Enolase

By Targets:	Enolase (9) ACSL Family (1) Antibiotic (2) Apoptosis (4) ATP Synthase (1) Bacterial (2) Biochemical Assay Reagents (3) Endogenous Metabolite (1) Ferroptosis (1) Glutathione Peroxidase (1) IRAK (1) MDM-2/p53 (1) Microtubule/Tubulin (1) NF-κB (1) Parasite (1) Phosphoglycerate Dehydrogenase (PHGDH) (1) PROTACs (1) Reactive Oxygen Species (ROS) (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (1) Infection (4) Inflammation/Immunology (1) Metabolic Disease (5) Neurological Disease (2)

Targets Recommended: Enolase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15858

AP-III-a4 Maximum Cited Publications 16 Publications Verification ENOblock	Enolase Apoptosis	Metabolic Disease Cancer
AP-III-a4 (ENOblock) is a nonsubstrate analogue *enolase* inhibitor with an IC₅₀ of 0.576 uM. AP-III-a4 can be used for the research of cancer and diabetic .

HY-131904

POMHEX 3 Publications Verification	Enolase Apoptosis	Metabolic Disease Cancer
POMHEX, a racemic mixture and a cell-permeable pivaloyloxymethyl (POM) proagent of HEX, is a potent, ENO2-specific inhibitor of enolase. POMHEX exhibits low-nanomolar potency against ENO1-deleted cells in vitro and is capable of eradicating ENO1-deleted xenografted tumours in vivo. POMHEX is a potent glycolysis inhibitor .

HY-141412

D-(-)-3-Phosphoglyceric acid disodium 1 Publications Verification 3-Phospho-D-glyceric acid disodium	Enolase Phosphoglycerate Dehydrogenase (PHGDH) MDM-2/p53 Apoptosis	Infection
D-(-)-3-Phosphoglyceric acid (3-Phospho-D-glyceric acid) disodium is an important intermediate in the enzyme-catalyzed glycolysis process. D-(-)-3-Phosphoglyceric acid disodium competitively inhibits yeast enolase (enolase). D-(-)-3-Phosphoglyceric acid disodium can regulate the activity of phosphoglycerate dehydrogenase (PHGDH) to modulate p53 protein and apoptosis .

HY-117778

SF2312	Enolase Bacterial Antibiotic	Infection Cancer
SF2312, a natural phosphonate antibiotic (Antibiotic), is a highly potent *Enolase* inhibitor with IC₅₀s of 37.9 nM and 42.5 nM for human recombinant ENO1 and ENO2, respectively. SF2312 is active against bacteria under anaerobic conditions .

HY-113167

2-Phosphoglyceric acid DL-2-phosphoglyceric acid	ACSL Family Endogenous Metabolite Ferroptosis Glutathione Peroxidase Reactive Oxygen Species (ROS)	Metabolic Disease
2-Phosphoglyceric acid (DL-2-phosphoglyceric acid) is a glycolytic substrate that is catalyzed by enolase to form phosphoenolpyruvate ester (PEP). 2-Phosphoglyceric acid inhibits the ferroptosis pathway by down-regulating ACSL4 and up-regulating GPX4, and has significant neuroprotective effects. 2-Phosphoglyceric acid reflects the overall metabolic state and flux of the cell .

HY-131904A

Hex	Enolase Parasite	Infection Cancer
Hex is an *enolase* inhibitor and antimalarial agent with K_i values of 74.4 nM and 269.4 nM for ENO2 and ENO1, respectively. Hex is a NfENO and TbENO inhibitor with IC₅₀s value of 0.14 μM and 2.1 μM, respectively. Hex has antimalarial activity against Plasmodium falciparum 3D7, Naegleria fowleri trophozoites and Plasmodium berghei ANKA strain. Hex has anti-tumor effects against intracranial tumors .

HY-15858A

AP-III-a4 hydrochloride Maximum Cited Publications 16 Publications Verification ENOblock hydrochloride	Enolase Apoptosis	Metabolic Disease Cancer
AP-III-a4 (ENOblock) hydrochloride is a nonsubstrate analogue *enolase* inhibitor with an IC₅₀ of 0.576 uM. AP-III-a4 hydrochloride can be used for the research of cancer and diabetic .

HY-P2862

Enolase, S.cerevisiae	Biochemical Assay Reagents	Others
Enolase is a glycolytic enzyme present in the cell wall of S. cerevisiae. Enolase exhibits specific affinity to imported tRNA and can facilitate formation of preMsk1p-tRNA complex. Enolase can be overproduced in tumor cells where rate of glycolysis is increased. Enolase depletion can lead to tRNA inhibition in vivo .

HY-179094

PSP-0119	PROTACs IRAK NF-κB Enolase	Inflammation/Immunology Cancer
PSP-0119 is a highly efficient and effective PROTAC degrader targeting IRAK4 (IC₅₀ = 2.83 nM). PSP-0119 can inhibit IRAK4 kinase activity, NF-κβ activity, and IL-1β-induced IRAK4 phosphorylation. PSP-0119 degrades IRAK4 in FLT3-mutant AML cell lines, sparing FLT3-wild-type AML cells, FLT3-wild-type samples, and normal bone marrow. PSP-0119 downregulates *alpha-enolase* (eNOS)** of MOLM-13 cells. PSP-0119 can be used for the study of Acute Myeloid Leukemia (AML) .

HY-117778B

SF2312 ammonium	Enolase Bacterial Antibiotic ATP Synthase	Infection Cancer
SF2312 ammonium is a phosphonate Antibiotic and *Enolase* inhibitor, with an IC₅₀ of 18.4 nM against E. coli enolase. SF2312 ammonium reduces intracellular ATP levels and inhibits glycolytic flux. SF2312 ammonium exhibits activity against both Gram-positive and Gram-negative bacteria, and exerts synergistic effects against E. coli when combined with Fosfomycin (HY-B1075A). SF2312 ammonium shows selective toxicity toward gliomas with ENO1 gene knockout. SF2312 ammonium can be used in research related to bacterial infections and gliomas .

HY-108438

TCS 2210	Microtubule/Tubulin	Neurological Disease
TCS 2210 (compound 1) is a neuronal differentiation inducer in mesenchymal stem cells (MSCs). TCS 2210 increases expression of the neuronal markers β-III tubulin and neuron-specific enolase (NSE) .

HY-P2862A

*Neuron-specific enolase, Human*	Enolase	Neurological Disease
Neuron-specific enolase, Human (EC 4.2.1.11), an enolase, is a biomarker in traumatic brain injury (TBI), stroke and anoxic encephalopathy after cardiac arrest and acute SCI as well .

HY-E71291

*β-Enolase, Human*	Biochemical Assay Reagents	Others
β-Enolase, Human is one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in skeletal muscle cells in the adult.

HY-P2862B

*α-Enolase, Human*	Biochemical Assay Reagents	Others
α-Enolase, Human is one of three enolase isoenzymes and a glycolytic enzyme expressed in most tissues. This protein plays a key role in anaerobic metabolism under hypoxic conditions and may act as a cell surface plasminogen receptor during tissue invasion.

Cat. No.	Product Name

HY-L058

Glycolysis Compound Library	1,258 compounds
Glycolysis is a series of metabolic processes by which one molecule of glucose is catabolized to two molecules of pyruvate with a net gain of two ATP. Glycolysis takes place in 10 steps and catalyzed by a series of enzyme, such as hexokinase, Glucose-6-phosphate isomerase, Phosphofructokinase, etc. Glycolysis is used by all cells in the body for energy generation. Most cancer cells exhibit increased glycolysis and use this metabolic pathway for generation of ATP as a main source of their energy supply. This phenomenon is known as the Warburg effect and is considered as one of the most fundamental metabolic alterations during malignant transformation. Because increased aerobic glycolysis is commonly seen in a wide spectrum of human cancers, development of novel glycolytic inhibitors as a new class of anticancer agents is likely to have broad therapeutic applications. MCE provides a unique collection of 1,258 glycolysis compounds that mainly target hexokinase, glucokinase, enolase, pyruvate kinase, PDHK, etc. MCE Glycolysis Compound Library is a useful tool for glucose metabolism research and anti-cancer drug discovery.

Glycolysis Compound Library

1,258 compounds

Glycolysis is a series of metabolic processes by which one molecule of glucose is catabolized to two molecules of pyruvate with a net gain of two ATP. Glycolysis takes place in 10 steps and catalyzed by a series of enzyme, such as hexokinase, Glucose-6-phosphate isomerase, Phosphofructokinase, etc. Glycolysis is used by all cells in the body for energy generation.

Most cancer cells exhibit increased glycolysis and use this metabolic pathway for generation of ATP as a main source of their energy supply. This phenomenon is known as the Warburg effect and is considered as one of the most fundamental metabolic alterations during malignant transformation. Because increased aerobic glycolysis is commonly seen in a wide spectrum of human cancers, development of novel glycolytic inhibitors as a new class of anticancer agents is likely to have broad therapeutic applications.

MCE provides a unique collection of 1,258 glycolysis compounds that mainly target hexokinase, glucokinase, enolase, pyruvate kinase, PDHK, etc. MCE Glycolysis Compound Library is a useful tool for glucose metabolism research and anti-cancer drug discovery.

Cat. No.	Product Name	Target	Research Area

HY-P4094

CTP 2 Publications Verification Cardiac targeting peptide	Peptides	Cardiovascular Disease
CTP (cardiac targeting peptide) can transduce cardiomyocytes in vitro. CTP leads to efficient and specific transduction of heart tissue in mice model. CTP can be reversibly linked (e.g. via enolases, thiol groups) to cargo (e.g. miRNAs) for delivery specifically to cardiomyocytes over all other organs .

HY-P4698

Tri-valine NSC 35938	Peptides	Metabolic Disease
Tri-valine (NSC 35938) is a polypeptide that can be separated from Creatine kinase (HY-P2799), β-enolase, Triosephosphate isomerase (HY-P2931) and glyceraldehyde 3-phosphate dehydrogenase .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-117778

SF2312	Natural Products Microorganisms Source Classification	Enolase Bacterial Antibiotic
SF2312, a natural phosphonate antibiotic (Antibiotic), is a highly potent *Enolase* inhibitor with IC₅₀s of 37.9 nM and 42.5 nM for human recombinant ENO1 and ENO2, respectively. SF2312 is active against bacteria under anaerobic conditions .

HY-113167

2-Phosphoglyceric acid DL-2-phosphoglyceric acid	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	ACSL Family Endogenous Metabolite Ferroptosis Glutathione Peroxidase Reactive Oxygen Species (ROS)
2-Phosphoglyceric acid (DL-2-phosphoglyceric acid) is a glycolytic substrate that is catalyzed by enolase to form phosphoenolpyruvate ester (PEP). 2-Phosphoglyceric acid inhibits the ferroptosis pathway by down-regulating ACSL4 and up-regulating GPX4, and has significant neuroprotective effects. 2-Phosphoglyceric acid reflects the overall metabolic state and flux of the cell .

Species:	Human (4) Mouse (3) Rat (1)
Tag:	His (8)
Source:	P. pastoris (1) E. coli (7)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P70271

	*Gamma-enolase/Enolase* 2 Protein, Human (His)** rHuGamma-Enolase/ENO2, His; Gamma-Enolase; 2-phospho-D-glycerate hydro-lyase; Enolase 2; Neural Enolase; Neuron-specific Enolase; NSE; ENO2	Human	E. coli
	Gamma-enolase/Enolase 2 protein exhibits neurotrophic and neuroprotective properties, binding to neocortical neurons and promoting cell survival through a calcium-dependent mechanism. This suggests its potential role in supporting neuron viability within the central nervous system. Gamma-enolase/Enolase 2 Protein, Human (His) is the recombinant human-derived Gamma-enolase/Enolase 2 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P75732

	Enolase 3/ENO3 Protein, Human (His) Beta-Enolase; Enolase 3; MSE; Skeletal muscle Enolase	Human	E. coli
	Enolase 3/ENO3 protein acts as a glycolytic enzyme, promoting the conversion of 2-phosphoglycerate into phosphoenolpyruvate. In addition to its role in glycolysis, ENO3 appears to play a crucial role in the development and regeneration of striated muscle. Enolase 3/ENO3 Protein, Human (His) is the recombinant human-derived Enolase 3/ENO3 protein, expressed by E. coli , with N-His labeled tag.

HY-P705529

	ENO3 Protein, Mouse (P. pastoris, His) Beta-Enolase; 2-phospho-D-glycerate hydro-lyase; Enolase 3; Muscle-specific Enolase (MSE); Skeletal muscle Enolase	Mouse	P. pastoris

HY-P75253

	Enolase 1/ENO1 Protein, Rat (His) ENO1L1; Eno-1; Alpha-Enolase; NNE; MBP-1; Enolase 1	Rat	E. coli
	Enolase 1 (ENO1) plays a key role in carbohydrate degradation, particularly in the glycolytic pathway, where it catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate.This enzyme activity occurs during the fourth step of glycolysis and marks a critical stage in the conversion of glucose to pyruvate.Enolase 1/ENO1 Protein, Rat (His) is the recombinant rat-derived Enolase 1/ENO1 protein, expressed by E.coli , with N-His labeled tag.

HY-P705495

	*Gamma-enolase/Enolase* 2 Protein, Mouse (His)** phosphopyruvate hydratase; Eno2; 2-phospho-D-glycerate hydro-lyase	Mouse	E. coli

HY-P72182

	Enolase 1/ENO1 Protein, Mouse (His) Eno1; Eno-1; Alpha-Enolase; EC 4.2.1.11; 2-phospho-D-glycerate hydro-lyase; Enolase 1; Non-neural Enolase; NNE	Mouse	E. coli
	Enolase 1/ENO1 Proteins, as a glycolytic enzyme, convert 2-phosphoglycerate to phosphoenolpyruvate and have diverse roles in cellular processes like growth control, hypoxia tolerance, and allergic responses. They also function in the fibrinolytic system and stimulate immunoglobulin production, showing their involvement in immune responses. Enolase 1/ENO1 Protein, Mouse (His) is the recombinant mouse-derived Enolase 1/ENO1 protein, expressed by E. coli , with N-10*His labeled tag.

HY-P70260A

	Enolase 1/ENO1 Protein, Human (His) rHuAlpha-Enolase, His; Alpha-Enolase; 2-phospho-D-glycerate hydro-lyase; C-myc promoter-binding protein; Enolase 1; MBP-1; MPB-1; Non-neural Enolase; NNE; Phosphopyruvate hydratase; Plasminogen-binding protein; ENO1	Human	E. coli
	The ENO1 protein converts 2-phosphoglycerate to phosphoenolpyruvate and is involved in growth control, hypoxia tolerance, and allergic responses. It acts as a receptor and activator of plasminogen, stimulating immunoglobulin production. ENO1 binds to the myc promoter as a transcriptional repressor and may function as a tumor suppressor. Enolase 1/ENO1 Protein, Human (His) is the recombinant human-derived Enolase 1/ENO1 protein, expressed by E. coli , with C-6*His labeled tag.

HY-P70260

	Enolase 1/ENO1 Protein, Human (His, solution) rHuAlpha-Enolase, His; Alpha-Enolase; 2-phospho-D-glycerate hydro-lyase; C-myc promoter-binding protein; Enolase 1; MBP-1; MPB-1; Non-neural Enolase; NNE; Phosphopyruvate hydratase; Plasminogen-binding protein; ENO1	Human	E. coli
	The ENO1 protein converts 2-phosphoglycerate to phosphoenolpyruvate and is involved in growth control, hypoxia tolerance, and allergic responses. It acts as a receptor and activator of plasminogen, stimulating immunoglobulin production. ENO1 binds to the myc promoter as a transcriptional repressor and may function as a tumor suppressor. Enolase 1/ENO1 Protein, Human (His, solution) is the recombinant human-derived ENO1, expressed by E. coli , with C-His labeled tag.

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Host:	Mouse (4) Rabbit (2)
Reactivity:	Human (6) Rat (6) Mouse (6)
Application:	IHC-P (1) ICC/IF (3) IHC-F (1) WB (6) ELISA (3)
Isotype:	IgG (2) IgG1 (4)
Conjugation:	Non-conjugated (6)
Clonality:	Monoclonal (4) Recombinant (1)
Modification:	Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81290

	NSE Antibody (YA1004) ENO2; Gamma-Enolase; 2-phospho-D-glycerate hydro-lyase; Enolase 2; Neural Enolase; Neuron-specific Enolase; NSE	WB, ELISA	Human, Mouse, Rat
	NSE Antibody (YA1004) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NSE.

HY-P81290B

	NSE Antibody (YA1006) ENO2; Gamma-Enolase; 2-phospho-D-glycerate hydro-lyase; Enolase 2; Neural Enolase; Neuron-specific Enolase; NSE	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	NSE Antibody (YA1006) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NSE.

HY-P81290A

	NSE Antibody (YA1005) ENO2; Gamma-Enolase; 2-phospho-D-glycerate hydro-lyase; Enolase 2; Neural Enolase; Neuron-specific Enolase; NSE	WB, ELISA	Human, Mouse, Rat
	NSE Antibody (YA1005) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NSE.

HY-P81290AA

	NSE Antibody (YA1005)(PBS only) ENO2; Gamma-Enolase; 2-phospho-D-glycerate hydro-lyase; Enolase 2; Neural Enolase; Neuron-specific Enolase; NSE	WB, ELISA	Human, Mouse, Rat
	NSE Antibody (YA1005) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NSE.

HY-P83023

	ENO3 Antibody (YA2768) Enolase 3; MSE; GSD13	WB, ICC/IF	Human, Mouse, Rat
	ENO3 Antibody (YA2768) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ENO3.

HY-P83023A

	ENO3 Antibody (YA2768)(PBS only) Enolase 3; MSE; GSD13	WB, ICC/IF	Human, Mouse, Rat
	ENO3 Antibody (YA2768) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ENO3.

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