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Pathways Recommended:	MAPK/ERK Pathway

Results for "

PINK1/Parkin pathway

" in MedChemExpress (MCE) Product Catalog:

By Targets:	PINK1/Parkin (15) AMPK (3) Amyloid-β (1) Antibiotic (2) Apoptosis (10) Autophagy (8) Calcium Channel (2) Caspase (4) DNA/RNA Synthesis (2) Dynamin (2) Ferroptosis (1) Fungal (3) HDAC (2) Interleukin Related (1) JNK (3) Keap1-Nrf2 (1) Mitochondrial Metabolism (3) Mitophagy (8) Mitosis (1) MMP (1) NF-κB (3) NOD-like Receptor (NLR) (5) Notch (1) p62 (1) PROTACs (2) Pyroptosis (1) Reactive Oxygen Species (ROS) (6) Sirtuin (3)
By Research Areas:	Cancer (8) Cardiovascular Disease (5) Endocrinology (1) Infection (5) Inflammation/Immunology (4) Metabolic Disease (6) Neurological Disease (9)

By Targets:

PINK1/Parkin (15)

AMPK (3)

Amyloid-β (1)

Antibiotic (2)

Apoptosis (10)

Autophagy (8)

Calcium Channel (2)

Caspase (4)

DNA/RNA Synthesis (2)

Dynamin (2)

Ferroptosis (1)

Fungal (3)

HDAC (2)

Interleukin Related (1)

JNK (3)

Keap1-Nrf2 (1)

Mitochondrial Metabolism (3)

Mitophagy (8)

Mitosis (1)

MMP (1)

NF-κB (3)

NOD-like Receptor (NLR) (5)

Notch (1)

p62 (1)

PROTACs (2)

Pyroptosis (1)

Reactive Oxygen Species (ROS) (6)

Sirtuin (3)

By Research Areas:

Cancer (8)

Cardiovascular Disease (5)

Endocrinology (1)

Infection (5)

Inflammation/Immunology (4)

Metabolic Disease (6)

Neurological Disease (9)

Inhibitors & Agonists

Natural
Products

Targets Recommended: PINK1/Parkin Tissue Factor Pathway Inhibitor (TFPI)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112879

Mito-TEMPO Maximum Cited Publications 164 Publications Verification	Calcium Channel PINK1/Parkin Mitochondrial Metabolism Apoptosis Autophagy NOD-like Receptor (NLR)	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
Mito-TEMPO is a mitochondria-targeted antioxidant. Mito-TEMPO induces mitophagy by activating the *PINK1/Parkin* pathway, inhibits NLRP3 inflammasome activation, restores mitochondrial membrane potential, and improves renal function and podocyte injury. Mito-TEMPO regulates Ca ²⁺ homeostasis, inhibits Bnip3 overexpression, shortens action potential duration, and exerts antiarrhythmic effects. Mito-TEMPO reverses premature senescence, reduces trabecular bone loss, and decreases cell apoptosis. Mito-TEMPO can be used in studies of chronic kidney disease, age-related cardiac dysfunction, postmenopausal osteoporosis, and ischemic stroke .

HY-N0535

(+)-Magnoflorine chloride 1 Publications Verification Magnoflorine chloride; α-Magnoflorine chloride; Thalictrine chloride	Fungal Autophagy Apoptosis PINK1/Parkin NOD-like Receptor (NLR) Caspase JNK NF-κB Sirtuin AMPK Reactive Oxygen Species (ROS)	Infection Metabolic Disease
(+)-Magnoflorine (α-Magnoflorine) chloride is an orally active aporphine alkaloid with multiple biological activities. (+)-Magnoflorine chloride promotes *Parkin/PINK1*-mediated mitochondrial autophagy, inhibits the activation of NLRP3/Caspase-1 pathway, regulates the intestinal microbiota, and exhibits significant anti-inflammatory and immunomodulatory activities. (+)-Magnoflorine chloride inhibits JNK and TLR4/NF-κB signaling pathways, activates Sirt1/AMPK pathway, alleviates neuronal oxidative stress and apoptosis. Magnoflorine chloride upregulates miR-410-3p, inhibits HMGB1/NF-κB pathway, and has anti-tumor activity. (+)-Magnoflorine chloride also has significant antifungal activity .

HY-115576

P62-mediated mitophagy inducer 5 Publications Verification	p62 Mitophagy Autophagy Mitosis	Neurological Disease Cancer
P62-mediated mitophagy inducer (PMI) is a P62-mediated mitophagy activator. P62-mediated mitophagy inducer activates mitochondrial autophagy without recruitment of *Parkin* or collapse of the mitochondrial membrane potential and remains active in cells lacking a fully functional *PINK1/Parkin* pathway. P62-mediated mitophagy inducer serves as a pharmacological tool to study the molecular mechanisms of mitosis, avoiding toxicity and some of the non-specific effects associated with the sudden dissipation of mitochondria lacking membrane potential .

HY-N10470

Bleomycin A5 1 Publications Verification Pingyangmycin	Antibiotic DNA/RNA Synthesis Apoptosis Dynamin PINK1/Parkin Mitophagy	Infection Cancer
Bleomycin A5 (Pingyangmycin) is a glycopeptide antibiotic with multiple biological activities, which can be isolated from Streptomyces. Bleomycin A5 exerts cytotoxic effects by binding to Fe ²⁺ to form a complex, inducing single-strand and double-strand DNA breaks, and inhibiting DNA replication. Bleomycin A5 inhibits Drp1-mediated mitochondrial fission and suppresses *PINK1/Parkin* pathway-mediated mitophagy, ultimately triggering mitochondria-mediated cellular apoptosis. Bleomycin A5 can be used in cancer research .

HY-N0334

(+)-Magnoflorine Magnoflorine; α-Magnoflorine; Thalictrine	Fungal Autophagy Apoptosis PINK1/Parkin NOD-like Receptor (NLR) Caspase JNK NF-κB Sirtuin AMPK Reactive Oxygen Species (ROS)	Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
(+)-Magnoflorine (α-Magnoflorine) is an orally active aporphine alkaloid with multiple biological activities. (+)-Magnoflorine promotes *Parkin/PINK1* -mediated mitochondrial autophagy, inhibits the activation of NLRP3/Caspase-1 pathway, regulates the intestinal microbiota, and exhibits significant anti-inflammatory and immunomodulatory activities. (+)-Magnoflorine inhibits JNK and TLR4/NF-κB signaling pathways, activates Sirt1/AMPK pathway, alleviates neuronal oxidative stress and apoptosis. Magnoflorine upregulates miR-410-3p, inhibits HMGB1/NF-κB pathway, and has anti-tumor activity. (+)-Magnoflorine also has significant antifungal activity .

HY-125944

MitoTEMPO hydrate Maximum Cited Publications 164 Publications Verification	Mitochondrial Metabolism PINK1/Parkin NOD-like Receptor (NLR) Autophagy Calcium Channel Apoptosis	Cardiovascular Disease Neurological Disease Metabolic Disease Endocrinology
MitoTEMPO hydrate is a mitochondria-targeted antioxidant . MitoTEMPO hydrate induces mitophagy by activating the *PINK1/Parkin* pathway, inhibits NLRP3 inflammasome activation, restores mitochondrial membrane potential, and improves renal function and podocyte injury. MitoTEMPO hydrate regulates Ca ²⁺ homeostasis, inhibits Bnip3 overexpression, shortens action potential duration, and exerts antiarrhythmic effects. MitoTEMPO hydrate reverses premature senescence, reduces trabecular bone loss, and decreases cell apoptosis. MitoTEMPO hydrate can be used in studies of chronic kidney disease, age-related cardiac dysfunction, postmenopausal osteoporosis, and ischemic stroke .

HY-N0334A

(+)-Magnoflorine iodide 1 Publications Verification Magnoflorine iodide; α-Magnoflorine iodide; Thalictrine iodide	Fungal Autophagy Apoptosis PINK1/Parkin NOD-like Receptor (NLR) Caspase JNK NF-κB Sirtuin AMPK Reactive Oxygen Species (ROS)	Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
(+)-Magnoflorine (α-Magnoflorine) iodide is an orally active aporphine alkaloid with multiple biological activities. (+)-Magnoflorine iodide promotes *Parkin/PINK1* -mediated mitochondrial autophagy, inhibits the activation of NLRP3/Caspase-1 pathway, regulates the intestinal microbiota, and exhibits significant anti-inflammatory and immunomodulatory activities. (+)-Magnoflorine iodide inhibits JNK and TLR4/NF-κB signaling pathways, activates Sirt1/AMPK pathway, alleviates neuronal oxidative stress and apoptosis. Magnoflorine upregulates miR-410-3p, inhibits HMGB1/NF-κB pathway, and has anti-tumor activity. (+)-Magnoflorine iodide also has significant antifungal activity .

HY-174806

Y040-7904 7-(β-D-Galactopyranosyloxy)-4-phenylchromen-2-one	Mitophagy PINK1/Parkin Amyloid-β	Neurological Disease
Y040-7904 is a mitophagy activator. Y040-7904 enhances mitophagy by promoting mitochondria transport to autophagosomes and the fusion of autophagosomes with autolysosomes. Y040-7904 induces mitophagy through the SIRT1/FoxO3 pathway. Y040-7904 upregulates the levels of Parkin, PINK1, and LC3II/I. Y040-7904 reduces amyloid-β (Aβ) accumulation in both in vitro and in vivo models of Alzheimer’s disease.

HY-152265

PARL-IN-1	PINK1/Parkin Mitophagy	Neurological Disease
PARL-IN-1 is a potent PARL inhibitor with an IC₅₀ value of 28 nM. PARL-IN-1 inhibits PARL and leads to a robust activation of the PINK1/Parkin pathway. PARL-IN-1 promotes PINK1/Parkin-dependent mitophagy .

HY-125918

Bleomycin A5 hydrochloride Pingyangmycin hydrochloride	Antibiotic DNA/RNA Synthesis Apoptosis Dynamin PINK1/Parkin Mitophagy	Infection Cancer
Bleomycin A5 (Pingyangmycin) hydrochloride is a glycopeptide antibiotic with multiple biological activities, which can be isolated from Streptomyces. Bleomycin A5 hydrochloride exerts cytotoxic effects by binding to Fe ²⁺ to form a complex, inducing single-strand and double-strand DNA breaks, and inhibiting DNA replication. Bleomycin A5 hydrochloride inhibits Drp1-mediated mitochondrial fission and suppresses *PINK1/Parkin* pathway-mediated mitophagy, ultimately triggering mitochondria-mediated cellular apoptosis. Bleomycin A5 hydrochloride can be used in cancer research .

HY-145816A

JPS016 TFA 1 Publications Verification	HDAC PROTACs Apoptosis PINK1/Parkin Autophagy Reactive Oxygen Species (ROS)	Cancer
JPS016 TFA is a class I histone deacetylase (HDAC) PROTAC inhibitor. JPS016 TFA recruits the VHL E3 ligase (Ligands for E3 Ligase) to mediate the ubiquitination and proteasomal degradation of HDAC1, HDAC2 and HDAC3. JPS016 TFA reduces the viability of colon cancer cells and induces Apoptosis. JPS016 TFA activates the *PINK1/Parkin* mitochondrial Autophagy pathway, enhances cardiomyocyte viability, alleviates mitochondrial damage, and reduces mitochondrial ROS production in cells. JPS016 TFA is applicable to research related to colon cancer and sepsis cardiomyopathy .

HY-169380

PARL-IN-2 1 Publications Verification	PINK1/Parkin Mitophagy	Metabolic Disease
PARL-IN-2 (Compound 14) is a covalent inhibitor of the mitochondrial intramembrane protease PARL with an EC₅₀ value of 0.16 μM. PARL-IN-2 leads to a robust activation of the *PINK1/Parkin* pathway. PARL-IN-2 promotes *PINK1/Parkin*-dependent mitophagy .

HY-164826

Acetyl zingerone	Interleukin Related Reactive Oxygen Species (ROS) MMP Pyroptosis Ferroptosis Notch Keap1-Nrf2 PINK1/Parkin Mitophagy Caspase Apoptosis	Inflammation/Immunology Cancer
Acetyl zingerone is an analog of Zingerone (HY-14621). Acetyl zingerone downregulates the expression of ROS metabolism-related genes, fibroblast senescence-related genes, keratinocyte differentiation-related genes, and IL-17A target genes. Acetyl zingerone inhibits the activities of MMP-1, MMP-3, and MMP-12, as well as the activation of NLRP3 inflammasome, pyroptosis (pyroptosis), ferroptosis (ferroptosis), cartilage destruction, and UVA-induced cyclobutane pyrimidine dimer formation. Acetyl zingerone upregulates the expression of collagen, proteoglycan, extracellular matrix glycoprotein, Notch pathway, and GPX4 gene, activates Nrf2 and HO-1, induces extracellular matrix synthesis and *PINK1/Parkin*-mediated mitophagy (mitophagy), and promotes chondrocyte survival. Acetyl zingerone alleviates the progression of osteoarthritis in mice . Acetyl zingerone can be used in research related to skin aging, inflammatory skin diseases, osteoarthritis, melanoma, and non-melanoma skin cancer .

HY-178154

FB231	PINK1/Parkin Mitochondrial Metabolism	Neurological Disease
FB231 is a *Parkin* activator. FB231 can induce mild mitochondrial stress, resulting in impaired mitochondrial function and activation of the integrated stress response. FB231 can lower the threshold for mitochondrial toxins to induce *PINK1/Parkin*-mediated mitophagy. FB231 can cause activation of the integrated stress response (ISR) and perturbation to iron-dependent pathways. FB231 can be used for the research of neurological disease, such as Parkinson’s disease .

HY-152265A

PARL-IN-1 TFA	PINK1/Parkin Mitophagy	Neurological Disease
PARL-IN-1 TFA is a potent PARL inhibitor with an IC₅₀ value of 28 nM. PARL-IN-1 TFA inhibits PARL and leads to a robust activation of the PINK1/Parkin pathway. PARL-IN-1 TFA promotes PINK1/Parkin-dependent mitophagy .

HY-145816

JPS016	PROTACs HDAC Apoptosis PINK1/Parkin Autophagy Reactive Oxygen Species (ROS)	Cardiovascular Disease Cancer
JPS016 is a class I histone deacetylase (HDAC) PROTAC inhibitor. JPS016 recruits the VHL E3 ligase (Ligands for E3 Ligase) to mediate the ubiquitination and proteasomal degradation of HDAC1, HDAC2 and HDAC3. JPS016 reduces the viability of colon cancer cells and induces Apoptosis. JPS016 activates the *PINK1/Parkin* mitochondrial Autophagy pathway, enhances cardiomyocyte viability, alleviates mitochondrial damage, and reduces mitochondrial ROS production in cells. JPS016 is applicable to research related to colon cancer and sepsis cardiomyopathy .

(+)-Magnoflorine chloride 1 Publications Verification Magnoflorine chloride; α-Magnoflorine chloride; Thalictrine chloride	Structural Classification Classification of Application Fields Metabolic Disease Plants Aristolochiaceae Infection Alkaloids Piperidine Alkaloids other families Aristolochia debilis Sieb. et Zucc. Phenols Polyphenols Disease Research Fields Source Classification	Fungal Autophagy Apoptosis PINK1/Parkin NOD-like Receptor (NLR) Caspase JNK NF-κB Sirtuin AMPK Reactive Oxygen Species (ROS)
(+)-Magnoflorine (α-Magnoflorine) chloride is an orally active aporphine alkaloid with multiple biological activities. (+)-Magnoflorine chloride promotes *Parkin/PINK1*-mediated mitochondrial autophagy, inhibits the activation of NLRP3/Caspase-1 pathway, regulates the intestinal microbiota, and exhibits significant anti-inflammatory and immunomodulatory activities. (+)-Magnoflorine chloride inhibits JNK and TLR4/NF-κB signaling pathways, activates Sirt1/AMPK pathway, alleviates neuronal oxidative stress and apoptosis. Magnoflorine chloride upregulates miR-410-3p, inhibits HMGB1/NF-κB pathway, and has anti-tumor activity. (+)-Magnoflorine chloride also has significant antifungal activity .

Bleomycin A5 1 Publications Verification Pingyangmycin	Structural Classification Natural Products Microorganisms Animals Source Classification	Antibiotic DNA/RNA Synthesis Apoptosis Dynamin PINK1/Parkin Mitophagy
Bleomycin A5 (Pingyangmycin) is a glycopeptide antibiotic with multiple biological activities, which can be isolated from Streptomyces. Bleomycin A5 exerts cytotoxic effects by binding to Fe ²⁺ to form a complex, inducing single-strand and double-strand DNA breaks, and inhibiting DNA replication. Bleomycin A5 inhibits Drp1-mediated mitochondrial fission and suppresses *PINK1/Parkin* pathway-mediated mitophagy, ultimately triggering mitochondria-mediated cellular apoptosis. Bleomycin A5 can be used in cancer research .

(+)-Magnoflorine Magnoflorine; α-Magnoflorine; Thalictrine	Alkaloids Structural Classification Classification of Application Fields Coptis chinensis Franch. Ranunculaceae Phenols Polyphenols Metabolic Disease Plants Isoquinoline Alkaloids Disease Research Fields Source Classification	Fungal Autophagy Apoptosis PINK1/Parkin NOD-like Receptor (NLR) Caspase JNK NF-κB Sirtuin AMPK Reactive Oxygen Species (ROS)
(+)-Magnoflorine (α-Magnoflorine) is an orally active aporphine alkaloid with multiple biological activities. (+)-Magnoflorine promotes *Parkin/PINK1* -mediated mitochondrial autophagy, inhibits the activation of NLRP3/Caspase-1 pathway, regulates the intestinal microbiota, and exhibits significant anti-inflammatory and immunomodulatory activities. (+)-Magnoflorine inhibits JNK and TLR4/NF-κB signaling pathways, activates Sirt1/AMPK pathway, alleviates neuronal oxidative stress and apoptosis. Magnoflorine upregulates miR-410-3p, inhibits HMGB1/NF-κB pathway, and has anti-tumor activity. (+)-Magnoflorine also has significant antifungal activity .

(+)-Magnoflorine iodide 1 Publications Verification Magnoflorine iodide; α-Magnoflorine iodide; Thalictrine iodide	Alkaloids Structural Classification Classification of Application Fields Magnoliaceae Phenols Polyphenols Metabolic Disease Magnolia Liliflora Desr. Plants Isoquinoline Alkaloids Disease Research Fields Source Classification	Fungal Autophagy Apoptosis PINK1/Parkin NOD-like Receptor (NLR) Caspase JNK NF-κB Sirtuin AMPK Reactive Oxygen Species (ROS)
(+)-Magnoflorine (α-Magnoflorine) iodide is an orally active aporphine alkaloid with multiple biological activities. (+)-Magnoflorine iodide promotes *Parkin/PINK1* -mediated mitochondrial autophagy, inhibits the activation of NLRP3/Caspase-1 pathway, regulates the intestinal microbiota, and exhibits significant anti-inflammatory and immunomodulatory activities. (+)-Magnoflorine iodide inhibits JNK and TLR4/NF-κB signaling pathways, activates Sirt1/AMPK pathway, alleviates neuronal oxidative stress and apoptosis. Magnoflorine upregulates miR-410-3p, inhibits HMGB1/NF-κB pathway, and has anti-tumor activity. (+)-Magnoflorine iodide also has significant antifungal activity .

Bleomycin A5 hydrochloride Pingyangmycin hydrochloride	Structural Classification Microorganisms Antibiotics Source Classification	Antibiotic DNA/RNA Synthesis Apoptosis Dynamin PINK1/Parkin Mitophagy
Bleomycin A5 (Pingyangmycin) hydrochloride is a glycopeptide antibiotic with multiple biological activities, which can be isolated from Streptomyces. Bleomycin A5 hydrochloride exerts cytotoxic effects by binding to Fe ²⁺ to form a complex, inducing single-strand and double-strand DNA breaks, and inhibiting DNA replication. Bleomycin A5 hydrochloride inhibits Drp1-mediated mitochondrial fission and suppresses *PINK1/Parkin* pathway-mediated mitophagy, ultimately triggering mitochondria-mediated cellular apoptosis. Bleomycin A5 hydrochloride can be used in cancer research .

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PINK1/Parkin pathway

Inhibitors & Agonists

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