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Results for "

SERPINA1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Endogenous Metabolite (1) mRNA (1) Small Interfering RNA (siRNA) (4)
By Research Areas:	Cancer (2) Metabolic Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) mRNA (1) siRNA drugs (2) Human Pre-designed siRNA Sets (1) siRNAs (4)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-132604A

Fazirsiran sodium ARO-AAT sodium	Small Interfering RNA (siRNA)	Metabolic Disease
Fazirsiran sodium is a second-generation RNAi agent. Fazirsiran sodium consistes of a cholesterol-conjugated RNAi trigger (chol-RNAi) to selectively degrade Alpha1-antitrypsin (AAT) mRNA by RNAi and a melittin-derived peptide conjugated to N-acetylgalactosamine (NAG) formulated as the excipient EX1 to promote endosomal escape of the chol-RNAi in hepatocytes ^[1]. Fazirsiran sodium can be used in the study of Alpha-1 Antitrypsin Deficiency (AATD) liver disease. AATD is caused by mutations in the alpha-1 antitrypsin (SERPINA1) gene.

HY-174540

*Human SERPINA1* mRNA**	mRNA	Cancer
Human SERPINA1 mRNA encodes the human serpin family A member 1 (SERPINA1) protein, a serine protease inhibitor belonging to the serpin superfamily. SERPINA1’s major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).

HY-132604

Fazirsiran ARO-AAT	Small Interfering RNA (siRNA)	Metabolic Disease
Fazirsiran (ARO-AAT) is a second-generation RNAi agent. Fazirsiran consistes of a cholesterol-conjugated RNAi trigger (chol-RNAi) to selectively reduce Alpha1-antitrypsin (AAT) synthesis and a melittin-derived peptide conjugated to N-acetylgalactosamine (NAG) formulated as the excipient EX1 to promote endosomal escape of the chol-RNAi in hepatocytes ^[1]. Fazirsiran can be used in the study of Alpha-1 Antitrypsin Deficiency (AATD) liver disease. Alpha-1 antitrypsin deficiency (AATD) is caused by mutations in the alpha-1 antitrypsin (SERPINA1) gene.

HY-RS12696

SERPINA1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SERPINA1 Human Pre-designed siRNA Set A contains three designed siRNAs for SERPINA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SERPINA1 Human Pre-designed siRNA Set A SERPINA1 Human Pre-designed siRNA Set A

HY-RS23630

Serpina1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Serpina1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Serpina1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Serpina1 Rat Pre-designed siRNA Set A Serpina1 Rat Pre-designed siRNA Set A

HY-107098

PPL-100 free acid	Endogenous Metabolite	Cancer
PPL-100 free acid is a potential agent for SERPINA1. PPL-100 free acid can be metabolically cleaved into PL-100 (HY-107468) ^[1] .

Species:	Human (1) Mouse (6)
Tag:	His (4) Tag Free (1) Fc (2)
Source:	HEK293 (7)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P7542

	Serpin A1 Protein, Human (HEK293, His) rHuSerpin A1/alpha-1-Antitrypsin, His; Alpha-1-Antitrypsin; Alpha-1 Protease Inhibitor; Alpha-1-Antiproteinase; Serpin A1; SERPINA1; AAT; PI	Human	HEK293
	Serpin A1 Protein, Human (HEK293, His) produced in HEK293 cells is a mouse recombinant Serpin A1a with a His tag at the C-terminus. Alpha-1 Antitrypsin Exerts a hepatoprotective effect on immune-mediated hepatitis and acetaminophen-induced liver injury.

HY-P74555

	Serpin A1b Protein, Mouse (HEK293, Fc) Alpha-1-antitrypsin 1-2; AAT; SERPINA1b; Aat2; Dom2; Spi1-2	Mouse	HEK293
	Serpin A1b Protein, a vigilant guardian in cellular regulation, adeptly inhibits elastase, providing formidable defense against its enzymatic activity.Beyond this specialization, Serpin A1b shows moderate affinity for plasmin and thrombin, highlighting its versatility in interacting with various serine proteases.As a multifaceted sentinel, Serpin A1b contributes to the nuanced orchestration of proteolytic processes within cellular landscapes.Serpin A1b Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Serpin A1b protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P77484

	Serpina1d Protein, Mouse (HEK293) Alpha-1-antitrypsin 1-4; Serine protease inhibitor 1-4; Serpin A1d; Dom4; Spi1-4	Mouse	HEK293
	The Serpina1d protein is a vigilant sentinel in cellular regulation, acting specifically as an inhibitor of serine proteases, particularly trypsin and chymotrypsin. It effectively blocks their enzymatic activity but appears relatively ineffective against elastase. Serpina1d Protein, Mouse (HEK293) is the recombinant mouse-derived Serpina1d protein, expressed by HEK293 , with tag free.

HY-P77485

	Serpina1d Protein, Mouse (HEK293, Fc) Alpha-1-antitrypsin 1-4; Serine protease inhibitor 1-4; Serpin A1d; Dom4; Spi1-4	Mouse	HEK293
	The Serpina1d protein is a vigilant sentinel in cellular regulation, acting specifically as an inhibitor of serine proteases, particularly trypsin and chymotrypsin. It effectively blocks their enzymatic activity but appears relatively ineffective against elastase. Serpina1d Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Serpina1d protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P77486

	Serpina1d Protein, Mouse (HEK293, His) Alpha-1-antitrypsin 1-4; Serine protease inhibitor 1-4; Serpin A1d; Dom4; Spi1-4	Mouse	HEK293
	The Serpina1d protein is a vigilant sentinel in cellular regulation, acting specifically as an inhibitor of serine proteases, particularly trypsin and chymotrypsin. It effectively blocks their enzymatic activity but appears relatively ineffective against elastase. Serpina1d Protein, Mouse (HEK293, His) is the recombinant mouse-derived Serpina1d protein, expressed by HEK293 , with C-His labeled tag.

HY-P70979

	Serpin A1a Protein, Mouse (HEK293, His) Serpin A1a; Alpha-1-antitrypsin 1-1; Alpha-1-antitrypsin 1-3; Alpha-1 protease inhibitor 3; Alpha-1 protease inhibitor 6; Alpha-1-antitrypsin 1-6; Serine protease inhibitor 1-3; Serine protease inhibitor 1-6; Serine protease inhibitor A1c; Serpin A1c; SERPINA1c; Dom	Mouse	HEK293
	Serpin A1a Protein, Mouse (HEK 293, His) is the recombinant mouse-derived Serpin A1a, expressed by HEK293 , with C-6*His labeled tag. ,

HY-P71301

	Serpin A1c Protein, Mouse (HEK293, His) Alpha-1-antitrypsin 1-3; Alpha-1 protease inhibitor 3; Alpha-1 protease inhibitor 6; Alpha-1-antitrypsin 1-6; Serine protease inhibitor 1-3; Serine protease inhibitor 1-6; Serine protease inhibitor A1c; Serpin A1c; SERPINA1c; Dom3; Dom6; Spi1-3; Spi1-6	Mouse	HEK293
	The Serpin A1c protein is a skilled guardian of cellular regulation, specifically acting as an inhibitor of serine proteases, specifically trypsin and chymotrypsin. Its efficacy in blocking enzymatic activity contrasts with its relative ineffectiveness against elastase. Serpin A1c Protein, Mouse (HEK293, His) is the recombinant mouse-derived Serpin A1c protein, expressed by HEK293 , with C-6*His labeled tag.

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Host:	Mouse (2) Rabbit (2)
Reactivity:	Human (4) Mouse (2)
Application:	IHC-P (4) WB (2) ELISA (2)
Isotype:	IgG (2) IgG1 (2)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (1) Monoclonal Antibody (1) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P83894

	alpha 1 Antitrypsin Antibody (YA3591) PI; A1A; AAT; PI1; A1AT; SERPINA1	WB, IHC-P, ELISA	Human, Mouse
	alpha 1 Antitrypsin Antibody (YA3591) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to alpha 1 Antitrypsin.

HY-P83894A

	alpha 1 Antitrypsin Antibody (YA3591)(PBS only) PI; A1A; AAT; PI1; A1AT; SERPINA1	WB, IHC-P, ELISA	Human, Mouse
	alpha 1 Antitrypsin Antibody (YA3591) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to alpha 1 Antitrypsin.

HY-P81377

	alpha 1 Antitrypsin Antibody (YA1122) SERPINA1; AAT; PI; Alpha-1-antitrypsin; Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Serpin A1	IHC-P	Human
	alpha 1 Antitrypsin Antibody (YA1122) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to alpha 1 Antitrypsin.

HY-P81377A

	alpha 1 Antitrypsin Antibody (YA1122)(PBS only) SERPINA1; AAT; PI; Alpha-1-antitrypsin; Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Serpin A1	IHC-P	Human
	alpha 1 Antitrypsin Antibody (YA1122) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to alpha 1 Antitrypsin.