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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
142 Results for "
HCL
" in MedChemExpress (MCE) Product Catalog:
Products (142)
142 Results for "HCL" in MCE Product Catalog:
494
494 Publications Verification
Synonyms: MK-2206 (2HCL)
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MK-2206 dihydrochloride (MK-2206 2HCl) is an orally active pan-AKT inhibitor, with IC50 values of 8 nM, 12 nM and 65 nM against AKT1, AKT2 and AKT3, respectively. MK-2206 dihydrochloride inhibits the Akt/mTOR signaling pathway and reduces the levels of downstream GSK3β and Mcl-1 via proteasomal degradation. MK-2206 dihydrochloride induces G1-phase cell cycle arrest, apoptosis, epithelial-mesenchymal transition, fibroblast activation and extracellular matrix deposition. MK-2206 dihydrochloride causes transient hyperglycemia and hyperinsulinemia in animals. MK-2206 dihydrochloride can be used in research related to solid tumors, renal fibrosis and hypercholesterolemia .
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43 Cited Publications
Synonyms: Tubastatin A HCL; TSA HCL
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Tubastatin A Hydrochloride (Tubastatin A HCl) is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). Tubastatin A Hydrochloride also inhibits HDAC10 and metallo-β-lactamase domain-containing protein 2 (MBLAC2).
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Cyproheptadine hydrochloride (Cyproheptadine HCl) acts as a p38 MAP kinase activator, CHK2 activator, histamine H1 receptor inhibitor and serotonin receptor inhibitor. Cyproheptadine hydrochloride mediates cell cycle arrest via G1 phase arrest, G1/S transition arrest, G0/G1 phase arrest, reduced expression of cyclins D1/D2/D3, upregulated expression of HBP1, p16, p21, p27, and decreased phosphorylation of retinoblastoma protein. Cyproheptadine hydrochloride induces Apoptosis by increasing PARP and cleaved PARP, as well as activating the mitochondrial caspase pathway. Cyproheptadine hydrochloride inhibits tumor growth with extremely low toxicity to normal cells. Cyproheptadine hydrochloride can be used in research related to hepatocellular carcinoma, multiple myeloma and acute myeloid leukemia .
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CC-401 hydrochloride is a potent inhibitor of all three forms of JNK with Ki of 25 to 50 nM.
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Vitaceae Extract Microorganisms Vitis vinifera cv. Zalema Plants Disease Research Fields Inflammation/Immunology Saccharides Monosaccharides
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3 Cited Publications
Synonyms: Tris HCL; Tris(hydroxymethyl)aminomethane hydrochloride
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THAM hydrochloride (Tris HCl) is a biologically inert amino alcohol of low toxicity, which buffers carbon dioxide and acids in vitro and in vivo. THAM hydrochloride is an effective amine compound for pH control in the physiological range .
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2 Cited Publications
Synonyms: Tris HCL (≥99%, reagent grade); Tris hydrochloride (≥99%, reagent grade)
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2 Cited Publications
Synonyms: Tris HCL (≥99%, for cell culture); Tris hydrochloride (≥99%, for cell culture)
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1 Cited Publications
Cat. No.: HY-W016427
CAS No.: 7517-19-3
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1 Cited Publications
Cat. No.: HY-W012228
CAS No.: 3417-91-2
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H-Tyr-OMe.HCl is an amino acid derivative and also a coordinating ligand for Cu II ions. H-Tyr-OMe.HCl can serve as a surface functionalization reagent for carbon dots, and is used to prepare fluorescent probes for biothiol sensing. H-Tyr-OMe.HCl is oxidized to quinone under the catalysis of Tyrosinase via its phenolic hydroxyl group, which quenches the fluorescence of carbon dots. H-Tyr-OMe.HCl contains potential coordination sites, including carboxyl, amino and phenolic hydroxyl groups .
Cat. No.: HY-W019028
CAS No.: 847658-45-1
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Cat. No.: HY-W008029
CAS No.: 5978-22-3
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Cat. No.: HY-W007578
CAS No.: 58620-93-2
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Cat. No.: HY-W011830
CAS No.: 15100-75-1
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Cat. No.: HY-W013622
CAS No.: 5619-04-5
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Cat. No.: HY-W007020
CAS No.: 815619-80-8
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Cat. No.: HY-W009562
CAS No.: 91183-71-0
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Cat. No.: HY-W012451
CAS No.: 138165-77-2
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
