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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
G protein-coupled receptor kinase 2
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "G protein-coupled receptor kinase 2" in MCE Product Catalog:
6
6 Publications Verification
Cat. No.: HY-18990
CAS No.: 817194-38-0
Research Areas:
GSK180736A is potent Rho-associated coiled-coil kinase 1 (ROCK1) inhibitor with an IC50 of 100 nM. GSK180736A is also a selective and ATP-competitive G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC50 of 0.77 μM.
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Research Areas:
Locostatin (UIC-1005) is a potent RKIP inhibitor. Locostatin binds Raf kinase inhibitor RKIP protein and disrupts the interaction of RKIP with Raf-1 kinase and G protein-coupled receptor kinase 2. Locostatin inhibits cell proliferation and migration. Locostatin can be used to synthesize chemical probes toward PEBP-proteins. Locostatin aggravates thioacetamide (HY-Y0698)-induced acute liver failure in mice .
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1 Cited Publications
Research Areas:
GRK2 Inhibitor 2 is an orally active and selective G protein-coupled receptor kinase 2 (GRK) inhibitor with an IC50 of 19 nM. GRK2 Inhibitor 2 also inhibits Aurora-A with an IC50 of 137 nM. GRK2 Inhibitor 2 can be used in the study of congestive heart failure (HF) .
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Research Areas:
CCG258208 (GRK2-IN-1) hydrochloride is a potent and selective GRK2 (G protein-coupled receptor kinase 2) inhibitor (IC50=30 nM) while maintaining 230-fold selectivity over GRK5 (IC50=7.09 μM) and more than 2500-fold selectivity over GRK1 (IC50=87.3 μM), PKA, and ROCK1. CCG258208 hydrochloride can be used in heart failure research .
Cat. No.: HY-P1396
CAS No.: 148505-03-7
Research Areas:
Cat. No.: HY-109562
CAS No.: 2055990-90-2
Synonyms: GRKs-IN-1
Research Areas:
CCG258208 (GRK2-IN-1) is a potent and selective GRK2 (G protein-coupled receptor kinase 2) inhibitor (IC50=30 nM) while maintaining 230-fold selectivity over GRK5 (IC50=7.09 μM) and more than 2500-fold selectivity over GRK1 (IC50=87.3 μM), PKA, and ROCK1. CCG258208 can be used in heart failure research .
Cat. No.: HY-W013411
CAS No.: 133812-16-5
Synonyms: (E/Z)-UIC-1005
(E/Z)-Locostatin ((E/Z)-UIC-1005) is a racemic of Locostatin. Locostatin (UIC-1005) is a potent RKIP inhibitor. Locostatin binds Raf kinase inhibitor RKIP protein and disrupts the interaction of RKIP with Raf-1 kinase and G protein-coupled receptor kinase 2. Locostatin inhibits cell proliferation and migration. Locostatin aggravates thioacetamide (HY-Y0698)-induced acute liver failure in mice .
Cat. No.: HY-168971
CAS No.: 1390658-79-3
Synonyms: CP-25
Target:
IFNAR STAT TNF Receptor Interleukin Related CXCR JAK G Protein-coupled Receptor Kinase (GRK)
Research Areas:
Paeoniflorin-6′-O-benzene sulfonate (CP-25) is the inhibitor for G protein-coupled receptor kinase 2 (GRK2) that inhibits the translocation of GRK2 to the cell membrane, inhibits JAK1/STAT3 signaling pathway. Paeoniflorin-6′-O-benzene sulfonate inhibits IL-17A/CXCL2-induced proliferation of HaCaT. Paeoniflorin-6′-O-benzene sulfonate reduces the levels of inflammatory factors and chemokines such as IL-17A, IL-17F, IFN-γ, TNF-α, IL-22, IL-23, CXCL2, CXCL3 and CXCL9, alleviates Imiquimod (HY-B0180)-induced psoriasis in mouse model .
Cat. No.: HY-123254
CAS No.: 1870843-22-3
Research Areas:
CCG-224406 is a selective G protein-coupled receptor kinase 2 (GRK2) inhibitor with the IC50 values of 13 nM, greater than 700-fold selectivity over other GRK subfamilies, and no inhibition of ROCK1. CCG-224406 can be used for study of heart failure .
Cat. No.: HY-P703086
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: GRK3; Beta-Adrenergic receptor kinase 2; Prev. ADRBK2; Beta-ARK-2; BARK2; G protein-coupled receptor kinase 3; Adrenergic, Beta, receptor kinase 2
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P705841
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: GRK2; Adrenergic, Beta, receptor kinase 1; Prev. ADRBK1; Adrenergic Beta receptor kinase 1; BARK1; G protein-coupled receptor kinase; Beta-Adrenergic receptor kinase 1; BETA-ARK1; Beta-ARK-1; BARK; G protein-coupled receptor kinase 2; G-protein coupled Re
Species:
Human
Source:
sf9 insect cells
Cat. No.: HY-P85534
Synonyms: ADRBK 1; ADRBK1; Adrenergic beta receptor kinase 1; Adrenergic beta receptor kinase 1; ARBK1_HUMAN; BARK 1; BARK; BARK1; Beta adrenergic receptor kinase 1; Beta ARK 1; Beta ARK1; Beta-adrenergic receptor kinase 1; Beta-ARK-1; FLJ16718; G protein coupled receptor kinase 2; G protein dependent receptor kinase 2; G-protein coupled receptor kinase 2; GRK 2; GRK2.
Cat. No.: HY-P701814
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MKNK2; G protein-coupled receptor kinase 7; Prev. GPRK7; CDNA FLJ10868 Fis, Clone NT2RP4001644, Weakly Similar To MYOSIN LIGHT CHAIN kinase; MNK2; Putative Map kinase Interacting kinase; MAP kinase-Interacting Serine/Threonine-protein kinase 2; MKNK2 Prot
Species:
Human
Source:
E. coli
Cat. No.: HY-P11764
Research Areas:
Cat. No.: HY-P701815
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: MKNK2; G protein-coupled receptor kinase 7; Prev. GPRK7; CDNA FLJ10868 Fis, Clone NT2RP4001644, Weakly Similar To MYOSIN LIGHT CHAIN kinase; MNK2; Putative Map kinase Interacting kinase; MAP kinase-Interacting Serine/Threonine-protein kinase 2; MKNK2 Prot
Species:
Human
Source:
E. coli
Cat. No.: HY-120718
CAS No.: 2055990-82-2
Research Areas:
CCG 224061 is a G protein-coupled receptor kinase 2 (GRK2) inhibitor with a IC50 of 0.066 μM. CCG 224061 inhibits GRK activity in cardiomyocytes . CCG 224061 is applicable to research related to heart disease, heart failure, myocardial hypertrophy and hypertension .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
