75 Results for "

Heme oxygenase

" in MedChemExpress (MCE) Product Catalog:
Products (75)

75 Results for "Heme oxygenase" in MCE Product Catalog:

94
94 Publications Verification
Cat. No.: HY-19424
CAS No.: 16009-13-5
Synonyms: Hemin chloride
Hemin is an iron-containing porphyrin. Hemin is an Heme oxygenase (HO)-1 inducer.
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71
71 Cited Publications
Cat. No.: HY-101193
CAS No.: 15442-64-5
Purity:  99.87%
Synonyms: Zn(II)-protoporphyrin IX; ZnPP; Zinc Protoporphyrin-9
Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor. Zinc Protoporphyrin regulates expression of HO-1 at the transcriptional level. The effect of Zinc Protoporphyrin on HO-1 expression is controversial.  It was shown to induce HO-1 expression in some cells, but suppress it in others. Zinc Protoporphyrin is used as a screening marker of iron deficiency in vivo. Zinc Protoporphyrin has anti-cancer activity .
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24
24 Cited Publications
Cat. No.: HY-101194
CAS No.: 14325-05-4
Purity:  96.2%
Synonyms: Tin-protoporphyrin IX; Sn-Protoporphyrin; SnPPIX
Research Areas:  

Cancer

Tin protoporphyrin IX dichloride (SnPPIX) is a potent Heme oxygenase-1 (HO-1) inhibitor. Tin protoporphyrin IX dichloride sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model .
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17
17 Cited Publications
Cat. No.: HY-N0643
CAS No.: 5957-80-2
Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC50 of ~5.5 μM . Carnosol, a Nrf2 activator, increases the nuclear levels of Nrf2 and can promote the expression of heme oxygenase 1 (HMOX1) .
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17
17 Cited Publications
Cat. No.: HY-15477
CAS No.: 132836-42-1
Purity:  99.92%
YS-49 is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors .
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17
17 Cited Publications
Cat. No.: HY-15477A
CAS No.: 3028631-24-2
Purity:  99.71%
YS-49 (monohydrate) is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors .
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12
12 Cited Publications
Cat. No.: HY-111798A
CAS No.: 1092851-70-1
Purity:  99.03%
Research Areas:  

Cancer

Heme Oxygenase-1-IN-1 (Compound 2) hydrochloride is a heme oxygenase 1 (HO-1) inhibitor with an IC50 of 0.25 μM .
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12
12 Cited Publications
Cat. No.: HY-111798
CAS No.: 1093058-52-6
Purity:  99.11%
Research Areas:  

Cancer

Heme Oxygenase-1-IN-1 (compound 2) is a potent heme oxygenase 1 (HO-1) inhibitor, with an IC50 of 0.25 μM. Heme Oxygenase-1-IN-1 can be used for cancer research .
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4
4 Cited Publications
Cat. No.: HY-N0061
CAS No.: 4046-02-0
Ethyl ferulate, a naturally lipophilic derivative of ferulic acid originally derived from Rhizoma Chuanxiong, induces heme oxygenase-1 (HO-1) and protects rat neurons against oxidative stress . Ethyl ferulate also protects neurons against amyloid β peptide (1-42)-induced oxidative stress and neurotoxicity .
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4
4 Cited Publications
Cat. No.: HY-N1353
CAS No.: 569-92-6
Rhamnocitrin is an anti-inflammatory and antioxidant agent that targets STIM-1, NFATc3 and MAPK pathways and can scavenge DPPH (IC50=28.38 mM). Rhamnocitrin selectively inhibits oxidative stress and inflammatory responses in vascular endothelial cells and neurons. Rhamnocitrin up-regulates miR-185 to inhibit STIM-1-mediated store-operated calcium entry (SOCE), thereby blocking NFATc3 nuclear translocation and downstream inflammatory factor expression, while inducing heme oxygenase HO-1 expression and regulating the ERK/p38 MAPK pathway, inhibiting antioxidant and pro-inflammatory cytokines (such as IL-6, IL-8) and adhesion molecules (such as ICAM-1, VCAM-1). Rhamnocitrin can be used in the study of endothelial-related inflammatory diseases (such as sepsis, acute lung injury, atherosclerosis) and neuroprotection (such as oxidative damage of PC12 cells) .
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3
3 Cited Publications
Cat. No.: HY-N5027
CAS No.: 549-21-3
Synonyms: Oxyberberin; Berlambine; 8-Oxoberberine
Oxyberberine (Oxyberberin; Berlambine) is an orally effective heme oxygenase HO-1 agonist that can activate antioxidant mechanisms by regulating the PI3K/Akt/AMPK signaling pathway. Oxyberberine induces HO-1 expression, increases SOD and GSH-Px activity, inhibits NF-κB-mediated inflammatory responses, and improves insulin sensitivity and glucose metabolism. Oxyberberine has anti-diabetic, neuroprotective, anti-inflammatory and antioxidant effects, and can be used to study type 2 diabetes, traumatic brain injury (TBI) and inflammatory bowel disease .
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3
3 Cited Publications
Cat. No.: HY-P70276
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HMOX1; Heme oxygenase; Heme oxygenase 1; HMOX1D; HO-1; HSP32; BK286B10; HO1; Heme oxygenase (Decycling) 1; HO; Heat Shock Protein, 32-KD
Species:  
Human
Source:  
E. coli
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2
2 Cited Publications
Cat. No.: HY-B2184
CAS No.: 64506-49-6
Target:  

Autophagy Bacterial

Research Areas:  

Infection Inflammation/Immunology

Sofalcone, a gastric antiulcer agent, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.
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1
1 Cited Publications
Cat. No.: HY-N0310
CAS No.: 51330-27-9
Soyasaponin Bb is an orally active, covalent inducer of heme oxygenase HO-1 and an inhibitor of aldose reductase AKR1B1. Soyasaponin Bb can regulate oxidative stress pathways, enhance antioxidant capacity, reduce reactive oxygen species (ROS) generation, and inhibit lipid peroxidation and hepatocyte apoptosis. Soyasaponin Bb improves alcohol-induced hepatocyte membrane damage and liver function abnormalities, and improves Scopolamine (HY-N0296)-induced memory impairment. Soyasaponin Bb has antioxidant, hepatoprotective, and neuroprotective activities .
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1
1 Cited Publications
Cat. No.: HY-N2535
CAS No.: 458-36-6
Synonyms: 4-Hydroxy-3-methoxycinnamaldehyde
Coniferaldehyde (4-Hydroxy-3-methoxycinnamaldehyde) is an effective inducer of heme oxygenase-1 (HO-1). Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Coniferaldehyde has antioxidant and anti-inflammatory activities .
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1
1 Cited Publications
Cat. No.: HY-P80499
Synonyms: HO, HO1, HMOX1, Heme oxygenase 1, HO-1

Host:  

Rabbit

Application:  

WB, IHC-P, IP, FC, IF-Tissue

Reactivity:  

Human

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Cat. No.: HY-134608
CAS No.: 14325-03-2
Synonyms: Co-PPIX
Research Areas:  

Infection

Cobalt protoporphyrin IX (Co-PPIX) is a potent and specific heme oxygenase-1 (HO-1) inducer. Cobalt protoporphyrin IX exhibits broad-spectrum antiviral activities against Influenza A virus (IAV) .
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Cat. No.: HY-W013812
CAS No.: 544-35-4
Synonyms: Linoleic Acid ethyl ester; Mandenol
Ethyl linoleate (Linoleic Acid ethyl ester) is an orally active unsaturated fatty acid. Ethyl linoleate inhibits the Akt/GSK3β/β-catenin signaling pathway and the activation of NF-κB. Ethyl linoleate induces heme oxygenase-1 and inhibits tyrosinase. Ethyl linoleate has whitening and anti-inflammatory effects. Ethyl linoleate promotes compound absorption. Ethyl linoleate has a significant influence on atherosclerosis. Ethyl linoleate is used in the research of inflammatory diseases. Ethyl linoleate can be used in cosmetics
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Cat. No.: HY-13707
CAS No.: 106344-20-1
Purity:  ≥95.0%
Synonyms: Stannsoporfin; SnMP
Tin(IV) mesoporphyrin IX dichloride (Stannsoporfin) is an orally active heme oxygenase (HO) inhibitor. Tin(IV) mesoporphyrin IX dichloride increases DENV RNA replication. Tin(IV) mesoporphyrin IX dichloride enhances the bactericidal activity of the SPaO regimen against chronic Mycobacterium tuberculosis (Mtb)-infected mice. Tin(IV) mesoporphyrin IX dichloride exhibits antitumor effects. Tin(IV) mesoporphyrin IX dichloride is being developed to prevent the development of jaundice in infants with hyperbilirubinemia .
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Cat. No.: HY-147817
CAS No.: 2994198-37-5
Purity:  99.37%
Heme Oxygenase-2-IN-1 (Compound 9) is a potent, selective heme oxygenase-2 (HO-2) inhibitor with IC50 values of 0.9 μM and 14.9 μM against HO-2 and HO-1, respectively .
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