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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
37 Results for "
GST-P
" in MedChemExpress (MCE) Product Catalog:
Products (37)
37 Results for "GST-P" in MCE Product Catalog:
7
7 Publications Verification
Synonyms: TER199free base; TLK199
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2 Cited Publications
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NBDHEX is a potent glutathione S-transferase P1-1 (GSTP1-1) inhibitor. NBDHEX induces apoptosis of tumor cells. NBDHEX acts as an anticancer agent by inhibiting GSTs catalytic activity, avoiding inconvenience of the inhibitor extrusion from the cell by specific pumps and disrupting the interaction between the GSTP1-1 and key signaling effectors. NBDHEX can also act as late-phase autophagy inhibitor .
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GSTO-IN-2 is a glutathione S-transferase inhibitor with IC50s of 3.6, 16.3, and 1.4 μM for GSTA2, GSTM1, and GSTP1-1.
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1 Cited Publications
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LAS17 is a potent and selective tyrosine-directed irreversible inhibitor for glutathione S-Transferase Pi (GSTP1) . LAS17 inhibits GSTP1 activity with an IC50 of 0.5 μM . LAS17 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Keap1-Nrf2-IN-9 (Compound 11) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) inhibitor with an IC50 of 0.575 μM. Keap1-Nrf2-IN-9 increases the expression of Nrf2 target genes including heme oxygenase 1 (Hmox1), glutathione S-transferase P (GstP), and glutamate-cysteine ligase catalytic (Gclc) and modulatory (Gclm) subunits. Keap1-Nrf2-IN-9 shows no cytotoxic activity in ARPE19 cells .
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Cat. No.: HY-P2961
CAS No.: 50812-37-8
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Glutathione S-transferase is a phase II metabolic enzyme composed of three superfamilies: cytosolic, mitochondrial, and microsomal. Glutathione S-transferase possesses multiple catalytic activities, including catalytic detoxification and thiol transfer, as well as molecular chaperone functions. The Glutathione S-transferase isoform GSTP1 is highly expressed in malignant tumors and serves as a tumor biomarker .
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GSTP1-1 inhibitor 1 (compound 6b) is an irreversible, long-acting, glutathione S-transferase inhibitor with an IC50 of 21 μM targeting GSTP1-1 . GSTP1-1 is a key tumor suppressor target, and GSTP1-1 inhibitor 1 has potential anticancer activity .
Cat. No.: HY-RS23077
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Gstp1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Gstp1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS05886
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GSTP1 Human Pre-designed siRNA Set A contains three designed siRNAs for GSTP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-13634
CAS No.: 286942-97-0
Synonyms: TER199; TLK199 hydrochloride
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Cat. No.: HY-W615446
CAS No.: 158890-32-5
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GSTO1-IN-3 is a potent GSTO1-1 inhibitor with an IC50 of 0.11 μM, and shows selectivity over GSTO2-2, GSTA1-1 and GSTP1-1 (IC50 > 100 μM). GSTO1-IN-3 enhances the cytotoxicity of Cisplatin (HY-17394) against human breast cancer cells. GSTO1-IN-3 inhibits IL-1β release in mouse bone marrow-derived macrophage (BMDM) cells. GSTO1-IN-3 attenuates inflammation in mice. GSTO1-IN-3 can be used for breast cancer and inflammation research .
Cat. No.: HY-169058
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GSTP1-1 inhibitor 2 (Compound 5g) is an hGSTP1-1 (glutathione S-transferase P1-1) inhibitor with an IC50 value of 12.2 μM. GSTP1-1 inhibitor 2 exhibits significant cytotoxicity against DU-145, PC3, and MCF-7 cell lines, with CC50 values of 36.6 μM, 11.9 μM, and 17.4 μM, respectively. It can be used in cancer research .
Cat. No.: HY-RS16643
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Gstp1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gstp1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-16123
CAS No.: 439943-59-6
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Canfosfamide (hydrochloride) is a prodrug that upon activation by glutathione s-transferase P1-1 (GSTP1-1) yields an anticancer alkylating agent and a glutathione derivative.
Cat. No.: HY-N11778
CAS No.: 152175-74-1
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Cat. No.: HY-169350
CAS No.: 1354444-72-6
EA-B2L is a GSTP degrader with a DC50 of 48 μM in HeLa cells. EA-B2L inhibits GSTP enzymatic activity, induces dose-dependent GSTP degradation via the ubiquitin-proteasome and autophagy pathways, and does not activate the 20S proteasome subunit. EA-B2L induces dose-dependent apoptosis in cancer cells, a process associated with GSTP degradation, caspase 3 activation, and PARP cleavage. EA-B2L exerts dose-dependent antiproliferative effects on cancer cells with high GSTP expression. EA-B2L can be used in the research of cervical cancer, lung cancer, and fibrosarcoma .
Cat. No.: HY-114688
CAS No.: 62959-30-2
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BITC-SG is the conjugate of phenylisothiocyanate (BITC) and glutathione (GSH). BITC-SG is involved in the irreversible inhibition of GST P1-1 .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
