637 Results for "

Plant Inhibitors

" in MedChemExpress (MCE) Product Catalog:
Products (637)

637 Results for "Plant Inhibitors" in MCE Product Catalog:

85
Kaempferol
Kaempferol
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85 Publications Verification
Cat. No.: HY-14590
CAS No.: 520-18-3
Purity:  99.92%
Synonyms: Kempferol; Robigenin
Category:  

Flavonols Anti-aging Plants Endogenous metabolite Human Gut Microbiota Metabolites other families Flavonoids Microorganisms Sunscreen Phenols Polyphenols Cosmetic Research Disease Research Fields Cancer

Target:  

Estrogen Receptor/ERR Autophagy Mitophagy Apoptosis HIV Parasite Endogenous Metabolite

Kaempferol (Kempferol), a flavonoid found in many edible plants, inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK. Kaempferol can be uesd for the research of breast cancer .
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34
Artemisinin
Artemisinin
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34 Cited Publications
Cat. No.: HY-B0094
CAS No.: 63968-64-9
Synonyms: Qinghaosu; NSC 369397
Category:  

Infection Piscidia erythrina L. Neurological Disease Terpenoids Sesquiterpenes Plants Compositae Disease Research Fields

Target:  

HCV Parasite Akt Ferroptosis

Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .
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34
Rutin
Rutin
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34 Cited Publications
Cat. No.: HY-N0148
CAS No.: 153-18-4
Synonyms: Rutoside; Quercetin 3-O-rutinoside
Category:  

Flavonols Plants other families Flavonoids Leguminosae Sunscreen Phenols Polyphenols Cosmetic Research Disease Research Fields Glycyrrhiza uralensis Fisch. Cancer

Target:  

Amyloid-β Autophagy Apoptosis Endogenous Metabolite

Rutin (Rutoside) is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin is also a CBR1 inhibitor, which can cross the blood brain barrier. Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress .
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24
Lycorine
Lycorine
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24 Cited Publications
Cat. No.: HY-N0288
CAS No.: 476-28-8
Category:  

Alkaloids other families Pyrrole Alkaloids Plants Disease Research Fields Isoquinoline Alkaloids Inflammation/Immunology Amaryllidaceae

Target:  

Fatty Acid Synthase (FASN) Virus Protease Bacterial Apoptosis

Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant. Lycorine is a potent and orally active SCAP inhibitor with a Kd value 15.24 nM. Lycorine downregulates the SCAP protein level without changing its transcription . Lycorine is also a melanoma vasculogenic inhibitor . Lycorine can be used for the study of prostate cancer and metabolic diseases .
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22
Guggulsterone
Guggulsterone
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22 Cited Publications
Cat. No.: HY-107738
CAS No.: 95975-55-6
Purity:  99.81%
Synonyms: Z/E-Guggulsterone
Category:  

Triterpenes Terpenoids Plants Burseraceae Disease Research Fields Commiphora wightii Cancer

Target:  

Apoptosis JNK Akt Caspase FXR Autophagy

Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt . Guggulsterone, a farnesoid X receptor (FXR) antagonist, with IC50s of 24.06 μM and 39.05 μM for (-)-(E)-Guggulsterone (HY-N7781) and (Z)-Guggulsterone (HY-110066), respectively .
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18
Rosmarinic acid
Rosmarinic acid
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18 Cited Publications
Cat. No.: HY-N0529
CAS No.: 20283-92-5
Synonyms: Labiatenic acid
Category:  

Paramacrolobium coeruleum (Taub.) J.Léonard Labiatae Other Phenylpropanoids Phenylpropanoids Plants Endogenous metabolite Disease Research Fields Cancer

Target:  

Monoamine Oxidase COMT Apoptosis Endogenous Metabolite

Rosmarinic acid is a widespread phenolic ester compound in the plants. Rosmarinic acid inhibits MAO-A, MAO-B and COMT enzymes with IC50s of 50.1, 184.6 and 26.7 μM, respectively.
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10
Morin
Morin
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10 Cited Publications
Cat. No.: HY-N0621
CAS No.: 480-16-0
Category:  

Flavonols other families Flavonoids Phenols Polyphenols Plants Disease Research Fields Cancer

Target:  

Environmental Pollutants Reactive Oxygen Species (ROS) Phosphatase Insulin Receptor Apoptosis

Morin is an orally active plant-derived flavonoid. Morin inhibits ROS generation. Morin induces Apoptosis. Morin inhibits PTP1B (IC50 of 15 μM) and activates the insulin receptor. Morin has a detoxifying effect. Morin can be used in diabetes, leukemia, colon cancer, cervical cancer, Parkinson's disease and hypertension research .
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10
Spermine
Spermine
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10 Cited Publications
Cat. No.: HY-B1777
CAS No.: 71-44-3
Synonyms: NSC 268508; Neuridine
Category:  

Human Gut Microbiota Metabolites Natural Products Microorganisms Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite Bacterial Reactive Oxygen Species (ROS) DNA/RNA Synthesis

Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells. Spermine is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine inhibits primary human embryo lung fibroblasts in vitro .
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10
Spermine tetrahydrochloride
Spermine tetrahydrochloride
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10 Cited Publications
Cat. No.: HY-B1777A
CAS No.: 306-67-2
Category:  

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite Bacterial Reactive Oxygen Species (ROS) DNA/RNA Synthesis

Spermine tetrahydrochloride is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine tetrahydrochloride occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine tetrahydrochloride inhibits primary human embryo lung fibroblasts in vitro. Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine induces neurotoxicity in the striarum dose-dependently. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells .
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8
Forsythoside B
Forsythoside B
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8 Cited Publications
Cat. No.: HY-N0029
CAS No.: 81525-13-5
Category:  

Oleaceae Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Plants Forsythia suspensa (Thunb.) Vahl Disease Research Fields Inflammation/Immunology

Target:  

TNF Receptor NF-κB

Forsythoside B is a phenylethanoid glycoside isolated from Forsythia suspensa (Thunb.) Vahl, a Chinese folk medicinal plant for treating inflammatory diseases and promoting blood circulation. Forsythoside B could inhibit TNF-alpha, IL-6, IκB and modulate NF-κB.
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8
SL 0101-1
SL 0101-1
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8 Cited Publications
Cat. No.: HY-15237
CAS No.: 77307-50-7
Purity:  ≥98.0%
Synonyms: SL0101
Category:  

Flavonols other families Flavonoids Pityrogramma triangularis Plants Disease Research Fields Cancer

Target:  

Ribosomal S6 Kinase (RSK)

SL 0101-1 (SL0101), a kaempferol glycoside, isolated from the tropical plant F. refracta, is a cell-permeable, selective, reversible, ATP-competitive p90 Ribosomal S6 Kinase (RSK) inhibitor, with an IC50 of 89 nM . SL 0101-1 (SL0101) is a selective RSK1/2 inhibitor, with a Ki of 1 μM .
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8
(Z)-Guggulsterone
(Z)-Guggulsterone
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8 Cited Publications
Cat. No.: HY-110066
CAS No.: 39025-23-5
Purity:  99.30%
Category:  

Commiphora myrrha (Nees) Engl. Plants Burseraceae Disease Research Fields Cancer Steroids

Target:  

Apoptosis VEGFR Akt Angiotensin-converting Enzyme (ACE) SARS-CoV FXR

(Z)-Guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. (Z)-Guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis . (Z)-Guggulsterone is also a potent FXR antagonist. (Z)-Guggulsterone reduces ACE2 expression and SARS-CoV-2 infection .
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8
Tryptanthrin
Tryptanthrin
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8 Cited Publications
Cat. No.: HY-N6607
CAS No.: 13220-57-0
Category:  

Alkaloids Polygonaceae Plants Disease Research Fields Inflammation/Immunology Polygonum tinctorium Ait. Indole Alkaloids

Target:  

Leukotriene Receptor NO Synthase NF-κB COX TNF Receptor Interleukin Related

Tryptanthrin is an indole quinazoline that could be an alkaloid from indigo-bearing plants. Tryptanthrin is a potent and orally active cellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin has anticancer activity. Tryptanthrin suppresses the expression levels of NOS1, COX-2, and NF-κB and regulates the expression levels of IL-2, IL-10, and TNF-α .
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8
Daphnetin
Daphnetin
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8 Cited Publications
Cat. No.: HY-N0281
CAS No.: 486-35-1
Synonyms: 7,8-Dihydroxycoumarin
Category:  

Daphne  Thymelaeaceae Coumarins Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Cancer

Target:  

EGFR PKA PKC Autophagy Apoptosis AMPK Akt mTOR Reactive Oxygen Species (ROS) Caspase Bcl-2 Family PARP Parasite

Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1β, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research .
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7
Cyclo(Phe-Pro)
Cyclo(Phe-Pro)
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7 Cited Publications
Cat. No.: HY-P1934
CAS No.: 14705-60-3
Synonyms: Cyclo(phenylalanylprolyl); A-64863
Target:  

HCV Bacterial Antibiotic Reactive Oxygen Species (ROS)

Research Areas:  

Infection

Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)) is a quorum-sensing molecule of Vibrio vulnificus that specifically interacts with RIG-I, inhibiting RIG-I polyubiquitination, suppressing IRF-3 activation, and reducing type I interferon production. Cyclo(Phe-Pro) enhances susceptibility to HCV and influenza virus and also alleviates plant aluminum toxicity stress. The mechanism of Cyclo(Phe-Pro) involves the regulation of host immune signaling pathways, bacterial virulence gene expression, and plant antioxidant systems, making it a promising candidate for research in viral infections, bacterial virulence regulation, and agricultural stress resistance .
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7
Hinokiflavone
Hinokiflavone
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7 Cited Publications
Cat. No.: HY-N2360
CAS No.: 19202-36-9
Category:  

Flavonoids Phenols Polyphenols Selaginellaceae Plants Disease Research Fields Selaginella tamariscina (P. Beauv.) Spring Biflavones Cancer

Target:  

E1/E2/E3 Enzyme Apoptosis MMP ClpP

Hinokiflavone is a novel modulator of pre-mRNA splicing activity extracted from plants with anti-inflammatory, anti-tumor and antiviral activities. Hinokiflavone is also a potent inhibitor for matrix metalloproteinases (MMPs). Hinokiflavone attenuates the virulence of Methicillin (HY-121544)-resistant staphylococcus aureus by inhibiting caseinolytic protease P (ClpP) with an IC50 value of 34.36 mg/mL. Hinokiflavone induces apoptosis via the reactive oxygen species-mitochondria-mediated apoptotic pathway and inhibits tumor cell migration and invasion. Hinokiflavone is a SUMO protease inhibitor against sentrin-specific protease 1 (SENP1) activity .
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6
Jarin-1
Jarin-1
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6 Cited Publications
Cat. No.: HY-115521
CAS No.: 1212704-51-2
Purity:  99.17%
Target:  

Phytohormone

Research Areas:  

Others

Jarin-1 is a jasmonic acid-amido synthetase (JAR1) inhibitor with an IC50 of 3.8 μM. Jarin-1 specific inhibits bioactive JA (jasmonoyl-isoleucine, JA-Ile) biosynthesis in Arabidopsis and other plants .
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6
2'-Deoxyguanosine
2'-Deoxyguanosine
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6 Cited Publications
Cat. No.: HY-17563
CAS No.: 961-07-9
Synonyms: Deoxyguanosine; Guanine deoxyriboside
Target:  

Endogenous Metabolite

Research Areas:  

Cancer

2’-Deoxyguanosine (Deoxyguanosine) is a purine nucleoside with a variety of biological activities. 2’-Deoxyguanosine can induce DNA division in mouse thymus cells. 2’-Deoxyguanosine is a potent cell division inhibitor in plant cells .
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6
Solasodine
Solasodine
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6 Cited Publications
Cat. No.: HY-N0068
CAS No.: 126-17-0
Synonyms: Purapuridine; Solancarpidine; Solasodin
Category:  

Cardiovascular Disease Neurological Disease Plants Infection Alkaloids Piperidine Alkaloids Solanum nigrum Linn. Solanaceae Disease Research Fields Inflammation/Immunology

Target:  

MDM-2/p53 Fungal E1/E2/E3 Enzyme Apoptosis

Solasodine (Purapuridine) is a steroidal alkaloid that occurs in plants of the Solanaceae family. Solasodine induces apoptosis by inhibiting the p53-MDM2 complex, p21Waf1/Cip1, and Bcl-2 proteins. Solasodine has neuroprotective, antifungal, hypotensive, anticancer, antiatherosclerotic, antiandrogenic and anti-inflammatory activities .
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5
Syringaldehyde
Syringaldehyde
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5 Cited Publications
Cat. No.: HY-N1390
CAS No.: 134-96-3
Category:  

Microorganisms Monophenols Ketones, Aldehydes, Acids Manihot esculenta Crantz Phenols Euphorbiaceae Plants Disease Research Fields Inflammation/Immunology

Target:  

COX

Syringaldehyde is a polyphenolic compound belonging to the group of flavonoids and is found in different plant species like Manihot esculenta and Magnolia officinalis . Syringaldehyde moderately inhibits COX-2 activity with an IC50 of 3.5 μg/mL . Anti-hyperglycemic and anti-inflammatory activities .
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