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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
Geldanamycin
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "Geldanamycin" in MCE Product Catalog:
43
43 Cited Publications
Category:
Infection Quinones Microorganisms Benzene Quinones Disease Research Fields Inflammation/Immunology
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1 Cited Publications
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2,6-Diisopropyl-p-benzoquinone is a drug intermediate that can be used for the synthesis of Geldanamycin (HY-15230) .
Cat. No.: HY-W013675
CAS No.: 824-46-4
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2-Methoxyhydroquinone is a phenolic compound that reduces TNF-α-induced production of chemokine (C-C motif) ligand 2 (CCL2) with an IC50 value of 64.3 µM. 2-Methoxyhydroquinone is also a precursor in the synthesis of the Hsp90 inhibitor Geldanamycin (HY-15230) .
Cat. No.: HY-W077634
CAS No.: 76045-71-1
Synonyms: AHBA
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3-Amino-5-hydroxybenzoic acid is a biosynthetic precursor of the mC7N unit of ansamycin antibiotics, including ansatrienin A and geldanamycin, as well as the antitumor antibiotic mitomycin C. 3-Amino-5-hydroxybenzoic acid may be an early intermediate in the shikimic acid pathway from glucose .
Cat. No.: HY-15230R
CAS No.: 30562-34-6
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Synonyms: AHGDM
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Aminohexylgeldanamycin (AHGDM), a Geldanamycin derivative, is a potent HSP90 inhibitor. Aminohexylgeldanamycin shows antiangiogenic and antitumor activities .
Cat. No.: HY-133571A
CAS No.: 1146534-45-3
Synonyms: AHGDM hydrochloride
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Aminohexylgeldanamycin (AHGDM) hydrochloride, a Geldanamycin derivative, is a potent HSP90 inhibitor. Aminohexylgeldanamycin hydrochloride shows antiangiogenic and antitumor activities .
Cat. No.: HY-121881
CAS No.: 352519-21-2
PU3 is an Hsp90 inhibitor that competes with geldanamycin (GM) and others for the conserved ATP/ADP pocket of Hsp90. PU3 also induces degradation of proteins such as Her2 and inhibits breast cancer cell growth by causing retinoblastoma protein hypophosphorylation, G1 arrest, and cell differentiation. PU3 has the potential to be a cancer inhibitor. .
Cat. No.: HY-W766357
Cat. No.: HY-120625
CAS No.: 601519-75-9
PU3 is a small molecule inhibitor of Hsp90 that competes with geldanamycin for Hsp90. PU3 induces degradation of proteins, including Her2, similar to geldanamycin. PU3 inhibits the growth of breast cancer cells, causing retinoblastoma protein hypophosphorylation, G1 arrest, and differentiation. PU3 represents a novel class of synthetic compounds that bind to Hsp90 and inhibit the proliferation of cancer cells. PU3 could provide a new strategy for the treatment of cancers .
Cat. No.: HY-136312
CAS No.: 169521-68-0
17-DMAP-GA, a Geldanamycin (HY-15230) analogue, is an inhibitor of HSP90. 17-DMAP-GA causes cell cycle abnormalities .
Cat. No.: HY-12933
CAS No.: 911398-13-5
BIIB-028 is an orally active inhibitor for heat shock protein 90 (Hsp90). BIIB-028 targets the ATP-binding site of Hsp90, disrupts the function of Hsp90, leads to the degradation of client proteins, that are crucial for cancer cell survival and proliferation .
Cat. No.: HY-149367
CAS No.: 3049419-74-8
Anticancer agent 136 (compound 22), a C17-triazole analogue of Geldanamycin (GDM; HY-15230), has an IC50 of 3.38 μM for HDF and a Kd of 3.86 μM for Hsp90. Anticancer agent 136 is an apoptosis-inducing agent .
Cat. No.: HY-178299S
CAS No.: 773801-41-5
Cat. No.: HY-W740576
CAS No.: 169564-26-5
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7-Descarbamoyl-17-amino geldanamycin is a Geldanamycin (HY-15230) derivative. 7-Descarbamoyl-17-amino geldanamycin exerts very low activity in depleting p185erbB-2 protein in human breast cancer cells in vitro .
Cat. No.: HY-121706
CAS No.: 422508-29-0
PU-20F is a Hsp90 inhibitor with an EC50 of 6.8 μM. PU-20F competes with Geldanamycin (HY-15230) for binding to Hsp90 and regulates the function of this molecular chaperone. PU-20F induces the degradation of oncogenic Her2 tyrosine kinase. PU-20F blocks the growth of breast cancer cells. PU-20F can be used in breast cancer-related research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
