58 Results for "

ICOS

" in MedChemExpress (MCE) Product Catalog:
Products (58)

58 Results for "ICOS" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-P99420
CAS No.: 2797026-97-0
Synonyms: ALPN-101

Target:  

CD28

Research Areas:  

Inflammation/Immunology

Acazicolcept (ALPN-101), an Fc fusion protein, is a dual inducible T cell costimulator (ICOS)/CD28 antagonist. Acazicolcept has anti-inflammatory activities .
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1
1 Cited Publications
Cat. No.: HY-P99414
CAS No.: 1523164-68-2
Synonyms: AMG 557
Prezalumab (AMG 557) is a humanized IgG2 monoclonal antibody targeting ICOSL. Prezalumab inhibits T cell activation and related immune responses by binding to ICOSL and blocking the interaction between ICOS and ICOSL. Prezalumab can be used in the research of autoimmune diseases and inflammatory diseases such as systemic lupus erythematosus. Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002) .
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Cat. No.: HY-150743
CAS No.: 1254617-22-5
Purity:  98.20%
ODN 2395 is a C class oligodeoxynucleotide and can be used as vaccine adjuvant. ODN 2395 is also a TLR9 agonist. ODN 2395 can be used in the research of immunological vaccines. Sequence: 5'-tcgtcgttttcggcgc:gcgccg-3' (Note: The bases are phosphorothioate; ODN 2395 contains the partial palindromic sequence cggcgc:gcgccg) .
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Cat. No.: HY-P99363
CAS No.: 2252518-85-5
Synonyms: Anti-ICOS/CD278 Reference Antibody (feladilimab); GSK3359609

Research Areas:  

Cancer

Feladilimab (Anti-ICOS/CD278 Reference Antibody (feladilimab); GSK3359609) is humanized IgG4 anti-ICOS/CD278 agonist monoclonal antibody. Feladilimab can be used for the research of cancer .
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Cat. No.: HY-P99382
CAS No.: 2039148-04-2
Synonyms: JTX 2011; 37A10

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology Cancer

Vopratelimab (JTX-2011) is a humanized immunoglobulin G1-kappa agonist monoclonal antibody that pecifically binds to the Inducible CO-Stimulator of T cells (ICOS). Vopratelimab retains species cross-reactivity with affinities of 0.93 nM to hICOS, 0.46 nM to cynomolgus ICOS, 3.7 nM to rat ICOS, and 0.64 nM to mICOS. Vopratelimab has antitumor immune response .
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Cat. No.: HY-W011267
CAS No.: 2390-09-2
(Z)-Methyl icos-11-enoate is a biochemical reagent that can be used to synthesize surfactants .
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Cat. No.: HY-P99431
CAS No.: 2489390-15-8
Synonyms: Alomfilimab; SAR 445256

Target:  

CD28

Research Areas:  

Inflammation/Immunology Cancer

KY-1044 (Alomfilimab; SAR 445256) is a fully human IgG1 antibody targeting inducible costimulatory receptor (ICOS). KY-1044 depletes ICOS high cells via antibody-dependent cellular cytotoxicity (ADCC) through the engagement of FcgRIIIa. KY-1044 act as a costimulatory molecule on cells expressing lower ICOS levels, such as CD8 + TEff cells (through FcgR-dependent clustering). KY-1044 exploit the differential expression of ICOS on T-cell subtypes to improve the intratumoral immune contexture and restore an antitumor immune response .
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Cat. No.: HY-P99474
CAS No.: 375348-49-5
Synonyms: CAT 213; iCo-008

Target:  

CCR

Research Areas:  

Inflammation/Immunology

Bertilimumab (CAT 213; iCo-008) is a human monoclonal antibody targeting eotaxin-1 (CCL11). Bertilimumab has the potential for allergic disorders research .
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Cat. No.: HY-159692
CAS No.: 2603457-08-3
Synonyms: IONIS-1063734
Target:  

FOXP

Research Areas:  

Cancer

AZD8701 (IONIS-1063734) is an antisense oligonucleotide targeting FOXP3 in regulatory T cells (Tregs), with a human IC50 of 65.2 nM. AZD8701 binds to intronic sites of all FOXP3 pre-mRNA isoforms and mediates dose-dependent FOXP3 knockdown via free uptake. AZD8701 can be used in cancer-related research .
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Cat. No.: HY-P990237

Target:  

CD28

Research Areas:  

Inflammation/Immunology Cancer

Anti-Mouse ICOS Antibody (7E.17G9) is a mouse ICOS agonist IgG2b monoclonal antibody. Anti-Mouse ICOS Antibody (7E.17G9) can upregulate ICOS expression and enhance T cell function. Anti-Mouse ICOS Antibody (7E.17G9) can significantly inhibit the immune regulatory function of dendritic cells (DCs). Anti-Mouse ICOS Antibody (7E.17G9) can eliminate transplant tolerance. Anti-Mouse ICOS Antibody (7E.17G9) can be used for researches on inflammation conditions, cancer and xenotransplantation such as nephritis and pancreatic cancer .
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Cat. No.: HY-P99382A

Target:  

Inhibitory Antibodies

Research Areas:  

Cancer

Vopratelimab (Mouse IgG2a) is a agonist monoclonal antibody that selectively targets Inducible CO-Stimulator of T cells (ICOS). The variable region of Vopratelimab (Mouse IgG2a) is consistent with that of Vopratelimab (HY-P99382), while the constant region is of Mouse IgG2a sequence. Vopratelimab (Mouse IgG2a) has antitumor immune response and enhances combinatorial efficacy with anti-PD-1 (HY-P9902A) therapy .
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Cat. No.: HY-P990628
CAS No.: 2179209-59-5

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

MEDI-570 is a humanized antibody expressed in CHO that targets ICOS/CD278. MEDI-570 contains huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for MEDI-570 can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
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Cat. No.: HY-162810
CAS No.: 1006002-58-9
Target:  

CD28

Research Areas:  

Others

ICOS-IN-1 (compound 9) is an inhibitor of the interaction between ICOS and ICOS-L (IC50=29.38 μM) and has activity in recognizing immune checkpoints .
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Cat. No.: HY-148682R
CAS No.: 10251-38-4
Synonyms: Glycyrrhetic acid 3-O-hydrogen sulfate (Standard)
(Z)-Methyl icos-11-enoate (Standard) is the analytical standard of (Z)-Methyl icos-11-enoate. This product is intended for research and analytical applications. (Z)-Methyl icos-11-enoate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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Cat. No.: HY-P99679
CAS No.: 2329669-80-7

Target:  

PD-1/PD-L1

Research Areas:  

Inflammation/Immunology Cancer

Izuralimab is a bispecific IgG1 antibody targeting inducible T-cell costimulator (ICOS/CD278) and PD-1 .
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Cat. No.: HY-W011267R
CAS No.: 2390-09-2
(Z)-Methyl icos-11-enoate (Standard) is the analytical standard of (Z)-Methyl icos-11-enoate. This product is intended for research and analytical applications. (Z)-Methyl icos-11-enoate is a biochemical reagent that can be used to synthesize surfactants .
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Cat. No.: HY-RS06520
Research Areas:  

Others

ICOS Human Pre-designed siRNA Set A contains three designed siRNAs for ICOS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS23260
Research Areas:  

Others

Icos Rat Pre-designed siRNA Set A contains three designed siRNAs for Icos gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-166209
CAS No.: 150324-18-8
Synonyms: Ethyl (Z)-ICOS-8-enoate
Research Areas:  

Metabolic Disease

Ethyl 8(Z)-eicosenoate (Ethyl (Z)-icos-8-enoate) is an ester product.
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Cat. No.: HY-P990236
Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) is an anti-mouse/rat/monkey/human ICOS/CD278 IgG monoclonal antibody. Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) has limited effectiveness in improving T cell function and immune activation. Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) can be used for researches on cancer and infection conditions such as gliomas and hepatitis B virus infection .
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