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Results for "

NKT

" in MedChemExpress (MCE) Product Catalog:

18

Inhibitors & Agonists

6

Inhibitory Antibodies

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-102022
    α-Galactosylceramide
    4 Publications Verification

    α-GalCer; KRN7000

    		 Transmembrane Glycoprotein Interleukin Related CD1 Inflammation/Immunology Cancer
    α-Galactosylceramide (α-GalCer) is a synthetic glycolipid with antitumorial and immunostimulatory. α-Galactosylceramide is a very potent NKT cell agonist and binds effectively to CD1d. The complex of α-Galactosylceramide plus CD1d binds the NKT cell TCR (T cell antigen receptor) .
    α-Galactosylceramide
  • HY-P990273
    Anti-Mouse CD38 Antibody (NIMR5)

    		CD38 ERK CD1 Apoptosis Inflammation/Immunology Cancer
    Anti-Mouse CD38 Antibody (NIMR5) is an anti-mouse CD38 IgG2a monoclonal antibody. Anti-Mouse CD38 Antibody (NIMR5) can activate the ERK signaling pathway and promote cell apoptosis. Anti-Mouse CD38 Antibody (NIMR5) can restore T cell function. Anti-Mouse CD38 Antibody (NIMR5) upregulates the expression of CD1d protein and enhances spleen cell proliferation, dendritic cell (DC) and natural killer T cell (NKT) expansion. Anti-Mouse CD38 Antibody (NIMR5) can be used for researches on cancer and immunology such as melanoma and colon cancer .
    Anti-Mouse CD38 Antibody (NIMR5)
  • HY-P990808
    Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1)

    		Interleukin Related Infection Metabolic Disease Inflammation/Immunology Cancer
    Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1) is a rat-derived IgG2b κ type antibody inhibito, targeting to mouse CD122/IL-2Rβ. Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1) can block IL-2 and IL-15. Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1) can deplete natural killer (NK) cells and NKT cells. Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1) can be used for the researches of cancer, infection, inflammation, immunology and metabolic disease, such as melanoma, experimental autoimmune encephalomyelitis (EAE) and diabetes .
    Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1)
  • HY-P991112
    Anti-Mouse CD8α Antibody (YTS169.4)

    		Transmembrane Glycoprotein Infection
    Anti-Mouse CD8α Antibody (YTS169.4) is an IgG2 monoclonal antibody targeting mouse CD8α. Anti-Mouse CD8α Antibody (YTS169.4) rapidly depletes or downregulates CD8 + T cells in the spleens of Biozzi AB/H mice. Anti-Mouse CD8α Antibody (YTS169.4) is applicable to research related to hepatitis B virus infection . Recommended isotype control: Rat IgG2b kappa, Isotype Control (HY-P990682).
    Anti-Mouse CD8α Antibody (YTS169.4)
  • HY-108480
    SDZ NKT 343

    		Neurokinin Receptor Neurological Disease
    SDZ NKT 343 is a selective, orally active NK1 receptor antagonist with an IC50 of 0.62 nM against human NK1 receptor. SDZ NKT 343 has good analgesic activity .
    SDZ NKT 343
  • HY-13644A
    Gusperimus trihydrochloride

    Spanidin; NKT-01; BMS181173

    		 Antibiotic Inflammation/Immunology Cancer
    Gusperimus trihydrochloride (Spanidin) is a derivative of the antitumor antibiotic spergualin with immunosuppressant activity .
    Gusperimus trihydrochloride
  • HY-175365
    GCS-12–6

    		CD1 Inflammation/Immunology
    GCS-12–6 is a potent Th2-selective NKT cell agonist targeting CD1d protein. GCS-12–6 is promising for research of autoimmune diseases (e.g., inflammatory bowel disease, multiple sclerosis) .
    GCS-12–6
  • HY-156997
    ABX196

    		Interleukin Related Others
    ABX196 is NKT agonist. ABX196 is an analog of the parental compound -GalCer .
    ABX196
  • HY-RS03341
    Ctsl Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Cathepsin Others

    Ctsl Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ctsl gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Ctsl Mouse Pre-designed siRNA Set A
    Ctsl Mouse Pre-designed siRNA Set A
  • HY-162727
    GCS-12

    		IFNAR Interleukin Related CD1 Inflammation/Immunology Cancer
    GCS-12 is a Th1/2-balanced sulfonamide glycolipid with improved interaction with CD1d. GCS-12 is an agonist for natural killer T (NKT) cell, that induces the secretion of cytokine IFN-γ and IL-4, and exhibits immunomodulatory and anti-tumor activities in mice .
    GCS-12
  • HY-162726
    GCS-11

    		Interleukin Related Cancer
    GCS-11 is a powerful natural killer T (NKT) cell agonist. It boosts the production of IFN-γ and IL-4, with a particular selectivity for IFN-γ. GCS-11 exhibits anticancer activity. GCS-11 has the potential for research into cancer immunotherapies or vaccine development as a promising adjuvant .
    GCS-11
  • HY-P990807
    Anti-Mouse CD1d Antibody (20H2 (HB323))

    		CD1 Infection Inflammation/Immunology Cancer
    Anti-Mouse CD1d Antibody (20H2 (HB323)) is a rat-derived IgG1 κ type antibody inhibitor, targeting to mouse CD1d. Anti-Mouse CD1d Antibody (20H2 (HB323)) can block CD1d and neutralize invariant natural killer T (iNKT) cells. Anti-Mouse CD1d Antibody (20H2 (HB323)) can be used for the researches of cancer, infection, inflammation and immunology, such as melanoma, L. monocytogenes infection and arthritis .
    Anti-Mouse CD1d Antibody (20H2 (HB323))
  • HY-102022R
    α-Galactosylceramide (Standard)

    α-GalCer (Standard); KRN7000 (Standard)

    		 Reference Standards Transmembrane Glycoprotein Interleukin Related CD1 Inflammation/Immunology Cancer
    α-Galactosylceramide (Standard) is the analytical standard of α-Galactosylceramide (HY-102022). This product is intended for research and analytical applications. α-Galactosylceramide (α-GalCer) is a synthetic glycolipid with antitumorial and immunostimulatory. α-Galactosylceramide is a very potent NKT cell agonist and binds effectively to CD1d. The complex of α-Galactosylceramide plus CD1d binds the NKT cell TCR (T cell antigen receptor) .
    α-Galactosylceramide (Standard)
  • HY-181740
    GCB-27b

    		CD1 Cancer
    GCB-27b is an immunostimulant that binds to CD1d. GCB-27b forms a stable and long-lasting complex with CD1d, which is presented to the TCR of NKT cells to drive immune responses. GCB-27b induces a Th1-skewed immune response in *Mus musculus*, resulting in high expression of IFN−γ with restricted IL-4 levels. GCB-27b is applicable to research related to lung metastasis of melanoma .
    GCB-27b
  • HY-180332
    NSC-624871

    		Drug Derivative SARS-CoV Infection Inflammation/Immunology
    NSC-624871 (JD-87), an analog of Miltefosine (HY-13685), is natural killer T-2 (NKT-2) activator. NSC-624871 activates type II NKT cells. NSC-624871 can be used for the study of SARS-CoV-2-mediated inflammatory conditions .
    NSC-624871
  • HY-P992059
    Anti-Mouse CD1d Antibody (1B1)

    		CD1 Cancer
    Anti-Mouse CD1d Antibody (1B1) is an antibody targeting mouse CD1d (Kd=12.5 nM). By inserting into the lipid-binding groove of CD1d, Anti-Mouse CD1d Antibody (1B1) overlaps with the binding sites of type I and type II NKT cell receptors (TCR), thereby effectively blocking TCR-mediated interactions. Anti-Mouse CD1d Antibody (1B1) activates antigen-presenting cells such as dendritic cells and macrophages, induces them to release IL-12p70, and increases the levels of key cytokines including IL-12, IFN-γ and IFN-α in mouse serum. Anti-Mouse CD1d Antibody (1B1) can be used in studies related to renal cancer, breast cancer and colon adenocarcinoma. When combined with anti-DR5 or anti-CD137 antibodies and chemotherapeutic drugs, Anti-Mouse CD1d Antibody (1B1) exhibits significant tumor inhibitory and even eradication effects in mice .
    Anti-Mouse CD1d Antibody (1B1)
  • HY-181739
    GCB-27a

    		CD1 Cancer
    GCB-27a is a CD1d-binding immunostimulant and antitumor agent. GCB-27a binds to CD1d to form a stable complex and presents it to NKT cells, enhancing hydrophobic interactions within the A' pocket of CD1d through branched-chain conformation restriction. GCB-27a induces a Th1-biased immune response, drives IFN−γ production and limits IL-4 levels. GCB-27a is applicable to research related to melanoma lung metastasis .
    GCB-27a
  • HY-P992061
    Anti-Mouse CD3E Antibody (500A2)

    		CD3 Calcium Channel Inflammation/Immunology
    Anti-Mouse CD3E Antibody (500A2) is an antibody targeting mouse CD3ε, which specifically binds to the region on CD3ε adjacent to the T cell receptor binding site. Anti-Mouse CD3E Antibody (500A2) triggers functional signal transduction in immature T cells and activates naive T cells. When cross-linked, Anti-Mouse CD3E Antibody (500A2) induces a rapid, robust and transient increase in cytoplasmic calcium concentration, acting as a potent calcium flux inducer. Anti-Mouse CD3E Antibody (500A2) is suitable for multiple experimental techniques such as flow cytometry, immunoprecipitation and EMARS reactions. It can be used to detect CD3E expression on thymocytes, mature T lymphocytes and NK-T cells from different mouse strains, or to identify membrane cluster components of the TCR complex, and shows no cross-reactivity with rat leukocytes .
    Anti-Mouse CD3E Antibody (500A2)

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