25 Results for "

Prostaglandin D Metabolite

" in MedChemExpress (MCE) Product Catalog:
Products (25)

25 Results for "Prostaglandin D Metabolite" in MCE Product Catalog:

3
3 Cited Publications
Cat. No.: HY-108568
CAS No.: 87893-55-8
Purity:  97.50%
Synonyms: 15d-PGJ2; 15-Deoxy-Δ12,14-PGJ2
15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC50 of 2 µM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC50 of 7 μM .
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1 Cited Publications
Cat. No.: HY-118830
CAS No.: 59894-07-4
Purity:  99.90%
Synonyms: DK-PGD2; 15-Oxo-13,14-dihydro-PGD2; 13,14-Dihydro-15-keto-PGD2
13,14-Dihydro-15-keto prostaglandin D2 (DK-PGD2; 15-Oxo-13,14-dihydro-PGD2; 13,14-Dihydro-15-keto-PGD2) is a metabolite of Prostaglandin D2 (HY-101988) and acts as a CRTH2 agonist. 13,14-Dihydro-15-keto-prostaglandin D2 exhibits binding activity to CRTH2, induces cellular calcium signaling flux, and mediates eosinophilia in vivo. 13,14-Dihydro-15-keto-prostaglandin D2 activates the CRTH2 receptor, triggering Gi-dependent intracellular calcium mobilization and promoting the migration and recruitment of leukocytes from bone marrow to peripheral blood in vivo. 13,14-Dihydro-15-keto prostaglandin D2 is used in research on inflammation-related diseases, such as bronchial asthma .
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1 Cited Publications
Cat. No.: HY-N4237
CAS No.: 5573-16-0
Saikogenin D is isolated from?Bupleurum chinense, has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of [Ca 2+]i due to Ca 2+ release from intracellular stores .
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1 Cited Publications
Cat. No.: HY-108568S
CAS No.: 1542166-82-4
Purity:  98.10%
Synonyms: 15d-PGJ2-d4; 15-Deoxy-Δ12,14-PGJ2-d4
15-Deoxy-Δ-12,14-prostaglandin J2-d4 is the deuterium labeled 15-Deoxy-Δ-12,14-prostaglandin J2. 15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC50 of 2 μM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC50 of 7 μM .
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Cat. No.: HY-113366
CAS No.: 60203-57-8
Purity:  98.10%
Synonyms: PGJ2
Prostaglandin J2 (PGJ2), an endogenous metabolite of Prostaglandin D2 (PGD2; HY-101988), is a potent PGD2 receptor (DP) agonist with Kis of 0.9 nM and 6.6 nM for hDP and hCRTH2, respectively. Prostaglandin J2 stimulates intracellular cyclic AMP production with an EC50 value of 1.2 nM. Prostaglandin J2 induces oxidative stress and neuronal apoptosis. Prostaglandin J2 induces the accumulation/aggregation of ubiquitinated (Ub) proteins. Prostaglandin J2 is highly neurotoxic and potentially contributes to many neurodegenerative conditions, including Alzheimer's (AD) and Parkinson's diseases (PD) .
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Cat. No.: HY-17357S
CAS No.: 1246814-53-8
Synonyms: AHR-9434-d5; AL-6515-d5
Nepafenac-d5 (AHR-9434-d5; AL-6515-d5) is the deuterium labeled Nepafenac (HY-17357). Nepafenac, a nonsteroidal anti-inflammatory agent, is a topically administered COX-2 inhibitor with an IC50 of 0.12 μM. Nepafenac exhibits only weak COX-1 inhibitory activity (IC50 = 64.3 μM). Nepafenac possesses unique prodrug properties, which enable it to rapidly convert into the active metabolite Amfenac (HY-17479) in the ocular tissues, thereby achieving high concentrations in the retina and choroid. Nepafenac reduces inflammation and pain by inhibiting the activity of cyclooxygenase (COX) enzymes and thereby decreasing the production of prostaglandin PGE₂. Nepafenac can delay the metastasis of uveal melanoma (UM) in rabbit eyes. Nepafenac is mainly used for pain management and inflammation control after ophthalmic surgeries.
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Cat. No.: HY-176301
Synonyms: Tetranor-Prostaglandin D Metabolite lactone
Tetranor-PGDM lactone (Tetranor-prostaglandin D metabolite lactone) is a urinary metabolite of PGD2 (HY-101988). Prostaglandin D2 (PGD2) is one of the most potent endogenous sleep promoting substances. PGD2 plays a protective role by suppressing inflammation .
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Cat. No.: HY-117659
CAS No.: 133161-96-3
Synonyms: Prostaglandin D Metabolite
Research Areas:  

Inflammation/Immunology

PGDM (Prostaglandin D Metabolite) is the main urinary metabolite of Prostaglandin D2 and is prone to reversible cyclization. PGDM may serve as a biomarker for the endogenous production of PGD2 or be used to evaluate the severity of acute allergic reactions .
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Cat. No.: HY-126986
CAS No.: 70803-91-7
Research Areas:  

Metabolic Disease

Tetranor-PGDM is an abundant urinary metabolite reflects biosynthesis of prostaglandin D2 .
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Cat. No.: HY-116083
CAS No.: 1204116-69-7
Target:  

Endogenous Metabolite

Research Areas:  

Others

13,14-Dihydro-15-keto-tetranor prostaglandin D2 (Compound VI) is a prostaglandin D2 metabolite. 13,14-Dihydro-15-keto-tetranor prostaglandin D2 as a biomarker can be used to study prostaglandin D2-related diseases .
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Cat. No.: HY-113459S
CAS No.: 1542166-81-3
Prostaglandin F1a-d9 is the deuterium labeled Prostaglandin F1a . Prostaglandin F1a is an endogenous metabolite and a cyclooxygenase product with platelet activity inhibitory effects. Prostaglandin F1a can be used as a marker in coagulation-related studies .
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Cat. No.: HY-116028S1
CAS No.: 2750534-91-7
Synonyms: 15-Deoxy-Δ12,14-PGD2-d4
15-Deoxy-Δ12,14-Prostaglandin D2-d4 (15-Deoxy-Δ12,14-PGD2-d4) is the deuterium labeled 15-deoxy-Δ12,14-Prostaglandin D2. 15-deoxy-Δ12,14-Prostaglandin D2 (15-Deoxy-Δ12,14-PGD2) is a metabolite of prostaglandin D₂ (PGD₂) (HY-101988), which can undergo further dehydration metabolism to 15-deoxy-Δ12,14-PGJ₂. 15-deoxy-Δ12,14-Prostaglandin D2 is a highly selective agonist for DP2 receptor and PPARγ. 15-deoxy-Δ12,14-Prostaglandin D2 causes morphological changes in eosinophils and migration of type II innate lymphoid cells (ILC2). 15-deoxy-Δ12,14-Prostaglandin D2 has a growth inhibitory effect on prostate cancer cells expressing PPARγ, induces cell cycle arrest and promotes apoptosis. 15-deoxy-Δ12,14-Prostaglandin D2 can be used in related research on asthma and prostate cancer.
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Cat. No.: HY-116028
CAS No.: 85235-11-6
Purity:  ≥98.0%
Synonyms: 15-Deoxy-Δ12,14-PGD2
15-deoxy-Δ12,14-Prostaglandin D2 (15-Deoxy-Δ12,14-PGD2) is a metabolite of prostaglandin D₂ (PGD₂) (HY-101988), which can undergo further dehydration metabolism to 15-deoxy-Δ12,14-PGJ₂. 15-deoxy-Δ12,14-Prostaglandin D2 is a highly selective agonist for DP2 receptor and PPARγ. 15-deoxy-Δ12,14-Prostaglandin D2 causes morphological changes in eosinophils and migration of type II innate lymphoid cells (ILC2). 15-deoxy-Δ12,14-Prostaglandin D2 has a growth inhibitory effect on prostate cancer cells expressing PPARγ, induces cell cycle arrest and promotes apoptosis. 15-deoxy-Δ12,14-Prostaglandin D2 can be used in related research on asthma and prostate cancer .
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Cat. No.: HY-113205S
CAS No.: 2738376-66-2
15-Keto-prostaglandin E2-d9 is the d9 labeled 15-keto-Prostaglandin E2 (HY-113205). 15-keto-Prostaglandin E2 (15-keto-PGE2) is an endogenous PGE2 metabolite. 15-keto-Prostaglandin E2 inhibits STAT3 activation by binding to the Cys259 residue of STAT3. 15-keto-Prostaglandin E2 binds to and stabilizes EP2 and EP4 receptors. 15-keto-Prostaglandin E2 inhibits the growth and progression of breast cancer cells. 15-keto-Prostaglandin E2 activates PPAR-γ and promotes fungal growth. 15-keto-Prostaglandin E2 disrupts glomerular vascularization during zebrafish development and reduces the surface area of the glomerular filtration barrier .
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Cat. No.: HY-113205S1
CAS No.: 2738376-85-5
15-Keto-prostaglandin E2-d4 is the d4 labeled 15-keto-Prostaglandin E2 (HY-113205). 15-keto-Prostaglandin E2 (15-keto-PGE2) is an endogenous PGE2 metabolite. 15-keto-Prostaglandin E2 inhibits STAT3 activation by binding to the Cys259 residue of STAT3. 15-keto-Prostaglandin E2 binds to and stabilizes EP2 and EP4 receptors. 15-keto-Prostaglandin E2 inhibits the growth and progression of breast cancer cells. 15-keto-Prostaglandin E2 activates PPAR-γ and promotes fungal growth. 15-keto-Prostaglandin E2 disrupts glomerular vascularization during zebrafish development and reduces the surface area of the glomerular filtration barrier .
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Cat. No.: HY-129953S
Synonyms: 9α,11β-PGF2α-d-d4
9α,11β-Prostaglandin F2α-d4 is a deuterated labeled 9α,11β-Prostaglandin F2α . 9α,11β-Prostaglandin F2α is an endogenous metabolite present in Urine that can be used for the research of Asthma .
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Cat. No.: HY-176243
CAS No.: 1947405-90-4
15-Deoxy-Δ12,14-Prostaglandin J2-2-glyceryl ester is a derivate of 15-Deoxy-Δ-12,14-prostaglandin J2 (HY-108568). 15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC50 of 2 µM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC50 of 7 μM .
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Cat. No.: HY-113459S1
CAS No.: 42932-59-2
Synonyms: 13,14-Dihydro-15-keto-PGF2α-d4
13,14-Dihydro-15-keto Prostaglandin F2α-d4 (13,14-Dihydro-15-keto-PGF2α-d4) is a deuterated labeled 13,14-Dihydro-15-keto Prostaglandin F2α (HY-113208). 13,14-Dihydro-15-keto Prostaglandin F2α-d4 is an endogenous metabolite present in Blood that can be used for the research of Pregnancy .
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Cat. No.: HY-118830S1
CAS No.: 2738376-77-5
Synonyms: DK-PGD2-d9; 15-Oxo-13,14-dihydro-PGD2-d9; 13,14-Dihydro-15-keto-PGD2-d9
13,14-Dihydro-15-keto prostaglandin D2-d9 (DK-PGD2-d9; 15-Oxo-13,14-dihydro-PGD2-d9; 13,14-Dihydro-15-keto-PGD2-d9) is the deuterated-labeled 13,14-Dihydro-15-keto prostaglandin D2 (HY-118830). 13,14-Dihydro-15-keto prostaglandin D2 (DK-PGD2; 15-Oxo-13,14-dihydro-PGD2; 13,14-Dihydro-15-keto-PGD2) is a metabolite of Prostaglandin D2 (HY-101988) and acts as a CRTH2 agonist. 13,14-Dihydro-15-keto-prostaglandin D2 exhibits binding activity to CRTH2, induces cellular calcium signaling flux, and mediates eosinophilia in vivo. 13,14-Dihydro-15-keto-prostaglandin D2 activates the CRTH2 receptor, triggering Gi-dependent intracellular calcium mobilization and promoting the migration and recruitment of leukocytes from bone marrow to peripheral blood in vivo. 13,14-Dihydro-15-keto prostaglandin D2 is used in research on inflammation-related diseases, such as bronchial asthma .
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Cat. No.: HY-W740777
CAS No.: 1246819-23-7
4-Hydroxyphenylbutazone-d9 is the deuterium labeled 4-Hydroxyphenylbutazone (HY-139199). 4-Hydroxyphenylbutazone is a metabolite of Phenylbutazone. Phenylbutazone, a nonsteroidal anti-inflammatory agent (NSAID), is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS) .
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