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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
PRDX6
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "PRDX6" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-P71145
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PRDX6; PRX; Peroxiredoxin 6; P29; AiPLA2; Red Blood Cells Page Spot 12; NSGPx; Lyso-PC Acyltransferase 5; AOP2; LPC Acyltransferase 5; Acidic Calcium-Independent Phospholipase A2; Antioxidant Protein 2; Lysophosphatidylcholine Acyltransferase 5; Liver 2D
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P73375
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PRDX5; B166; Peroxiredoxin 5; Thioredoxin-Dependent Peroxiredoxin 5; AOEB166; Peroxiredoxin-5, Mitochondrial; ACR1; Alu Co-Repressor 1; PLP; Peroxiredoxin V; Peroxisomal Antioxidant Enzyme; MGC142285; Liver Tissue 2D-Page Spot 71B; MGC117264; Thioredoxin
Species:
Mouse
Source:
E. coli
Research Areas:
MJ-33 lithium salt is a competitive phospholipase A2 (PLA2) inhibitor with an IC50 of 0.3 μM. MJ-33 lithium salt inhibits NOX2 activation and reduces ROS production by blocking the PLA2 activity of Prdx6. MJ-33 lithium salt effectively inhibits the activity of acidic PLA2 (pH 4.0) and reduces the degradation of alveolar surfactant phosphatidylcholine (PC), but exerts no effect on alkaline PLA2 (pH 8.5). MJ-33 lithium salt significantly alleviates lung oxidative injury induced by ischemia-reperfusion (I/R). MJ-33 lithium salt significantly inhibits the invasion, migration and adhesion abilities of prostate cancer cells by suppressing the MAPK, AKT, NF-κB and AP-1 signaling pathways. MJ-33 lithium salt can be used for the research of ROS-related diseases and prostate cancer .
Research Areas:
CCW16 is a non-selective cysteine-reactive covalent ligand and an RNF4 E3 ubiquitin ligase recruiter with an IC50 of 1.8 μM against human RNF4[. CCW16 covalently modifies accessible cysteine residues on RNF4, PRDX1, PRDX2, and PRDX6, attenuating the peroxide-scavenging activity of peroxiredoxins. CCW16 induces oxidative stress through upregulation of HMOX1 and NRF2, and triggers ferroptosis via lipid peroxidation and ROS signaling pathways in an RNF4-independent manner. CCW16 serves as an RNF4-recruiting moiety; it does not induce RNF4 degradation when used alone and can be used to synthesize protein degraders, such as the PROTAC compound CCW 28-3 (HY-156774). CCW16 can be used for research on acute myeloid leukemia and hepatocellular carcinoma .
Cat. No.: HY-129944
CAS No.: 199106-13-3
Target:
Research Areas:
MJ33-OH is a metabolite of MJ33. MJ33 is an active-site-directed, specific, competitive, and reversible phospholipase A2 (PLA2) inhibitor. MJ33 blocks the calcium-independent phospholipase A2 (iPLA2) activity of Prdx6 .
Cat. No.: HY-RS11079
Target:
Research Areas:
PRDX6 Human Pre-designed siRNA Set A contains three designed siRNAs for PRDX6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17470
Target:
Research Areas:
Prdx6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prdx6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23928
Target:
Research Areas:
Prdx6 Rat Pre-designed siRNA Set A contains three designed siRNAs for Prdx6 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-129944A
CAS No.: 1135306-36-3
Target:
Research Areas:
MJ33-OH lithium is a metabolite of MJ33. MJ33 is an active-site-directed, specific, competitive, and reversible phospholipase A2 (PLA2) inhibitor. MJ33 blocks the calcium-independent phospholipase A2 (iPLA2) activity of Prdx6 .
Cat. No.: HY-136271
CAS No.: 137300-78-8
Research Areas:
MJ-33 is a competitive phospholipase A₂ (PLA₂) inhibitor with an IC50 of 0.3 μM. MJ-33 inhibits the activation of NOX2 by blocking the PLA₂ activity of Prdx6, thereby reducing the production of ROS. MJ-33 effectively inhibits the activity of acidic PLA₂ (pH 4.0), reduces the degradation of pulmonary surfactant phosphatidylcholine (PC), but has no effect on alkaline PLA₂ (pH 8.5). MJ-33 significantly alleviates lung oxidative damage induced by ischemia-reperfusion (I/R). MJ-33 significantly inhibits the invasive, migratory and adhesive abilities of prostate cancer cells by suppressing the MAPK, AKT, NF-κB and AP-1 signaling pathways. MJ-33 can be used to study ROS-related diseases and prostate cancer .
Cat. No.: HY-P83409A
Synonyms: Peroxiredoxin-6; Antioxidant protein 2; Liver 2D page spot 40; NSGPx; PRDX6; AOP2; KIAA
Cat. No.: HY-P790076
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PRDX6; PRX; Peroxiredoxin 6; P29; AiPLA2; Red Blood Cells Page Spot 12; NSGPx; Lyso-PC Acyltransferase 5; AOP2; LPC Acyltransferase 5; Acidic Calcium-Independent Phospholipase A2; Antioxidant Protein 2; Lysophosphatidylcholine Acyltransferase 5; Liver 2D
Species:
Mouse
Source:
E. coli
Cat. No.: HY-RS17919
Target:
Research Areas:
Prdx5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prdx5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS11078
Target:
Research Areas:
PRDX5 Human Pre-designed siRNA Set A contains three designed siRNAs for PRDX5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P73711
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PRDX5; B166; Peroxiredoxin 5; Thioredoxin-Dependent Peroxiredoxin 5; AOEB166; Peroxiredoxin-5, Mitochondrial; ACR1; Alu Co-Repressor 1; PLP; Peroxiredoxin V; Peroxisomal Antioxidant Enzyme; MGC142285; Liver Tissue 2D-Page Spot 71B; MGC117264; Thioredoxin
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
