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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
MASTL
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "MASTL" in MCE Product Catalog:
1
1 Cited Publications
Synonyms: MASTL Kinase Inhibitor-1
MKI-1, an inhibitor of MASTL (microtubule-associated serine/threonine kinase-like) with an IC50 of 9.9 μM, exerts antitumor and radiosensitizer activities through PP2A activation in breast cancer .
MASTL-IN-1 is a selective and orally active MASTL inhibitor with a Ki <0.03 nM. MASTL-IN-1 inhibits phosphorylation of ENSA and inhibits proliferation in cancer cells. MASTL-IN-1 induces tumor growth inhibition and stasis in pancreatic cancer xenograft models .
MASTL-IN-2 is an MASTL (microtubule-associated serine/threonine kinase-like) inhibitor. MASTL-IN-2 inhibits human epithelial MIA PaCa cancer cell proliferation with IC50 of 2.8 nM .
Cat. No.: HY-162732
CAS No.: 2883041-36-7
MASTL-IN-4(compound 70) is a potent MASTL inhibitor with a pIC50 value of 9.15. MASTL-IN-4 shows anti-proliferative activity .
Cat. No.: HY-W231513
CAS No.: 321945-24-8
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MASTL/Aurora A-IN-1 (Compound MA4) is a dual inhibitor of MASTL and Aurora A kinases with IC50 values of 0.56 μM and 0.16 μM, respectively. MASTL/Aurora A-IN-1 has broad-spectrum anticancer activity and has potent anticancer activity against SR (leukemia), K-562 (leukemia), MDA-MB-435 (melanoma), MOLT-4 (leukemia), and SK-MEL-2 (melanoma) cell lines in NCI-60 cancer cell lines with GI50 values of 0.023, 0.032, 0.037, 0.044, and 0.051 μM, respectively. MASTL/Aurora A-IN-1 inhibits Aurora A and MASTL kinases, inducing cell cycle G2/M arrest, thereby inhibiting cancer cell proliferation. MASTL/Aurora A-IN-1 can be used in cancer research, especially for tumors with dysregulated mitosis .
Cat. No.: HY-162731
CAS No.: 2883041-26-5
MASTL-IN-3 (compound 60) is a potent MASTL inhibitor with a pIC50 value of 9.10 M. MASTL-IN-3 shows anti-proliferative activity .
Cat. No.: HY-159653
CAS No.: 3024916-78-4
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MASTL-IN-5 (compound 11) is a MASTL (microtubule-associated serine/threonine kinase-like) inhibitor, with a Ki of 0.018 nM .
Cat. No.: HY-E70743
MASTL kinase is a master regulator of mitosis, essential for ensuring that mitotic substrate phosphorylation is correctly maintained. It achieves this through the phosphorylation of alpha-endosulfine and subsequent inhibition of the tumor suppressor PP2A-B55 phosphatase. MASTL Recombinant Human Active Protein Kinase is a recombinant MASTL protein that can be used to study MASTL-related functions .
Cat. No.: HY-RS08165
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MASTL Human Pre-designed siRNA Set A contains three designed siRNAs for MASTL gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17985
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Mastl Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mastl gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24456
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Mastl Rat Pre-designed siRNA Set A contains three designed siRNAs for Mastl gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-182391
CAS No.: 3084702-28-0
MKI-3 is a selective microtubule-associated serine/threonine kinase-like (MASTL) inhibitor with an IC50 of 5.72 nM and a Kd of 1.89 nM. MKI-3 disrupts the MASTL-ENSA-Aurora A signaling axis. MKI-3 induces chromosomal instability, mitotic catastrophe and apoptosis (apoptosis) in cancer cells. MKI-3 is applicable to research related to triple-negative breast cancer .
Cat. No.: HY-185310
CAS No.: 438204-56-9
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MKI-2 is a selective MASTL inhibitor with an IC50 of 37.44 nM. MKI-2 induces mitotic catastrophe resulting from the modulation of the MASTL-PP2A axis in breast cancer cells. MKI-2 reduces phospho-ENSA, total, phospho-c-Myc levels. MKI-2 inhibts cancer cells proliferation, migration and induces DNA damage. MKI-2 inhibits germinal vesicle breakdown in mouse oocytes. MKI-2 can be used for the research of cancer, such as breast cancer .
Cat. No.: HY-P86892
Synonyms: 2700091H24Rik C88295 FLJ14813 GREATWALL Greatwall protein kinase GW GWL GWL_HUMAN hGWL MAST-L 2700091H24Rik C88295 FLJ14813 GREATWALL Greatwall protein kinase GW GWL GWL_HUMAN hGWL MAST-L MASTL MGC117975 Microtubule associated serine/threonine kinase like Microtubule-associated serine/threonine-protein kinase-like RP11 85G18.2 Serine/threonine-protein kinase greatwall THC2
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
