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Results for "

MICA

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

1

Fluorescent Dye

2

Inhibitory Antibodies

11

Recombinant Proteins

2

Antibodies

1

Click Chemistry

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-155311
    NKG2D-IN-1

    		C-type Lectin-like Receptors (CTLRs) Inflammation/Immunology
    NKG2D-IN-1 (compound 21) is a natural killer group 2D receptor (NKG2D) inhibitor. NKG2D-IN-1 inhibits the protein-protein interaction between NKG2D and its ligands MICA and ULBP6, with IC50 values of 0.3 μM and 0.7 μM. NKG2D-IN-1 can be used in the research of autoimmune diseases .
    NKG2D-IN-1
  • HY-D0916
    Thiazole orange dimer YOYO 1

    YOYO 1; YOYO1

    		 Fluorescent Dye Others
    Thiazole orange dimer YOYO 1 (YOYO 1) is a cell-impermeable cyanine dimer with no inherent fluorescence, and its fluorescence intensity increases significantly upon binding to double-stranded DNA (dsDNA) . Thiazole orange dimer YOYO 1 can serve as a nuclear counterstain or a dead cell indicator (Ex/Em = 505/512 nm).
    Thiazole orange dimer YOYO 1
  • HY-155312
    NKG2D-IN-2

    		C-type Lectin-like Receptors (CTLRs) Cancer
    NKG2D-IN-2 (compound 47) is a natural killer group 2D receptor (NKG2D) inhibitor with IC50s of 0.1 µM and 0.2 µM in NKG2D/MICA and ULBP6 TR-FRET assays, respectively .
    NKG2D-IN-2
  • HY-151782
    H-(Gly)3-Lys(N3)-OH

    		ADC Linker Others
    The azide function is widely used for coupling to alkyne-containing fragments via the renowned Click reaction. Polyglycine fragments containing up to 7 glycines are reported to bind to surfaces and have potential application in nanotechnology constructs: constructs of Gly7-NHCH2-fragment containing peptides bind on mica surface in aqueous solution . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    H-(Gly)3-Lys(N3)-OH
  • HY-RS08424
    MICA Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    MICA Human Pre-designed siRNA Set A contains three designed siRNAs for MICA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    MICA Human Pre-designed siRNA Set A
    MICA Human Pre-designed siRNA Set A
  • HY-101780A
    Tinostamustine hydrochloride

    EDO-S101 hydrochloride; NL-101 hydrochloride

    		 HDAC Cancer
    Tinostamustine hydrochloride (EDO-S101 hydrochloride) is a compound with anti-multiple myeloma activity and the ability to promote CD38 expression. Tinostamustine hydrochloride enhances the sensitivity of tumor cells to the anti-CD38 monoclonal antibody daratumumab by increasing the acetylation level of histone H3. Tinostamustine hydrochloride can increase the expression of MICA and MICB, thereby activating NK cells. Tinostamustine hydrochloride can significantly delay tumor growth and improve the survival rate of mice .
    Tinostamustine hydrochloride
  • HY-P992391
    IPH4301

    IPH43

    		 C-type Lectin-like Receptors (CTLRs) Apoptosis Cancer
    IPH4301 is a monoclonal antibody targeting MICA/B, with dual activities of cytotoxicity and immunoregulation . IPH4301 blocks the interaction between MICA/B and NKG2D, inhibits their hydrolysis into soluble sMICA/B, and mediates antibody-dependent cellular cytotoxicity and antibody-dependent cellular phagocytosis against tumor cells expressing MICA/MICB. IPH4301 restores the expression and function of NKG2D on primary NK cells and T cells, reverses the immunosuppression induced by M2 macrophages, and enhances NK cell-mediated tumor cell apoptosis. IPH4301 can be used in research related to cancer and triple-negative breast cancer .
    IPH4301
  • HY-P992266
    Anti-MICA/B Antibody (7C6)

    Anti-MICA/B Antibody (7C6)

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