17 Results for "

PRLR

" in MedChemExpress (MCE) Product Catalog:
Products (17)

17 Results for "PRLR" in MCE Product Catalog:

Cat. No.: HY-P99238
CAS No.: 2095467-30-2

Target:  

ADC Antibodies

Research Areas:  

Inflammation/Immunology Cancer

Rolinsatamab is a IgG1κ type chimeric antibody targeting to PRLR (prolactin receptor). Rolinsatamab can be conjugated with pyrrolobenzodiazepine (PDB) dimer SGD-1882 (HY-101127) via a cleavable maleimidocaproyl type linker, to form an antibody-drug conjugate, Rolinsatamab talirine. One Rolinsatamab talirine has an average of 2 site-specific drug attachment engineered cysteines (S239C). The linker equips the valine-alanine dipeptide, as cathepsine B cleavage site. on an average of 2 site-specific drug attachment engineered cysteines (S239C) .
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Cat. No.: HY-P991358
Synonyms: LFA-102; X213

Research Areas:  

Cancer

XOMA-213 (LFA-102; X213) is a human monoclonal antibody (mAb) targeting the prolactin receptor (PRLR), with a Kd value of 2 nM against the human target. XOMA-213 blocks PRL-induced cell proliferation and inhibits the activation of multiple PRLR ligands, including PRL and human growth hormone (hGH). XOMA-213 suppresses PRL-induced phosphorylation of Stat5, Akt and ERK1/2 in cells. XOMA-213 induces tumor regression, delays disease progression, and inhibits PRLR signaling as well as tumor growth. XOMA-213 can be used in research related to breast cancer .
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Cat. No.: HY-P99881
CAS No.: 2095467-44-8
Synonyms: ABBV 176

Research Areas:  

Cancer

Rolinsatamab talirine (ABBV 176) is a prolactin receptor (PRLR)-targeting antibody-drug conjugate (ADC), compoused of Rolinsatamab (HY-P99238) and SGD-1882 (HY-101127). Rolinsatamab talirine binds to PRLR to deliver a cytotoxin to tumor cells. Rolinsatamab talirine induces DNA damage, and exhibits cytotoxicity against multiple breast tumor models, including triple negative and low PRLR-expressing models. Rolinsatamab talirine demonstrates enhanced anti-tumor activity in several breast cancer models. Rolinsatamab talirine can be used for the research of breast cancer, hepatocellular carcinoma, ovarian cancer, endometrial cancer, prostate cancer, colorectal cancer, adrenocortical carcinoma, and solid tumors .
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Cat. No.: HY-RS11163
Research Areas:  

Others

PRLR Human Pre-designed siRNA Set A contains three designed siRNAs for PRLR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS17413
Research Areas:  

Others

Prlr Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prlr gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS23867
Research Areas:  

Others

Prlr Rat Pre-designed siRNA Set A contains three designed siRNAs for Prlr gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS11411
Research Areas:  

Others

PTP4A3 Human Pre-designed siRNA Set A contains three designed siRNAs for PTP4A3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-P992449
Synonyms: PRLR ADC antibody

Target:  

ADC Antibodies

Research Areas:  

Cancer

REGN2878 (PRLR ADC antibody) is a monoclonal antibody targeting the prolactin receptor (PRLR) and can block prolactin‑mediated activation of PRLR. REGN2878 exhibits an equilibrium dissociation constant (KD) of 1.05 nM and an IC50 of 0.344 nM for human PRLR. REGN2878 can be rapidly internalized and degraded in lysosomes by PRLR‑positive tumor cells, showing antigen‑specific binding and targeted enrichment properties. REGN2878 derivatives can be used as an immunoPET agent for antigen‑specific imaging of PRLR‑related tumors, and can also serve as a component of ADCs to exert anti‑tumor activity in breast cancer xenograft models. REGN2878 can be used in the research of breast cancer and prostate cancer. Isotype Comparison HY-P99001 .
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Cat. No.: HY-P71235
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Prolactin receptor; PRL-R; PRLR; Prolactin R; PRLR
Species:  
Source:  
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Cat. No.: HY-P73693
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Prolactin receptor; PRL-R; Prolactin R
Species:  
Rat
Source:  
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Cat. No.: HY-P73696
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Prolactin receptor; PRL-R; Prolactin R
Species:  
Source:  
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Cat. No.: HY-P73694
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Prolactin receptor; PRL-R; Prolactin R
Species:  
Source:  
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Cat. No.: HY-P700814
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PRL-R; HPRL; MFAB; Prolactin R
Species:  
Source:  
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Cat. No.: HY-P77822
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: PRL-R; HPRL; MFAB; Prolactin R
Species:  
Source:  
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Cat. No.: HY-P701033
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PRL-R; Protein-tyrosine phosphatase 4a3; Protein-tyrosine phosphatase of regenerating liver 3; PRL-3; PRL3; PTP4A3
Species:  
Source:  
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Cat. No.: HY-P87635

Host:  

Rabbit

Application:  

IHC-P, IHC-F, IF-Tissue, ICC/IF

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Cat. No.: HY-P82666
Synonyms: CPRLP; HPRL; hPRL receptor; Lactogen receptor; MFAB; OPR; Pr-1; Pr-3; PRLR; Prolactin receptor a

Host:  

Rabbit

Application:  

WB

Reactivity:  

Human, Mouse, Rat

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