SHH

By Targets:	Antibiotic (4) Apoptosis (2) Bacterial (4) Caspase (1) Fluorescent Dye (1) Gli (1) Hedgehog (16) Histone Methyltransferase (2) Interleukin Related (1) Isotope-Labeled Compounds (2) Parasite (4) Reference Standards (3) Small Interfering RNA (siRNA) (3) Smo (6) Wnt (2)
By Research Areas:	Cancer (18) Infection (4) Inflammation/Immunology (3) Neurological Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100224

SANT-1 4 Publications Verification	Smo Hedgehog	Cancer
SANT-1, a potent Smo antagonist, inhibits Hedgehog signaling. SANT-1 shows IC₅₀s of 20 nM and 30 nM in Shh-LIGHT2 and SmoA1-LIGHT2 assay, respectively .

HY-108439

Neurodazine	Wnt Hedgehog	Neurological Disease
Neurodazine is a neurogenic inducer, serve as a promoter of neurogenesisin pluripotent cells. Neurodazine promotes neurogenesis by activating Wnt and *Shh* signaling pathways. .

HY-B0508

Ornidazole 2 Publications Verification Ro 7-0207	Bacterial Parasite Antibiotic Hedgehog	Infection Cancer
Ornidazole (Ro 7-0207) is a nitroimidazole derivative with anti-trichomonad activity and in vitro activity against a variety of anaerobic bacteria. Ornidazole inhibits Sonic hedgehog (Shh) signaling pathway, exhibits antitumor activity. Ornidazole can be used in research of Crohn’s disease .

HY-100515

Robotnikinin 3 Publications Verification	Hedgehog	Inflammation/Immunology
Robotnikinin is a small molecule capable of binding to and inhibiting the activity of Sonic Hedgehog (Shh) signaling up stream of Smo .

HY-158059

DS-1-38	Hedgehog	Cancer
DS-1-38 is an EYA1 antagonist that blocks Sonic Hedgehog (SHH) signaling. EYA1 is a haloacid dehalogenase phosphatase and transcription factor that regulates tumorigenesis and proliferation in SHH medulloblastoma (SHH-MB) .

HY-P10875

HL2-m5	Hedgehog	Cancer
HL2-m5 is the inhibitor for the interaction between sonic hedgehog/patched (Shh/PTCH1) with K_d of 170 nM for *Shh. HL2-m5 inhibits activation of Hedgehog* signaling pathway and transcription of Gli-controlled gene with an IC₅₀ of 230 nM .

HY-144881

(S)-HH2853	Histone Methyltransferase	Inflammation/Immunology Cancer
(S)-HH2853 (compound 200), a PYRIDINO five membered aromatic ring compound, is a potent EZH1/2 dual inhibitor with an IC₅₀ of <100 nM for EZH2_Y641F. (S)-HH2853 has the potential to be used in the research of anti-tumor or autoimmune diseases .

HY-145387

MRT-81	Smo	Cancer
MRT-81 is a potent antagonist of human and rodent smoothened (Smo) receptors, with an IC₅₀ value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 can be used for the research of cancer .

HY-123781A

RUSKI-201 dihydrochloride	Hedgehog	Cancer
RUSKI-201 dihydrochloride is a potent and specific Hedgehog acyltransferase (Hhat) inhibitor with an IC₅₀ of 0.20 μM. RUSKI-201 dihydrochloride is able to block Hh signaling from Shh overexpressing cells and inhibits Hh palmitoylation. RUSKI-201 dihydrochloride is potential Hhat chemical probe in cells and can used in studies of Hhat catalytic function .

HY-B0508S1

Ornidazole-13C2,15N2 Ro 7-0207-¹³C₂,¹⁵N₂	Isotope-Labeled Compounds Bacterial Parasite Antibiotic Hedgehog	Infection
Ornidazole- ¹³C₂, ¹⁵N₂ is the ¹³C, ¹⁵N labeled Ornidazole. Ornidazole (Ro 7-0207) is a nitroimidazole derivative with anti-trichomonad activity and in vitro activity against a variety of anaerobic bacteria. Ornidazole inhibits Sonic hedgehog (Shh) signaling pathway, exhibits antitumor activity. Ornidazole can be used in research of Crohn’s disease .

HY-RS12865

SHH Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SHH Human Pre-designed siRNA Set A contains three designed siRNAs for SHH gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SHH Human Pre-designed siRNA Set A SHH Human Pre-designed siRNA Set A

HY-147743

SMO-IN-1	Smo	Cancer
SMO-IN-1 (Compound 15) is an orally active Smoothened (SMO) inhibitor with an EC₅₀ of 89 nM against sonic Hh protein (shh) .

HY-147744

AZD7254	Smo	Cancer
AZD7254 is an orally active Smoothened (SMO) inhibitor with an EC₅₀ of 1.0 nM against sonic Hh protein (shh) .

HY-164500

MC3629	Apoptosis Histone Methyltransferase	Cancer
MC3629 is an inhibitor of histone methyltransferase (EZH2) with anti-tumor activity. MC3629 inhibits SHH MB cancer cell proliferation and self-renewal and induces apoptosis. MC3629 can be used to study drug resistance in tumor aggressiveness .

HY-120664

BRD50837	Hedgehog	Cancer
BRD50837 is a potent inhibitor of Sonic Hedgehog (Shh), with the EC₅₀ of 0.09 μM. BRD50837 plays an important role in cancer research .

HY-B0508S

Ornidazole-d5 Ro 7-0207-d₅	Isotope-Labeled Compounds Bacterial Parasite Antibiotic Hedgehog	Infection Cancer
Ornidazole-d₅ is deuterium labeled Ornidazole. Ornidazole (Ro 7-0207) is a nitroimidazole derivative with anti-trichomonad activity and in vitro activity against a variety of anaerobic bacteria. Ornidazole inhibits Sonic hedgehog (Shh) signaling pathway, exhibits antitumor activity. Ornidazole can be used in research of Crohn’s disease .

HY-123781

RUSKI-201	Hedgehog	Cancer
RUSKI-201 is a potent and specific Hedgehog acyltransferase (Hhat) inhibitor, with an IC₅₀ of 0.20 μM. RUSKI-201 is able to block Hh signaling from Shh overexpressing cells and inhibits Hh palmitoylation. RUSKI-201 is potential Hhat chemical probe in cells and can used in studies of Hhat catalytic function .

HY-116455

BRD-9526	Fluorescent Dye	Cancer
BRD-9526 is a potent and selective Sonic Hedgehog (Shh) pathway inhibitor with potential anti-cancer activity. The mechanism of BRD-9526 is similar in some ways to commonly used inhibitors such as cyclopamine, but is significantly different in other ways. The discovery of BRD-9526 may provide a useful probe for studying complex signaling pathways .

HY-B0508R

Ornidazole (Standard) Ro 7-0207 (Standard)	Reference Standards Bacterial Parasite Antibiotic Hedgehog	Infection Cancer
Ornidazole (Standard) is the analytical standard of Ornidazole. This product is intended for research and analytical applications. Ornidazole (Ro 7-0207) is a nitroimidazole derivative with anti-trichomonad activity and in vitro activity against a variety of anaerobic bacteria. Ornidazole inhibits Sonic hedgehog (Shh) signaling pathway, exhibits antitumor activity. Ornidazole can be used in research of Crohn’s disease .

HY-RS16599

Shh Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Shh Mouse Pre-designed siRNA Set A contains three designed siRNAs for Shh gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Shh Mouse Pre-designed siRNA Set A Shh Mouse Pre-designed siRNA Set A

HY-RS23033

Shh Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Shh Rat Pre-designed siRNA Set A contains three designed siRNAs for Shh gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Shh Rat Pre-designed siRNA Set A Shh Rat Pre-designed siRNA Set A

HY-P992409

MEDI-5304	Hedgehog	Cancer
MEDI-5304 is a hedgehog pathway inhibitor with human sonic hedgehog (SHH) K_D of 5.13 pmol/L, and human Indian hedgehog (IHH) K_D of 34.7 pmol/L. MEDI-5304 binds and neutralizes SHH and IHH, blocks downstream target gene transcription, inhibits osteoblast differentiation. MEDI-5304 can be used for the research of colon cancer .

HY-N18954

Heparin disaccharide III-S trisodium	Interleukin Related	Inflammation/Immunology
Heparin disaccharide III-S trisodium (Compound SHH-7) is a heparin-derived disaccharide. Heparin disaccharide III-S trisodium acts as an inhibitor of spontaneous IL-8 and IL-1β secretion by intestinal epithelial cells. Heparin disaccharide III-S trisodium functions at the post-translational stage and does not reduce mRNA or intracellular mediator levels .

HY-108439R

Neurodazine (Standard)	Reference Standards Wnt Hedgehog	Neurological Disease
Neurodazine (Standard) is the analytical standard of Neurodazine (HY-108439). This product is intended for research and analytical applications. Neurodazine is a neurogenic inducer, serve as a promoter of neurogenesisin pluripotent cells. Neurodazine promotes neurogenesis by activating Wnt and Shh signaling pathways. .

HY-100224R

SANT-1 (Standard)	Smo Reference Standards Hedgehog	Cancer
SANT-1 (Standard) is the analytical standard of SANT-1 (HY-100224). This product is intended for research and analytical applications. SANT-1, a potent Smo antagonist, inhibits Hedgehog signaling. SANT-1 shows IC50s of 20 nM and 30 nM in Shh-LIGHT2 and SmoA1-LIGHT2 assay, respectively .

HY-183335

SMO-IN-6	Smo Hedgehog Gli Apoptosis Caspase	Cancer
Anticancer agent 321 is a Smoothened (SMO) inhibitor with a human IC₅₀ of 0.12 μM, enhanced aqueous solubility, good plasma and metabolic stability, moderate therapeutic index, preliminary safety profile, and moderate oral bioavailability in rats.Anticancer agent 321 binds to SMO’s 7-transmembrane helical channel, forming hydrogen bonds with Asp384 and hydrophobic/π-π interactions with His470, Phe391, Tyr394, stabilizing SMO’s inactive conformation to inhibit Hedgehog/GLI signaling.Anticancer agent 321 inhibits proliferation, suppresses colony formation, induces apoptosis, and downregulates Hedgehog/GLI pathway target genes GLI1, GLI2, Ptch1, HHip in cancer cells.Anticancer agent 321 inhibits tumor growth, downregulates Ki67 and SOX2, and upregulates cleaved-caspase 3 in tumor tissues.Anticancer agent 321 can be used for the research of cutaneous squamous cell carcinoma .

Cat. No.	Product Name	Target	Research Area

HY-P10875

HL2-m5	Hedgehog	Cancer
HL2-m5 is the inhibitor for the interaction between sonic hedgehog/patched (Shh/PTCH1) with K_d of 170 nM for *Shh. HL2-m5 inhibits activation of Hedgehog* signaling pathway and transcription of Gli-controlled gene with an IC₅₀ of 230 nM .

Cat. No.	Product Name	Target	Research Area	Image

HY-P992409

MEDI-5304	Hedgehog	Cancer
MEDI-5304 is a hedgehog pathway inhibitor with human sonic hedgehog (SHH) K_D of 5.13 pmol/L, and human Indian hedgehog (IHH) K_D of 34.7 pmol/L. MEDI-5304 binds and neutralizes SHH and IHH, blocks downstream target gene transcription, inhibits osteoblast differentiation. MEDI-5304 can be used for the research of colon cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0508

Ornidazole 2 Publications Verification Ro 7-0207	Infection Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial Parasite Antibiotic Hedgehog
Ornidazole (Ro 7-0207) is a nitroimidazole derivative with anti-trichomonad activity and in vitro activity against a variety of anaerobic bacteria. Ornidazole inhibits Sonic hedgehog (Shh) signaling pathway, exhibits antitumor activity. Ornidazole can be used in research of Crohn’s disease .

HY-B0508R

Ornidazole (Standard) Ro 7-0207 (Standard)	Structural Classification Microorganisms Antibiotics Antibacterial Disease Research Other Antibiotics Source Classification	Reference Standards Bacterial Parasite Antibiotic Hedgehog
Ornidazole (Standard) is the analytical standard of Ornidazole. This product is intended for research and analytical applications. Ornidazole (Ro 7-0207) is a nitroimidazole derivative with anti-trichomonad activity and in vitro activity against a variety of anaerobic bacteria. Ornidazole inhibits Sonic hedgehog (Shh) signaling pathway, exhibits antitumor activity. Ornidazole can be used in research of Crohn’s disease .

HY-N18954

Heparin disaccharide III-S trisodium	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Interleukin Related
Heparin disaccharide III-S trisodium (Compound SHH-7) is a heparin-derived disaccharide. Heparin disaccharide III-S trisodium acts as an inhibitor of spontaneous IL-8 and IL-1β secretion by intestinal epithelial cells. Heparin disaccharide III-S trisodium functions at the post-translational stage and does not reduce mRNA or intracellular mediator levels .

Species:	Human (4) Mouse (5)
Tag:	His (2) Tag Free (7)
Source:	HEK293 (3) CHO (1) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P70467

	SHH Protein, Human 1 Publications Verification Sonic Hedgehog Protein; SHH; HHG-1	Human	E. coli
	Sonic Hedgehog (SHH) Protein is a secretory glycoprotein of the Hedgehog family that can self-cleave to form N-SHH. SHH Protein activates Smo by binding to Frizzled and LRP6, inhibits GSK-3β to stabilize β-catenin, and activates FOXM1. SHH Protein also promotes NO release and shortens myocardial APD by phosphorylating eNOS through PI3K/Akt. SHH Protein can promote the maturation of sweat gland cells in three-dimensional culture and play a cardioprotective role in the pig ischemia-reperfusion model. SHH Protein, Human is a recombinant human SHH protein expressed in E. coli with tag-free.

HY-P701100

	SHH Protein, Mouse (HEK293) rMuSHH; HHG-1; SHHNC	Mouse	HEK293
	SHH Protein, Mouse (HEK293) is a morphogenic factor that actively orchestrates many aspects of cerebellar development and maturation.

HY-P7288

	SHH Protein, Mouse (CHO) rMuSHH; HHG-1; SHHNC	Mouse	CHO
	SHH Protein, Mouse (CHO) is a morphogenic factor that actively orchestrates many aspects of cerebellar development and maturation.

HY-P7290

	SHH Protein, Mouse rMuSHH; HHG-1; SHHNC	Mouse	E. coli
	SHH Protein, Mouse is a morphogenic factor that actively orchestrates many aspects of cerebellar development and maturation.

HY-P73418

	SHH Protein, Mouse (HEK293, His) 1 Publications Verification Sonic Hedgehog Protein; SHH; HHG-1; SHHNC	Mouse	HEK293
	Sonic hedgehog (SHH) undergoes autoproteolysis in the endoplasmic reticulum to produce ShhN and ShhC.ShhN is covalently linked to cholesterol to form ShhNp, a morphogen critical for developmental patterning.SHH Protein, Mouse (HEK293, His) is the recombinant mouse-derived SHH protein, expressed by HEK293 , with C-His labeled tag.

HY-P73417

	SHH Protein, Human (HEK293, His) Sonic Hedgehog Protein; SHH; HHG-1; SHHNC	Human	HEK293
	Sonic Hedgehog (SHH) Protein is a secretory glycoprotein of the Hedgehog family that can self-cleave to form N-SHH. SHH Protein activates Smo by binding to Frizzled and LRP6, inhibits GSK-3β to stabilize β-catenin, and activates FOXM1. SHH Protein also promotes NO release and shortens myocardial APD by phosphorylating eNOS through PI3K/Akt. SHH Protein can promote the maturation of sweat gland cells in three-dimensional culture and play a cardioprotective role in the pig ischemia-reperfusion model. SHH Protein, Human (HEK293, His) is a recombinant human SHH protein expressed in HEK293 cells with C-terminal His-tag.

HY-P7409

	SHH Protein, Mouse (C25II) 3 Publications Verification rMuSonic Hedgehog, C25II; Hhg1	Mouse	E. coli
	SHH Protein, Mouse (C25II) is a recombinant mouse sonic hedgehog variant.

HY-P7407

	SHH Protein, Human (C24II) rHuSonic Hedgehog, C24II; HHG1	Human	E. coli
	Sonic Hedgehog (SHH) Protein is a secretory glycoprotein of the Hedgehog family that can self-cleave to form N-SHH. SHH Protein activates Smo by binding to Frizzled and LRP6, inhibits GSK-3β to stabilize β-catenin, and activates FOXM1. SHH Protein also promotes NO release and shortens myocardial APD by phosphorylating eNOS through PI3K/Akt. SHH Protein can promote the maturation of sweat gland cells in three-dimensional culture and play a cardioprotective role in the pig ischemia-reperfusion model. SHH Protein, Human (C24II) is a recombinant human SHH protein expressed in E. coli with C24II-mutation and tag-free.

HY-P7408

	SHH Protein, Human (C24IVI) rHuSonic Hedgehog, C24IVI; HHG1	Human	E. coli
	Sonic Hedgehog (SHH) Protein is a secretory glycoprotein of the Hedgehog family that can self-cleave to form N-SHH. SHH Protein activates Smo by binding to Frizzled and LRP6, inhibits GSK-3β to stabilize β-catenin, and activates FOXM1. SHH Protein also promotes NO release and shortens myocardial APD by phosphorylating eNOS through PI3K/Akt. SHH Protein can promote the maturation of sweat gland cells in three-dimensional culture and play a cardioprotective role in the pig ischemia-reperfusion model. SHH Protein, Human (C24IVI) is a recombinant human SHH protein expressed in E. coli with C24IVI-mutation and tag-free.

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Cat. No.	Product Name	Chemical Structure

HY-B0508S1

Ornidazole-13C2,15N2
Ornidazole- ¹³C₂, ¹⁵N₂ is the ¹³C, ¹⁵N labeled Ornidazole. Ornidazole (Ro 7-0207) is a nitroimidazole derivative with anti-trichomonad activity and in vitro activity against a variety of anaerobic bacteria. Ornidazole inhibits Sonic hedgehog (Shh) signaling pathway, exhibits antitumor activity. Ornidazole can be used in research of Crohn’s disease .

HY-B0508S

Ornidazole-d5
Ornidazole-d₅ is deuterium labeled Ornidazole. Ornidazole (Ro 7-0207) is a nitroimidazole derivative with anti-trichomonad activity and in vitro activity against a variety of anaerobic bacteria. Ornidazole inhibits Sonic hedgehog (Shh) signaling pathway, exhibits antitumor activity. Ornidazole can be used in research of Crohn’s disease .

Host:	Mouse (2) Rabbit (3)
Reactivity:	Human (5) Rat (2) Mouse (4) Monkey (2)
Application:	IHC-P (5) ICC/IF (3) IF-Tissue (1) IHC-F (2) WB (5) FC (3) ELISA (4)
Isotype:	IgG,Kappa (1) IgG (2) IgG1 (2)
Conjugation:	Non-conjugated (5)
Clonality:	Polyclonal (1) Monoclonal (3) Recombinant (2)
Modification:	Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85366

	Shh Antibody (YA5058) SHH; Sonic hedgehog protein; SHH; HHG-1	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue, FC	Human
	Shh Antibody (YA5058) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to Shh.

HY-P87706

	Shh Antibody (YA7391)	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	Shh Antibody (YA7391) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to Shh.

HY-P81157

	Shh Antibody Sonic hedgehog; Vhh-1; Sonic hedgehog protein; SHH; HHG 1; HHG1; HLP 3; HLP3; Holoprosencephaly 3; HPE 3; HPE3; MCOPCB5; SMMC I; SMMCI; Sonic Hedgehog (Drosophila) homolog; sonic hedgehog homolog (Drosophila); Sonic hedgehog homolog; Sonic hedgehog protein; TPT; TPTPS; Sonic hedgehog protein N-product; SHH_HUMAN.	WB, ELISA, IHC-P, IHC-F, ICC/IF	Human, Mouse, Rat
	Shh Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Shh.

HY-P84589

	Shh Antibody (YA4286) TPT; HHG1; HLP3; HPE3; SMMCI; TPTPS; MCOPCB5	WB, IHC-P, FC, ELISA	Human, Mouse, Monkey
	Shh Antibody (YA4286) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Shh.

HY-P84589A

	Shh Antibody (YA4286)(PBS only) TPT; HHG1; HLP3; HPE3; SMMCI; TPTPS; MCOPCB5	WB, IHC-P, FC, ELISA	Human, Mouse, Monkey
	Shh Antibody (YA4286) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Shh.

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Cat. No.	Product Name		Classification

HY-RS12865

SHH Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SHH Human Pre-designed siRNA Set A contains three designed siRNAs for SHH gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS16599

Shh Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Shh Mouse Pre-designed siRNA Set A contains three designed siRNAs for Shh gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23033

Shh Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Shh Rat Pre-designed siRNA Set A contains three designed siRNAs for Shh gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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