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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
PCLAF
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "PCLAF" in MCE Product Catalog:
1
1 Cited Publications
Target:
Research Areas:
AD4 is a PROTAC that induces the degradation of PCLAF by recruiting cereblon. AD4 is also an artemisinin derivative. AD4 directly binds to PCLAF with a KD of 6.1 μM, and induces apoptosis and G1-phase cell cycle arrest. By degrading PCLAF, AD4 upregulates p21, reduces Rb phosphorylation, downregulates Bcl-2 and upregulates Bax, thereby activating the p21/Rb axis. AD4 can be used in studies related to acute B-lymphoblastic leukemia and PCLAF-dependent anticancer mechanisms .
Cat. No.: HY-RS10154
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Research Areas:
PCLAF Human Pre-designed siRNA Set A contains three designed siRNAs for PCLAF gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS25716
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Research Areas:
Pclaf Rat Pre-designed siRNA Set A contains three designed siRNAs for Pclaf gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-174301
CAS No.: 3052223-40-9
Research Areas:
USP7-IN-18 is a naphthalene derivative. USP7-IN-18 is a selective USP7 inhibitor (IC50 : 130.9 nM), with no or very weak inhibition of the other 8 DUBs including USP47. USP7-IN-18 specifically binds to the catalytic domain of USP7, blocking its deubiquitinase activity. USP7-IN-18 causes degradation of the oncogenic proteins MDM2 and DNMT1, and also degrades the novel target PCLAF. USP7-IN-18 activates the p53-p21 pathway. USP7-IN-18 exerts anti-tumor effects in colon cancer animal models and reshapes the tumor immune microenvironment. USP7-IN-18 achieves both direct cytotoxic and immune-synergistic anti-tumor actions.
Cat. No.: HY-162393
CAS No.: 2637949-91-6
XL44, an hRpn13 binder, induces hRpn13-dependent apoptosis and also restricts cell viability by a PCLAF-dependent mechanism. XL44 induces ubiquitin-dependent loss of hRpn13 Pru and ubiquitin-independent loss of select KEN box containing proteins .
Cat. No.: HY-RS19227
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Research Areas:
Pclaf Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pclaf gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P75900
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PCLAF; Overexpressed In Anaplastic Thyroid Carcinoma 1; Prev. KIAA0101; PCNA-Clamp-Associated Factor; PCNA-Associated Factor; P15PAF; NS5ATP9; PAF; OEATC-1; P15/PAF; PAF15; OEATC1; PCNA-Associated Factor Of 15 KDa; OEATC; P15(PAF); L5; Hepatitis C Virus N
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
