PRLR

By Targets:	ADC Antibody (2) Akt (1) Drug-Linker Conjugates for ADC (1) Estrogen Receptor/ERR (1) Small Interfering RNA (siRNA) (4) STAT (1)
By Research Areas:	Cancer (4) Inflammation/Immunology (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (2) siRNAs (4)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99238

Rolinsatamab	ADC Antibody	Inflammation/Immunology Cancer
Rolinsatamab is a IgG1κ type chimeric antibody targeting to *PRLR* (prolactin receptor). Rolinsatamab can be conjugated with pyrrolobenzodiazepine (PDB) dimer SGD-1882 (HY-101127) via a cleavable maleimidocaproyl type linker, to form an antibody-drug conjugate, Rolinsatamab talirine. One Rolinsatamab talirine has an average of 2 site-specific drug attachment engineered cysteines (S239C). The linker equips the valine-alanine dipeptide, as cathepsine B cleavage site. on an average of 2 site-specific drug attachment engineered cysteines (S239C) .

HY-P991358

XOMA-213 LFA-102; X213	Estrogen Receptor/ERR STAT Akt	Cancer
XOMA-213 (LFA-102; X213) is a human monoclonal antibody (mAb) targeting the prolactin receptor (PRLR), with a K_d value of 2 nM against the human target. XOMA-213 blocks PRL-induced cell proliferation and inhibits the activation of multiple *PRLR* ligands, including PRL and human growth hormone (hGH). XOMA-213 suppresses PRL-induced phosphorylation of Stat5, Akt and ERK1/2 in cells. XOMA-213 induces tumor regression, delays disease progression, and inhibits *PRLR* signaling as well as tumor growth. XOMA-213 can be used in research related to breast cancer .

HY-P99881

Rolinsatamab talirine ABBV 176	Drug-Linker Conjugates for ADC	Cancer
Rolinsatamab talirine (ABBV 176) is an antibody-drug conjugate (ADC) targeting prolactin receptor (PRLR). Rolinsatamab talirine consists of rolinsatamab (HY-P99238), an enzymatically cleavable peptide linker, and SGD-1882 (HY-101127) .

HY-RS11163

PRLR Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PRLR Human Pre-designed siRNA Set A contains three designed siRNAs for PRLR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRLR Human Pre-designed siRNA Set A PRLR Human Pre-designed siRNA Set A

HY-RS17413

Prlr Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Prlr Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prlr gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Prlr Mouse Pre-designed siRNA Set A Prlr Mouse Pre-designed siRNA Set A

HY-RS23867

Prlr Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Prlr Rat Pre-designed siRNA Set A contains three designed siRNAs for Prlr gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Prlr Rat Pre-designed siRNA Set A Prlr Rat Pre-designed siRNA Set A

HY-RS11411

PTP4A3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PTP4A3 Human Pre-designed siRNA Set A contains three designed siRNAs for PTP4A3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PTP4A3 Human Pre-designed siRNA Set A PTP4A3 Human Pre-designed siRNA Set A

HY-P992449

REGN2878 PRLR ADC antibody	ADC Antibody	Cancer
REGN2878 (PRLR ADC antibody) is a monoclonal antibody targeting the prolactin receptor (PRLR) and can block prolactin‑mediated activation of PRLR. REGN2878 exhibits an equilibrium dissociation constant (K_D) of 1.05 nM and an IC₅₀ of 0.344 nM for human PRLR. REGN2878 can be rapidly internalized and degraded in lysosomes by PRLR‑positive tumor cells, showing antigen‑specific binding and targeted enrichment properties. REGN2878 derivatives can be used as an immunoPET agent for antigen‑specific imaging of PRLR‑related tumors, and can also serve as a component of ADCs to exert anti‑tumor activity in breast cancer xenograft models. REGN2878 can be used in the research of breast cancer and prostate cancer. Isotype Comparison HY-P99001 .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99238

Rolinsatamab	ADC Antibody	Inflammation/Immunology Cancer
Rolinsatamab is a IgG1κ type chimeric antibody targeting to *PRLR* (prolactin receptor). Rolinsatamab can be conjugated with pyrrolobenzodiazepine (PDB) dimer SGD-1882 (HY-101127) via a cleavable maleimidocaproyl type linker, to form an antibody-drug conjugate, Rolinsatamab talirine. One Rolinsatamab talirine has an average of 2 site-specific drug attachment engineered cysteines (S239C). The linker equips the valine-alanine dipeptide, as cathepsine B cleavage site. on an average of 2 site-specific drug attachment engineered cysteines (S239C) .

HY-P991358

XOMA-213 LFA-102; X213	Estrogen Receptor/ERR STAT Akt	Cancer
XOMA-213 (LFA-102; X213) is a human monoclonal antibody (mAb) targeting the prolactin receptor (PRLR), with a K_d value of 2 nM against the human target. XOMA-213 blocks PRL-induced cell proliferation and inhibits the activation of multiple *PRLR* ligands, including PRL and human growth hormone (hGH). XOMA-213 suppresses PRL-induced phosphorylation of Stat5, Akt and ERK1/2 in cells. XOMA-213 induces tumor regression, delays disease progression, and inhibits *PRLR* signaling as well as tumor growth. XOMA-213 can be used in research related to breast cancer .

HY-P99881

Rolinsatamab talirine ABBV 176	Drug-Linker Conjugates for ADC	Cancer
Rolinsatamab talirine (ABBV 176) is an antibody-drug conjugate (ADC) targeting prolactin receptor (PRLR). Rolinsatamab talirine consists of rolinsatamab (HY-P99238), an enzymatically cleavable peptide linker, and SGD-1882 (HY-101127) .

HY-P992449

REGN2878 PRLR ADC antibody	ADC Antibody	Cancer
REGN2878 (PRLR ADC antibody) is a monoclonal antibody targeting the prolactin receptor (PRLR) and can block prolactin‑mediated activation of PRLR. REGN2878 exhibits an equilibrium dissociation constant (K_D) of 1.05 nM and an IC₅₀ of 0.344 nM for human PRLR. REGN2878 can be rapidly internalized and degraded in lysosomes by PRLR‑positive tumor cells, showing antigen‑specific binding and targeted enrichment properties. REGN2878 derivatives can be used as an immunoPET agent for antigen‑specific imaging of PRLR‑related tumors, and can also serve as a component of ADCs to exert anti‑tumor activity in breast cancer xenograft models. REGN2878 can be used in the research of breast cancer and prostate cancer. Isotype Comparison HY-P99001 .

Species:	Human (2) Rat (1) Mouse (2) Cynomolgus (1) Canine (1)
Tag:	His (6) Fc (2)
Source:	HEK293 (6) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71235

	Prolactin R Protein, Mouse (HEK293, His) Prolactin receptor; PRL-R; PRLR; Prolactin R; PRLR	Mouse	HEK293
	Prolactin R protein serves as a receptor for the anterior pituitary hormone prolactin and significantly interacts with SMARCA1, NEK3, and VAV2.The latter two interactions are prolactin-dependent, emphasizing the role of the receptor in transducing prolactin-induced signals that are critical for multiple physiological processes, particularly in reproduction and lactation.Prolactin R Protein, Mouse (HEK293, His) is the recombinant mouse-derived Prolactin R protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P73693

	Prolactin R Protein, Rat (HEK293, His) Prolactin receptor; PRL-R; Prolactin R	Rat	HEK293
	Prolactin R protein is a receptor for prolactin and can initiate signaling cascades to regulate physiological processes.Interacting with SMARCA1, it may be involved in chromatin remodeling.Prolactin R Protein, Rat (HEK293, His) is the recombinant rat-derived Prolactin R protein, expressed by HEK293 , with C-His labeled tag.

HY-P73696

	Prolactin R Protein, Human (HEK293, His) Prolactin receptor; PRL-R; Prolactin R	Human	HEK293
	The prolactin R protein is the receptor for prolactin, encoded by this gene, and promotes prolactin-dependent signaling through ligand-induced dimerization. This gene exhibits multiple splice variants, encodes multiple isoforms, and has a potential role in regulating the endocrine and autocrine effects of prolactin. Prolactin R Protein, Human (HEK293, His) is the recombinant human-derived Prolactin R protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P73694

	Prolactin R Protein, Mouse (HEK293, His-Fc) Prolactin receptor; PRL-R; Prolactin R	Mouse	HEK293
	Prolactin R protein serves as a receptor for the anterior pituitary hormone prolactin and significantly interacts with SMARCA1, NEK3, and VAV2.The latter two interactions are prolactin-dependent, emphasizing the role of the receptor in transducing prolactin-induced signals that are critical for multiple physiological processes, particularly in reproduction and lactation.Prolactin R Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived Prolactin R protein, expressed by HEK293 , with C-hFc, C-His labeled tag.

HY-P700814

	Prolactin R Protein, Cynomolgus (HEK293, His) PRL-R; HPRL; MFAB; Prolactin R	Cynomolgus	HEK293
	The prolactin R protein is a receptor for prolactin that promotes multiple molecular interactions, such as association with SMARCA1, suggesting a possible involvement in chromatin remodeling. Its prolactin-dependent interaction with NEK3 and VAV2 suggests interactions that regulate responses to stimuli. Prolactin R Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Prolactin R protein, expressed by HEK293 , with C-His labeled tag.

HY-P77822

	Prolactin R Protein, Canine (HEK293, Fc) PRL-R; HPRL; MFAB; Prolactin R	Canine	HEK293
	Prolactin R protein serves as a receptor for the anterior pituitary hormone prolactin and significantly interacts with SMARCA1, NEK3, and VAV2. The latter two interactions are prolactin-dependent, emphasizing the role of the receptor in transducing prolactin-induced signals that are critical for multiple physiological processes, particularly in reproduction and lactation. Prolactin R Protein, Canine (HEK293, Fc) is the recombinant canine-derived Prolactin R protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P701033

	PTP4A3 Protein, Human (His) PRL-R; Protein-tyrosine phosphatase 4a3; Protein-tyrosine phosphatase of regenerating liver 3; PRL-3; PRL3; PTP4A3	Human	E. coli
	PTP4A3 Protein, a tyrosine phosphatase, accelerates cell cycle progression from G1 to S phase, fostering cell proliferation, motility, and invasion. Its role extends to promoting cancer metastasis, and it may contribute to cardiac hypertrophy progression by inhibiting intracellular calcium mobilization in response to angiotensin II. PTP4A3 Protein, Human (His) is the recombinant human-derived PTP4A3 protein, expressed by E. coli , with N-His labeled tag.

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Host:	Rabbit (2)
Reactivity:	Human (1) Rat (1) Mouse (1)
Application:	IHC-P (1) ICC/IF (1) IF-Tissue (1) WB (1) IHC-F (1)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (2) Recombinant (2)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P87635

	PRLR Antibody (YA7319)	IHC-P, IHC-F, IF-Tissue, ICC/IF
	PRLR Antibody (YA7319) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PRLR.

HY-P82666

	Prolactin Receptor Antibody (YA2411) CPRLP; HPRL; hPRL receptor; Lactogen receptor; MFAB; OPR; Pr-1; Pr-3; PRLR; Prolactin receptor a	WB	Human, Mouse, Rat
	Prolactin Receptor Antibody (YA2411) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Prolactin Receptor.

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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-RS11163

PRLR Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PRLR Human Pre-designed siRNA Set A contains three designed siRNAs for PRLR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17413

Prlr Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Prlr Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prlr gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23867

Prlr Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Prlr Rat Pre-designed siRNA Set A contains three designed siRNAs for Prlr gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS11411

PTP4A3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PTP4A3 Human Pre-designed siRNA Set A contains three designed siRNAs for PTP4A3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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