129 Results for "

P-388

" in MedChemExpress (MCE) Product Catalog:
Products (129)

129 Results for "P-388" in MCE Product Catalog:

5
5 Cited Publications
Cat. No.: HY-N2306
CAS No.: 57576-44-0
Synonyms: Aclarubicin
Aclacinomycin A (Aclarubicin) is an orally active and potent anthracycline antitumor antibiotic. Aclacinomycin A is an inhibitor of topoisomerase I and II. Aclacinomycin A inhibits synthesis of nucleic acid, especially RNA. Aclacinomycin A might inhibit the 26S protease complex as well as the ubiquitin-ATP-dependent proteolysis .
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-N3308
CAS No.: 32383-76-9
Medicarpin is a flavonoid isolated from Medicago sativa. Medicarpin induces apoptosis and overcome multidrug resistance in leukemia P388 cells by modulating P-gp-mediated efflux of agents .
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-N0128
CAS No.: 515-03-7
Sclareol is isolated from Salvia sclarea with anticarcinogenic activity. Sclareol shows strong cytotoxic activity against mouse leukemia (P-388), human epidermal carcinoma (KB) cells and human leukemia cell lines. Sclareol induces cell apoptosis .
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-N6065
CAS No.: 73069-27-9
Synonyms: (+)-Praeruptorin A
Praeruptorin A ((+)-Praeruptorin A) is an orally active isomer of (±)-Praeruptorin A (HY-N0081). Praeruptorin A also acts as a Calcium channel blocker. Praeruptorin A can be isolated from Peucedanum. Praeruptorin A serves as a substrate for CYP3A4. Praeruptorin A downregulates NMDA receptors containing GluN2B and inhibits neuronal Apoptosis. Praeruptorin A mediates vasodilation, inhibits vascular hypertrophy and reduces blood pressure. Praeruptorin A can be used in research related to neurological diseases, myocardial ischemia, heart failure, exertional angina, renovascular hypertension and spontaneous hypertension .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-120504
CAS No.: 1202-66-0
Purity:  98.90%
Target:  

Bacterial

Research Areas:  

Infection Cancer

N-Acetyltyramine is a quorum-sensing inhibitor (QSI) compound produced by V. alginolyticus M3-10. N-Acetyltyramine is capable of inhibiting the QS of C. violaceum ATCC 12472. N-acetyltyramine reverses resistance in Doxorubicin-resistant leukemia P388 cells .
loading...
    loading...
Cat. No.: HY-18351
CAS No.: 915303-09-2
Synonyms: LMP-400; NSC-724998
Target:  

Topoisomerase

Research Areas:  

Infection Cancer

Indotecan (LMP-400), an indenoisoquinoline derivative, is a potent Topoisomerase I inhibitor, with IC50s of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. Indotecan prevents the relaxation of supercoiled DNA and can be used for the research of visceral leishmaniasis .
loading...
    loading...
Cat. No.: HY-18351A
CAS No.: 1228035-68-4
Synonyms: LMP-400 hydrochloride; NSC-724998 hydrochloride
Target:  

Topoisomerase

Research Areas:  

Infection Cancer

Indotecan hydrochloride, an indenoisoquinoline derivative, is a potent Topoisomerase I inhibitor, with IC50s of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. Indotecan hydrochloride prevents the relaxation of supercoiled DNA and can be used for the research of visceral leishmaniasis .
loading...
    loading...
Cat. No.: HY-P3116
CAS No.: 173046-02-1
Target:  

Bacterial

Research Areas:  

Cancer

Thiocoraline is a depsipeptide that can be isolated by marine Micromonospora. Thiocoraline has antitumor activity with IC50s of 0.002, 0.002, 0.01 and 0.002 μg/mL in P388, A549, HT-29 and MEL-28 cells, respectively. Thiocoraline also a strong antimicrobial activity against Gram-positive microorganisms .
loading...
    loading...
Cat. No.: HY-108603
CAS No.: 87745-28-6
Synonyms: (+)-Bryostatin 2
Target:  

PKC

Research Areas:  

Cancer

Bryostatin 2 ((+)-Bryostatin 2) is a 20-membered ring lactone that can be found in Bryozoan Eugufa neritina L. Bryostatin 2 has the potential for the research of P-388 lymphocytic leukemia .
loading...
    loading...
Cat. No.: HY-N6955
CAS No.: 757202-08-7
Eupalinilide B is a guaiane type sesquiterpene lactone that can be found in Eupatorium lindleyanum. Eupalinilide B shows potent cytotoxicity against P-388 and A-549 tumor cell lines .
loading...
    loading...
Cat. No.: HY-N10208
CAS No.: 1216840-17-3
Aspericin C is a pyran derivative found in the marine-derived fungus Rhizopus sp. 2-PDA-61. Aspericin C shows cytotoxic activities against P388, A549, HL-60, and BEL-7420 cell lines (IC50=14.6, 7.1, 61.4, and 24.2 μM, respectively) .
loading...
    loading...
Cat. No.: HY-N1631
CAS No.: 53600-24-1
Synonyms: 1-Hydroxyrutaecarpine
Target:  

Drug Derivative

Research Areas:  

Others

1-Hydroxyrutaecarpine (compound 1a) is a hydroxy-derivative of rutaecarpine. 1-Hydroxyrutaecarpine shows cytotoxicities with ED50s of 3.72, 7.44 µg/mL for P-388 and HT-29 cells, respectively. 1-Hydroxyrutaecarpine shows antiplatelet activity .
loading...
    loading...
Cat. No.: HY-125037
CAS No.: 1190948-58-3
Diptoindonesin G is a 2-arylbenzofuran derivative and a modulator of estrogen receptor and HSP90 middle domain. Diptoindonesin G exhibits strong cytotoxicity against mouse leukemia P-388 cells with an IC50 of 13.2 μM. Diptoindonesin G has antitumor activity and can be used in the research of tumors such as breast cancer .
loading...
    loading...
Cat. No.: HY-N1655
CAS No.: 873999-88-3
2,3-Dihydroamentoflavone 7,4'-dimethyl ether is a biflavonoid, which can be isolated from the aerial parts of Selaginella delicatula. 2,3-Dihydroamentoflavone 7,4'-dimethyl ether exhibits cytotoxicities against P-388 and HT-29 cell lines, with ED50 (median effective dose) values of 3.50 and 5.25 µg/mL, respectively .
loading...
    loading...
Cat. No.: HY-12458
CAS No.: 118292-36-7
Target:  

DNA/RNA Synthesis

Research Areas:  

Infection Cancer

Pyrindamycin A is an antibiotic that inhibits DNA synthesis. Pyrindamycin A shows antitumor activities against murine leukemia, exhibits stronger cytotoxic activities towards murine and human tumor cell lines and especially towards doxorubicin-resistant cells, inhibits P388 and P388/ADR cells with the same IC50 of 3.9 μg/ml .
loading...
    loading...
Cat. No.: HY-23120
CAS No.: 6345-29-5
Research Areas:  

Infection Cancer

1-Hydroxyguanidine sulfate is an antitumor agent that inhibits mast cell P815, leukaemia P388, leukaemia L1210 and carcinosarcoma Walker 256 cells growth. 1-Hydroxyguanidine sulfate also has antiviral activity .
loading...
    loading...
Cat. No.: HY-121123
CAS No.: 42381-05-5
Purity:  ≥97.0%
Synonyms: 2-Aminoadamantane-2-carboxylic acid
Target:  

Aminopeptidase

Research Areas:  

Cancer

Adamantanine (2-Aminoadamantane-2-carboxylic acid) inhibits the transport of methionine (Ki is 0.76 mM) and leucine into Ehrlich ascites carcinoma cells. Adamantanine inhibits proliferation of P388 lymphocytic leukemia cells with an IC50 of >1 mM. Adamantanine inhibits the leucine aminopeptidase with an I/S0.5 of 10.5 .
loading...
    loading...
Cat. No.: HY-N15640
CAS No.: 62311-75-5
Synonyms: (-)-Filiformin
Filiformin ((-)-Filiformin) is a sesquiterpene compound that can be isolated from Laurencia filiformis forma heteroclada. Filiformin exhibits certain cytotoxicity against P388 and BSC-1 cells. Filiformin has antimicrobial activity against Bacillus subtilis, Trichophyton mentagrophytes and Candida albicans. In addition, Filiformin can inhibit oxygen uptake in isolated rat liver mitochondria at a concentration of 150 μM .
loading...
    loading...
Cat. No.: HY-114648
CAS No.: 339300-34-4
Target:  

Bacterial

Research Areas:  

Infection Cancer

AJI-9561 is a benzoxazole derivative produced by Streptomyces sp. AJI-9561 exhibits cytotoxicity and antibacterial activity. AJI-9561 inhibits the proliferation of Jurkat T cells and mouse P388 leukemia cells, with its IC50 being 0.88 and 1.63 μM respectively. AJI-9561 can be used for research on anti-cancer and antibacterial properties .
loading...
    loading...
Cat. No.: HY-N2835
CAS No.: 62394-00-7
Alboctalol can be isolated from Morus australis. Alboctalol has weak cytotoxicity against P-388 cells .
loading...
    loading...