42 Results for "

PACAP

" in MedChemExpress (MCE) Product Catalog:
Products (42)

42 Results for "PACAP" in MCE Product Catalog:

5
5 Cited Publications
Cat. No.: HY-P0221
CAS No.: 137061-48-4
Synonyms: Pituitary Adenylate Cyclase Activating Polypeptide 38
PACAP (1-38), human, ovine, rat is a PAC1 receptor agonist. PACAP (1-38), human, ovine, rat binds to PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2 with IC50s of 4 nM, 2 nM, and 1 nM, respectively. PACAP (1-38), human, ovine, rat increases the α-secretase activity. PACAP (1-38), human, ovine, rat elevates cytosolic Ca 2+, increases proliferation and increases phosphorylation of extracellular regulates kinase (ERK) and the epidermal growth factor receptor (EGFR). PACAP (1-38), human, ovine, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. PACAP (1-38), human, ovine, rat can be used for neurotrophic and neuroprotective research .
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3
3 Cited Publications
Cat. No.: HY-P0176
CAS No.: 127317-03-7
Synonyms: PACAP 1-27
Target:  

PACAP Receptor

PACAP (1-27), human, ovine, rat (PACAP 1-27) is the N-terminal fragment of PACAP-38, and is a potent PACAP receptor agonist with IC50s of 3 nM, 2 nM and 5 nM for rat PAC1, rat VPAC1 and human VPAC2, respectively .
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3
3 Cited Publications
Cat. No.: HY-P0176A
Synonyms: PACAP 1-27 TFA
Target:  

PACAP Receptor

PACAP (1-27), human, ovine, rat TFA (PACAP 1-27 TFA) is the N-terminal fragment of PACAP-38, and is a potent PACAP receptor agonist with IC50s of 3 nM, 2 nM and 5 nM for rat PAC1, rat VPAC1 and human VPAC2, respectively .
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2
2 Cited Publications
Cat. No.: HY-133529
CAS No.: 878437-15-1
Purity:  97.00%
PA-8 is a potent, selective and orally active PACAP type I (PAC1) receptor antagonist. PA-8 inhibits the phosphorylation of CREB induced by PACAP in PAC1-, but not VPAC1- or VPAC2-receptor. PA-8 also inhibits PACAP-induced cAMP elevation with an IC50 of 2 nM .
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2
2 Cited Publications
Cat. No.: HY-P0220A
Target:  

PACAP Receptor

Research Areas:  

Neurological Disease

PACAP (6-38), human, ovine, rat TFA is a potent PACAP receptor antagonist with IC50s of 30, 600, and 40 nM for PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2, respectively.
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2
2 Cited Publications
Cat. No.: HY-P0220
CAS No.: 143748-18-9
Target:  

PACAP Receptor

Research Areas:  

Neurological Disease

PACAP (6-38), human, ovine, rat is a potent PACAP receptor antagonist with IC50s of 30, 600, and 40 nM for PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2, respectively.
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1
1 Cited Publications
Cat. No.: HY-147557
CAS No.: 2305204-24-2
Purity:  99.17%
Synonyms: PAC1R antagonist 1
Target:  

PACAP Receptor

Research Areas:  

Neurological Disease

PA-915 (PAC1R antagonist 1) is a potent and orally active antagonist of PAC1 receptor. PA-915 inhibits pituitary adenylate cyclase-activating polypeptide (PACAP)-induced CREB phosphorylation. PA-915 can inhibit PACAP- and nerve injury-induced allodynia. PA-915 can be used for the research of neuropathic pain .
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Cat. No.: HY-P99509
CAS No.: 2225850-33-7
Synonyms: AMG-301

Target:  

Adenylate Cyclase

Research Areas:  

Neurological Disease

Zelminemab (AMG-301) is a humanized monoclonal antibody that inhibits PACAP type I (PAC1) receptor .
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Cat. No.: HY-P0221C
CAS No.: 129405-61-4
Target:  

PACAP Receptor

Research Areas:  

Metabolic Disease

PACAP (1-38) free acid is a desamido-PACAP (1-38), human, ovine, rat (HY-P0221). PACAP (1-38) free acid can activate the human PAC1 receptor. PACAP (1-38) free acid induces cyclic AMP (cAMP) generation in both NS-1 neuroendocrine cells and non-neuroendocrine HEK293 cells .
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Cat. No.: HY-P1845
CAS No.: 138764-85-9
Research Areas:  

Others

PACAP-38 (31-38), human, mouse, rat is a fragment containing the C-terminal 31-38 fragment of PACAP (1-38), human, ovine, rat (HY-P0221). PACAP-38 (31-38), human, mouse, rat does not bind to the PACAP receptor .
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Cat. No.: HY-P990481

Target:  

PACAP Receptor

Research Areas:  

Inflammation/Immunology

Anti-PACAP38 Antibody is a human antibody expressed in CHO cells, targeting PACAP38. The Anti-PACAP38 Antibody has a huIgG4SP type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-PACAP38 Antibody can refer to Human IgG4 kappa, Isotype Control (HY-P99003).
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Cat. No.: HY-P2609F
Target:  

PACAP Receptor

Research Areas:  

Others

PACAP (1-38), amide, Biotin-labeled is a biological active peptide. (Biotin-labeled HY-P0221)
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Cat. No.: HY-129421
CAS No.: 1436004-46-4
Purity:  99.73%
PA-9 is a pituitary adenylate cyclase-activating polypeptide (PACAP) type I (PAC1) receptor antagonist. PA-9 dose dependently inhibits PACAP-induced cAMP elevation with an IC50 of 5.6 nM. PA-9 can be used for the research of neuropathic and/or inflammatory pain .
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Cat. No.: HY-P4127A
M65 TFA is a deleted peptide of maxadilan (61 a.a.) with deletion of the residues between positions 24 and 42 and is a specific antagonist of PACAP type 1 receptor that inhibits ANP secretion and can be used for relevant researches .
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Cat. No.: HY-P1845A
Research Areas:  

Neurological Disease

PACAP-38 (31-38), human, mouse, rat TFA is a fragment containing the C-terminal 31-38 fragment of PACAP (1-38), human, ovine, rat (HY-P0221). PACAP-38 (31-38), human, mouse, rat TFA does not bind to the PACAP receptor .
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Cat. No.: HY-P4127
CAS No.: 1872440-65-7
Target:  

Peptides

Research Areas:  

Neurological Disease

M65 is a deleted peptide of maxadilan (61 a.a.) with deletion of the residues between positions 24 and 42 and is a specific antagonist of PACAP type 1 receptor that inhibits ANP secretion and can be used for relevant researches .
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Cat. No.: HY-P3117
CAS No.: 136134-68-4
Synonyms: Pituitary adenylate cyclase-activating peptide (6-27)
Target:  

Adenylate Cyclase

Research Areas:  

Neurological Disease

PACAP (6-27) (human, ovine, rat) is a PACAP receptor antagonist that blocks the canine adrenal catecholamine response to exogenous vasoactive intestinal peptide (VIP). PACAP (6-27) (human, ovine, rat) has the potential to study cardiovascular and neurological diseases .
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Cat. No.: HY-P3875
CAS No.: 176785-25-4
Synonyms: BM-PACAP
Target:  

PACAP Receptor

[Arg-15,-20,-21,Leu17]-PACAP-Gly-Lys-Arg-NH2 (BM-PACAP) is a synthetic PACAP 1-27 (HY-P0176) analogue with relaxant effect .
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Cat. No.: HY-P1511
Target:  

PACAP Receptor

Research Areas:  

Neurological Disease

PACAP-Related Peptide (PRP), human is a 29 amino-acid region of the PACAP precursor protein.
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Cat. No.: HY-P1817
CAS No.: 144025-82-1
Target:  

PACAP Receptor

Research Areas:  

Cardiovascular Disease

PACAP-38 (16-38), human, mouse, rat is a peptide fragment encompassing the C-terminal 16-38 segment of PACAP (1-38), human, ovine, rat (HY-P0221). PACAP-38 (16-38), human, mouse, rat lacks the N-terminal 1-15 receptor activation core, but retains the ability to bind to the PAC/VPAC receptor family (PAC1/VPAC1/VPAC2 receptor). PACAP-38 (16-38), human, mouse, rat promotes histamine release and exerts a certain degree of hypotensive effect .
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