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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
FXIIa
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "FXIIa" in MCE Product Catalog:
2
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1 Cited Publications
Cat. No.: HY-163348
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FXIIa-IN-4 (compound 22) is a potent, selective human FXIIa inhibitor with the IC50 of 0.032 μM, 0.30 μM, ＞50 μM for FXIIa, thrombin and FXIa, respectively. FXIIa-IN-4 can be used for study of anticoagulant .
Cat. No.: HY-P99415
CAS No.: 2098724-83-3
Synonyms: MAA868
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Cat. No.: HY-P4331
CAS No.: 113865-85-3
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Cat. No.: HY-175735
CAS No.: 2563884-39-7
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Factor XI-IN-2 is a Factor XI activation inhibitor with an IC50 of 20 nM. Factor XI-IN-2 does not directly inhibit the enzymatic activity of FXIa, but specifically binds to the FXI enzyme precursor and allosterically inhibits the process by which it is activated by FXIIa. Factor XI-IN-2 inhibits thrombosis in the rabbit arteriovenous (AV) shunt thrombosis model. Factor XI-IN-2 can be used for the study of antithrombus .
Cat. No.: HY-149397
CAS No.: 3052551-17-1
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FXIIa-IN-1-IN-2 (Compound 21) is a Factor XIIa inhibitor (Ki app: 62.2 nM). FXIIa-IN-1-IN-2 can be used for research of thrombosis .
Cat. No.: HY-152150
CAS No.: 2866508-00-9
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Thrombin inhibitor 7 is a potent FXIIa inhibitor with IC50 values of 28 nM, >132 µM for FXIIa and FXIa, respectively. Thrombin inhibitor 7 shows low cytotoxicity .
Cat. No.: HY-149396A
CAS No.: 3052551-20-6
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FXIIa-IN-1 hydrochloride is the hydrochloride of FXIIa-IN-1 (HY-149396). FXIIa-IN-1 (Compound 22) is a Factor XIIa inhibitor (Ki app: 97.8 nM). FXIIa-IN-1 can be used for research of thrombosis .
Cat. No.: HY-163347
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FXIIa-IN-3 (Compound 8) is a potent and selective Factor XIIa (FXIIa) inhibitor, with an IC50 of 0.045 μM. FXIIa-IN-3 also exhibits a substantial margin of selectivity against related serine proteases, including FXIa, FXa, and FIXa. FXIIa-IN-3 can be used for the research of thromboembolic diseases .
Cat. No.: HY-162646
CAS No.: 3047411-80-0
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FXIIa-IN-5 (Compound 4J) is an orally active, selective inhibitor for factor XIIa (FXIIa), with IC50 of 21 nM. FXIIa-IN-5 inhibits the intrinsic coagulation pathways, and exhibits anti-inflammatory and antithrombotic activity in Carrageenan (HY-125474)-induced mice thrombosis models. FXIIa-IN-5 exhibits moderate pharmacokinetic characteristics and slightly toxicity (at 100 mg/kg) .
Cat. No.: HY-184008
CAS No.: 3107571-66-1
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FXIIa-IN-6 is a potent, selective, and irreversible covalent inhibitor of Factor XIIa (FXIIa) with an IC50 of 2 nM. FXIIa-IN-6 exhibits ≥2,500-fold selectivity over related serine proteases. FXIIa-IN-6 exhibits favorable anticoagulant and anti-inflammatory activities and can be used in sepsis research .
Cat. No.: HY-149396
CAS No.: 3052551-19-3
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XIIa-IN-1-IN-3 (Compound 22) is a Factor XIIa inhibitor (Ki app: 97.8 nM). XIIa-IN-1-IN-3 can be used for research of thrombosis .
Cat. No.: HY-P10860
CAS No.: 2853605-24-8
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Cat. No.: HY-P4333
CAS No.: 73554-94-6
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Cat. No.: HY-P991994
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Cat. No.: HY-P991993
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
