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Results for "

IgM

" in MedChemExpress (MCE) Product Catalog:

27

Inhibitors & Agonists

1

MCE Kits

12

Inhibitory Antibodies

1

Natural
Products

3

Recombinant Proteins

32

Antibodies

5

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P99901

    VIS649

    SARS-CoV Inflammation/Immunology Cancer
    Sibeprenlimab (VIS649) is a humanized IgG2 monoclonal antibody which inhibits a proliferation-inducing ligand (APRIL). Sibeprenlimab suppresses pathogenic immunoglobulins (IgA and IgM), while preserving antibody responses to mRNA-based vaccines against SARS-COV-2. Sibeprenlimab reduces urinary protein-to-creatinine ratio (UPCR) and glomerular filtration rate (GFR). Sibeprenlimab is promising for the research of IgA nephropathy (IgAN) .
    Sibeprenlimab
  • HY-170333

    CICL1

    Liposome Inflammation/Immunology
    Lipid A-11 (Compound A-11) (CICL1) is an ionizable cationic lipid. Lipid A-11 can be used to prepare lipid nanoparticles. Lipid A-11 can be used in research involving T cell-targeted transfection .
    Lipid A-11
  • HY-W020658
    L-α-Phosphatidylinositol
    1 Publications Verification

    HIV Infection
    L-α-Phosphatidylinositol is a type of phospholipid. L-α-Phosphatidylinositol can serve as an antigen in ELISA assays for screening antiphospholipid antibodies. L-α-Phosphatidylinositol can be used in studies related to HIV-1 infection .
    L-α-Phosphatidylinositol
  • HY-P990070

    BION-1301

    TNF Receptor
    Zigakibart (BION-1301) is an IgG4-kappa, humanized monoclonal antibody against TNFSF13 (tumor necrosis factor (TNF) superfamily member 13, APRIL, CD256). Zigakibart exhibits anti-inflammatory activity .
    Zigakibart
  • HY-160719

    Peptide-Drug Conjugates (PDCs) Inflammation/Immunology
    NHS-activated 2-octynoic acid-BSA is an immunogen used to establish a mouse model of primary biliary cholangitis (PBC). When used in combination with Complete Freund's Adjuvant (HY-153808), NHS-activated 2-octynoic acid-BSA stimulates the body's immune system, which recognizes it as a foreign antigen and triggers an immune response against autologous biliary epithelial cells. This leads to the production of anti-PDC-E2 antibodies, causing bile duct damage and inflammation. NHS-activated 2-octynoic acid-BSA is promising for use in primary biliary cholangitis research .
    2-octynoic acid-BSA
  • HY-101813

    HR325

    Dihydroorotate Dehydrogenase DNA/RNA Synthesis Prostaglandin Receptor Inflammation/Immunology
    Laflunimus (HR325) is an immunosuppressive agent and an analogue of the Leflunomide-active metabolite A77 1726. Laflunimus is an orally active inhibitor of dihydroorotate dehydrogenase (DHODH). Laflunimus suppresses immunoglobulin (Ig) secretion, with IC50 values of 2.5 and 2 µM for IgM and IgG, respectively. Laflunimus also is a prostaglandin endoperoxide H synthase (PGHS) -1 and -2 inhibitor .
    Laflunimus
  • HY-113512

    Influenza Virus Inflammation/Immunology
    17-HDHA is a DHA-derived specialized proresolving mediator (SPM). 17-HDHA enhances the antibody-mediated immune response against influenza virus. 17-HDHA enhances the differentiation of B cells toward the CD27 + CD38 + antibody-secreting cell phenotype, thereby strongly increasing IgM and IgG production by activated B cells .
    17-HDHA
  • HY-P99214

    KBPA101

    Bacterial Infection
    Panobacumab (KBPA101) is a fully human IgM/κ monoclonal antibody generated by immortalizing human B lymphocytes against the LPS O polysaccharide of serotype O11 of P. aeruginosa .
    Panobacumab
  • HY-P991086

    PRV-3279

    Fc Receptor (FcR) Inflammation/Immunology
    MGD010 (PRV-3279) is a bispecific antibody targeting CD32B (FcγRIIb) and CD79B. MGD010 transmits negative signals by simultaneously co-linking CD32B (FcγRIIb) with CD79B, a component of the B-cell receptor (BCR), thereby inhibiting activated B cells. MGD010 can be used in research related to autoimmune diseases .
    MGD010
  • HY-111782

    8-Thioguanosine

    Toll-like Receptor (TLR) Inflammation/Immunology
    8-Mercaptoguanosine is an immunoadjuvant that affects the in vivo antibody response to the T-cell-independent antigen TNP-Ficoll. 8-Mercaptoguanosine enhances IgG1, IgG2, and IgG3 antibody responses, but has no effect on IgM antibody responses. 8-Mercaptoguanosine also enhances antibody responses to very weak antigens such as pneumococcal polysaccharide and restores antibody responses in immunodeficient xid mice that are non-reactive to TNP-Ficoll .
    8-Mercaptoguanosine
  • HY-P990299

    Phosphatase Inflammation/Immunology Cancer
    Anti-Mouse B220 Antibody (RA3.3A1/6.1) is a rat-derived IgM type antibody inhibitor, targeting to mouse B220. Anti-Mouse B220 Antibody (RA3.3A1/6.1) can deplete B cells. Anti-Mouse B220 Antibody (RA3.3A1/6.1) can be used for the researches of cancer and immunology, such as 4T1 and B16 tumor .
    Anti-Mouse B220 Antibody (RA3.3A1/6.1)
  • HY-120471

    PI3K Inflammation/Immunology
    AM-0687 is a selective inhibitor for PI3Kδ with an IC50 of 2.9 nM. AM-0687 decreases the levels of IgG and IgM specific antibodies, inhibits the anti-IgM/CD40L-induced proliferation of human B cell (IC50=0.8 nM) and the phosphorylation of AKT (IC50=0.7 nM), and exhibits anti-inflammatory efficacy .
    AM-0687
  • HY-120255

    17(R)-HDoHE

    Drug Derivative Inflammation/Immunology
    17(R)-HDHA (17(R)-HDoHE) is a pro-resolving mediator (SPM). 17(R)-HDHA enhances the differentiation of B cells toward the CD27(+)CD38(+) antibody-secreting cell phenotype, thereby strongly increasing IgM and IgG production by activated B cells. 17(R)-HDHA does not affect cell proliferation and is non-toxic to cells .
    17(R)-HDHA
  • HY-P99660

    IgM-2323

    CD20 CD3 Inflammation/Immunology Cancer
    Imvotamab (IGM-2323) is a CD20 and CD3 bispecific IGM antibody with dual action mechanism. Imvotamab is used to induce physiological T cell activation to prevent over-stimulation and subsequent down-regulation of immune function. Imvotamab can be used for the study of B-cell malignant tumors, multiple myeloma (MM) and non-Hodgkin's lymphoma (NHL) .
    Imvotamab
  • HY-124605

    Syk Btk Apoptosis Cancer
    IQS-019 is a B cell receptor (BCR) kinase inhibitor. IQS-019 can inhibit the de-phosphorylation of constitutive and IgM-activated Syk, Lyn, and Btk. IQS-019 can inhibit cell proliferation, migration and induce apoptosis. IQS-019 exhibits antitumor activity and can be used for the research of cancer, such as B cell lymphoma .
    IQS-019
  • HY-P990901

    IgM-8444

    TNF Receptor Apoptosis Inflammation/Immunology Cancer
    Aplitabart (IGM-8444) is a a pentameric IgM DR5 agonist antibody with 10 binding sites specific for DR5. Aplitabart multimerizes DR5 to selectively and potently induce tumor cell apoptosis. Aplitabart can be used for the study of lung cancer, breast cancer, cute myeloid leukemia (AML) and low-grade B-cell non-Hodgkin lymphoma (B-NHL) .
    Aplitabart
  • HY-RS22206

    Small Interfering RNA (siRNA) Others

    Ighm Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ighm gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Ighm Mouse Pre-designed siRNA Set A
    Ighm Mouse Pre-designed siRNA Set A
  • HY-RS16527

    Small Interfering RNA (siRNA) Others

    Cd40 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cd40 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Cd40 Mouse Pre-designed siRNA Set A
    Cd40 Mouse Pre-designed siRNA Set A
  • HY-RS02247

    Small Interfering RNA (siRNA) Others

    CD40LG Human Pre-designed siRNA Set A contains three designed siRNAs for CD40LG gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CD40LG Human Pre-designed siRNA Set A
    CD40LG Human Pre-designed siRNA Set A
  • HY-118374

    PI3K Akt Inflammation/Immunology
    AM-9635 is a selective PI3Kδ inhibitor with oral bioavailability, good in vitro and in vivo activity and pharmacodynamic properties. AM-9635 inhibits PI3Kδ-dependent B cell receptor-mediated AKT phosphorylation and suppresses the production of specific IgG and IgM antibodies in rats immunized with Aplysia leocyanin (KLH).
    AM-9635
  • HY-101813R

    HR325 (Standard)

    Reference Standards Dihydroorotate Dehydrogenase DNA/RNA Synthesis Prostaglandin Receptor Inflammation/Immunology
    Laflunimus (Standard) is the analytical standard of Laflunimus. This product is intended for research and analytical applications. Laflunimus (HR325) is an immunosuppressive agent and an analogue of the Leflunomide-active metabolite A77 1726. Laflunimus is an orally active inhibitor of dihydroorotate dehydrogenase (DHODH). Laflunimus suppresses immunoglobulin (Ig) secretion, with IC50 values of 2.5 and 2 μM for IgM and IgG, respectively. Laflunimus also is a prostaglandin endoperoxide H synthase (PGHS) -1 and -2 inhibitor .
    Laflunimus (Standard)
  • HY-P991816

    Fc Receptor (FcR) Inflammation/Immunology
    Mouse IgM, Isotype Control, a mouse monoclonal antibody, is an isotype control for mouse IgM antibody.
    Mouse IgM, Isotype Control
  • HY-129442

    X 910279; HMR-279; FK-779

    Drug Derivative Inflammation/Immunology
    MNA 279 (X 910279) is an orally active, immunosuppressive malononitrilamide and A 771726 derivative. MNA 279 suppresses IgM and IgG antibody production. MNA 279 prevents the development of systemic lupus erythematosus (SLE)-like disease in mice. MNA 279 prolongs skin xenograft survival in a mouse-to-rat model .
    MNA 279
  • HY-P991814

    Transmembrane Glycoprotein Inflammation/Immunology
    Anti-Mouse Ly-6C Antibody (7B10) reacts with the mouse Ly-6C. Ly-6C antigens are encoded by a complex multigene family and have primarily been defined as novel T cell-activating determinants. Recommend Isotype Controls: Armenian Hamster IgM .
    Anti-Mouse Ly-6C Antibody (7B10)
  • HY-RS17669

    Small Interfering RNA (siRNA) Others

    Cd40lg Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cd40lg gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Cd40lg Mouse Pre-designed siRNA Set A
    Cd40lg Mouse Pre-designed siRNA Set A
  • HY-120116

    PI3K Akt Inflammation/Immunology
    AM-8508 is an orally bioactive PI3Kδ inhibitor with an IC50 of 0.016 μM. AM-8508 selectively inhibits PI3Kδ, thereby blocking AKT phosphorylation mediated by the B cell receptor. AM-8508 suppresses the formation of antigen-specific IgG and IgM in rats immunized with keyhole limpet hemocyanin. AM-8508 can be used for the research of inflammatory diseases .
    AM-8508
  • HY-175073

    Toll-like Receptor (TLR) Interleukin Related Neurological Disease Inflammation/Immunology
    Ganglioside GT1b bovine trisodium is a trisialic acid ganglioside. Ganglioside GT1b bovine trisodium binds to botulinum toxin type A (BTxA), BTxA heavy chain, and tetanus toxin with IC50 values of 11, 0.74, and 7.2 μM, respectively. Ganglioside GT1b bovine trisodium acts as a TLR2 agonist, leading to microglial activation, increased expression of pro-inflammatory factors, and increased pain sensitivity in spinal microglia. Ganglioside GT1b bovine trisodium also reduces the production of IL-6, IL-10, IgG, IgM, and IgA in human peripheral blood mononuclear cells (PBMCs). Ganglioside GT1b bovine trisodium increases extracellular glutamate levels in neural cell models. Ganglioside GT1b bovine trisodium has potential applications in research on immune system diseases and nervous system diseases .
    Ganglioside GT1b (bovine) trisodium

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