferase G9a inhibitor with an IC₅₀ of 6.3 μM. BRD9539 also inhibits PRC2 activity and is inactive against SUV39H1, NSD2 and DNMT1 ^[1].

HY-12747

DC_517 2 Publications Verification	DNA Methyltransferase	Cancer
DC_517 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC₅₀ and a K_d of 1.7 μM and 0.91 μM, respectively.

HY-139015

5-Aza-4'-thio-2'-deoxycytidine 5-Aza-T-dCyd; NTX-301	DNA Methyltransferase	Cancer
5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd) is an orally active DNA methyltransferase I (DNMT1) inhibitor. 5-Aza-4'-thio-2'-deoxycytidine, a sulfur-containing deoxy-cytidine analog, has the potential for DNA hypomethylating and has antitumor effects ^[1].

HY-RS03908

DNMT1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DNMT1 Human Pre-designed siRNA Set A contains three designed siRNAs for DNMT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DNMT1 Human Pre-designed siRNA Set A DNMT1 Human Pre-designed siRNA Set A

HY-150249

GSK3735967 1 Publications Verification	DNA Methyltransferase	Cancer
GSK3735967 is an selective, reversible, non-nucleoside inhibitor of *DNMT1* with an IC₅₀ value of 40 nM. GSK3735967 contains a planar dicyanopyridine core that can specifically embed DNMT1 bound hemimethylated CpG dinucleotides. GSK3735967 has three binding sites, one of which can bind to histone H4K20me3 ^[1] .

HY-135146A

(Rac)-GSK-3484862	DNA Methyltransferase	Cancer
(Rac)-GSK-3484862 is the isomer of GSK-3484862 (HY-135146), and can be used as an experimental control. GSK-3484862 is a non-covalent inhibitor for DNA methyltransferase (Dnmt1). GSK-3484862 induces DNA hypomethylation to against cancer. GSK-3484862 mediates dramatic demethylation in murine embryonic stem cells with minimal non-specific toxicity ^[1] .

HY-139664A

(R)-GSK-3685032	DNA Methyltransferase	Cancer
(R)-GSK-3685032 is the R-enantiomer of GSK-3685032. GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible *DNMT1*-selective inhibitor, with an IC₅₀ of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition ^[1] .

HY-121093

DC-S239	Histone Methyltransferase	Cancer
DC-S239 is a selective histone methyltransferase SET7 inhibitor with an IC₅₀ value of 4.59 μM. DC-S239 also displays selectivity for DNMT1, DOT1L, EZH2, NSD1, SETD8 and G9a. DC-S239 has anticancer activity ^[1].

HY-123346

SW155246	DNA Methyltransferase	Cancer
SW155246 is a DNA methyltransferase (DNMT1) selective inhibitor with IC₅₀s of 1.2 and 38 μM for hDNMT1 and mDNMT3A, respectively. SW155246 can be used for the research of cancer and other diseases ^[1].

HY-146887

USP7-IN-9	Deubiquitinase Apoptosis	Cancer
USP7-IN-9 is a highly potent ubiquitin-specific protease 7 (USP7) inhibitor with an IC₅₀ value of 40.8 nM. USP7-IN-9 can induce apoptosis and arrest cell progression at G0/G1 and S phases in RS4; 11 cells. USP7-IN-9 reduces the protein levels of oncoproteins MDM2 and DNMT1 and increases the protein levels of tumor suppressors p53 and p21 ^[1].

HY-177807

DNMT1 aptamer sodium	DNA Methyltransferase	Cancer
DNMT1 aptamer sodium is a DNA aptamer for binding and inhibition of DNA methyltransferase 1 (DNMT1).

HY-173002

MS9024	DNA Methyltransferase	Cancer
MS9024 is the degrader for DNA methyltransferase 1 that degrades *DNMT1* in cell HCT116 through the ubiquitin-proteasome pathway with a DC₅₀ of 35 nM (DC₅₀ in MDA-MB-468 and H1299 is 254 nM and 101 nM). MS9024 also inhibits *DNMT1* with an IC₅₀ of 0.43 μM ^[1].

HY-175988

DNMT/HDAC-IN-2	DNA Methyltransferase HDAC	Cancer
DNMT/HDAC-IN-2 (Compound Y7) is a *DNMT* and HDAC inhibitor with IC₅₀ values for DNMT1, HDAC1, and HDAC6 of 365, 0.2, and 8.91 nM respectively. DNMT/HDAC-IN-2 inhibits the proliferation of breast cancer cells. DNMT/HDAC-IN-2 significantly reduces tumor growth in xenografts and transgenic breast cancer mouse models. DNMT/HDAC-IN-2 can be used for the study of breast cancer ^[1].

HY-119054

DNMT1-IN-4	DNA Methyltransferase	Cancer
DNMT1-IN-4 is a potent non-nucleoside DNA methyltransferase 1 (DNMT1) inhibitor with an IC₅₀ value of 2.5 µM and selectivity towards other AdoMet-dependent protein methyltransferases. DNMT1-IN-4 significantly inhibits cancer cell proliferation ^[1].

HY-RS03909

Dnmt1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Dnmt1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dnmt1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dnmt1 Mouse Pre-designed siRNA Set A Dnmt1 Mouse Pre-designed siRNA Set A

HY-RS03910

Dnmt1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Dnmt1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Dnmt1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dnmt1 Rat Pre-designed siRNA Set A Dnmt1 Rat Pre-designed siRNA Set A

HY-168088

DNMT1/HDAC-IN-1	HDAC DNA Methyltransferase	Cancer
DNMT1/HDAC-IN-1 (compound (R)-23a) is a *DNMT1/HDAC* dual inhibitor (HDAC1:IC₅₀=0.05 μM), *HDAC1* is a major HDAC isoform that interacts with *DNMT1* in multiple protein complexes for transcriptional silencing of TSGs. DNMT1/HDAC-IN-1 can reshape the tumor immune microenvironment and induce tumor regression, and effectively reverse cancer-specific epigenetic abnormalities ^[1].

HY-172217

DNMT1-IN-5	DNA Methyltransferase Apoptosis	Cancer
DNMT1-IN-5 (Compound 55) is the inhibitor for *DNMT* that inhibits *DNMT1* and *DNMT3A* with IC₅₀ of 2.42 μM and 14.4 μM. DNMT1-IN-5 exhibits antiproliferative activity in a variety of cancer cell lines (IC₅₀s for TMD-8, DOHH2, MOLM-13, THP-1, RPIM-8226 and HCT116 are 0.19-2.37 μM), arrests the cell cycle at G2/M phase, and induces apoptosis in TMD-8 and DOHH2 cells. DNMT1-IN-5 exhibits antitumor efficacy in TMD-8 xenograft mouse models ^[1].

HY-182956

DNMT1 Degrader-1	Molecular Glues DNA Methyltransferase	Cancer
DNMT1 Degrader-1 is a selective *DNMT1* degrader with an IC₅₀ of 202.87 nM and a Kd value of 122 nM. As a molecular glue, DNMT1 Degrader-1 forms a ternary complex with *DNMT1* and *UHRF1, thereby triggering UHRF1*-mediated ubiquitination and degradation of *DNMT1, and inhibiting the enzymatic activity of DNMT1. DNMT1* Degrader-1 inhibits the proliferation of primary acute myeloid leukemia cells and exerts anti-tumor activity. DNMT1 Degrader-1 can be used for the research of acute myeloid leukemia ^[1].

HY-17389R

Genipin (Standard) (+)-Genipin (Standard)	Reference Standards Autophagy	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Genipin (Standard) is the analytical standard of Genipin. This product is intended for research and analytical applications. Genipin ((+)-Genipin) is a natural crosslinking reagent derived from Gardenia jasminoides Ellis fruits. Genipin inhibits UCP2 (uncoupling protein 2) in cells. Genipin has a variety of bioactivities, including modulation on proteins, antitumor, anti-inflammation, immunosuppression, antithrombosis, and protection of hippocampal neurons. Genipin also can be used for type 2 diabetes research ^[1] .

HY-178446

METTL3-IN-11	METTL3 c-Myc Bcl-2 Family	Cancer
METTL3-IN-11 is an excellent, selective METTL3 inhibitor (IC₅₀ = 45.31 nM). METTL3-IN-11 exhibits high selectivity towards METTL3 compared to DNMT1, EZH1, MLL1, and PRMT1. METTL3-IN-11 reduces the m6A level of total RNA in MOLM-13 and SKOV3 cells, induces cell apoptosis, and inhibits cell migration. METTL3-IN-11 can reduce the expression of m6A downstream target genes (c-MYC and BCL2). METTL3-IN-11 can be used for the study of ovarian cancer and acute myeloid leukemia ^[1].

HY-161694

DNMT1-IN-3	DNA Methyltransferase	Cancer
DNMT1-IN-3 (compound 7t-S) is an effective DNA methyltransferase 1 (DNMT1) inhibitor with an IC₅₀ value of 0.777 μM and a K_D value of 0.183 μM. DNMT1-IN-3 can bind to the methyl donor S-adenosyl-l-methionine (SAM) site in DNMT1. DNMT1-IN-3 can inhibit cell proliferation in K562 cells by inducing cells apoptosis and arresting cell cycle at G0 / G1 phase, which has the potential to be used for the research of hematologic tumor ^[1].

HY-19826

Isofistularin-3	DNA Methyltransferase ADC Payload Autophagy Apoptosis	Cancer
Isofistularin-3 is a direct, DNA-competitive *DNMT1* inhibitor, with an IC₅₀ of 13.5 μM. Isofistularin-3, as a DNA demethylating agent, induces cell cycle arrest and sensitization to TRAIL in cancer cells. Isofistularin-3 can be used as an ADC cytotoxin ^[1].

HY-139664B

(S)-GSK-3685032	DNA Methyltransferase	Cancer
(S)-GSK-3685032 is the isomer of GSK-3685032 (HY-139664), and can be used as an experimental control. GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible *DNMT1*-selective inhibitor, with an IC₅₀ of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition ^[1].

HY-B2230R

Hinokitiol (Standard) β-Thujaplicin (Standard)	Keap1-Nrf2 DNA Methyltransferase Virus Protease Reference Standards	Infection Cancer
Hinokitiol (Standard) is the analytical standard of Hinokitiol. This product is intended for research and analytical applications. Hinokitiol is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases DNMT1 and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities.

HY-123577

TPC-144	Histone Demethylase Apoptosis	Cancer
TPC-144 is a *LSD1/KDM1A* inhibitor. TPC-144 inhibits LSD1, and leads to a decrease in the protein level of DNMT1, causing low methylation of the LINE-1 element. TPC-144 can also produce a synergistic effect with Decitabine (HY-A0004) (a DNMT inhibitor), jointly promoting DNA demethylation and thereby inducing differentiation and apoptosis of leukemia cells. TPC-144 has also demonstrated anti-tumor efficacy in acute myeloid leukemia (AML) models. TPC-144 can be used for the study of AML ^[1] .

HY-111544

EML741	Histone Methyltransferase	Cancer
EML741 is a histone lysine methyltransferase G9a/GLP inhibitor, with an IC₅₀ of 23 nM, K_d of 1.13 μM for G9a. EML741 also inhibits DNMT1 (IC₅₀, 3.1 μM), with no effect on DNMT3a or DNMT3b. EML741 exhibits low cell toxicity, and is membrane permeable and blood-brain barrier penetrated ^[1].

HY-149389

PNMT-IN-1	Adrenergic Receptor	Endocrinology
PNMT-IN-1 (inhibtor 4) is a specific inhibitor of phenylethanolamine N-methyltransferas (PNMT) with a K_i value of 1.2 nM and a IC₅₀ value of 81 nM. PNMT-IN-1 also inhibits the vitality of DNMT1 and DNMT3b, with the IC₅₀ value of 61 μM and 17 μM, respectively, and has an antagonistic effect on epinephrine.PNMT-IN-1 (inhibtor 4 ) is a second generation inhibitor ^[1].

HY-174301

USP7-IN-18	Deubiquitinase DNA Methyltransferase MDM-2/p53	Cancer
USP7-IN-18 is a naphthalene derivative. USP7-IN-18 is a selective USP7 inhibitor (IC₅₀ : 130.9 nM), with no or very weak inhibition of the other 8 DUBs including USP47. USP7-IN-18 specifically binds to the catalytic domain of USP7, blocking its deubiquitinase activity. USP7-IN-18 causes degradation of the oncogenic proteins MDM2 and *DNMT1, and also degrades the novel target PCLAF. USP7-IN-18 activates the p53-p21* pathway. USP7-IN-18 exerts anti-tumor effects in colon cancer animal models and reshapes the tumor immune microenvironment. USP7-IN-18 achieves both direct cytotoxic and immune-synergistic anti-tumor actions.

HY-13642A

(Rac)-RG108 (Rac)-N-Phthalyl-L-tryptophan	DNA Methyltransferase	Others
(Rac)-RG108 (NSC401077), a *DNMT1* inhibitor, inhibits DNA methyltransferases ^[1].

HY-A0084AR

Procainamide (Standard) Procaine amide (Standard); SP 100 (Standard)	Reference Standards DNA Methyltransferase Potassium Channel	Cardiovascular Disease Cancer
Procainamide (Standard) is the analytical standard of Procainamide. This product is intended for research and analytical applications. Procainamide (Procaine amide) is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1), which reactivates the expression of tumor suppressor factors by demethylating tumor suppressor genes. Procainamide induces vacuolization in various cell types and reduces cell proliferation and migration. Procainamide relaxes airway smooth muscle by activating potassium channels. Procainamide can be used in cancer and arrhythmia research ^[1] .

HY-N0353R

Curdione (Standard) (+)-Curdione (Standard)	Reference Standards Ferroptosis Apoptosis Reactive Oxygen Species (ROS) Autophagy Glutathione Peroxidase Keap1-Nrf2 Heme Oxygenase (HO) TGF-β Receptor Indoleamine 2,3-Dioxygenase (IDO)	Others
Curdione (Standard) is the analytical standard of Curdione. This product is intended for research and analytical applications. Curdione ((+)-Curdione) is an orally active sesquiterpenoid. Curdione inhibits platelet aggregation. Curdione induces ferroptosis in colorectal cancer via m6A methylation mediated by METTL14 and YTHDF2. Curdione inhibits ferroptosis in Isoproterenol (HY-B0468)-induced myocardial infarction by regulating the Keap1/Trx1/GPX4 signaling pathway, suppressing oxidative stress (ROS) and apoptosis. Curdione ameliorates Doxorubicin (HY-15142)-induced cardiotoxicity by inhibiting oxidative stress (ROS) and activating the *Nrf2/HO-1* pathway. Curdione ameliorates sepsis-induced lung injury by inhibiting platelet-mediated neutrophil extracellular trap formation. Curdione ameliorates Bleomycin (HY-17565A)-induced pulmonary fibrosis by inhibiting TGF-β-induced fibroblast-to-myofibroblast differentiation. Curdione exhibits neuroprotective effects against focal cerebral ischemia-reperfusion injury in rats. Curdione exerts antiproliferative effects against human uterine leiomyosarcoma by targeting *IDO1. Curdione protects vascular endothelial cells and atherosclerosis by regulating DNMT1-mediated* ERBB4 promoter methylation. Curdione inhibits inducible prostaglandin E2 production (IC₅₀ = 1.1 μM) and cyclooxygenase 2 expression ^[1] .

HY-179409

MC3817	DNA Methyltransferase Caspase MDM-2/p53 DNA/RNA Synthesis Apoptosis	Cancer
MC3817 is a selective *DNMT1* inhibitor. MC3817 inhibits *DNMT1* and *DNMT3A/3L* with IC₅₀s of 0.044 μM and > 10μM, respectively. MC3817 inhibits P53-dependent cancer cell proliferation, induces apoptosis and DNA damage MC3817 elevates cleaved Caspase 3, P53, and γH2AX. MC3817 can be used in non-small cell lung cancer, colon cancer, cervical cancer, triple-negative breast cancer and histiocytic lymphoma research ^[1].

HY-181955

MS1129	Apoptosis DNA Methyltransferase HIF/HIF Prolyl-Hydroxylase Caspase	Cancer
MS1129 is a *DNMT* degrader that induces proteasomal degradation of *DNMT1, DNMT3A* and *DNMT3B* proteins. MS1129 upregulates TRAIL, DR4 and DR5 proteins, downregulates the decoy receptor DcR2, and activates TRAIL-dependent apoptosis via the HIF-1/2 and Caspase-10 pathways. MS1129 is applicable to the research of VHL-deficient clear cell renal cell carcinoma ^[1].

HY-179409A

MC3817 free base	DNA Methyltransferase Caspase MDM-2/p53 DNA/RNA Synthesis Apoptosis	Cancer
MC3817 free base is a selective *DNMT1* inhibitor. MC3817 free base inhibits *DNMT1* and *DNMT3A/3L* with IC₅₀s of 0.044 μM and > 10μM, respectively. MC3817 free base inhibits P53-dependent cancer cell proliferation, induces apoptosis and DNA damage. MC3817 free base elevates cleaved Caspase 3, P53, and γH2AX. MC3817 free base can be used in non-small cell lung cancer, colon cancer, cervical cancer, triple-negative breast cancer and histiocytic lymphoma research ^[1].

HY-101925R

CM-272 (Standard)	Reference Standards Histone Methyltransferase DNA Methyltransferase Apoptosis	Cancer
CM-272 (Standard) is the analytical standard of CM-272 (HY-101925). This product is intended for research and analytical applications. CM-272 is a first-in-class, potent, selective, substrate-competitive and reversible dual G9a/DNA methyltransferases (DNMTs) inhibitor with antitumor activities. CM-272 inhibits G9a, DNMT1, DNMT3A, DNMT3B and GLP with IC₅₀s of 8 nM, 382 nM, 85 nM, 1200 nM and 2 nM, respectively. CM-272 inhibits cell proliferation and promotes apoptosis, inducing IFN-stimulated genes and immunogenic cell death ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-17389

Genipin Maximum Cited Publications 22 Publications Verification (+)-Genipin	Neurological Disease Classification of Application Fields Metabolic Disease Plants Endogenous metabolite Human Gut Microbiota Metabolites Iridoids Terpenoids Rubiaceae Gardenia jasminoides Ellis Inflammation/Immunology Disease Research Fields Source Classification	Autophagy
Genipin ((+)-Genipin) is a natural crosslinking reagent derived from Gardenia jasminoides Ellis fruits. Genipin inhibits UCP2 (uncoupling protein 2) in cells. Genipin has a variety of bioactivities, including modulation on proteins, antitumor, anti-inflammation, immunosuppression, antithrombosis, and protection of hippocampal neurons. Genipin also can be used for type 2 diabetes research ^[1] .

HY-B2230

Hinokitiol 5+ Cited Publications β-Thujaplicin	Infection Cupressaceae Classification of Application Fields Ketones, Aldehydes, Acids Chamaecyparis obtusa (Siebold & Zucc.) Endl. Plants Disease Research Fields Source Classification	Keap1-Nrf2 DNA Methyltransferase Virus Protease
Hinokitiol is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases *DNMT1* and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities.

HY-B2194

γ-Oryzanol 5+ Cited Publications	Monophenols other families Classification of Application Fields Phenols Plants Disease Research Fields Steroids Source Classification Cancer	DNA Methyltransferase
γ-Oryzanol is a potent DNA methyltransferases (DNMTs) inhibitor in the striatum of mice. γ-Oryzanol significantly inhibits the activities of *DNMT1* (IC₅₀=3.2 μM), *DNMT3a* (IC₅₀=22.3 μM).

HY-N0353

Curdione 2 Publications Verification (+)-Curdione	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Other Diseases Curcuma phaeocaulis Valeton Plants Disease Research Fields Source Classification Zingiberaceae	Ferroptosis Apoptosis Reactive Oxygen Species (ROS) Autophagy Glutathione Peroxidase Keap1-Nrf2 Heme Oxygenase (HO) TGF-β Receptor Indoleamine 2,3-Dioxygenase (IDO)
Curdione ((+)-Curdione) is an orally active sesquiterpenoid. Curdione inhibits platelet aggregation. Curdione induces ferroptosis in colorectal cancer via m6A methylation mediated by METTL14 and YTHDF2. Curdione inhibits ferroptosis in Isoproterenol (HY-B0468)-induced myocardial infarction by regulating the Keap1/Trx1/GPX4 signaling pathway, suppressing oxidative stress (ROS) and apoptosis. Curdione ameliorates Doxorubicin (HY-15142)-induced cardiotoxicity by inhibiting oxidative stress (ROS) and activating the *Nrf2/HO-1* pathway. Curdione ameliorates sepsis-induced lung injury by inhibiting platelet-mediated neutrophil extracellular trap formation. Curdione ameliorates Bleomycin (HY-17565A)-induced pulmonary fibrosis by inhibiting TGF-β-induced fibroblast-to-myofibroblast differentiation. Curdione exhibits neuroprotective effects against focal cerebral ischemia-reperfusion injury in rats. Curdione exerts antiproliferative effects against human uterine leiomyosarcoma by targeting *IDO1. Curdione protects vascular endothelial cells and atherosclerosis by regulating DNMT1-mediated* ERBB4 promoter methylation. Curdione inhibits inducible prostaglandin E2 production (IC₅₀ = 1.1 μM) and cyclooxygenase 2 expression ^[1] .

HY-17389R

Genipin (Standard) (+)-Genipin (Standard)	Structural Classification Human Gut Microbiota Metabolites Iridoids Terpenoids Rubiaceae Plants Gardenia jasminoides Ellis Endogenous metabolite Source Classification	Reference Standards Autophagy
Genipin (Standard) is the analytical standard of Genipin. This product is intended for research and analytical applications. Genipin ((+)-Genipin) is a natural crosslinking reagent derived from Gardenia jasminoides Ellis fruits. Genipin inhibits UCP2 (uncoupling protein 2) in cells. Genipin has a variety of bioactivities, including modulation on proteins, antitumor, anti-inflammation, immunosuppression, antithrombosis, and protection of hippocampal neurons. Genipin also can be used for type 2 diabetes research ^[1] .

HY-B2230R

Hinokitiol (Standard) β-Thujaplicin (Standard)	Structural Classification Cupressaceae Ketones, Aldehydes, Acids Chamaecyparis obtusa (Siebold & Zucc.) Endl. Plants Source Classification	Keap1-Nrf2 DNA Methyltransferase Virus Protease Reference Standards
Hinokitiol (Standard) is the analytical standard of Hinokitiol. This product is intended for research and analytical applications. Hinokitiol is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases DNMT1 and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities.

HY-N0353R

Curdione (Standard) (+)-Curdione (Standard)	Structural Classification Terpenoids Sesquiterpenes Curcuma phaeocaulis Valeton Plants Source Classification Zingiberaceae	Reference Standards Ferroptosis Apoptosis Reactive Oxygen Species (ROS) Autophagy Glutathione Peroxidase Keap1-Nrf2 Heme Oxygenase (HO) TGF-β Receptor Indoleamine 2,3-Dioxygenase (IDO)
Curdione (Standard) is the analytical standard of Curdione. This product is intended for research and analytical applications. Curdione ((+)-Curdione) is an orally active sesquiterpenoid. Curdione inhibits platelet aggregation. Curdione induces ferroptosis in colorectal cancer via m6A methylation mediated by METTL14 and YTHDF2. Curdione inhibits ferroptosis in Isoproterenol (HY-B0468)-induced myocardial infarction by regulating the Keap1/Trx1/GPX4 signaling pathway, suppressing oxidative stress (ROS) and apoptosis. Curdione ameliorates Doxorubicin (HY-15142)-induced cardiotoxicity by inhibiting oxidative stress (ROS) and activating the *Nrf2/HO-1* pathway. Curdione ameliorates sepsis-induced lung injury by inhibiting platelet-mediated neutrophil extracellular trap formation. Curdione ameliorates Bleomycin (HY-17565A)-induced pulmonary fibrosis by inhibiting TGF-β-induced fibroblast-to-myofibroblast differentiation. Curdione exhibits neuroprotective effects against focal cerebral ischemia-reperfusion injury in rats. Curdione exerts antiproliferative effects against human uterine leiomyosarcoma by targeting *IDO1. Curdione protects vascular endothelial cells and atherosclerosis by regulating DNMT1-mediated* ERBB4 promoter methylation. Curdione inhibits inducible prostaglandin E2 production (IC₅₀ = 1.1 μM) and cyclooxygenase 2 expression ^[1] .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P703564

	DNMT1 Protein, Human AIM; CXXC9; Dnmt	Human	E. coli
	DNMT1 Protein, Human is the recombinant human-derived DNMT1, expressed by E. coli , with tag Free labeled tag.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-A0084AS

Procainamide-d4

Procainamide-d₄ (Procaine amide-d₄) is the deuterium labeled Procainamide (HY-A0084A). Procainamide (Procaine amide) is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1), which reactivates the expression of tumor suppressor factors by demethylating tumor suppressor genes. Procainamide induces vacuolization in various cell types and reduces cell proliferation and migration. Procainamide relaxes airway smooth muscle by activating potassium channels. Procainamide can be used in cancer and arrhythmia research ^[1] .

Host:	Mouse (3) Rabbit (2)
Reactivity:	Human (5) Rat (1) Mouse (2) Monkey (2)
Application:	IHC-P (5) ICC/IF (2) IP (1) WB (5) FC (1) ELISA (3)
Isotype:	IgG (2) IgG1 (3)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (3) Monoclonal Antibody (1) Recombinant (1)
Modification:	Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80106

	Dnmt1 Antibody (YA476)	WB, ICC/IF, IHC-P	Human, Mouse
	Dnmt1 Antibody (YA476) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Dnmt1.

HY-P80105

	Dnmt1 Antibody (YA781)	WB, IHC-P, FC	Human
	Dnmt1 Antibody (YA781) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Dnmt1.

HY-P86366

	Dnmt1 Antibody (YA6058)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Dnmt1 Antibody (YA6058) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Dnmt1.

HY-P84218

	Dnmt1 Antibody (YA3915) AIM; Dnmt; MCMT; CXXC9; HSN1E	WB, IHC-P, ELISA	Human, Monkey
	Dnmt1 Antibody (YA3915) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Dnmt1.

HY-P84218A

	Dnmt1 Antibody (YA3915)(PBS only) AIM; Dnmt; MCMT; CXXC9; HSN1E	WB, IHC-P, ELISA	Human, Monkey
	Dnmt1 Antibody (YA3915) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Dnmt1.