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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
N-Heterocyclic carbine
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "N-Heterocyclic carbine" in MCE Product Catalog:
8
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Infection Microorganisms Antibiotics Disease Research Anticancer Disease Research Fields Other Antibiotics
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1 Cited Publications
Cat. No.: HY-P1206
CAS No.: 174688-78-9
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CH 275 is a peptidic somatostatin analog that acts as an agonist of SST1 (IC50 = 30.9 nM, Ki = 52 nM). The IC50 values of CH 275 for sst3, sst4, sst2, and sst5 are 345 nM, >1 μM, >10 μM, and >10 μM, respectively. CH 275 binds to SSTR1 via the IAmp9-Asp137 ion pair interaction and the hydrophobic interaction between the isopropyl group of IAmp9 and Leu107, and reduces the extracellular acidification rate. CH 275 induces weak sst1 internalization, exerts immunosuppressive effects on macrophages, and decreases macrophage viability, MCP-1 expression/secretion, and IL-8 secretion, but does not alter proMMP-9 secretion or IL-8 mRNA levels. CH 275 reduces hippocampal β-amyloid levels and alleviates plaque pathology without inducing hippocampal microglial activation. CH 275 is used in research on Alzheimer's disease, Parkinson's disease, and depression .
Cat. No.: HY-P10033
CAS No.: 245080-24-4
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Cat. No.: HY-W016477
CAS No.: 92-82-0
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Phenazine belongs to the family of N-heterocyclic compounds. Phenazine can be found in terrestrial and marine microorganisms. Phenazine attracts attention due to its diverse biological activities, including Antimicrobial and enzyme inhibitory properties. Phenazine can be used in breast cancer research .
Cat. No.: HY-P4102
CAS No.: 1810853-35-0
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Cat. No.: HY-142956
Purity: 99.65%
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ROS-ERS inducer 1 is a type II ICD (immunogenic cell death) inducer. ROS-ERS inducer 1 is a Pt(II)-N-heterocyclic carbene (Pt(II)-NHC) complex derived from 4,5-diarylimidazole. ROS-ERS inducer 1 successfully induces endoplasmic reticulum stress (ERS) accompanied by reactive oxygen species (ROS) generation and finally lead to the release of damage-associated molecular patterns (DAMPs) in HCC cells. ROS-ERS inducer 1 displays much higher anticancer activities than Cisplatin .
Cat. No.: HY-P3193A
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Cat. No.: HY-P10027A
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Cat. No.: HY-P10027
CAS No.: 2247194-77-8
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Cat. No.: HY-P3193
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Cat. No.: HY-156403
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AuM1Phe, an N-Heterocyclic carbene (NHC) metal complexe, blocks the human topoisomerase I activity and actin polymerization reaction. AuM1Phe affects the growth of MDA-MB-231 breast cancer cells, with an IC50 value of 1.2 μM .
Cat. No.: HY-W016477R
CAS No.: 92-82-0
Phenazine (Standard) is the analytical standard of Phenazine (HY-W016477). This product is intended for research and analytical applications. Phenazine belongs to the family of N-heterocyclic compounds. Phenazine can be found in terrestrial and marine microorganisms. Phenazine attracts attention due to its diverse biological activities, including Antimicrobial and enzyme inhibitory properties. Phenazine can be used in breast cancer research .
Cat. No.: HY-175048
CAS No.: 3035433-94-1
Synonyms: Platinum(II)-N-Heterocyclic carbene complex 2C
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Pt(II)-NHC Complex 2C (Platinum(II)-N-Heterocyclic Carbene complex 2C) (Compound 2C) is a platinum(II) complex based on N-heterocyclic carbene (NHC). Pt(II)-NHC Complex 2C is an immunogenic cell death (ICD) inducer that can induce endoplasmic reticulum stress (ERS) in liver cancer cells and produce reactive oxygen species (ROS), ultimately leading to the release of damage-associated molecular patterns (DAMP). Pt(II)-NHC Complex 2C blocks the cell cycle at the S phase and significantly induces cell apoptosis. Pt(II)-NHC Complex 2C shows anti-liver cancer potential in mouse models and activates immune cells in liver injury models.
Cat. No.: HY-P10672
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
