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Mirvetuximab soravtansine (IMGN853) solution is an anti-folatereceptor α (FRα) antibody drug-conjugate (ADC) consisting of the cytotoxic maytansinoid, DM4, covalently linked to the humanized monoclonal antibody M9346A, and the drug-linker conjugate for ADC is sulfo-SPDB-DM4 (HY-101141). Mirvetuximab soravtansine selectively binds to folatereceptor 1 (FOLR1). Mirvetuximab soravtansine has an anti-proliferative effect via growth arrest and augmented DNA damage .
Mirvetuximab (M9346A) is an anti-FOLR1 (folatereceptor 1) monoclonal antibody. Mirvetuximab is the antibody moiety of folatereceptor alpha (FRα)-targeting ADC (Mirvetuximab soravtansine). Mirvetuximab soravtansine can be used in ovarian and other FRα-positive cancer research .
Plevitrexed (ZD 9331; BGC 9331) is an orally active and potent thymidylate synthase (TS) inhibitor with a Ki of 0.44 nM. Plevitrexed is taken up via the α-folatereceptor as well as the reduced folate carrier. Plevitrexed is used for gastric cancer in clinical . Plevitrexed is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
DSPE-PEG-Folate, MW 3350 is a PEG derivative containing folic acid. DSPE-PEG-Folate has a targeting effect and bind to folatereceptors in cancer cells. DSPE-PEG-Folate form micelles/lipid bilayer and can be used to targeted drug delivery system research .
DSPE-PEG2000-Folate (DSPE-PEG2000 Folate) is a folate-containing PEG derivative. DSPE-PEG2000-Folate possesses targeting activity and binds to folatereceptors in cancer cells. DSPE-PEG2000-Folate can be post-inserted into preformed liposomal bilayers to prepare folate-targeted liposomal formulations. DSPE-PEG2000-Folate forms micelles/lipid bilayers and can be used in studies of targeted drug delivery systems [2].
EC-17 disodium salt is a folatereceptor alpha (FRα) targeting contrast agent with fluorescent properties in the visible light spectrum. The EC-17 maximum excitation and emission wavelengths are 490 nm and 520 nm, respectively .
Farletuzumab (MORAb-003) is a potent folatereceptor-alpha (FRα) inhibitor. Farletuzumab is a humanized monoclonal antibody with high affinity for FRα. Farletuzumab possesses growth-inhibitory functions on cells overexpressing FRα. Farletuzumab can be used in research of cancer .
Farletuzumab ecteribulin (MORAb-202) is an antibody-drug conjugate (ADC), consisting of the humanized anti-human folatereceptor alpha (FRA) antibody Farletuzumab (HY-P99153) conjugated via reduced interchain disulfide bonds to Mal-PEG2-Val-Cit-PAB-eribulin. Farletuzumab ecteribulin has a agent-to-antibody ratio of 4.0. Farletuzumab ecteribulin is highly cytotoxic to FRA-positive cells in vitro. Farletuzumab ecteribulin has potent antitumor activity.
Folate-FITC (EC-17) is a folatereceptor alpha (FRα) targeting contrast agent with fluorescent properties in the visible light spectrum. The Folate-FITC maximum excitation and emission wavelengths are 490 nm and 520 nm, respectively .
Mirvetuximab (M9346A) (powder) is an anti-FOLR1 (folatereceptor 1) monoclonal antibody. Mirvetuximab (powder) is the antibody moiety of folatereceptor alpha (FRα)-targeting ADC (Mirvetuximab soravtansine). Mirvetuximab soravtansine can be used in ovarian and other FRα-positive cancer research .
DBCO-PEG1000-FA (DBCO-PEG1000-Folate) is a multifunctional bioconjugation reagent, which is a copolymer of DBCO and Folic acid (FA) (HY-16637) and can target folatereceptors (FR). Folatereceptors are highly overexpressed on the surface of many cancer cells (such as lung cancer, nasopharyngeal cancer, ovarian cancer, etc.), but exhibit extremely low expression levels in normal tissues. DBCO-PEG-FA can be used for click chemistry conjugation via its DBCO terminal, and thus applies to various bioconjugation and drug delivery applications .
DSPE-PEG-Folate, MW 5000 is a PEG derivative containing folic acid. DSPE-PEG-Folate, MW 5000 has a targeting effect and bind to folatereceptors in cancer cells. DSPE-PEG-Folate, MW 5000 form micelles/lipid bilayer and can be used to targeted drug delivery system research .
FRα-targeting peptide C7 TFA is a selective peptide ligand for folatereceptor α (FRα) that has specific binding to FRα expressing cells and in vivo tumor targeting ability. FRα-targeting peptide C7 TFA can be used in the research of tumor diagnosis and treatment .
Idetrexed (ONX 0801) is a thymidylate synthase (TS) inhibitor with a Ki of 1.2 nM. Idetrexed can be specifically transported into α-folatereceptor (α-FR)-overexpressing tumors, such as ovarian cancer .
mPEG3400-amine can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
mPEG4000-amine can be used to synthesize folate-conjugated polymer micelles for encapsulating anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
mPEG350-amine can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
DBCO-PEG2000-FA (DBCO-PEG2000-Folate) is a multifunctional bioconjugation reagent, which is a copolymer of DBCO and Folic acid (FA) (HY-16637) and can target folatereceptors (FR). Folatereceptors are highly overexpressed on the surface of many cancer cells (such as lung cancer, nasopharyngeal cancer, ovarian cancer, etc.), but exhibit extremely low expression levels in normal tissues. DBCO-PEG-FA can be used for click chemistry conjugation via its DBCO terminal, and thus applies to various bioconjugation and drug delivery applications .
PEG-bis-amine (MW 1000) synthesizes folate-conjugated polymeric micelles for encapsulation of the anticancer agent 9-nitrocamptothecin HY-16560 (HY-16560). Folic acid-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
PEG4000-bis-amine synthesizes folate-conjugated polymeric micelles for encapsulation of the anticancer agent 9-nitrocamptothecin HY-16560 (HY-16560). Folic acid-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
Idetrexed (ONX 0801) trisodium is a thymidylate synthase (TS) inhibitor with a Ki of 1.2 nM. Idetrexed trisodium can be specifically transported into α-folatereceptor (α-FR)-overexpressing tumors, such as ovarian cancer .
EC-0225, a folate conjugate of two agents- one a potent microtubule inhibiting agent, and the second a DNA alkylating agent. EC-0225 inhibits the growth of folatereceptor (FR)-positive KB cells with an IC50 of ~1 nM. EC-0225 can be selectively delivered to advanced FR-positive tumors without causing overt toxicity, such as lung carcinoma .
FRα-targeting peptide C7 is a selective peptide ligand for folatereceptor α (FRα) that has specific binding to FRα expressing cells and in vivo tumor targeting ability. FRα-targeting peptide C7 can be used in the research of tumor diagnosis and treatment .
DBCO-PEG-FA (DBCO-PEG-Folate) (MW 3400) is a multifunctional bioconjugation reagent, which is a copolymer of DBCO and Folic acid (FA) (HY-16637) and can target folatereceptors (FR). Folatereceptors are highly overexpressed on the surface of many cancer cells (such as lung cancer, nasopharyngeal cancer, ovarian cancer, etc.), but exhibit extremely low expression levels in normal tissues. DBCO-PEG-FA can be used for click chemistry conjugation via its DBCO terminal, and thus applies to various bioconjugation and drug delivery applications .
mPEG2000-FA (mPEG2000-Folate) is a polyethylene glycol derivative of Folic acid (HY-16637). Folic acid has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
Cy3-PEG2000-FA is a fluorescent folate-PEG derivative with excitation/emission wavelengths of ~550 nm/~570 nm. Cy3-PEG2000-FA can be readily traced by its intense red fluorescent signal. Cy3-PEG2000-FA can be used for cell imaging, folatereceptor targeting and detection.
FRα-IN-1 (Compound 4) is a tumor-targeting agent. FRα-IN-1 shows selective anticancer activity towards folatereceptors (FRα and FRβ) expression cells .
DBCO-PEG10000-FA (DBCO-PEG10000-Folate) is a multifunctional bioconjugation reagent, which is a copolymer of DBCO and Folic acid (FA) (HY-16637) and can target folatereceptors (FR). Folatereceptors are highly overexpressed on the surface of many cancer cells (such as lung cancer, nasopharyngeal cancer, ovarian cancer, etc.), but exhibit extremely low expression levels in normal tissues. DBCO-PEG-FA can be used for click chemistry conjugation via its DBCO terminal, and thus applies to various bioconjugation and drug delivery applications .
DBCO-PEG5000-FA (DBCO-PEG5000-Folate) is a multifunctional bioconjugation reagent, which is a copolymer of DBCO and Folic acid (FA) (HY-16637) and can target folatereceptors (FR). Folatereceptors are highly overexpressed on the surface of many cancer cells (such as lung cancer, nasopharyngeal cancer, ovarian cancer, etc.), but exhibit extremely low expression levels in normal tissues. DBCO-PEG-FA can be used for click chemistry conjugation via its DBCO terminal, and thus applies to various bioconjugation and drug delivery applications .
mPEG1000-FA (mPEG1000-Folate) is a polyethylene glycol derivative of Folic acid (HY-16637). Folic acid has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
DSPE-PEG3400-Folate is a PEG derivative containing folic acid. DSPE-PEG-Folate has a targeting effect and bind to folatereceptors in cancer cells. DSPE-PEG-Folate form micelles/lipid bilayer and can be used to targeted drug delivery system research .
DSPE-PEG1000-Folate is a PEG derivative containing folic acid. DSPE-PEG-Folate has a targeting effect and bind to folatereceptors in cancer cells. DSPE-PEG-Folate form micelles/lipid bilayer and can be used to targeted drug delivery system research .
DSPE-PEG5000-Folate is a PEG derivative containing folic acid. DSPE-PEG-Folate has a targeting effect and bind to folatereceptors in cancer cells. DSPE-PEG-Folate form micelles/lipid bilayer and can be used to targeted drug delivery system research .
BOC-NH-PEG1000-FA (BOC-NH-PEG1000-Folate) is a PEG derivative modified with Folic acid (HY-16637). Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
BOC-NH-PEG400-FA (BOC-NH-PEG400-Folate) is a PEG derivative modified with Folic acid (HY-16637). Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
8-Arm-PEG400-FA (8-Arm-PEG400-Folate) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
EC1454 is a peptide compound with anticancer activity that targets folatereceptor-expressing cancers. EC1454 is a folate-tubulysin conjugate that can be used to prepare drug delivery conjugates for targeted therapy .
Desacetylvinblastine hydrazide (Deacetylvinblastine hydrazide; DAVLBH) is an active component of EC145, a folate-targeted drug conjugate. Desacetylvinblastine hydrazide interferes with the formation of the mitotic spindle, and thus inhibits cell division and leads to cell death. Desacetylvinblastine hydrazide exhibits antitumor activity against folatereceptor (FR)-positive tumor .
FA-PEG2000-COOH (Folate-PEG2000-COOH) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folatereceptor and can be used to target cell membrane receptors for drug delivery .
FA-PEG3400-COOH (Folate-PEG3400-COOH) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folatereceptor and can be used to target cell membrane receptors for drug delivery .
EET analog 7 is an epoxyeicosatrienoic acid (EET) analog that can be conjugated with folatereceptor ligands to target kidney cells expressing high levels of folatereceptors. EET analog 7 can be used for constructing kidney-targeted drug conjugates .
PLLA5000-PEG2000-FOL is a polylactic acid derivative. Polylactic acid derivatives have strong binding affinity to folatereceptors and clear biodegradability. PLLA5000-PEG2000-FOL can be used in drug delivery research .
PLLA10000-PEG5000-FOL is a polylactic acid derivative. Polylactic acid derivatives have strong binding affinity to folatereceptors and clear biodegradability. PLLA10000-PEG5000-FOL can be used in drug delivery research .
PLLA20000-PEG5000-FOL is a polylactic acid derivative. Polylactic acid derivatives have strong binding affinity to folatereceptors and clear biodegradability. PLLA20000-PEG5000-FOL can be used in drug delivery research .
PLLA5000-PEG5000-FOL is a polylactic acid derivative. Polylactic acid derivatives have strong binding affinity to folatereceptors and clear biodegradability. PLLA5000-PEG5000-FOL can be used in drug delivery research .
PLLA10000-PEG2000-FOL is a polylactic acid derivative. Polylactic acid derivatives have strong binding affinity to folatereceptors and clear biodegradability. PLLA10000-PEG2000-FOL can be used in drug delivery research .
PLLA20000-PEG2000-FOL is a polylactic acid derivative. Polylactic acid derivatives have strong binding affinity to folatereceptors and clear biodegradability. PLLA20000-PEG2000-FOL can be used in drug delivery research .
4A-BFA-11 is a folate-targeted PEG-MMAE conjugate that exhibits specific binding affinity for the folatereceptor α (FR-α) (KD = 106.7 nM). 4A-BFA-11 achieves tumor enrichment by combining PEG-mediated long circulation (EPR effect) and folatereceptor targeting. 4A-BFA-11 undergoes enzymatic cleavage at the tumor site to release the active payload, enabling precise action. 4A-BFA-11 sefficiently carries, targets, and controls the release of MMAE in tumor tissues in a HeLa mouse model. 4A-BFA-11 can be used for cervical cancer, ovarian cancer, and lung cancer research .
Onvontatug (BAT8006 Antibody) is a humanized monoclonal antibody targeting folatereceptor α (FRα). Onvontatug can be used to construct antibody-drug conjugates (ADCs), such as BAT8006. It is applicable to research related to platinum-resistant ovarian cancer .
AMT-151 Antibody is a monoclonal antibody inhibitor targeting folatereceptor α. AMT-151 Antibody can be used to synthesize the antibody-drug conjugate (ADC) AMT-151. AMT-151 Antibody can be used to research related to cancer .
IKS012 Antibody (Isumab01) is a monoclonal antibody inhibitor targeting folatereceptor α (FRA). IKS012 Antibody can be used to synthesize the antibody-drug conjugate (ADC) IKS012. IKS012 Antibody can be used to research related to platinum-resistant ovarian cancer .
mPEG5000-FA (mPEG5000-Folate) is a polyethylene glycol derivative of Folic acid (HY-16637). Folic acid has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
Opugotamig olatansine (IMGN151) is a folatereceptor alpha (FRα)-targeting antibody-drug conjugate (ADC). Opugotamig olatansine comprises antibody Opugotamig (HY-P990935) and linker-payload NMS-P945 (HY-185569). Opugotamig olatansine binds to two independent epitopes of FRα and promotes antibody binding, internalization, and processing. Opugotamig olatansine can be used for the research of FRα-positive ovarian cancer .
BOC-NH-PEG3400-FA (BOC-NH-PEG3400-Folate) is a PEG derivative modified with Folic acid (HY-16637). Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
BOC-NH-PEG5000-FA (BOC-NH-PEG5000-Folate) is a PEG derivative modified with Folic acid (HY-16637). Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
BOC-NH-PEG2000-FA (BOC-NH-PEG2000-Folate) is a PEG derivative modified with Folic acid (HY-16637). Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
BOC-NH-PEG10000-FA (BOC-NH-PEG10000-Folate) is a PEG derivative modified with Folic acid (HY-16637). Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
BOC-NH-PEG600-FA (BOC-NH-PEG600-Folate) is a PEG derivative modified with Folic acid (HY-16637). Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
4-Arm-PEG5000-FA (4-Arm-PEG5000-Folate) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
8-Arm-PEG2000-FA (8-Arm-PEG2000-Folate) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
4-Arm-PEG400-FA (4-Arm-PEG400-folate) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
4-Arm-PEG600-FA (4-Arm-PEG600-Folate) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
8-Arm-PEG5000-FA (8-Arm-PEG5000-Folate) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
8-Arm-PEG600-FA (8-Arm-PEG600-Folate) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
4-Arm-PEG2000-FA (4-Arm-PEG2000-Folate) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
8-Arm-PEG10000-FA (8-Arm-PEG10000-Folate) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
8-Arm-PEG3400-FA (8-Arm-PEG3400-Folate) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
4-Arm-PEG10000-FA (4-Arm-PEG10000-Folate) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
8-Arm-PEG1000-FA (8-Arm-PEG1000-Folate) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
4-Arm-PEG1000-FA (4-Arm-PEG1000-Folate) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
4-Arm-PEG3400-FA (4-Arm-PEG3400-Folate) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
6-Arm-PEG5000-FA (6-Arm-PEG5000-Folate) is a PEG derivative modified with Folic acid (HY-16637). Polyethylene glycol can increase solubility and stability and reduce the immunogenicity of peptides and proteins. It can also inhibit the nonspecific binding of charged molecules to modified surfaces. Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
6-Arm-PEG1000-FA (6-Arm-PEG1000-Folate) is a PEG derivative modified with Folic acid (HY-16637). Polyethylene glycol can increase solubility and stability and reduce the immunogenicity of peptides and proteins. It can also inhibit the nonspecific binding of charged molecules to modified surfaces. Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
6-Arm-PEG3400-FA (6-Arm-PEG3400-Folate) is a PEG derivative modified with Folic acid (HY-16637). Polyethylene glycol can increase solubility and stability and reduce the immunogenicity of peptides and proteins. It can also inhibit the nonspecific binding of charged molecules to modified surfaces. Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
6-Arm-PEG600-FA (6-Arm-PEG600-Folate) is a PEG derivative modified with Folic acid (HY-16637). Polyethylene glycol can increase solubility and stability and reduce the immunogenicity of peptides and proteins. It can also inhibit the nonspecific binding of charged molecules to modified surfaces. Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
6-Arm-PEG2000-FA (6-Arm-PEG2000-Folate) is a PEG derivative modified with Folic acid (HY-16637). Polyethylene glycol can increase solubility and stability and reduce the immunogenicity of peptides and proteins. It can also inhibit the nonspecific binding of charged molecules to modified surfaces. Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
6-Arm-PEG400-FA (6-Arm-PEG400-Folate) is a PEG derivative modified with Folic acid (HY-16637). Polyethylene glycol can increase solubility and stability and reduce the immunogenicity of peptides and proteins. It can also inhibit the nonspecific binding of charged molecules to modified surfaces. Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
6-Arm-PEG10000-FA (6-Arm-PEG10000-Folate) is a PEG derivative modified with Folic acid (HY-16637). Polyethylene glycol can increase solubility and stability and reduce the immunogenicity of peptides and proteins. It can also inhibit the nonspecific binding of charged molecules to modified surfaces. Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
FA-PEG1000-COOH (Folate-PEG1000-COOH) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folatereceptor and can be used to target cell membrane receptors for drug delivery .
FA-PEG5000-COOH (Folate-PEG5000-COOH) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folatereceptor and can be used to target cell membrane receptors for drug delivery .
FA-PEG10000-COOH (Folate-PEG10000-COOH) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folatereceptor and can be used to target cell membrane receptors for drug delivery .
FA-PEG400-COOH (Folate-PEG400-COOH) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folatereceptor and can be used to target cell membrane receptors for drug delivery .
FA-PEG600-COOH (Folate-PEG600-COOH) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folatereceptor and can be used to target cell membrane receptors for drug delivery .
Etarfolatide (EC 20) is a valuable noninvasive imaging agent. Etarfolatide identifies folatereceptor expression. Etarfolatide can be used in research on ovarian cancer and disease diagnosis after being radiolabeled .
FA-PEG10000-ACA (Folate-PEG10000-ACA) is a compound composed of Folic acid (HY-16637), PEG, and acrylamide. Folic acid (-FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery.
FA-PEG1000-ACA (Folate-PEG1000-ACA) is a compound composed of Folic acid (HY-16637), PEG, and acrylamide. Folic acid (-FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery.
FA-PEG2000-ACA (Folate-PEG2000-ACA) is a compound composed of Folic acid (HY-16637), PEG, and acrylamide. Folic acid (-FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery.
FA-PEG3400-ACA (Folate-PEG3400-ACA) is a compound composed of Folic acid (HY-16637), PEG, and acrylamide. Folic acid (-FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery.
FA-PEG5000-ACA (Folate-PEG5000-ACA) is a compound composed of Folic acid (HY-16637), PEG, and acrylamide. Folic acid (-FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery.
FA-PEG400-ACA (Folate-PEG400-ACA) is a compound composed of Folic acid (HY-16637), PEG, and acrylamide. Folic acid (-FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery.
FA-PEG600-ACA (Folate-PEG600-ACA) is a compound composed of Folic acid (HY-16637), PEG, and acrylamide. Folic acid (-FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery.
FA-PEG1000-NH2 (Folate-PEG1000-NH2) is a multifunctional drug delivery system composed of Folic acid (HY-16637), polyethylene glycol (PEG), and NH2. Folic acid (FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery.
FA-PEG2000-NH2 (Folate-PEG2000-NH2) is a multifunctional drug delivery system composed of Folic acid (HY-16637), polyethylene glycol (PEG), and NH2. Folic acid (FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery.
FA-PEG5000-NH2 (Folate-PEG5000-NH2) is a multifunctional drug delivery system composed of Folic acid (HY-16637), polyethylene glycol (PEG), and NH2. Folic acid (FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery.
FA-PEG3400-NH2 (Folate-PEG3400-NH2) is a multifunctional drug delivery system composed of Folic acid (HY-16637), polyethylene glycol (PEG), and NH2. Folic acid (FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery.
Eliroptamig is a multispecific antibody targeting albumin, folatereceptor α (FOLR1) and cluster of differentiation 3 (CD3). Eliroptamig extends its half-life by binding to albumin, while targeting FOLR1 on tumor cells and activating T cells to achieve precise tumor killing .
Antifolate agent 1 is a 6-substituted pyrrolopyrimidine antifolate with a 1-carbon bridge. Antifolate agent 1 shows no activity against cells expressing FRα and FRβ, and has no GARFTase inhibitory activity. Antifolate agent 1 can be used as a negative control in the development of folatereceptor-targeted antifolates .
FA-PEG600-Cholesterol (Folate-PEG600-Cholesterol) is a multifunctional drug delivery system composed of Folic acid (HY-16637), polyethylene glycol (PEG), and Cholesterol (HY-N0322). Folic acid (FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery. Cholesterol can improve the circulation time of encapsulated drugs .
FA-PEG400-Cholesterol (Folate-PEG400-Cholesterol) is a multifunctional drug delivery system composed of Folic acid (HY-16637), polyethylene glycol (PEG), and Cholesterol (HY-N0322). Folic acid (FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery. Cholesterol can improve the circulation time of encapsulated drugs .
FA-PEG2000-Cholesterol (Folate-PEG2000-Cholesterol) is a multifunctional drug delivery system composed of Folic acid (HY-16637), polyethylene glycol (PEG), and Cholesterol (HY-N0322). Folic acid (FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery. Cholesterol can improve the circulation time of encapsulated drugs .
FA-PEG10000-Cholesterol (Folate-PEG10000-Cholesterol) is a multifunctional drug delivery system composed of Folic acid (HY-16637), polyethylene glycol (PEG), and Cholesterol (HY-N0322). Folic acid (FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery. Cholesterol can improve the circulation time of encapsulated drugs .
FA-PEG5000-Cholesterol (Folate-PEG5000-Cholesterol) is a multifunctional drug delivery system composed of Folic acid (HY-16637), polyethylene glycol (PEG), and Cholesterol (HY-N0322). Folic acid (FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery. Cholesterol can improve the circulation time of encapsulated drugs .
FA-PEG3400-Cholesterol (Folate-PEG3400-Cholesterol) is a multifunctional drug delivery system composed of Folic acid (HY-16637), polyethylene glycol (PEG), and Cholesterol (HY-N0322). Folic acid (FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery. Cholesterol can improve the circulation time of encapsulated drugs .
FA-PEG1000-Cholesterol (Folate-PEG1000-Cholesterol) is a multifunctional drug delivery system composed of Folic acid (HY-16637), polyethylene glycol (PEG), and Cholesterol (HY-N0322). Folic acid (FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery. Cholesterol can improve the circulation time of encapsulated drugs .
SC239 is a cleavable 2-aminophenyl hemiasterlin agent-linker. SC239 can be as the agent-linker for ADC . SC239 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
S0456 is a raw material that plays a crucial role in the construction of the folatereceptor-targeted near-infrared dye OTL 38 (HY-139579). S0456 is connected to the modified folic acid to form OTL 38, endowing OTL 38 with good optical properties, high affinity, and specificity. S0456 can be used in the research of tumor optical imaging agents .
RB-PEG2000-FA (Rhodamine B-PEG2000-FA) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and Folic acid (FA) (HY-16637). RB-PEG2000-FA can be used for cell imaging, folatereceptor targeting and detection (Ex/Em=546/610 nm) .
RB-PEG5000-FA (Rhodamine B-PEG5000-FA) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and Folic acid (FA) (HY-16637). RB-PEG5000-FA can be used for cell imaging, folatereceptor targeting and detection (Ex/Em=546/610 nm) .
RB-PEG600-FA (Rhodamine B-PEG600-FA) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and Folic acid (FA) (HY-16637). RB-PEG600-FA can be used for cell imaging, folatereceptor targeting and detection (Ex/Em=546/610 nm) .
RB-PEG1000-FA (Rhodamine B-PEG1000-FA) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and Folic acid (FA) (HY-16637). RB-PEG1000-FA can be used for cell imaging, folatereceptor targeting and detection (Ex/Em=546/610 nm) .
RB-PEG400-FA (Rhodamine B-PEG400-FA) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and Folic acid (FA) (HY-16637). RB-PEG400-FA can be used for cell imaging, folatereceptor targeting and detection (Ex/Em=546/610 nm) .
RB-PEG10000-FA (Rhodamine B-PEG10000-FA) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and Folic acid (FA) (HY-16637). RB-PEG10000-FA can be used for cell imaging, folatereceptor targeting and detection (Ex/Em=546/610 nm) .
RB-PEG3400-FA (Rhodamine B-PEG3400-FA) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and Folic acid (FA) (HY-16637). RB-PEG3400-FA can be used for cell imaging, folatereceptor targeting and detection (Ex/Em=546/610 nm) .
mPEG750-amine (mPEG750-NH2) is a chemical modification reagent for nanoparticles, capable of covalently binding to Ad-PVA to form Ad-PVA-PEG polymers. mPEG750-amine stabilizes gene delivery complexes by providing steric hindrance, reducing particle aggregation, while enhancing the water solubility and serum stability of the complex, reducing carrier cytotoxicity, and assisting in the efficient condensation of pDNA by cationic components to form nanoparticles that can be endocytosed by cells. mPEG750-amine can also be used to synthesize folate-conjugated polymer micelles for encapsulating the anticancer agent Camptothecin (HY-16560). Folate-conjugated polymer micelles are effective carriers for poorly soluble anticancer drugs, capable of avoiding macrophages and acting through folatereceptor (FR)-mediated endocytosis to target tumor cells. mPEG750-amine can be applied to research in the field of non-viral gene delivery, as a component of gene delivery vectors, facilitating the safe and efficient delivery of nucleic acid drugs to target cells .
Carboxymethyl-β-cyclodextrin sodium salt is a negatively charged β-cyclodextrin derivative, as well as a metal ion chelator and solubilizing reagent. Carboxymethyl-β-cyclodextrin sodium salt forms stable aqueous complexes with Ba 2+, Ca 2+, Cd 2+, Ni 2+, Pb 2+, Sr 2+, and Zn 2+ ions. Carboxymethyl-β-cyclodextrin sodium salt derived hydrogel carriers support oral insulin delivery via paracellular permeation across Caco-2 monolayers and produce sustained hypoglycemic effects in diabetic mice. Carboxymethyl-β-cyclodextrin sodium salt can be conjugated onto folate-modified BSA nanoparticles to boost folatereceptor-mediated endocytosis, elevate intracellular anticancer drug uptake and trigger cell apoptosis. Carboxymethyl-β-cyclodextrin sodium salt can be utilized for chiral separation in capillary electrophoresis, development of nanoscale drug carriers and nucleic acid transfection research .
Pteroic acid is a precursor to significant compounds like Folic acid (HY-16637) and Vitamin B12 (HY-B0315). Pteroic acid facilitates the examination of how different compounds influence cell growth and development .
Tetraxetan (DOTA) is a macrocyclic chelating agent. Tetraxetan can form stable coordination complexes with a variety of metal ions (e.g., 68Ga, 111In, 177Lu). Tetraxetan can be conjugated with targeting molecules (e.g., RGD peptide, folic acid) to enable the complex to target specific biomolecules or cells. Tetraxetan can be used for imaging studies of tumors, including melanoma and folatereceptor-positive tumors (e.g., cervical cancer) .
AG2034 is an inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), with a Ki of 28 nM against human GARFT, and it binds with high affinity to the folatereceptor (Kd of 0.0042 nM). Additionally, AG2034 is a substrate for rat liver folylpolyglutamate synthetase, with a Km of 6.4 µM. AG2034 inhibits the growth of L1210 and CCRF-CEM cells, with IC50 values of 4 nM and 2.9 nM, respectively, and it has demonstrated antitumor activity in xenograft models such as 6C3HED .
Ricorfotide vedotin (CBP-1008) is a dual-ligand peptide-drug conjugate (PDC) conjugated to MMAE (HY-15162), targeting Folatereceptor α (FRα) and TRPV6. Ricorfotide vedotin binds to FRα with high affinity and TRPV6 with low affinity. Ricorfotide vedotin has antitumor activity, and can be used in advanced solid tumor research (eg: colorectal cancer, breast cancer, non-small cell lung cancer, ovarian cancer, adrenocortical carcinoma and follicular dendritic cell sarcoma) .
Tetraxetan (Standard) is the analytical standard of Tetraxetan (HY-W053583). This product is intended for research and analytical applications. Tetraxetan (DOTA) is a macrocyclic chelating agent. Tetraxetan can form stable coordination complexes with a variety of metal ions (e.g., 68Ga, 111In, 177Lu). Tetraxetan can be conjugated with targeting molecules (e.g., RGD peptide, folic acid) to enable the complex to target specific biomolecules or cells. Tetraxetan can be used for imaging studies of tumors, including melanoma and folatereceptor-positive tumors (e.g., cervical cancer) .
KHK2805 (RA15-7) is a humanized antibody against folatereceptor α (FOLR1), with a Kd of 0.647 nM for human FOLR1. KHK2805 binds to a unique epitope of FOLR1 and mediates antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity against FOLR1-expressing cells. KHK2805 exhibits cytotoxicity against both ovarian cancer cells and Platinum (HY-W096169D)-resistant ovarian cancer cells. KHK2805 can be used for the research of tumors such as ovarian cancer .
Biotin-PEG-CHO (with a molecular weight of 5000) is a biotin-attached PEG derivative that can be used for biotinylation of biological molecules or other material surfaces. Biotin can be easily detected through the biotin/streptavidin binding test, and is widely used in molecular targeted detection.
FGT-4 is a folatereceptor β (FR-β) targeting chimeric molecule. FGT-4 is a TLR7 agonist. FGT-4 facilitates the secretion of iNOS and proinflammatory cytokine IL-6 associated with M1 macrophages and enhances the proliferation of cytotoxic CD8 + T cells. FGT-4 has anti-tumor activity in the 4T1 breast cancer mouse model. FGT-4 can be used for the study of cancer immunity. (Pink: target protein TLR7/8 agonist 1 ligand (HY-103698); black: linker (HY-172936); blue: FR-β ligand (HY-172935)) .
CBP-1018 is a PDC (peptide-drug conjugate) formed by conjugating Monomethyl auristatin E (HY-15162) to a dual-targeting ligand of FLOR1/PSMA (prostate-specific membrane antigen) via a linker (HY-78738). CBP-1018 binds to FLOR1 and prostate-specific membrane antigen (PSMA). CBP-1018 is applicable to the research of solid tumors and metastatic castration-resistant prostate cancer .
S0456 is a raw material that plays a crucial role in the construction of the folatereceptor-targeted near-infrared dye OTL 38 (HY-139579). S0456 is connected to the modified folic acid to form OTL 38, endowing OTL 38 with good optical properties, high affinity, and specificity. S0456 can be used in the research of tumor optical imaging agents .
Cy3-PEG2000-FA is a fluorescent folate-PEG derivative with excitation/emission wavelengths of ~550 nm/~570 nm. Cy3-PEG2000-FA can be readily traced by its intense red fluorescent signal. Cy3-PEG2000-FA can be used for cell imaging, folatereceptor targeting and detection.
RB-PEG600-FA (Rhodamine B-PEG600-FA) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and Folic acid (FA) (HY-16637). RB-PEG600-FA can be used for cell imaging, folatereceptor targeting and detection (Ex/Em=546/610 nm) .
RB-PEG400-FA (Rhodamine B-PEG400-FA) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and Folic acid (FA) (HY-16637). RB-PEG400-FA can be used for cell imaging, folatereceptor targeting and detection (Ex/Em=546/610 nm) .
RB-PEG3400-FA (Rhodamine B-PEG3400-FA) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and Folic acid (FA) (HY-16637). RB-PEG3400-FA can be used for cell imaging, folatereceptor targeting and detection (Ex/Em=546/610 nm) .
RB-PEG2000-FA (Rhodamine B-PEG2000-FA) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and Folic acid (FA) (HY-16637). RB-PEG2000-FA can be used for cell imaging, folatereceptor targeting and detection (Ex/Em=546/610 nm) .
RB-PEG5000-FA (Rhodamine B-PEG5000-FA) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and Folic acid (FA) (HY-16637). RB-PEG5000-FA can be used for cell imaging, folatereceptor targeting and detection (Ex/Em=546/610 nm) .
RB-PEG1000-FA (Rhodamine B-PEG1000-FA) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and Folic acid (FA) (HY-16637). RB-PEG1000-FA can be used for cell imaging, folatereceptor targeting and detection (Ex/Em=546/610 nm) .
RB-PEG10000-FA (Rhodamine B-PEG10000-FA) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and Folic acid (FA) (HY-16637). RB-PEG10000-FA can be used for cell imaging, folatereceptor targeting and detection (Ex/Em=546/610 nm) .
DSPE-PEG-Folate, MW 3350 is a PEG derivative containing folic acid. DSPE-PEG-Folate has a targeting effect and bind to folatereceptors in cancer cells. DSPE-PEG-Folate form micelles/lipid bilayer and can be used to targeted drug delivery system research .
Tetraxetan (DOTA) is a macrocyclic chelating agent. Tetraxetan can form stable coordination complexes with a variety of metal ions (e.g., 68Ga, 111In, 177Lu). Tetraxetan can be conjugated with targeting molecules (e.g., RGD peptide, folic acid) to enable the complex to target specific biomolecules or cells. Tetraxetan can be used for imaging studies of tumors, including melanoma and folatereceptor-positive tumors (e.g., cervical cancer) .
DSPE-PEG2000-Folate (DSPE-PEG2000 Folate) is a folate-containing PEG derivative. DSPE-PEG2000-Folate possesses targeting activity and binds to folatereceptors in cancer cells. DSPE-PEG2000-Folate can be post-inserted into preformed liposomal bilayers to prepare folate-targeted liposomal formulations. DSPE-PEG2000-Folate forms micelles/lipid bilayers and can be used in studies of targeted drug delivery systems [2].
mPEG750-amine (mPEG750-NH2) is a chemical modification reagent for nanoparticles, capable of covalently binding to Ad-PVA to form Ad-PVA-PEG polymers. mPEG750-amine stabilizes gene delivery complexes by providing steric hindrance, reducing particle aggregation, while enhancing the water solubility and serum stability of the complex, reducing carrier cytotoxicity, and assisting in the efficient condensation of pDNA by cationic components to form nanoparticles that can be endocytosed by cells. mPEG750-amine can also be used to synthesize folate-conjugated polymer micelles for encapsulating the anticancer agent Camptothecin (HY-16560). Folate-conjugated polymer micelles are effective carriers for poorly soluble anticancer drugs, capable of avoiding macrophages and acting through folatereceptor (FR)-mediated endocytosis to target tumor cells. mPEG750-amine can be applied to research in the field of non-viral gene delivery, as a component of gene delivery vectors, facilitating the safe and efficient delivery of nucleic acid drugs to target cells .
DBCO-PEG1000-FA (DBCO-PEG1000-Folate) is a multifunctional bioconjugation reagent, which is a copolymer of DBCO and Folic acid (FA) (HY-16637) and can target folatereceptors (FR). Folatereceptors are highly overexpressed on the surface of many cancer cells (such as lung cancer, nasopharyngeal cancer, ovarian cancer, etc.), but exhibit extremely low expression levels in normal tissues. DBCO-PEG-FA can be used for click chemistry conjugation via its DBCO terminal, and thus applies to various bioconjugation and drug delivery applications .
DSPE-PEG-Folate, MW 5000 is a PEG derivative containing folic acid. DSPE-PEG-Folate, MW 5000 has a targeting effect and bind to folatereceptors in cancer cells. DSPE-PEG-Folate, MW 5000 form micelles/lipid bilayer and can be used to targeted drug delivery system research .
mPEG3400-amine can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
mPEG4000-amine can be used to synthesize folate-conjugated polymer micelles for encapsulating anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
mPEG350-amine can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
Tetraxetan (Standard) is the analytical standard of Tetraxetan (HY-W053583). This product is intended for research and analytical applications. Tetraxetan (DOTA) is a macrocyclic chelating agent. Tetraxetan can form stable coordination complexes with a variety of metal ions (e.g., 68Ga, 111In, 177Lu). Tetraxetan can be conjugated with targeting molecules (e.g., RGD peptide, folic acid) to enable the complex to target specific biomolecules or cells. Tetraxetan can be used for imaging studies of tumors, including melanoma and folatereceptor-positive tumors (e.g., cervical cancer) .
DBCO-PEG2000-FA (DBCO-PEG2000-Folate) is a multifunctional bioconjugation reagent, which is a copolymer of DBCO and Folic acid (FA) (HY-16637) and can target folatereceptors (FR). Folatereceptors are highly overexpressed on the surface of many cancer cells (such as lung cancer, nasopharyngeal cancer, ovarian cancer, etc.), but exhibit extremely low expression levels in normal tissues. DBCO-PEG-FA can be used for click chemistry conjugation via its DBCO terminal, and thus applies to various bioconjugation and drug delivery applications .
PEG-bis-amine (MW 1000) synthesizes folate-conjugated polymeric micelles for encapsulation of the anticancer agent 9-nitrocamptothecin HY-16560 (HY-16560). Folic acid-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
PEG4000-bis-amine synthesizes folate-conjugated polymeric micelles for encapsulation of the anticancer agent 9-nitrocamptothecin HY-16560 (HY-16560). Folic acid-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
DBCO-PEG-FA (DBCO-PEG-Folate) (MW 3400) is a multifunctional bioconjugation reagent, which is a copolymer of DBCO and Folic acid (FA) (HY-16637) and can target folatereceptors (FR). Folatereceptors are highly overexpressed on the surface of many cancer cells (such as lung cancer, nasopharyngeal cancer, ovarian cancer, etc.), but exhibit extremely low expression levels in normal tissues. DBCO-PEG-FA can be used for click chemistry conjugation via its DBCO terminal, and thus applies to various bioconjugation and drug delivery applications .
mPEG2000-FA (mPEG2000-Folate) is a polyethylene glycol derivative of Folic acid (HY-16637). Folic acid has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
DBCO-PEG10000-FA (DBCO-PEG10000-Folate) is a multifunctional bioconjugation reagent, which is a copolymer of DBCO and Folic acid (FA) (HY-16637) and can target folatereceptors (FR). Folatereceptors are highly overexpressed on the surface of many cancer cells (such as lung cancer, nasopharyngeal cancer, ovarian cancer, etc.), but exhibit extremely low expression levels in normal tissues. DBCO-PEG-FA can be used for click chemistry conjugation via its DBCO terminal, and thus applies to various bioconjugation and drug delivery applications .
DBCO-PEG5000-FA (DBCO-PEG5000-Folate) is a multifunctional bioconjugation reagent, which is a copolymer of DBCO and Folic acid (FA) (HY-16637) and can target folatereceptors (FR). Folatereceptors are highly overexpressed on the surface of many cancer cells (such as lung cancer, nasopharyngeal cancer, ovarian cancer, etc.), but exhibit extremely low expression levels in normal tissues. DBCO-PEG-FA can be used for click chemistry conjugation via its DBCO terminal, and thus applies to various bioconjugation and drug delivery applications .
mPEG1000-FA (mPEG1000-Folate) is a polyethylene glycol derivative of Folic acid (HY-16637). Folic acid has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
DSPE-PEG3400-Folate is a PEG derivative containing folic acid. DSPE-PEG-Folate has a targeting effect and bind to folatereceptors in cancer cells. DSPE-PEG-Folate form micelles/lipid bilayer and can be used to targeted drug delivery system research .
DSPE-PEG1000-Folate is a PEG derivative containing folic acid. DSPE-PEG-Folate has a targeting effect and bind to folatereceptors in cancer cells. DSPE-PEG-Folate form micelles/lipid bilayer and can be used to targeted drug delivery system research .
DSPE-PEG5000-Folate is a PEG derivative containing folic acid. DSPE-PEG-Folate has a targeting effect and bind to folatereceptors in cancer cells. DSPE-PEG-Folate form micelles/lipid bilayer and can be used to targeted drug delivery system research .
BOC-NH-PEG1000-FA (BOC-NH-PEG1000-Folate) is a PEG derivative modified with Folic acid (HY-16637). Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
BOC-NH-PEG400-FA (BOC-NH-PEG400-Folate) is a PEG derivative modified with Folic acid (HY-16637). Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
8-Arm-PEG400-FA (8-Arm-PEG400-Folate) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
FA-PEG2000-COOH (Folate-PEG2000-COOH) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folatereceptor and can be used to target cell membrane receptors for drug delivery .
FA-PEG3400-COOH (Folate-PEG3400-COOH) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folatereceptor and can be used to target cell membrane receptors for drug delivery .
PLLA5000-PEG2000-FOL is a polylactic acid derivative. Polylactic acid derivatives have strong binding affinity to folatereceptors and clear biodegradability. PLLA5000-PEG2000-FOL can be used in drug delivery research .
PLLA10000-PEG5000-FOL is a polylactic acid derivative. Polylactic acid derivatives have strong binding affinity to folatereceptors and clear biodegradability. PLLA10000-PEG5000-FOL can be used in drug delivery research .
PLLA20000-PEG5000-FOL is a polylactic acid derivative. Polylactic acid derivatives have strong binding affinity to folatereceptors and clear biodegradability. PLLA20000-PEG5000-FOL can be used in drug delivery research .
PLLA5000-PEG5000-FOL is a polylactic acid derivative. Polylactic acid derivatives have strong binding affinity to folatereceptors and clear biodegradability. PLLA5000-PEG5000-FOL can be used in drug delivery research .
PLLA10000-PEG2000-FOL is a polylactic acid derivative. Polylactic acid derivatives have strong binding affinity to folatereceptors and clear biodegradability. PLLA10000-PEG2000-FOL can be used in drug delivery research .
PLLA20000-PEG2000-FOL is a polylactic acid derivative. Polylactic acid derivatives have strong binding affinity to folatereceptors and clear biodegradability. PLLA20000-PEG2000-FOL can be used in drug delivery research .
mPEG5000-FA (mPEG5000-Folate) is a polyethylene glycol derivative of Folic acid (HY-16637). Folic acid has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
BOC-NH-PEG3400-FA (BOC-NH-PEG3400-Folate) is a PEG derivative modified with Folic acid (HY-16637). Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
BOC-NH-PEG5000-FA (BOC-NH-PEG5000-Folate) is a PEG derivative modified with Folic acid (HY-16637). Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
BOC-NH-PEG2000-FA (BOC-NH-PEG2000-Folate) is a PEG derivative modified with Folic acid (HY-16637). Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
BOC-NH-PEG10000-FA (BOC-NH-PEG10000-Folate) is a PEG derivative modified with Folic acid (HY-16637). Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
BOC-NH-PEG600-FA (BOC-NH-PEG600-Folate) is a PEG derivative modified with Folic acid (HY-16637). Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
4-Arm-PEG5000-FA (4-Arm-PEG5000-Folate) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
4-Arm-PEG400-FA (4-Arm-PEG400-folate) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
4-Arm-PEG600-FA (4-Arm-PEG600-Folate) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
8-Arm-PEG5000-FA (8-Arm-PEG5000-Folate) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
4-Arm-PEG2000-FA (4-Arm-PEG2000-Folate) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
8-Arm-PEG10000-FA (8-Arm-PEG10000-Folate) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
4-Arm-PEG10000-FA (4-Arm-PEG10000-Folate) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
4-Arm-PEG1000-FA (4-Arm-PEG1000-Folate) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
4-Arm-PEG3400-FA (4-Arm-PEG3400-Folate) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
6-Arm-PEG5000-FA (6-Arm-PEG5000-Folate) is a PEG derivative modified with Folic acid (HY-16637). Polyethylene glycol can increase solubility and stability and reduce the immunogenicity of peptides and proteins. It can also inhibit the nonspecific binding of charged molecules to modified surfaces. Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
6-Arm-PEG1000-FA (6-Arm-PEG1000-Folate) is a PEG derivative modified with Folic acid (HY-16637). Polyethylene glycol can increase solubility and stability and reduce the immunogenicity of peptides and proteins. It can also inhibit the nonspecific binding of charged molecules to modified surfaces. Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
6-Arm-PEG3400-FA (6-Arm-PEG3400-Folate) is a PEG derivative modified with Folic acid (HY-16637). Polyethylene glycol can increase solubility and stability and reduce the immunogenicity of peptides and proteins. It can also inhibit the nonspecific binding of charged molecules to modified surfaces. Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
6-Arm-PEG600-FA (6-Arm-PEG600-Folate) is a PEG derivative modified with Folic acid (HY-16637). Polyethylene glycol can increase solubility and stability and reduce the immunogenicity of peptides and proteins. It can also inhibit the nonspecific binding of charged molecules to modified surfaces. Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
6-Arm-PEG2000-FA (6-Arm-PEG2000-Folate) is a PEG derivative modified with Folic acid (HY-16637). Polyethylene glycol can increase solubility and stability and reduce the immunogenicity of peptides and proteins. It can also inhibit the nonspecific binding of charged molecules to modified surfaces. Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
6-Arm-PEG400-FA (6-Arm-PEG400-Folate) is a PEG derivative modified with Folic acid (HY-16637). Polyethylene glycol can increase solubility and stability and reduce the immunogenicity of peptides and proteins. It can also inhibit the nonspecific binding of charged molecules to modified surfaces. Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
6-Arm-PEG10000-FA (6-Arm-PEG10000-Folate) is a PEG derivative modified with Folic acid (HY-16637). Polyethylene glycol can increase solubility and stability and reduce the immunogenicity of peptides and proteins. It can also inhibit the nonspecific binding of charged molecules to modified surfaces. Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
FA-PEG1000-COOH (Folate-PEG1000-COOH) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folatereceptor and can be used to target cell membrane receptors for drug delivery .
FA-PEG5000-COOH (Folate-PEG5000-COOH) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folatereceptor and can be used to target cell membrane receptors for drug delivery .
FA-PEG10000-COOH (Folate-PEG10000-COOH) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folatereceptor and can be used to target cell membrane receptors for drug delivery .
FA-PEG400-COOH (Folate-PEG400-COOH) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folatereceptor and can be used to target cell membrane receptors for drug delivery .
FA-PEG600-COOH (Folate-PEG600-COOH) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folatereceptor and can be used to target cell membrane receptors for drug delivery .
FA-PEG10000-ACA (Folate-PEG10000-ACA) is a compound composed of Folic acid (HY-16637), PEG, and acrylamide. Folic acid (-FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery.
FA-PEG1000-ACA (Folate-PEG1000-ACA) is a compound composed of Folic acid (HY-16637), PEG, and acrylamide. Folic acid (-FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery.
FA-PEG2000-ACA (Folate-PEG2000-ACA) is a compound composed of Folic acid (HY-16637), PEG, and acrylamide. Folic acid (-FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery.
FA-PEG3400-ACA (Folate-PEG3400-ACA) is a compound composed of Folic acid (HY-16637), PEG, and acrylamide. Folic acid (-FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery.
FA-PEG5000-ACA (Folate-PEG5000-ACA) is a compound composed of Folic acid (HY-16637), PEG, and acrylamide. Folic acid (-FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery.
FA-PEG400-ACA (Folate-PEG400-ACA) is a compound composed of Folic acid (HY-16637), PEG, and acrylamide. Folic acid (-FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery.
FA-PEG600-ACA (Folate-PEG600-ACA) is a compound composed of Folic acid (HY-16637), PEG, and acrylamide. Folic acid (-FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery.
FA-PEG1000-NH2 (Folate-PEG1000-NH2) is a multifunctional drug delivery system composed of Folic acid (HY-16637), polyethylene glycol (PEG), and NH2. Folic acid (FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery.
FA-PEG2000-NH2 (Folate-PEG2000-NH2) is a multifunctional drug delivery system composed of Folic acid (HY-16637), polyethylene glycol (PEG), and NH2. Folic acid (FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery.
FA-PEG5000-NH2 (Folate-PEG5000-NH2) is a multifunctional drug delivery system composed of Folic acid (HY-16637), polyethylene glycol (PEG), and NH2. Folic acid (FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery.
FA-PEG3400-NH2 (Folate-PEG3400-NH2) is a multifunctional drug delivery system composed of Folic acid (HY-16637), polyethylene glycol (PEG), and NH2. Folic acid (FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery.
FA-PEG600-Cholesterol (Folate-PEG600-Cholesterol) is a multifunctional drug delivery system composed of Folic acid (HY-16637), polyethylene glycol (PEG), and Cholesterol (HY-N0322). Folic acid (FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery. Cholesterol can improve the circulation time of encapsulated drugs .
FA-PEG400-Cholesterol (Folate-PEG400-Cholesterol) is a multifunctional drug delivery system composed of Folic acid (HY-16637), polyethylene glycol (PEG), and Cholesterol (HY-N0322). Folic acid (FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery. Cholesterol can improve the circulation time of encapsulated drugs .
FA-PEG2000-Cholesterol (Folate-PEG2000-Cholesterol) is a multifunctional drug delivery system composed of Folic acid (HY-16637), polyethylene glycol (PEG), and Cholesterol (HY-N0322). Folic acid (FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery. Cholesterol can improve the circulation time of encapsulated drugs .
FA-PEG10000-Cholesterol (Folate-PEG10000-Cholesterol) is a multifunctional drug delivery system composed of Folic acid (HY-16637), polyethylene glycol (PEG), and Cholesterol (HY-N0322). Folic acid (FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery. Cholesterol can improve the circulation time of encapsulated drugs .
FA-PEG5000-Cholesterol (Folate-PEG5000-Cholesterol) is a multifunctional drug delivery system composed of Folic acid (HY-16637), polyethylene glycol (PEG), and Cholesterol (HY-N0322). Folic acid (FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery. Cholesterol can improve the circulation time of encapsulated drugs .
FA-PEG3400-Cholesterol (Folate-PEG3400-Cholesterol) is a multifunctional drug delivery system composed of Folic acid (HY-16637), polyethylene glycol (PEG), and Cholesterol (HY-N0322). Folic acid (FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery. Cholesterol can improve the circulation time of encapsulated drugs .
FA-PEG1000-Cholesterol (Folate-PEG1000-Cholesterol) is a multifunctional drug delivery system composed of Folic acid (HY-16637), polyethylene glycol (PEG), and Cholesterol (HY-N0322). Folic acid (FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery. Cholesterol can improve the circulation time of encapsulated drugs .
Biotin-PEG-CHO (with a molecular weight of 5000) is a biotin-attached PEG derivative that can be used for biotinylation of biological molecules or other material surfaces. Biotin can be easily detected through the biotin/streptavidin binding test, and is widely used in molecular targeted detection.
Ricorfotide vedotin (CBP-1008) is a dual-ligand peptide-drug conjugate (PDC) conjugated to MMAE (HY-15162), targeting Folatereceptor α (FRα) and TRPV6. Ricorfotide vedotin binds to FRα with high affinity and TRPV6 with low affinity. Ricorfotide vedotin has antitumor activity, and can be used in advanced solid tumor research (eg: colorectal cancer, breast cancer, non-small cell lung cancer, ovarian cancer, adrenocortical carcinoma and follicular dendritic cell sarcoma) .
FRα-targeting peptide C7 TFA is a selective peptide ligand for folatereceptor α (FRα) that has specific binding to FRα expressing cells and in vivo tumor targeting ability. FRα-targeting peptide C7 TFA can be used in the research of tumor diagnosis and treatment .
CBP-1018 is a PDC (peptide-drug conjugate) formed by conjugating Monomethyl auristatin E (HY-15162) to a dual-targeting ligand of FLOR1/PSMA (prostate-specific membrane antigen) via a linker (HY-78738). CBP-1018 binds to FLOR1 and prostate-specific membrane antigen (PSMA). CBP-1018 is applicable to the research of solid tumors and metastatic castration-resistant prostate cancer .
FRα-targeting peptide C7 is a selective peptide ligand for folatereceptor α (FRα) that has specific binding to FRα expressing cells and in vivo tumor targeting ability. FRα-targeting peptide C7 can be used in the research of tumor diagnosis and treatment .
Mirvetuximab (M9346A) is an anti-FOLR1 (folatereceptor 1) monoclonal antibody. Mirvetuximab is the antibody moiety of folatereceptor alpha (FRα)-targeting ADC (Mirvetuximab soravtansine). Mirvetuximab soravtansine can be used in ovarian and other FRα-positive cancer research .
Farletuzumab (MORAb-003) is a potent folatereceptor-alpha (FRα) inhibitor. Farletuzumab is a humanized monoclonal antibody with high affinity for FRα. Farletuzumab possesses growth-inhibitory functions on cells overexpressing FRα. Farletuzumab can be used in research of cancer .
Mirvetuximab (M9346A) (powder) is an anti-FOLR1 (folatereceptor 1) monoclonal antibody. Mirvetuximab (powder) is the antibody moiety of folatereceptor alpha (FRα)-targeting ADC (Mirvetuximab soravtansine). Mirvetuximab soravtansine can be used in ovarian and other FRα-positive cancer research .
Onvontatug (BAT8006 Antibody) is a humanized monoclonal antibody targeting folatereceptor α (FRα). Onvontatug can be used to construct antibody-drug conjugates (ADCs), such as BAT8006. It is applicable to research related to platinum-resistant ovarian cancer .
AMT-151 Antibody is a monoclonal antibody inhibitor targeting folatereceptor α. AMT-151 Antibody can be used to synthesize the antibody-drug conjugate (ADC) AMT-151. AMT-151 Antibody can be used to research related to cancer .
IKS012 Antibody (Isumab01) is a monoclonal antibody inhibitor targeting folatereceptor α (FRA). IKS012 Antibody can be used to synthesize the antibody-drug conjugate (ADC) IKS012. IKS012 Antibody can be used to research related to platinum-resistant ovarian cancer .
Eliroptamig is a multispecific antibody targeting albumin, folatereceptor α (FOLR1) and cluster of differentiation 3 (CD3). Eliroptamig extends its half-life by binding to albumin, while targeting FOLR1 on tumor cells and activating T cells to achieve precise tumor killing .
KHK2805 (RA15-7) is a humanized antibody against folatereceptor α (FOLR1), with a Kd of 0.647 nM for human FOLR1. KHK2805 binds to a unique epitope of FOLR1 and mediates antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity against FOLR1-expressing cells. KHK2805 exhibits cytotoxicity against both ovarian cancer cells and Platinum (HY-W096169D)-resistant ovarian cancer cells. KHK2805 can be used for the research of tumors such as ovarian cancer .
The FOLR1 protein is an important mediator of folate uptake, binding to folate and promoting the delivery of 5-methyltetrahydrofolate into cells. Studies show high affinity at neutral pH. FOLR1 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FOLR1 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag.
The FOLR1 protein is an important mediator of folate uptake, binding to folate and promoting the delivery of 5-methyltetrahydrofolate into cells. Studies show high affinity at neutral pH. FOLR1 Protein, Human (HEK293, Fc) is the recombinant human-derived FOLR1 protein, expressed by HEK293, with C-hFc labeled tag.
The FOLR1 protein is an important mediator of folate uptake, binding to folate and promoting the delivery of 5-methyltetrahydrofolate into cells. Studies show high affinity at neutral pH. FOLR1 Protein, Human (HEK293, His) is the recombinant human-derived FOLR1 protein, expressed by HEK293 , with C-His labeled tag.
FOLR1 Protein, binding to folate and reduced folic acid derivatives, facilitates their delivery into cells. It maintains high affinity under neutral pH but undergoes a conformational change upon endocytosis, reducing affinity and releasing folates in slightly acidic pH. Crucial for embryonic development, cell proliferation, and renal folate reabsorption. FOLR1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FOLR1 protein, expressed by HEK293 , with C-6*His labeled tag.
FOLR1 Protein, binding to folate and reduced folic acid derivatives, facilitates their delivery into cells. It maintains high affinity under neutral pH but undergoes a conformational change upon endocytosis, reducing affinity and releasing folates in slightly acidic pH. Crucial for embryonic development, cell proliferation, and renal folate reabsorption. FOLR1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived FOLR1 protein, expressed by HEK293, with C-hFc labeled tag.
FOLR3 protein is crucial in folate metabolism, binding to folate and aiding 5-methyltetrahydrofolate delivery into cells. Notably, the Isoform Short of FOLR3 lacks folate-binding capabilities, indicating diverse functional roles among FOLR3 isoforms. This highlights nuanced regulation in cellular folate transport processes. FOLR3 Protein, Human (HEK293, His) is the recombinant human-derived FOLR3 protein, expressed by HEK293 , with C-His labeled tag.
FOLR2 Protein binds folate, enabling the transport of 5-methyltetrahydrofolate into cells with high affinity under neutral pH. Upon endocytosis, exposure to slightly acidic pH induces a conformational change, substantially reducing FOLR2's folate affinity and releasing it from the receptor. FOLR2 Protein, Human (HEK293, His) is the recombinant human-derived FOLR2 protein, expressed by HEK293 , with C-His labeled tag.
The FOLR1 protein is a member of the folate receptor family. Folate receptors are cell surface proteins that bind folate (vitamin B9) and transport it into cells. FOLR1 Protein, Rat (HEK293, Fc) is the recombinant rat-derived FOLR1 protein, expressed by HEK293 , with C-hFc labeled tag.
The FOLR1 protein is a member of the folate receptor family. Folate receptors are cell surface proteins that bind folate (vitamin B9) and transport it into cells. FOLR1 Protein, Rat (HEK293, His) is the recombinant rat-derived FOLR1 protein, expressed by HEK293 , with C-His labeled tag.
FOLR1 is a folic acid receptor that binds to folic acid and reductive folic acid derivatives and promotes the entry of 5-methyltetrahydrofolate and folate analogs into the cell interior. FOLR1 enhances the stability and nuclear translocation of β-catenin through the EGFR/AKT/GSK3β axis, thereby promoting the proliferation and migration of laryngeal squamous cell carcinoma (LSCC). FOLR1 is highly expressed in a variety of tumors and is a potential prognostic and therapeutic target for many cancers. FOLR1 Protein, Canine (HEK293, His) is the recombinant canine-derived FOLR1 protein, expressed by HEK293 , with C-His labeled tag.
FOLR1 is a folic acid receptor that binds to folic acid and reductive folic acid derivatives and promotes the entry of 5-methyltetrahydrofolate and folate analogs into the cell interior. FOLR1 enhances the stability and nuclear translocation of β-catenin through the EGFR/AKT/GSK3β axis, thereby promoting the proliferation and migration of laryngeal squamous cell carcinoma (LSCC). FOLR1 is highly expressed in a variety of tumors and is a potential prognostic and therapeutic target for many cancers. FOLR1 Protein, Canine (HEK293, Fc) is the recombinant canine-derived FOLR1 protein, expressed by HEK293 , with C-hFc labeled tag.
The FOLR4 protein serves as a receptor for IZUMO1 on the egg membrane and plays a crucial role in species-specific gamete recognition and fertilization. The interaction between IZUMO1 and FOLR4 (IZUMO1R/JUNO) is an important adhesion event that is required for fertilization but not sufficient for cell fusion. FOLR4 Protein, Human (HEK293, His) is the recombinant human-derived FOLR4 protein, expressed by HEK293 , with C-His labeled tag.
FOLR4 is a receptor on the egg membrane that interacts with IZUMO1 and is essential for species-specific gamete recognition and fertilization. Although it is essential for fertilization, it is not sufficient by itself to achieve cell fusion. FOLR4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FOLR4 protein, expressed by HEK293 , with C-His labeled tag.
Plevitrexed (ZD 9331; BGC 9331) is an orally active and potent thymidylate synthase (TS) inhibitor with a Ki of 0.44 nM. Plevitrexed is taken up via the α-folatereceptor as well as the reduced folate carrier. Plevitrexed is used for gastric cancer in clinical . Plevitrexed is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
SC239 is a cleavable 2-aminophenyl hemiasterlin agent-linker. SC239 can be as the agent-linker for ADC . SC239 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
DBCO-PEG1000-FA (DBCO-PEG1000-Folate) is a multifunctional bioconjugation reagent, which is a copolymer of DBCO and Folic acid (FA) (HY-16637) and can target folatereceptors (FR). Folatereceptors are highly overexpressed on the surface of many cancer cells (such as lung cancer, nasopharyngeal cancer, ovarian cancer, etc.), but exhibit extremely low expression levels in normal tissues. DBCO-PEG-FA can be used for click chemistry conjugation via its DBCO terminal, and thus applies to various bioconjugation and drug delivery applications .
Idetrexed (ONX 0801) is a thymidylate synthase (TS) inhibitor with a Ki of 1.2 nM. Idetrexed can be specifically transported into α-folatereceptor (α-FR)-overexpressing tumors, such as ovarian cancer .
DBCO-PEG2000-FA (DBCO-PEG2000-Folate) is a multifunctional bioconjugation reagent, which is a copolymer of DBCO and Folic acid (FA) (HY-16637) and can target folatereceptors (FR). Folatereceptors are highly overexpressed on the surface of many cancer cells (such as lung cancer, nasopharyngeal cancer, ovarian cancer, etc.), but exhibit extremely low expression levels in normal tissues. DBCO-PEG-FA can be used for click chemistry conjugation via its DBCO terminal, and thus applies to various bioconjugation and drug delivery applications .
Idetrexed (ONX 0801) trisodium is a thymidylate synthase (TS) inhibitor with a Ki of 1.2 nM. Idetrexed trisodium can be specifically transported into α-folatereceptor (α-FR)-overexpressing tumors, such as ovarian cancer .
DBCO-PEG-FA (DBCO-PEG-Folate) (MW 3400) is a multifunctional bioconjugation reagent, which is a copolymer of DBCO and Folic acid (FA) (HY-16637) and can target folatereceptors (FR). Folatereceptors are highly overexpressed on the surface of many cancer cells (such as lung cancer, nasopharyngeal cancer, ovarian cancer, etc.), but exhibit extremely low expression levels in normal tissues. DBCO-PEG-FA can be used for click chemistry conjugation via its DBCO terminal, and thus applies to various bioconjugation and drug delivery applications .
DBCO-PEG10000-FA (DBCO-PEG10000-Folate) is a multifunctional bioconjugation reagent, which is a copolymer of DBCO and Folic acid (FA) (HY-16637) and can target folatereceptors (FR). Folatereceptors are highly overexpressed on the surface of many cancer cells (such as lung cancer, nasopharyngeal cancer, ovarian cancer, etc.), but exhibit extremely low expression levels in normal tissues. DBCO-PEG-FA can be used for click chemistry conjugation via its DBCO terminal, and thus applies to various bioconjugation and drug delivery applications .
DBCO-PEG5000-FA (DBCO-PEG5000-Folate) is a multifunctional bioconjugation reagent, which is a copolymer of DBCO and Folic acid (FA) (HY-16637) and can target folatereceptors (FR). Folatereceptors are highly overexpressed on the surface of many cancer cells (such as lung cancer, nasopharyngeal cancer, ovarian cancer, etc.), but exhibit extremely low expression levels in normal tissues. DBCO-PEG-FA can be used for click chemistry conjugation via its DBCO terminal, and thus applies to various bioconjugation and drug delivery applications .
DSPE-PEG-Folate, MW 3350 is a PEG derivative containing folic acid. DSPE-PEG-Folate has a targeting effect and bind to folatereceptors in cancer cells. DSPE-PEG-Folate form micelles/lipid bilayer and can be used to targeted drug delivery system research .
DSPE-PEG2000-Folate (DSPE-PEG2000 Folate) is a folate-containing PEG derivative. DSPE-PEG2000-Folate possesses targeting activity and binds to folatereceptors in cancer cells. DSPE-PEG2000-Folate can be post-inserted into preformed liposomal bilayers to prepare folate-targeted liposomal formulations. DSPE-PEG2000-Folate forms micelles/lipid bilayers and can be used in studies of targeted drug delivery systems [2].
mPEG750-amine (mPEG750-NH2) is a chemical modification reagent for nanoparticles, capable of covalently binding to Ad-PVA to form Ad-PVA-PEG polymers. mPEG750-amine stabilizes gene delivery complexes by providing steric hindrance, reducing particle aggregation, while enhancing the water solubility and serum stability of the complex, reducing carrier cytotoxicity, and assisting in the efficient condensation of pDNA by cationic components to form nanoparticles that can be endocytosed by cells. mPEG750-amine can also be used to synthesize folate-conjugated polymer micelles for encapsulating the anticancer agent Camptothecin (HY-16560). Folate-conjugated polymer micelles are effective carriers for poorly soluble anticancer drugs, capable of avoiding macrophages and acting through folatereceptor (FR)-mediated endocytosis to target tumor cells. mPEG750-amine can be applied to research in the field of non-viral gene delivery, as a component of gene delivery vectors, facilitating the safe and efficient delivery of nucleic acid drugs to target cells .
DSPE-PEG-Folate, MW 5000 is a PEG derivative containing folic acid. DSPE-PEG-Folate, MW 5000 has a targeting effect and bind to folatereceptors in cancer cells. DSPE-PEG-Folate, MW 5000 form micelles/lipid bilayer and can be used to targeted drug delivery system research .
mPEG3400-amine can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
mPEG4000-amine can be used to synthesize folate-conjugated polymer micelles for encapsulating anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
mPEG350-amine can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
PEG-bis-amine (MW 1000) synthesizes folate-conjugated polymeric micelles for encapsulation of the anticancer agent 9-nitrocamptothecin HY-16560 (HY-16560). Folic acid-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
PEG4000-bis-amine synthesizes folate-conjugated polymeric micelles for encapsulation of the anticancer agent 9-nitrocamptothecin HY-16560 (HY-16560). Folic acid-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
DSPE-PEG5000-Folate is a PEG derivative containing folic acid. DSPE-PEG-Folate has a targeting effect and bind to folatereceptors in cancer cells. DSPE-PEG-Folate form micelles/lipid bilayer and can be used to targeted drug delivery system research .
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Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
MedchemExpress Validation 03
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
MedchemExpress Validation 04
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
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