PEPCK

By Targets:	PEPCK (6) Aldehyde Dehydrogenase (ALDH) (1) Autophagy (1) Caspase (1) Drug Derivative (1) FOXO (1) Histone Acetyltransferase (1) Interleukin Related (1) Sirtuin (1) Small Interfering RNA (siRNA) (3) SOD (1) TNF Receptor (1) Topoisomerase (1)
By Research Areas:	Cancer (2) Inflammation/Immunology (1) Metabolic Disease (9) Neurological Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Targets Recommended: PEPCK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-128923

SKF-34288 hydrochloride Maximum Cited Publications 8 Publications Verification 3-Mercaptopicolinic acid hydrochloride; 3-MPA hydrochloride	PEPCK	Metabolic Disease
SKF-34288 (3-Mercaptopicolinic acid) hydrochloride is an orally active phosphoenolpyruvate carboxykinase (PEPCK) inhibitor (K_i: 2-9 μM). SKF-34288 hydrochloride is a potent hypoglycemic agent by inhibiting glucose synthesis. SKF-34288 hydrochloride also inhibits Asn metabolism and increases amino acids and amides .

HY-153347

JY-2 2 Publications Verification	FOXO	Metabolic Disease
JY-2 is a moderately selective and orally active Forkhead transcription factor forkhead box O1 (FoxO1) inhibitor that inhibits FoxO1 transcriptional activity with an IC₅₀ of 22 μM. JY-2 shows moderate inhibition against FoxO3a and FoxO4. JY-2 shows anti-diabetic activity .

HY-123046

AS1708727 3 Publications Verification	Autophagy	Metabolic Disease Cancer
AS1708727 is an orally active Foxo1 inhibitor, with EC₅₀ values of 0.33 μM and 0.59 μM for G6Pase and PEPCK, respectively .

HY-W115752

Hydrazine sulfate (99%) Diamine sulfate (99%)	PEPCK Aldehyde Dehydrogenase (ALDH)	Neurological Disease Metabolic Disease Cancer
Hydrazine sulfate is an orally active *PEPCK* inhibitor. Hydrazine sulfate inhibits *PEPCK* and low-K_m ALDH. Hydrazine sulfate impairs gluconeogenesis and enhances the protective effect of energy substrates against MPP ⁺ toxicity. Hydrazine sulfate exacerbates liver damage in rats when combined with Ethanol. Hydrazine sulfate can be used in the research of shock, non-small cell lung cancer, colorectal cancer and Parkinson's disease .

HY-N3720

Demethoxycapillarisin 6-Demethoxycapillarisin	PEPCK	Metabolic Disease
Demethoxycapillarisin (6-Demethoxycapillarisin) inhibits *PEPCK* mRNA levels (IC₅₀: 43 μM) by activation of the PI3K pathway. Demethoxycapillarisin decreases glucose production .

HY-W197205

SL010110	Sirtuin Histone Acetyltransferase PEPCK	Metabolic Disease
SL010110 is an anti-hyperglycemic agent. SL010110 potently inhibits gluconeogenesis by inhibiting SIRT2, activating p300, and subsequently promoting *PEPCK1* degradation. SL010110 downregulates the protein level of PEPCK1 without affecting the gene expressions of PEPCK, glucose-6-phosphatase, and fructose-1,6-bisphosphatase. SL010110 significantly improves glucose homeostasis in type 2 diabetic (T2D) mice model. SL010110 can be used for T2D research .

HY-111896

7-Methoxyrosmanol 7-O-Methoxyrosmanol	PEPCK	Others
7-Methoxyrosmanol (7-O-Methoxyrosmanol), a phenolic diterpene isolated from rosemary, suppresses the cAMP responsiveness of PEPCK and G6Pase promoters .

HY-RS17590

Pck1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pck1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pck1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pck1 Mouse Pre-designed siRNA Set A Pck1 Mouse Pre-designed siRNA Set A

HY-RS10153

PCK2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PCK2 Human Pre-designed siRNA Set A contains three designed siRNAs for PCK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PCK2 Human Pre-designed siRNA Set A PCK2 Human Pre-designed siRNA Set A

HY-RS24050

Pck1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pck1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pck1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pck1 Rat Pre-designed siRNA Set A Pck1 Rat Pre-designed siRNA Set A

HY-N8250

cis-THSG	Topoisomerase PEPCK	Metabolic Disease
cis-THSG is a selective and orally active DNA topoisomerase II inhibitor with no activity against DNA topoisomerase I. cis-THSG suppresses transcription of *PEPCK*. cis-THSG reduces blood glucose levels, ameliorates glucose intolerance, and alleviates insulin resistance in high fat diet-induced diabetic male CF-1 mice. cis-THSG can be used for the research of type 2 diabetes mellitus .

HY-N7773

Hibiscetin	TNF Receptor Interleukin Related Caspase SOD	Neurological Disease Metabolic Disease
Hibiscetin is an orally active anti-inflammatory, antioxidant, antihyperglycemic, hypolipidemic, hepatoprotective and neuroprotective agent. Hibiscetin reduces the levels of TNF-α, IL-1β and IL-6. Hibiscetin inhibits lipid peroxidation, reduces MDA levels, and induces the activities of antioxidant enzymes CAT, GSH and SOD. Hibiscetin lowers blood glucose, reverses reduced insulin levels, regulates adipokine levels, and reduces elevated AST and ALT levels. Hibiscetin alleviates Rotenone (HY-B1756)-induced akinesia and catalepsy, normalizes neurotransmitter levels, and modulates the activities of activated caspase 3 and BDNF. Hibiscetin can be used in the research of type 2 diabetes, Parkinson's disease and Huntington's disease .

HY-N13285

(-)-Epigallocatechin-4'-O-methylether (-)-EGC-4'-O-ME	Drug Derivative	Metabolic Disease Inflammation/Immunology
(-)-Epigallocatechin-4'-O-methylether ((-)-EGC-4'-O-ME) is an orally active natural phenolic catechin with antioxidant, free radical-scavenging and hepatoprotective activities. (-)-Epigallocatechin-4'-O-methylether interferes with radiation-induced free radical formation, scavenges DPPH free radicals, inhibits carbon tetrachloride-induced increases in serum GOT and GPT, suppresses carbon tetrachloride-induced TBA-RS formation, and counteracts carbon tetrachloride-induced hepatocyte toxicity. (-)-Epigallocatechin-4'-O-methylether binds specifically to human serum albumin. (-)-Epigallocatechin-4'-O-methylether can be used in studies related to liver injury .

Cat. No.	Product Name	Type

HY-W115752

Hydrazine sulfate (99%) Diamine sulfate (99%)	Biochemical Assay Reagents
Hydrazine sulfate is an orally active *PEPCK* inhibitor. Hydrazine sulfate inhibits *PEPCK* and low-K_m ALDH. Hydrazine sulfate impairs gluconeogenesis and enhances the protective effect of energy substrates against MPP ⁺ toxicity. Hydrazine sulfate exacerbates liver damage in rats when combined with Ethanol. Hydrazine sulfate can be used in the research of shock, non-small cell lung cancer, colorectal cancer and Parkinson's disease .

Hydrazine sulfate (99%)

Diamine sulfate (99%)

Biochemical Assay Reagents

Hydrazine sulfate is an orally active PEPCK inhibitor. Hydrazine sulfate inhibits PEPCK and low-K_m ALDH. Hydrazine sulfate impairs gluconeogenesis and enhances the protective effect of energy substrates against MPP ⁺ toxicity. Hydrazine sulfate exacerbates liver damage in rats when combined with Ethanol. Hydrazine sulfate can be used in the research of shock, non-small cell lung cancer, colorectal cancer and Parkinson's disease .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3720

Demethoxycapillarisin 6-Demethoxycapillarisin	Plants Compositae Machaerium incorruptibile (Vell.) Benth. Source Classification	PEPCK
Demethoxycapillarisin (6-Demethoxycapillarisin) inhibits *PEPCK* mRNA levels (IC₅₀: 43 μM) by activation of the PI3K pathway. Demethoxycapillarisin decreases glucose production .

HY-111896

7-Methoxyrosmanol 7-O-Methoxyrosmanol	Structural Classification other families Classification of Application Fields Terpenoids Other Diseases Phenols Polyphenols Diterpenoids Plants Disease Research Fields Source Classification	PEPCK
7-Methoxyrosmanol (7-O-Methoxyrosmanol), a phenolic diterpene isolated from rosemary, suppresses the cAMP responsiveness of PEPCK and G6Pase promoters .

HY-N8250

cis-THSG	Structural Classification Simple Phenylpropanols Polygonaceae Phenylpropanoids Fallopia multiflora (Thunb.) Harald. Plants Source Classification	Topoisomerase PEPCK
cis-THSG is a selective and orally active DNA topoisomerase II inhibitor with no activity against DNA topoisomerase I. cis-THSG suppresses transcription of *PEPCK*. cis-THSG reduces blood glucose levels, ameliorates glucose intolerance, and alleviates insulin resistance in high fat diet-induced diabetic male CF-1 mice. cis-THSG can be used for the research of type 2 diabetes mellitus .

HY-N7773

Hibiscetin	Malvaceae Structural Classification Flavonols Flavonoids Hibiscus sabdariffa Linn. Plants Source Classification	TNF Receptor Interleukin Related Caspase SOD
Hibiscetin is an orally active anti-inflammatory, antioxidant, antihyperglycemic, hypolipidemic, hepatoprotective and neuroprotective agent. Hibiscetin reduces the levels of TNF-α, IL-1β and IL-6. Hibiscetin inhibits lipid peroxidation, reduces MDA levels, and induces the activities of antioxidant enzymes CAT, GSH and SOD. Hibiscetin lowers blood glucose, reverses reduced insulin levels, regulates adipokine levels, and reduces elevated AST and ALT levels. Hibiscetin alleviates Rotenone (HY-B1756)-induced akinesia and catalepsy, normalizes neurotransmitter levels, and modulates the activities of activated caspase 3 and BDNF. Hibiscetin can be used in the research of type 2 diabetes, Parkinson's disease and Huntington's disease .

HY-N13285

(-)-Epigallocatechin-4'-O-methylether (-)-EGC-4'-O-ME	Structural Classification Ouratea Aubl. Phenols Polyphenols Plants Source Classification	Drug Derivative
(-)-Epigallocatechin-4'-O-methylether ((-)-EGC-4'-O-ME) is an orally active natural phenolic catechin with antioxidant, free radical-scavenging and hepatoprotective activities. (-)-Epigallocatechin-4'-O-methylether interferes with radiation-induced free radical formation, scavenges DPPH free radicals, inhibits carbon tetrachloride-induced increases in serum GOT and GPT, suppresses carbon tetrachloride-induced TBA-RS formation, and counteracts carbon tetrachloride-induced hepatocyte toxicity. (-)-Epigallocatechin-4'-O-methylether binds specifically to human serum albumin. (-)-Epigallocatechin-4'-O-methylether can be used in studies related to liver injury .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P75957

	PCK2 Protein, Human (sf9, His-GST) Phosphoenolpyruvate carboxykinase [GTP], mitochondrial; PEPCK-M; PCK2; PEPCK2	Human	Sf9 insect cells
	As a key enzyme in cellular metabolism, PCK2 protein catalyzes the conversion of oxaloacetate (OAA) into phosphoenolpyruvate (PEP), representing the rate-limiting step in the metabolic pathway and responsible for the production of glucose from other precursors derived from lactate and citric acid cycle. PCK2 Protein, Human (sf9, His-GST) is the recombinant human-derived PCK2 protein, expressed by Sf9 insect cells , with C-His, N-GST labeled tag.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Host:	Mouse (3) Rabbit (2)
Reactivity:	Human (5) Bovine (1) Mouse (3) Rat (5) Monkey (2) Dog (1) Pig (1)
Application:	IHC-P (4) ICC/IF (4) IHC-F (2) WB (5) FC (2) ELISA (2)
Isotype:	IgG (2) IgG1 (2)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (3) Recombinant (1)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84621

	PCK2 Antibody (YA4318) PEPCK; PEPCK2; PEPCK-M	WB, IHC-P, ICC/IF, FC, ELISA	Human, Rat, Monkey
	PCK2 Antibody (YA4318) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PCK2.

HY-P84621A

	PCK2 Antibody (YA4318)(PBS only) PEPCK; PEPCK2; PEPCK-M	WB, IHC-P, ICC/IF, FC, ELISA	Human, Rat, Monkey
	PCK2 Antibody (YA4318) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PCK2.

HY-P81802

	PCK2 Antibody (YA1547) PCK2; PEPCK2; Phosphoenolpyruvate carboxykinase [GTP]; mitochondrial; PEPCK-M; Phosphoenolpyruvate carboxylase	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	PCK2 Antibody (YA1547) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PCK2.

HY-P85451

	PCK2 Antibody (YA5143) PCK2; PEPCK2; Phosphoenolpyruvate carboxykinase [GTP]; mitochondrial; PEPCK-M; Phosphoenolpyruvate carboxylase	WB	Human, Mouse, Rat, Bovine, Dog, Pig
	PCK2 Antibody (YA5143) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to PCK2.

HY-P81802A

	PCK2 Antibody (YA1547)(PBS only) PCK2; PEPCK2; Phosphoenolpyruvate carboxykinase [GTP]; mitochondrial; PEPCK-M; Phosphoenolpyruvate carboxylase	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	PCK2 Antibody (YA1547) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PCK2.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-RS17590

Pck1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Pck1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pck1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS10153

PCK2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PCK2 Human Pre-designed siRNA Set A contains three designed siRNAs for PCK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS24050

Pck1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Pck1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pck1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

PEPCK

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Recombinant Proteins

Antibodies

Oligonucleotides

Natural
Products