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Isoforms Recommended: TXA2/TP
Results for "

TP

" in MedChemExpress (MCE) Product Catalog:

244

Inhibitors & Agonists

2

Fluorescent Dye

1

Biochemical Assay Reagents

19

Peptides

1

Inhibitory Antibodies

8

Natural
Products

71

Recombinant Proteins

8

Isotope-Labeled Compounds

78

Antibodies

9

Click Chemistry

29

Oligonucleotides

1

GMP Molecules

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-16980A
    Eravacycline dihydrochloride
    25+ Cited Publications

    TP-434 dihydrochloride; TP-434-046

    		 Beta-lactamase Bacterial Infection
    Eravacycline dihydrochloride (TP-434 dihydrochloride) is a potent and broad-spectrum antibacterial agent.
    Eravacycline dihydrochloride
  • HY-101787
    TP-024
    2 Publications Verification

    FTBMT

    		 GPR52 Neurological Disease
    TP-024 (FTBMT), a chemical probe, is a selective GPR52 agonist with an EC50 of 75 nM . TP-024 has antipsychotic and procognitive properties .
    TP-024
  • HY-114965
    TP-064
    5+ Cited Publications

    		 Histone Methyltransferase Inflammation/Immunology Cancer
    TP-064, a chemical probe, is a potent and selective proteinarginine methyltransferase 4 (PRMT4; CARM1) inhibitor (IC50 <10 nM). TP-064 inhibits dimethylation of BAF155 (IC50 of 340 nM) and MED12 (IC50 of 43 nM). TP-064 is inactive against the other family members except for PRMT6 (IC50 of 1.3 μM). TP-064 has anticancer activities .
    TP-064
  • HY-101126
    TP-3654
    4 Publications Verification

    		 Pim Cancer
    TP-3654 is a second-generation Pim kinase inhibitor with Ki values of 5 and 42 nM for Pim-1 and Pim-3, respectively.
    TP-3654
  • HY-12963
    Dubermatinib
    5+ Cited Publications

    TP-0903

    		 TAM Receptor Apoptosis Cancer
    Dubermatinib (TP-0903) is a potent and selective Axl receptor tyrosine kinase inhibitor with an IC50 value of 27 nM.
    Dubermatinib
  • HY-15725
    CDDO-Im
    10+ Cited Publications

    RTA-403; TP-235; CDDO-Imidazolide

    		 Keap1-Nrf2 PPAR Ferroptosis Cancer
    CDDO-Im (RTA-403) is an activator of Nrf2 and PPAR, with Kis of 232 and 344 nM for PPARα and PPARγ .
    CDDO-Im
  • HY-14550
    TP-10
    2 Publications Verification

    		 Phosphodiesterase (PDE) Cardiovascular Disease Neurological Disease
    TP-10 is a selective PDE10A inhibitor with an IC50 value of 0.8 nM. TP-10 shows an antioxidant activity with IC50s of 31.72 and 16.04 μg/ml for DPPH and CUPRAC, respectively. TP-10 can be used for the research of neuropathy .
    TP-10
  • HY-147316
    TP-5801

    		STAT TNK1 Cancer
    TP-5801 is an orally active TNK1 (non-receptor tyrosine kinase) inhibitor (IC50=1.40 nM), and shows anti-tumor activity .
    TP-5801
  • HY-112144
    TP0463518
    1 Publications Verification

    		 HIF/HIF Prolyl-Hydroxylase Metabolic Disease Inflammation/Immunology
    TP0463518 is an orally active, competitive pan-inhibitor of hypoxia-inducible factor prolyl hydroxylases PHD1/2/3. TP0463518 competitively inhibits human PHD1 (IC50=18 nM), PHD2 (Ki=5.3 nM), and PHD3 (IC50=63 nM), and targets monkey PHD2 with an IC50 of 22 nM. TP0463518 inhibits PHD-catalyzed hydroxylation to stabilize HIFα, thereby upregulating erythropoietin (EPO) expression and enhancing intestinal iron absorption (such as increased DMT-1 and dCYTb expression), improving anemia. TP0463518 is mainly used for the research of renal anemia and inflammatory anemia .
    TP0463518
  • HY-105042
    Selank

    Selanc; TP-7

    		 Others GABA Receptor Neurological Disease
    Selank is a GABAA receptor modulator with anxiolytic activity. Selank allosterically modulates the specific binding of GABA to GABAA receptors and alters the affinity of endogenous ligands for these receptors. Selank reduces elevated anxiety levels, attenuates stress-induced exacerbation of anxiety, and produces a synergistic anxiolytic effect with diazepam. Selank can be used in the research of anxiety disorders .
    Selank
  • HY-16980S
    Eravacycline-d4 dihydrochloride

    TP-434-d4 dihydrochloride

    		 Isotope-Labeled Compounds Beta-lactamase Antibiotic Bacterial Infection
    Eravacycline-d4 (TP-434-d4) dihydrochloride is deuterium labeled Eravacycline. Eravacycline is a potent and broad-spectrum antibacterial agent .
    Eravacycline-d4 dihydrochloride
  • HY-12213
    CDDO-EA
    4 Publications Verification

    CDDO ethyl amide; TP319; RTA 405

    		 Keap1-Nrf2 Cancer
    CDDO-EA is an NF-E2 related factor 2/antioxidant response element (Nrf2/ARE) activator.
    CDDO-EA
  • HY-120868
    TP-004
    1 Publications Verification

    		 MetAP Metabolic Disease Cancer
    TP-004 is a potent and reversible inhibitor of methionine aminopeptidase 2 (MetAP2), with an IC50 of 6 nM against MetAP2. TP-004 is a chemical probe. TP-004 suppresses MetAP2 enzymatic activity, blocks N-terminal methionine cleavage, impairs protein maturation and stability, and thereby inhibits cell proliferation and angiogenesis. TP-004 can be used for the study of tumors and diseases associated with excessive angiogenesis .
    TP-004
  • HY-153260
    TP-1287

    		CDK Cancer
    TP-1287, a prodrug of Alvocidib (HY-10005), is an orally active CDK9 inhibitor .
    TP-1287
  • HY-P5557
    TP4 (Nile tilapia piscidin)

    		Bacterial Necroptosis Infection Inflammation/Immunology
    TP4 (Nile tilapia piscidin) is an orally active amphipathic α-helical cationic antimicrobial peptide. TP4 (Nile tilapia piscidin) exerts broad-spectrum bactericidal activity against Gram-positive and Gram-negative bacteria by disrupting cell membrane structures, and also exhibits certain hemolytic activity. TP4 (Nile tilapia piscidin) regulates the innate immune system and enhances the expression of lysozymes, cytokines and antioxidant enzymes to resist bacterial infection. TP4 (Nile tilapia piscidin) also stimulates the proliferation of keratinocytes and fibroblasts, and significantly promotes the healing of wounds infected with MRSA. TP4 (Nile tilapia piscidin) can be used in research related to bacterial infection, peritonitis, wound healing and other fields .
    TP4 (Nile tilapia piscidin)
  • HY-101857
    TP-020

    MGAT2-IN-1

    		 Acyltransferase Metabolic Disease
    TP-020 (MGAT2-IN-1), a chemical probe, is an orally active inhibitor of monoacylglycerol acyltransferase (MGAT2) with IC50 of 7.8 and 2.4 nM for human and mouse MGAT2, respectively.
    TP-020
  • HY-100517
    TP-472
    2 Publications Verification

    		 Epigenetic Reader Domain Apoptosis Cancer
    TP-472, a chemical probe, is a selective BRD9/7 inhibitor, with Kds of 33 nM and 340 nM for BRD9 and BRD7, respectively. TP-472 exhibits >30-fold selectivity for BRD9 over other bromodomain family members except BRD7 . TP-472 induces apoptosis of melanoma cells .
    TP-472
  • HY-131981
    TP0586532
    2 Publications Verification

    		 Bacterial Infection Cardiovascular Disease
    TP0586532 is a non-hydroxamate LpxC inhibitor (IC50=0.101 μM). TP0586532 as a compound with a low cardiovascular risk that is effective against K. pneumoniae, including resistant strains . TP0586532 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    TP0586532
  • HY-109179
    Itacnosertib

    TP-0184

    		 JAK Anaplastic lymphoma kinase (ALK) FLT3 STAT PI3K Akt mTOR TGF-beta/Smad TGF-β Receptor Cancer
    Itacnosertib (TP-0184) is the inhibitor for FLT3, ACVR1 (ALK2, IC50=8 nM) and JAK2 (IC50=8540 nM). Itacnosertib exhibits anti-leukemic activity .
    Itacnosertib
  • HY-161169A
    TP0628103 TFA

    		MMP Cancer
    TP0628103 (Compound 18) TFA is a selective inhibitor of MMP-7, with the IC50 value of 0.17 nM that plays an important role in cancer and fibrosis .
    TP0628103 TFA
  • HY-16980
    Eravacycline

    TP-434

    		 Beta-lactamase Bacterial Antibiotic Infection
    Eravacycline is a potent and broad-spectrum antibacterial agent.
    Eravacycline
  • HY-148239
    TP-030-2

    		RIP kinase Ser/Thr Protease Neurological Disease Inflammation/Immunology
    TP-030-2, a chemical probe, is a RIPK1 inhibitor (human Ki=0.43 nM; mouse IC50=100 nM) .
    TP-030-2
  • HY-125851
    TP-008

    		TGF-β Receptor Inflammation/Immunology
    TP-008, a chemical probe, is a potent, selective and orally active (Activin-Like Kinase 5) ALK5 inhibitor with pIC50 and pEC50 values of 7.6 and 6.63, respectively. TGFβRI-IN-2 can produce observed cardiac toxicity in vivo at high dose .
    TP-008
  • HY-130495
    CDDO-TFEA

    CDDO-Trifluoethyl amide; RTA 404; TP-500

    		 Keap1-Nrf2 Apoptosis Cancer
    CDDO-TFEA (RTA 404; TP-500) is a trifluoroacetamide derivative of CDDO with enhanced ability to cross the blood-brain barrier. CDDO is an Nrf2 activator that inhibits proliferation and induces differentiation and apoptosis in various cancer cells. CDDO-TFEA can enhance Nrf2 expression and signaling in various neurodegenerative disease models, including those mimicking multiple sclerosis, amyotrophic lateral sclerosis, and Huntington's disease. CDDO-TFEA induces apoptosis and blocks colony formation in Ewing's sarcoma and neuroblastoma cell lines with IC50 values ranging from 85-170 nM.
    CDDO-TFEA
  • HY-151810
    TP0472993

    		Cytochrome P450 Metabolic Disease
    CYP4A11/CYP4F2-IN-2 is a potent and orally active dual inhibitor of cytochrome P450 (CYP) 4A11 and CYP4F2, with IC50s of 140 nM and 40 nM, respectively. CYP4A11/CYP4F2-IN-2 has potential for the research of renal diseases .
    TP0472993
  • HY-144266
    TP-060

    Glucosylceramide synthase-IN-1

    		 Glucosylceramide Synthase (GCS) Neurological Disease Metabolic Disease
    Glucosylceramide synthase-IN-1 (T-036), a chemical probe, a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC50s of 31 nM and 51 nM for human GCS and mouse GCS, respectively. Glucosylceramide synthase-IN-1 can be used for Gaucher's disease research .
    TP-060
  • HY-176990
    TP receptor antagonist-3

    		Prostaglandin Receptor Cardiovascular Disease Neurological Disease Inflammation/Immunology
    TP receptor antagonist-3 (compound 51280) is a potent thromboxane A2 prostanoid (TP) receptor with an IC50 of 15.7 nM against Human TP. TP receptor antagonist-3 can be used for alzheimer's disease, cardiovascular and respiratory diseases, and cancer research .
    TP receptor antagonist-3
  • HY-148253
    TP-030-1

    		RIP kinase Neurological Disease Inflammation/Immunology
    TP-030-1, a chemical probe, is an inhibitor of RIPK1. TP-030-1 inhibits hRIPK1 with a Ki value of 3.9 nM and inhibits mRIPK1 with an IC50 value of 4.2 μM. TP-030-1 can be used for the research of inflammatory diseases and neurodegenerative diseases .
    TP-030-1
  • HY-114205A
    TP-238 hydrochloride

    		Epigenetic Reader Domain Cancer
    TP-238 hydrochloride is a potent and selective dual CECR2/BPTF probe with IC50 values of 30 nM and 350 nM, respectively. TP-238 hydrochloride also inhibits BRD9 with a pIC50 of 5.9 and is less active against other 338 kinases .
    TP-238 hydrochloride
  • HY-P0316
    TP508

    		Thrombin NO Synthase Cardiovascular Disease
    TP508 is a 23-amino acid nonproteolytic thrombin peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508 activates endothelial NO synthase (eNOS) and stimulates production of NO in human endothelial cells. TP508 activates endothelial cells and stem cells to revascularize and regenerate tissues .
    TP508
  • HY-147316A
    TP-5801 TFA

    		STAT TNK1 Cancer
    TP-5801 TFA is an orally active TNK1 (non-receptor tyrosine kinase) inhibitor (IC50=1.40 nM), and shows anti-tumor activity .
    TP-5801 TFA
  • HY-118528A
    TP0427736 hydrochloride
    2 Publications Verification

    		 TGF-β Receptor Endocrinology
    TP0427736 hydrochloride is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50=836 nM). TP0427736 hydrochloride also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM. TP0427736 hydrochloride can be used for the research of androgenic alopecia (AGA) .
    TP0427736 hydrochloride
  • HY-109179A
    Itacnosertib hydrochloride

    TP-0184 hydrochloride

    		 JAK Anaplastic lymphoma kinase (ALK) FLT3 STAT PI3K Akt mTOR TGF-beta/Smad TGF-β Receptor Cancer
    Itacnosertib hydrochloride (TP-0184 hydrochloride) is the inhibitor for FLT3, ACVR1 (ALK2, IC50=8 nM) and JAK2 (IC50=8540 nM). Itacnosertib hydrochloride exhibits anti-leukemic activity .
    Itacnosertib hydrochloride
  • HY-131979
    TP-040

    O-GlcNAcase-IN-1

    		 OGA Neurological Disease
    TP-040 (O-GlcNAcase-IN-1), a chemical probe, is a potent and novel OGA inhibitor with an IC50 value of 46 nM.
    TP-040
  • HY-RS14912
    TP53 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    TP53 Human Pre-designed siRNA Set A contains three designed siRNAs for TP53 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    TP53 Human Pre-designed siRNA Set A
    TP53 Human Pre-designed siRNA Set A
  • HY-105025A
    Thymocartin TFA

    Thymopoietin II (32-35) TFA; TP 4 TFA

    		 Apoptosis Inflammation/Immunology
    Thymocartin TFA is the TFA salt form of Thymocartin (HY-105025). Thymocartin TFA inhibits apoptosis of peripheral blood lymphocytes in HIV infected individuals. Thymocartin TFA is potential for immunodeficiency diseases research .
    Thymocartin TFA
  • HY-148235
    TP-051

    		Free Fatty Acid Receptor Metabolic Disease
    TP-051, a chemical probe, is a potent FFAR1 agonist with an Ki value of 16 nM for human FFAR1. TP-051 can increase insulin secretion in rat insulinoma cells. TP-051 can be used to research type 2 diabetes .
    TP-051
  • HY-13952
    TP-808

    		Drug Intermediate Bacterial Others
    TP-808 is a key enone intermediate for the discovery and manufacture of Tetracycline (HY-A0107) analogs and synthetic tetracyclines including eravacycline .
    TP-808
  • HY-160151
    TP1L

    		PROTACs Phosphatase JAK IFNAR MHC Cancer
    TP1L is a potent and selective T-cell protein tyrosine phosphatase (TC-PTP) PROTAC degrader, with a DC50 value of 35.8 nM. TP1L elevates the phosphorylation level of TC-PTP substrates including pSTAT1 and pJAK1. TP1L selectively enhances IFN-γ signaling and increases MHC-I expression. TP1L activates TCR signaling through increases phosphorylation of LCK. TP1L enhances CAR-T cell mediated tumor killing efficacy through activation of the CAR-T cells. TP1L can be used for the study of cancer. (Pink: TC-PTP ligand: (HY-138964), Blue: E3 ligase CRBN Ligand (HY-A0003), Black: Linker: (HY-140002)) .
    TP1L
  • HY-P0316A
    TP508 TFA

    		Thrombin NO Synthase Cardiovascular Disease
    TP508 TFA is a 23-amino acid nonproteolytic thrombin peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508 TFA activates endothelial NO synthase (eNOS) and stimulates production of NO in human endothelial cells. TP508 TFA activates endothelial cells and stem cells to revascularize and regenerate tissues .
    TP508 TFA
  • HY-119402
    TP-021
    1 Publications Verification

    BCL6-IN-8c

    		 Bcl-2 Family Cancer
    TP-021 (BCL6-IN-8c), a chemical probe, is a potent and orally active B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor with an IC50 of 0.10 μM in cell-free enzyme-linked immunosorbent assay .
    TP-021
  • HY-118522
    TP-110

    		Proteasome NF-κB Caspase PARP IAP Apoptosis Cancer
    TP-110 is a proteasome inhibitor. TP-110 specifically inhibits the protease-like activity of the 20S proteasome, but does not affect the trypsin-like or peptidyl-glutamyl peptide hydrolysis activity. TP-110 inhibits the NF-κB pathway, activates caspase-8, -9, and -3, and causes PARP cleavage, significantly reducing the levels of cIAP-1 and XIAP. TP-110 causes cell cycle arrest at the G2/M phase and promotes apoptosis of cancer cells. TP-110 can be used in cancer research of prostate cancer and multiple myeloma, etc .
    TP-110
  • HY-148250
    TP-050

    		iGluR Neurological Disease
    TP-050, a chemical probe, is a potent, orally active and selective NMDAR agonist with an EC50 value of 0.51 μM and 9.6 μM for GluN2A and GluN2D, respecticely. TP-050 can cross the blood-brain barrier (BBB). TP-050 induces hippocampal long-term (LPT) potentiation enhancemen and enhances neuronal signal transmission .
    TP-050
  • HY-P11089
    TP53 neoepitope

    		MHC Cancer
    TP53 neoepitope is a high-affinity antigenic peptide targeting HLA-A. TP53 neoepitope can triggers CD8 + T cell-mediated killing of TP53-mutant tumor cells. TP53 neoepitope is promising for research of solid tumors harboring TP53 hotspot mutations (e.g., R175H, R273H) .
    TP53 neoepitope
  • HY-114205
    TP-238

    		Epigenetic Reader Domain Cancer
    TP-238 is a potent and selective dual CECR2/BPTF probe with IC50 values of 30 nM and 350 nM, respectively. TP-238 also inhibits BRD9 with a pIC50 of 5.9 and is less active against other 338 kinases .
    TP-238
  • HY-135888
    TP748

    		Drug Intermediate Others
    TP748,an isoxazole, is a key intermediate for fully synthetic tetracyclines .
    TP748
  • HY-118528
    TP0427736

    		TGF-β Receptor Cancer
    TP0427736 is a selective inhibitor of ALK5 with an IC50 of 2.72 nM. TP0427736 inhibits Smad2/3 phosphorylation in A549 cells. TP0427736 decreases the growth inhibition of human outer root sheath cells .
    TP0427736
  • HY-148571
    TP0597850

    		MMP Inflammation/Immunology Cancer
    TP0597850 is a selective inhibitor of MMP2 (IC50=0.22 nM). TP0597850 has a long MMP2 dissociation half-life (t1/2=265 min) .
    TP0597850
  • HY-161169
    TP0628103

    		MMP Cancer
    TP0628103 (compound 18) is a selective inhibitor of MMP-7, with the IC50 value of 0.17 nM that plays an important role in cancer and fibrosis .
    TP0628103
  • HY-103512
    TP003

    		GABA Receptor Neurological Disease
    TP003 is a non-selective benzodiazepine site agonist with EC50s of 20.3, 10.6, 3.24, 5.64 nM for α1β2γ2, α2β3γ2, α3β3γ2, α5β2γ2, respectively. TP003 induces anxiolysis via α2GABAA receptors .
    TP003

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