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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
SERPINA1
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "SERPINA1" in MCE Product Catalog:
Synonyms: ARO-AAT sodium
Target:
Research Areas:
Fazirsiran sodium is a second-generation RNAi agent. Fazirsiran sodium consistes of a cholesterol-conjugated RNAi trigger (chol-RNAi) to selectively degrade Alpha1-antitrypsin (AAT) mRNA by RNAi and a melittin-derived peptide conjugated to N-acetylgalactosamine (NAG) formulated as the excipient EX1 to promote endosomal escape of the chol-RNAi in hepatocytes [1]. Fazirsiran sodium can be used in the study of Alpha-1 Antitrypsin Deficiency (AATD) liver disease. AATD is caused by mutations in the alpha-1 antitrypsin (SERPINA1) gene.
Cat. No.: HY-174540
Human SERPINA1 mRNA encodes the human serpin family A member 1 (SERPINA1) protein, a serine protease inhibitor belonging to the serpin superfamily. SERPINA1’s major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).
Cat. No.: HY-132604
CAS No.: 2175009-08-0
Synonyms: ARO-AAT
Target:
Research Areas:
Fazirsiran (ARO-AAT) is a second-generation RNAi agent. Fazirsiran consistes of a cholesterol-conjugated RNAi trigger (chol-RNAi) to selectively reduce Alpha1-antitrypsin (AAT) synthesis and a melittin-derived peptide conjugated to N-acetylgalactosamine (NAG) formulated as the excipient EX1 to promote endosomal escape of the chol-RNAi in hepatocytes [1]. Fazirsiran can be used in the study of Alpha-1 Antitrypsin Deficiency (AATD) liver disease. Alpha-1 antitrypsin deficiency (AATD) is caused by mutations in the alpha-1 antitrypsin (SERPINA1) gene.
Cat. No.: HY-RS12696
Target:
Research Areas:
SERPINA1 Human Pre-designed siRNA Set A contains three designed siRNAs for SERPINA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23630
Target:
Research Areas:
Serpina1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Serpina1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-107098
CAS No.: 874339-65-8
Target:
Research Areas:
PPL-100 free acid is a potential agent for SERPINA1. PPL-100 free acid can be metabolically cleaved into PL-100 (HY-107468) [1] .
Cat. No.: HY-P81377A
Synonyms: SERPINA1; AAT; PI; Alpha-1-antitrypsin; Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Serpin A1
Cat. No.: HY-RS29511
Target:
Research Areas:
Serpina1a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Serpina1a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Components
Serpina1a siRNA-1: 5 nmol (HPLC)
Serpina1a siRNA-2: 5 nmol (HPLC)
Serpina1a siRNA-3: 5 nmol (HPLC)
siRNA Negative Control: 5 nmol (HPLC)
FAM-labeled siRNA Negative Control: 5 nmol (HPLC)
GAPDH siRNA Positive Control: 5 nmol (HPLC)
Components
Serpina1a siRNA-1: 5 nmol (HPLC)
Serpina1a siRNA-2: 5 nmol (HPLC)
Serpina1a siRNA-3: 5 nmol (HPLC)
siRNA Negative Control: 5 nmol (HPLC)
FAM-labeled siRNA Negative Control: 5 nmol (HPLC)
GAPDH siRNA Positive Control: 5 nmol (HPLC)
Cat. No.: HY-P7542
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SERPINA1; Serpin A1; Prev. PI; Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 1, Isoform CRA_a; Alpha-1-Antitrypsin; Serine (Or Cysteine) Proteinase Inhibitor, Clade A, Member 1; AAT; Protease Inhibitor 1 (Anti-Elastase)
Cat. No.: HY-P74556
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SERPINA1; Serpin A1; Prev. PI; Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 1, Isoform CRA_a; Alpha-1-Antitrypsin; Serine (Or Cysteine) Proteinase Inhibitor, Clade A, Member 1; AAT; Protease Inhibitor 1 (Anti-Elastase)
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
