20 Results for "

PEPCK

" in MedChemExpress (MCE) Product Catalog:
Products (20)

20 Results for "PEPCK" in MCE Product Catalog:

  • Targets Recommended:
10
10 Publications Verification
Cat. No.: HY-128923
CAS No.: 320386-54-7
Purity:  96.35%
Synonyms: 3-Mercaptopicolinic acid hydrochloride; 3-MPA hydrochloride
Target:  

PEPCK

Research Areas:  

Metabolic Disease

SKF-34288 (3-Mercaptopicolinic acid) hydrochloride is an orally active phosphoenolpyruvate carboxykinase (PEPCK) inhibitor (Ki: 2-9 μM). SKF-34288 hydrochloride is a potent hypoglycemic agent by inhibiting glucose synthesis. SKF-34288 hydrochloride also inhibits Asn metabolism and increases amino acids and amides .
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3
3 Cited Publications
Cat. No.: HY-123046
CAS No.: 1253226-93-5
Purity:  99.44%
Target:  

Autophagy

Research Areas:  

Metabolic Disease Cancer

AS1708727 is an orally active Foxo1 inhibitor, with EC50 values of 0.33 μM and 0.59 μM for G6Pase and PEPCK, respectively .
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2
2 Cited Publications
Cat. No.: HY-153347
CAS No.: 339103-05-8
Purity:  99.75%
Target:  

FOXO

Research Areas:  

Metabolic Disease

JY-2 is a moderately selective and orally active Forkhead transcription factor forkhead box O1 (FoxO1) inhibitor that inhibits FoxO1 transcriptional activity with an IC50 of 22 μM. JY-2 shows moderate inhibition against FoxO3a and FoxO4. JY-2 shows anti-diabetic activity .
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Cat. No.: HY-W115752
CAS No.: 10034-93-2
Synonyms: Diamine sulfate (99%)
Hydrazine sulfate is an orally active PEPCK inhibitor. Hydrazine sulfate inhibits PEPCK and low-Km ALDH. Hydrazine sulfate impairs gluconeogenesis and enhances the protective effect of energy substrates against MPP + toxicity. Hydrazine sulfate exacerbates liver damage in rats when combined with Ethanol. Hydrazine sulfate can be used in the research of shock, non-small cell lung cancer, colorectal cancer and Parkinson's disease .
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Cat. No.: HY-N3720
CAS No.: 61854-36-2
Synonyms: 6-Demethoxycapillarisin
Demethoxycapillarisin (6-Demethoxycapillarisin) inhibits PEPCK mRNA levels (IC50: 43 μM) by activation of the PI3K pathway. Demethoxycapillarisin decreases glucose production .
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Cat. No.: HY-W197205
CAS No.: 380173-90-0
Research Areas:  

Metabolic Disease

SL010110 is an anti-hyperglycemic agent. SL010110 potently inhibits gluconeogenesis by inhibiting SIRT2, activating p300, and subsequently promoting PEPCK1 degradation. SL010110 downregulates the protein level of PEPCK1 without affecting the gene expressions of PEPCK, glucose-6-phosphatase, and fructose-1,6-bisphosphatase. SL010110 significantly improves glucose homeostasis in type 2 diabetic (T2D) mice model. SL010110 can be used for T2D research .
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Cat. No.: HY-111896
CAS No.: 113085-62-4
Purity:  98.56%
Synonyms: 7-O-Methoxyrosmanol
7-Methoxyrosmanol (7-O-Methoxyrosmanol), a phenolic diterpene isolated from rosemary, suppresses the cAMP responsiveness of PEPCK and G6Pase promoters .
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Cat. No.: HY-RS17590
Research Areas:  

Others

Pck1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pck1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS10153
Research Areas:  

Others

PCK2 Human Pre-designed siRNA Set A contains three designed siRNAs for PCK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS24050
Research Areas:  

Others

Pck1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pck1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-P84621
Synonyms: PEPCK; PEPCK2; PEPCK-M

Host:  

Mouse

Application:  

WB, IHC-P, ICC/IF, FC, ELISA

Reactivity:  

Human, Rat, Monkey

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Cat. No.: HY-P84621A
Synonyms: PEPCK; PEPCK2; PEPCK-M

Host:  

Mouse

Application:  

WB, IHC-P, ICC/IF, FC, ELISA

Reactivity:  

Human, Rat, Monkey

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Cat. No.: HY-P81802
Synonyms: PCK2; PEPCK2; Phosphoenolpyruvate carboxykinase [GTP]; mitochondrial; PEPCK-M; Phosphoenolpyruvate carboxylase

Host:  

Rabbit

Application:  

WB, IHC-F, IHC-P, ICC/IF

Reactivity:  

Human, Mouse, Rat

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Cat. No.: HY-P85451
Synonyms: PCK2; PEPCK2; Phosphoenolpyruvate carboxykinase [GTP]; mitochondrial; PEPCK-M; Phosphoenolpyruvate carboxylase

Host:  

Mouse

Application:  

WB

Reactivity:  

Human, Mouse, Rat, Bovine, Dog, Pig

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Cat. No.: HY-P75957
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Phosphoenolpyruvate carboxykinase [GTP], mitochondrial; PEPCK-M; PCK2; PEPCK2
Species:  
Source:  
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Cat. No.: HY-P81802A
Synonyms: PCK2; PEPCK2; Phosphoenolpyruvate carboxykinase [GTP]; mitochondrial; PEPCK-M; Phosphoenolpyruvate carboxylase

Host:  

Rabbit

Application:  

WB, IHC-F, IHC-P, ICC/IF

Reactivity:  

Human, Mouse, Rat

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Cat. No.: HY-N8250
CAS No.: 928205-59-8
cis-THSG is a selective and orally active DNA topoisomerase II inhibitor with no activity against DNA topoisomerase I. cis-THSG suppresses transcription of PEPCK. cis-THSG reduces blood glucose levels, ameliorates glucose intolerance, and alleviates insulin resistance in high fat diet-induced diabetic male CF-1 mice. cis-THSG can be used for the research of type 2 diabetes mellitus .
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Cat. No.: HY-N20719
CAS No.: 3162-56-9
Vulgarin is an orally active, naturally occurring eudesmane sesquiterpene with multiple biological activities including anti-inflammatory and antioxidant properties. Vulgarin targets and inhibits HMGB1, NF-κB and iNOS, while regulating key genes involved in hepatic gluconeogenesis; it also blocks inflammatory signaling pathways and inhibits the production and release of pro-inflammatory cytokines such as TNF-α and IL-1β. Vulgarin effectively alleviates pancreatic oxidative stress by reducing lipid peroxidation levels and restoring antioxidant enzyme activity. Vulgarin reverses abnormally elevated serum pancreatic enzyme levels, preserves the integrity of pancreatic acinar cells, and reduces pancreatic edema, hemorrhage and inflammatory infiltration. Vulgarin remodels the function of pancreatic endocrine cells, restores insulin content in β cells, and downregulates glucagon levels in α cells and somatostatin levels in δ cells. Vulgarin can be used in studies related to pancreatic injury and diabetes .
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Cat. No.: HY-N7773
CAS No.: 577-24-2
Hibiscetin is an orally active anti-inflammatory, antioxidant, antihyperglycemic, hypolipidemic, hepatoprotective and neuroprotective agent. Hibiscetin reduces the levels of TNF-α, IL-1β and IL-6. Hibiscetin inhibits lipid peroxidation, reduces MDA levels, and induces the activities of antioxidant enzymes CAT, GSH and SOD. Hibiscetin lowers blood glucose, reverses reduced insulin levels, regulates adipokine levels, and reduces elevated AST and ALT levels. Hibiscetin alleviates Rotenone (HY-B1756)-induced akinesia and catalepsy, normalizes neurotransmitter levels, and modulates the activities of activated caspase 3 and BDNF. Hibiscetin can be used in the research of type 2 diabetes, Parkinson's disease and Huntington's disease .
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Cat. No.: HY-N13285
CAS No.: 17291-05-3
Synonyms: (-)-EGC-4'-O-ME
(-)-Epigallocatechin-4'-O-methylether ((-)-EGC-4'-O-ME) is an orally active natural phenolic catechin with antioxidant, free radical-scavenging and hepatoprotective activities. (-)-Epigallocatechin-4'-O-methylether interferes with radiation-induced free radical formation, scavenges DPPH free radicals, inhibits carbon tetrachloride-induced increases in serum GOT and GPT, suppresses carbon tetrachloride-induced TBA-RS formation, and counteracts carbon tetrachloride-induced hepatocyte toxicity. (-)-Epigallocatechin-4'-O-methylether binds specifically to human serum albumin. (-)-Epigallocatechin-4'-O-methylether can be used in studies related to liver injury .
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