Search Result

Results for "

Pro-Gly-Pro

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (3) Aminopeptidase (2) Amyloid-β (2) Angiotensin-converting Enzyme (ACE) (1) Apelin Receptor (APJ) (2) Apoptosis (2) Bacterial (5) Bcl-2 Family (1) BCL6 (1) Biochemical Assay Reagents (1) Calcium Channel (1) Calmodulin (1) Caspase (1) Collagen (2) CXCR (1) Drug Derivative (1) Drug Intermediate (1) Endogenous Metabolite (2) ERK (1) Fungal (2) GABA Receptor (1) Gli (1) GnRH Receptor (1) HIV (2) IFNAR (1) Interleukin Related (1) JNK (2) Leukotriene Receptor (2) Mas-related G-protein-coupled Receptor (MRGPR) (1) mTOR (1) nAChR (2) Opioid Receptor (2) Orexin Receptor (OX Receptor) (1) p38 MAPK (1) PERK (1) PI3K (1) PKA (1) Sodium Channel (1) TNF Receptor (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (6) Endocrinology (2) Infection (9) Inflammation/Immunology (11) Metabolic Disease (7) Neurological Disease (10)

By Targets:

Akt (3)

Aminopeptidase (2)

Amyloid-β (2)

Angiotensin-converting Enzyme (ACE) (1)

Apelin Receptor (APJ) (2)

Apoptosis (2)

Bacterial (5)

Bcl-2 Family (1)

BCL6 (1)

Biochemical Assay Reagents (1)

Calcium Channel (1)

Calmodulin (1)

Caspase (1)

Collagen (2)

CXCR (1)

Drug Derivative (1)

Drug Intermediate (1)

Endogenous Metabolite (2)

ERK (1)

Fungal (2)

GABA Receptor (1)

Gli (1)

GnRH Receptor (1)

HIV (2)

IFNAR (1)

Interleukin Related (1)

JNK (2)

Leukotriene Receptor (2)

Mas-related G-protein-coupled Receptor (MRGPR) (1)

mTOR (1)

nAChR (2)

Opioid Receptor (2)

Orexin Receptor (OX Receptor) (1)

p38 MAPK (1)

PERK (1)

PI3K (1)

PKA (1)

Sodium Channel (1)

TNF Receptor (1)

By Research Areas:

Cancer (4)

Cardiovascular Disease (6)

Endocrinology (2)

Infection (9)

Inflammation/Immunology (11)

Metabolic Disease (7)

Neurological Disease (10)

Inhibitors & Agonists

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P4486

*H-Pro-Gly-Pro-OH* Pro-Gly-Pro	Drug Derivative	Others
H-Pro-Gly-Pro-OH is a collagen-derived matrikine that has classically been described as a neutrophil chemoattractant. H-Pro-Gly-Pro-OH is perfectly positioned to focus neutrophils on the site required and direct a localized repair response. H-Pro-Gly-Pro-OH activates the transcription of neurotrophins and their receptor genes after cerebral ischemia .

HY-P4860

Adropin (34-76) (human, mouse, rat) 1 Publications Verification	Akt Gli JNK PKA	Metabolic Disease
Adropin (34-76) is a secretory domain of Adropin. Adropin (34-76) can inhibit cAMP level and glucose production in hepatocytes, and has a hypoglycemic effect. Adropin (34-76) plays an antifibrotic role by inhibiting the GLI1 signaling pathway .

HY-P1146

Semax 1 Publications Verification	Amyloid-β	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Semax is a BBB-penetrable adrenocorticotropic hormone-like peptide and can form stable complexes with Cu ²⁺. Semax is a synthetic peptide analog of Adrenocorticotropic hormone (ACTH) (4-10). Semax has immunomodulatory, nootropic and neuroprotective activities. Semax can be used in the research of central nervous system diseases such as Alzheimer's disease and cerebral ischemia .

HY-P0179

β-Casomorphin, bovine β-Casomorphin-7 (bovine); Bovine β-casomorphin-7	Opioid Receptor	Neurological Disease Metabolic Disease
β-Casomorphin, bovine (β-Casomorphin-7 (bovine) ) is a opioid peptide with an IC₅₀ of 14 μM in an Opioid receptors binding assay .

HY-105042

Selank Selanc; TP-7	GABA Receptor	Neurological Disease
Selank (Selanc; TP-7) is a GABAA receptor modulator with anxiolytic activity. Selank allosterically modulates the specific binding of GABA to GABAA receptors and alters the affinity of endogenous ligands for these receptors. Selank reduces elevated anxiety levels, attenuates stress-induced exacerbation of anxiety, and produces a synergistic anxiolytic effect with diazepam. Selank can be used in the research of anxiety disorders .

HY-P4846

*Ac-Pro-Gly-Pro-OH* 2 Publications Verification	CXCR Apoptosis IFNAR TNF Receptor Interleukin Related	Infection Inflammation/Immunology
Ac-Pro-Gly-Pro-OH is an endogenous degradation product of extracellular collagen and acts as a CXCR2 agonist . Ac-Pro-Gly-Pro-OH exerts bactericidal activity by generating hydrogen peroxide, inhibits pulmonary inflammation, and reduces immune cell apoptosis (apoptosis). Ac-Pro-Gly-Pro-OH promotes the production of IFN-γ and inhibits the production of TNF-α and IL-6 in leukocytes. Ac-Pro-Gly-Pro-OH increases the survival rate of mice in sepsis models, enhances the bactericidal activity of neutrophils, acts as a neutrophil chemoattractant, induces neutrophil polarization, and regulates inflammatory and repair processes. Ac-Pro-Gly-Pro-OH induces chronic inflammation and tissue remodeling through sustained action. Ac-Pro-Gly-Pro-OH is released via alkaline hydrolysis of corneal proteins in alkali-injured eyes, thereby driving the early infiltration of neutrophils into the cornea. Ac-Pro-Gly-Pro-OH is applicable to research related to sepsis, chronic obstructive pulmonary disease, cystic fibrosis, bronchiolitis obliterans syndrome, severe asthma, idiopathic pulmonary fibrosis, and corneal ulcer .

HY-P10904

Vezocolmitide ST-100	Collagen	Others
Vezocolmitide (ST-100) is a collagen mimetic peptide. Vezocolmitide can rapidly repair damaged collagen triple helix structures, thereby quickly reversing damage to the ocular surface and extracellular matrix, and restoring corneal nerve function while repairing the epithelium. Vezocolmitide can be used for research of dry eye disease (DED) .

HY-P1146A

Semax acetate 1 Publications Verification	Amyloid-β	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Semax acetate is a BBB-penetrable adrenocorticotropic hormone-like peptide and can form stable complexes with Cu ²⁺. Semax acetate is a synthetic peptide analog of Adrenocorticotropic hormone (ACTH) (4-10). Semax acetate has immunomodulatory, nootropic and neuroprotective activities. Semax acetate can be used in the research of central nervous system diseases such as Alzheimer's disease and cerebral ischemia .

HY-P1349

Orexin B, rat, mouse 1 Publications Verification Rat orexin B; Orexin B (mouse)	Orexin Receptor (OX Receptor)	Neurological Disease Endocrinology
Orexin B, rat, mouse (Rat orexin B) is an endogenous agonist at Orexin receptor with K_is of 420 and 36 nM for OX1 and OX2, respectively.

HY-P11087

P15	Collagen	Others
P15 is a collagen mimetic peptide with the sequence of GTPGPQGIAGQRGVV. P15 can mimic the cell-binding domain of human type I collagen. P15 is capable of promoting the adhesion, proliferation, and differentiation of osteoblasts. Biomaterials modified with P15 can be used in research related to bone regeneration .

HY-P1064

Apelin-36(human)	Apelin Receptor (APJ) HIV	Infection Cardiovascular Disease Metabolic Disease
Apelin-36(human) is an endogenous orphan G protein-coupled receptor APJ agonist, with an EC₅₀ of 20 nM. Apelin-36(human) shows high affinity to human APJ receptors expressed in HEK 293 cells (pIC₅₀=8.61). Apelin-36 has been linked to two major types of biological activities: cardiovascular and metabolic. Apelin-36(human) inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ .

HY-P5731

Bac7(1-35)	Bacterial	Infection
Bac7(1-35) is a proline-rich antimicrobial peptide. Bac7(1-35) efficiently binds to different regions of prokaryote ribosomes, leading to the inhibition of protein synthesis. Bac7(1-35) demonstrates in vitro activity against P. aeruginosa strains .

HY-P3395

Catestatin (human) Human chromogranin A 352–372	nAChR	Cardiovascular Disease Inflammation/Immunology
Catestatin human, a catecholamine release-inhibitory peptide, is a pleiotropic peptide involved in cardiovascular protection with its antihypertensive and angiogenic effects. Catestatin human can be used in the study of inflammatory diseases .

HY-P1064A

Apelin-36(human) TFA	HIV Apelin Receptor (APJ)	Infection Cardiovascular Disease Metabolic Disease
Apelin-36(human) TFA is an endogenous orphan G protein-coupled receptor APJ agonist, with an EC₅₀ of 20 nM. Apelin-36(human) TFA shows high affinity to human APJ receptors expressed in HEK 293 cells (pIC5₅₀=8.61). Apelin-36(human) TFA has been linked to two major types of biological activities: cardiovascular and metabolic. Apelin-36(human) TFA inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ .

HY-P1067

Enterostatin(human,mouse,rat)	Endogenous Metabolite	Metabolic Disease
Enterostatin, human, mouse, rat is a pentapeptide that reduces fat intake.

HY-P5731A

Bac7(1-35) acetate	Bacterial	Infection
Bac7(1-35) acetate is a proline-rich antimicrobial peptide. Bac7(1-35) acetate efficiently binds to different regions of prokaryote ribosomes, leading to the inhibition of protein synthesis. Bac7(1-35) acetate demonstrates in vitro activity against P. aeruginosa strains .

HY-156960

JNJ-40929837	Aminopeptidase Leukotriene Receptor	Inflammation/Immunology
JNJ-40929837 is a selective and orally active LTA₄H (leukotriene A₄ hydrolase) inhibitor. JNJ-40929837 effectively inhibits aminopeptidase activity and causes serum accumulation of Pro-Gly-Pro. JNJ-40929837 can be used in asthma research .

HY-156960A

JNJ-40929837 succinate	Aminopeptidase Leukotriene Receptor	Inflammation/Immunology
JNJ-40929837 succinate is a selective and orally active LTA₄H (leukotriene A₄ hydrolase) inhibitor. JNJ-40929837 succinate effectively inhibits aminopeptidase activity and causes serum accumulation of Pro-Gly-Pro. JNJ-40929837 succinate can be used in asthma research .

HY-P5735

Bactenecin 7 Bac-7	Bacterial	Infection
Bactenecin 7 is an antibacterial peptide active against the growth of Enterobacter cloacae (MICs, 25 to 200μg/ml) .

HY-P10992

YVPGP	PI3K Akt mTOR Caspase Apoptosis Bcl-2 Family	Cancer
YVPGP is an oligopeptide exacted from Anthopleura anjunae. YVPGP has a significant antitumor activity by mediating PI3K/AKT/mTOR signaling pathway. YVPGP arrests DU-145 cells in the S phase and induces apoptosis via mitochondrial and death receptor pathways (caspase3, 7, 8, 9). YVPGP effectively inhibits tumor growth in DU-145 xenografts mice model, promising for prostate cancer research .

HY-P5440

ERKtide	ERK	Others
ERKtide is a biological active peptide. (ERKtide is a peptide substrate for ERK2. Extracellular regulated protein kinase 2 (ERK2) is a eukaryotic protein kinase whose activity is regulated by mitogenic stimuli.)

HY-P11313

Catestatin (rat) Rat chromogranin A367–387	nAChR Akt	Cardiovascular Disease
Catestatin (rat) (Rat chromogranin A367–387) is a potent, reversible, noncompetitive, and noncooperative nicotinic cholinergic antagonist derived from chromogranin A (A_367-387). Catestatin (rat) inhibits norepinephrine release in rat PC12 pheochromocytoma cells (IC₅₀ = 1.2 μM), and blocks desensitization of norepinephrine release (IC₅₀ = 0.62 μM). Catestatin (rat) exerts antiadrenergic effects through the endothelial PI3K-AKT-eNOS pathway in rat papillary muscles and isolated cardiomyocytes. Catestatin (rat) maintains mitochondrial membrane potential in I/R cardiomyocytes and increases phosphorylation of AKT at S473, GSK3β at S9, PLB at T17, and eNOS at S1179. Catestatin (rat) reverses desensitization of ²²Na ⁺ uptake. Catestatin (rat) can be used for the study of nicotinic cholinergic receptor regulation and catecholamine release control mechanisms .

HY-P5569

SP-B peptide	Fungal	Infection
SP-B peptide is an antimicrobial peptide. SP-B peptide has antifungal activity against strains of Cryptococcus neoformans, Candida albicans and Aspergillus fumigatus

HY-P1067A

Enterostatin(human,mouse,rat) TFA	Endogenous Metabolite	Metabolic Disease
Enterostatin (human,mouse,rat) TFA is a pentapeptide mainly formed in the intestine by the cleavage of secreted pancreatic procolipase. Enterostatin selectively reduces fat intake, bodyweight, and body fat in vivo .

HY-P0179A

β-Casomorphin, bovine TFA β-Casomorphin-7 (bovine) TFA; Bovine β-casomorphin-7 TFA	Opioid Receptor	Neurological Disease Metabolic Disease
β-Casomorphin, bovine TFA (β-Casomorphin-7 (bovine) TFA) is a opioid peptide with an IC₅₀ of 14 μM in an Opioid receptors binding assay .

HY-P4979

Cdc25A (80-93) (human)	Biochemical Assay Reagents	Cancer
Cdc25A (80-93) (human) is a polypeptide that controls the cell proliferation and tumorigenesis by a change in expression of proteins involved in cyclin D1 regulation and G1/S transition. Cdc25A (80-93) (human) can be used in cancer research .

HY-P3041

Chromostatin (bovine)	Calcium Channel	Endocrinology
Chromostatin bovine is a chromogranin A (CGA) derivative peptide, which inhibits postassium or carbamoylcholine induced catecholamine release with an ID₅₀ of 5 nM. Chromostatin bovine reduces calcium flux, enhances the desensitization process of the cholinergic-evoked secretory response and modulates the endocrine response associated with catecholamine .

HY-P10566

BCOR(498-514), biotinylated	BCL6	Cancer
BCOR(498-514), biotinylated is the minimal BCL6 binding domain with an K_D value of 1.32 µM. BCOR(498-514), biotinylated blocks BCL6-mediated transcriptional repression and kills lymphoma cells .

HY-P2471

Neurogranin (48-76), mouse	Calmodulin	Neurological Disease
Neurogranin (48-76), mouse is a peptide corresponding to residues 48-76 of Neurogranin. Neurogranin, a calmodulin-binding protein, is exclusively expressed in the post-synapse, and mediates NMDAR driven synaptic plasticity by regulating the calcium-calmodulin (Ca ²⁺-CaM) pathway .

HY-P5783

δ-Buthitoxin-Hj2a	Sodium Channel	Neurological Disease
δ-Buthitoxin-Hj2a, a scorpion-venom peptide, is a potent NaV1.1 agonist with an EC₅₀ of 32 nM. δ-Buthitoxin-Hj2a can be used for the Dravet syndrome (DS) research .

HY-P11740

VYPFPGPIHN	Angiotensin-converting Enzyme (ACE) Drug Intermediate	Others
VYPFPGPIHN is a precursor peptide of β-casomorphin (HY-P0179) and also an ACE inhibitor (IC₅₀ = 123 μM). VYPFPGPIHN resists hydrolysis by peptidases associated with intestinal cell monolayers, maintaining structural integrity and ACE inhibitory activity. VYPFPGPIHN is not extensively taken up or transported by differentiated intestinal cell monolayers .

HY-P3395A

Catestatin sCst	PERK JNK p38 MAPK	Inflammation/Immunology
Catestatin sCst is a negative control peptide with a scrambled amino acid sequence. Catestatin sCst fails to activate human mast cells and is used to verify the specificity of Catestatin action .

HY-P11478

Catestatin (mouse)	Mas-related G-protein-coupled Receptor (MRGPR) Bacterial	Infection Inflammation/Immunology
Catestatin (mouse) is an antimicrobial peptide. Catestatin (mouse) robustly activates Mrgprb2 with an EC₅₀ of 59.73 μM. Catestatin (mouse) is effective in promoting MRSA clearance from wound infections. Catestatin (mouse) dampens the inflammatory immune response to MRSA infection .

HY-P11125

Metchnikowin	Bacterial Fungal	Infection
Metchnikowin is a fruit fly antimicrobial peptide rich in proline, with dual antibacterial and antifungal activities. Metchnikowin can be independently regulated by TOLL and IMD pathways. Metchnikowin is often used in the research of infectious conditions .

HY-P11181

Chorionic Gonadotropin-beta (109-145) (human) hCGβ (109–145)	GnRH Receptor	Inflammation/Immunology
Chorionic Gonadotropin-beta (109-145) (human) is the carboxyl-terminal part (109-145) of the human chorionic gonadotropin beta subunit. Chorionic Gonadotropin-beta (109-145) (human) can be used in the research of immune responses .

Cat. No.	Product Name	Target	Research Area