Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
RNR
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "RNR" in MCE Product Catalog:
5
Target:
Research Areas:
COH29 (RNR Inhibitor COH29) is a potent ribonucleotide reductase (RNR) inhibitor with anticancer activity. COH29 inhibits α and β subunit of RNR with IC50s of 16 μM.
2
Monobenzone is a potent skin depigmenting agent. Monobenzone induces depigmentation and exhibits good potential for vitiligo research. Monobenzone is a potent inhibitor of RNR (Ribonucleotide reductase) enzyme activity by targeting RRM2 (a regulatory small subunit M2 of RNR) protein, and thus has significant anti-leukemia efficacy in vitro and in vivo. Monobenzone inhibits acute myeloid leukemia (AML) cells proliferation and DNA synthesis, induces cell cycle arrest, and Apoptosis .
2
2 Cited Publications
Cat. No.: HY-P700300
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NR2E3; Rd7; Nuclear Receptor Subfamily 2 Group E Member 3; RNR; PNR; Nuclear Receptor Subfamily 2, Group E, Member 3; Photoreceptor-Specific Nuclear Receptor; NR2E3 Protein; Retina-Specific Nuclear Receptor; ESCS1; RP37; ESCS
Species:
E.coli
Source:
E. coli
Cat. No.: HY-W015940
CAS No.: 1455-77-2
Target:
Guanazole is a ribonucleotide reductase (RNR) inhibitor that blocks replicative DNA synthesis by inhibiting deoxyribonucleotide biosynthesis. Guanazole selectively inhibits DNA synthesis in rapidly proliferating tissues, induces replication stress and G2/M phase arrest in Schizosaccharomyces pombe, and exhibits myelosuppressive, immunosuppressive, and anti-L1210 leukemia activities. Guanazole does not induce DNA repair and only shows slight mutagenicity towards Salmonella typhimurium TA102. Guanazole serves as an alternative tool to Hydroxyurea (HY-B0313) for replication checkpoint studies in Schizosaccharomyces pombe. Guanazole can be applied in research related to leukemia and solid tumors .
Cat. No.: HY-P10622
Research Areas:
Cat. No.: HY-RS09540
Target:
Research Areas:
NR2E3 Human Pre-designed siRNA Set A contains three designed siRNAs for NR2E3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS11841
Target:
Research Areas:
Ren1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ren1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-164497
CAS No.: 605685-94-7
Research Areas:
NSC 641396 is a ribonucleotide reductase (RNR) inhibitor with an IC50 value of 1.2 μM. NSC 641396 is also a protein arginine N-methyltransferase 9 (PRMT9) inhibitor. NSC 641396 has antitumor activity .
Cat. No.: HY-P10621
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Cat. No.: HY-P10624
CAS No.: 1191923-95-1
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Cat. No.: HY-P10623
CAS No.: 1191923-94-0
Target:
Research Areas:
Cat. No.: HY-P10625
CAS No.: 368431-25-8
Target:
Research Areas:
Cat. No.: HY-RS16371
Target:
Research Areas:
RNR1 Human Pre-designed siRNA Set A contains three designed siRNAs for RNR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P703481
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Mitochondrial-derived peptide MOTS-c; Mitochondrial open reading frame of the 12S rRNA-c; MT-RNR1
Species:
Human
Source:
E. coli
Cat. No.: HY-W791041
CAS No.: 116371-66-5
Synonyms: dFdCDP
Target:
Research Areas:
Gemcitabine 5'-diphosphate (dFdCDP) is a core active metabolic intermediate of Gemcitabine (HY-17026) and a potent ribonucleotide reductase (RNR) inhibitor. Gemcitabine 5'-diphosphate depletes deoxyribonucleotide pools, consumes deoxycytidine triphosphate and increases the phosphorylation level of gemcitabine. Gemcitabine 5'-diphosphate prolongs the intracellular retention duration of gemcitabine metabolites, enhances the nucleic acid incorporation of gemcitabine, and exerts anti-tumor/cytotoxic effects .
Cat. No.: HY-P71765
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NR4A2; NGFI-B/Nur77 Beta-Type Transcription Factor Homolog; Prev. NURR1; Nur Related Protein-1, Human Homolog Of; TINUR; Orphan Nuclear Receptor NR4A2 Isoform 1; NOT; Orphan Nuclear Receptor NR4A2 Isoform 2; HZF-3; Intermediate-Early Receptor Protein; RNR
Species:
Human
Source:
P. pastoris
Cat. No.: HY-P706173
Purity: ≥ 90%, as determined by SDS-PAGE.
Synonyms: MT-RNR2; Small Humanin-Like Peptide 3; Prev. MTRNR2; Formyl-Humanin; HN; L-RRNA; Humanin; SHLP2; 16S; SHLP4; Mitochondrially Encoded 16S RNA; SHLP5; Small Humanin-Like Peptide 2; SHLP1; Small Humanin-Like Peptide 4; SHLP6; Small Humanin-Like Peptide 5; SH
Species:
Virus
Source:
E. coli
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
