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Results for "

TTK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AAK1 (1) Aurora Kinase (3) CDK (2) Cyclin G-associated Kinase (GAK) (1) DNA/RNA Synthesis (1) FAK (1) Histone Acetyltransferase (1) Histone Demethylase (1) JAK (1) Ligands for Target Protein for PROTAC (2) LRRK2 (1) Mps1 (21) Polo-like Kinase (PLK) (1) PROTACs (5) Reference Standards (2) Small Interfering RNA (siRNA) (4) TLK (1)
By Research Areas:	Cancer (25) Neurological Disease (2)
Click Chemistry:	PROTAC Synthesis (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (1) siRNAs (4)

Inhibitors & Agonists

Recombinant Proteins

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101340

Luvixasertib 5+ Cited Publications CFI-402257	Mps1	Cancer
CFI-402257 is a highly selective and orally bioavailable *TTK/Mps1* inhibitor with an IC₅₀ of 1.7 nM for TTK in vitro. CFI-402257 has anti-cancer activity .

HY-116673

TTK21	Histone Acetyltransferase	Neurological Disease
TTK21 is an activator of the histone acetyltransferases CBP/p300. TTK21 passes the blood–brain barrier, induces no toxicity, and reaches different parts of the brain when conjugated to glucose-based carbon nanosphere (CSP). TTK21 has beneficial implications for the brain functions of neurogenesis and long-term memory ^[1].CSP-TTK21 can ameliorate Aβ-impaired long-term potentiation (LTP). CSP-TTK21 may enhance the transcription of genes that promote synaptic health and cognitive function . CSP-TTK21 is orally effective and leads to improvements in motor functions, histone acetylation dynamics in a spinal injury rat model .

HY-14710

AZ3146 Maximum Cited Publications 11 Publications Verification	Mps1	Cancer
AZ3146 is a reasonably potent Mps1 and TTK inhibitor, with IC₅₀ of 35 nM for Mps1 ^Cat.

HY-101340A

Luvixasertib hydrochloride 5+ Cited Publications CFI-402257 hydrochloride	Mps1	Cancer
CFI-402257 hydrochloride is a highly selective and orally bioavailable *TTK/Mps1* inhibitor with an IC₅₀ of 1.7 nM for TTK in vitro. CFI-402257 hydrochloride has anti-cancer activity .

HY-108709

CC-671 1 Publications Verification	CDK	Cancer
CC-671 is a dual TTK protein kinase/CDC2-like kinase (CLK2) inhibitor with IC₅₀s of 0.005 and 0.006 μM for TTK and CLK2, respectively.

HY-168543

PROTAC MPS1 degrader 2	PROTACs Aurora Kinase Mps1	Cancer
PROTAC MPS1 degrader 2 (Compound 15) is a potent degrader of monopolar spindle 1 (Mps1，TTK)，AURKA and AURKB，with DC₅₀s of 42.0，2.1 and 154.0 nM，respectively. PROTAC MPS1 degrader 1 can be used for the research of acute myeloid leukemia. (Pink: ligand for target protein (HY-168545); Black: linker (HY-N0420); Blue: ligand for E3 ligase (HY-10984) .

HY-143904

*PROTAC TTK* degrader-1**	PROTACs	Cancer
PROTAC TTK degrader-1 is a potent *TTK* (threonine tyrosine kinase) PROTAC degrader, with DC₅₀ values of 1.7 and 5.8 nM in COLO-205 and HCT-116 cell, respectively. PROTAC TTK degrader-1 exhibits target degradation and anticancer efficacy in a xenograft mouse model of COLO-205 human colorectal cancer cells .

HY-100024

NTRC 0066-0	Mps1	Cancer
NTRC 0066-0 is a selective threonine tyrosine kinase (TTK) inhibitor (IC₅₀=0.9 nM). NTRC 0066-0 can be used for the research of cancer .

HY-171770

dAurAB5	PROTACs Aurora Kinase AAK1 Cyclin G-associated Kinase (GAK) Mps1 FAK	Cancer
dAurAB5 is a dual Aurora-A (DC₅₀ = 8.8 nM) and Aurora-B (DC₅₀ = 6.1 nM) PROTAC degrader. dAurAB5 induces degradation of Aurora-A and Aurora-B, reduces N-Myc levels, and decreases viability in IMR32 neuroblastoma cells. dAurAB5 downregulates the levels of AAK1, PTK2, GAK, and TTK. dAurAB5 can be used to study cancers such as neuroblastoma. (Pink: TTK ligand 2: HY-168542, Blue: Thalidomide-O-COOH: HY-103597, Black: 6-Aminocaproic acid: HY-B0236) .

HY-19544

JAK3-IN-1	JAK	Cancer
JAK3-IN-1 is a potent, selective and orally active JAK3 inhibitor with an IC₅₀ of 4.8 nM. JAK3-IN-1 shows over 180-fold more selective for JAK3 than JAK1 (IC₅₀ of 896 nM) and JAK2 (IC₅₀ of 1050 nM) .

HY-168540

PROTAC MPS1 degrader 1	PROTACs Mps1 Aurora Kinase	Cancer
PROTAC MPS1 degrader 1 (Compound 19) is a potent degrader of monopolar spindle 1 (Mps1, TTK), AURKA and AURKB, with DC₅₀s of 17.7, 108.7 and 570.3 nM, respectively. PROTAC MPS1 degrader 1 can be used for the research of acute myeloid leukemia. (Pink: ligand for target protein (HY-168542); Black: linker (HY-W141926); Blue: ligand for E3 ligase (HY-10984) .

HY-168542

TTK ligand 2	Mps1 Ligands for Target Protein for PROTAC	Cancer
TTK ligand 2 is a monopolar spindle 1 (TTK) ligand that can be used in the synthesis of PROTACT (HY-168540) .

HY-132884

TTK inhibitor 3	Mps1	Cancer
TTK inhibitor 3 is a potent and selective *TTK* (an essential spindle assembly checkpoint enzyme) inhibitor with an IC₅₀ value of 3.0 nM.

HY-168545

TTK ligand 3	Ligands for Target Protein for PROTAC Mps1	Cancer
TTK ligand 3 (Compound 5) is a ligand of monopolar spindle 1 (Mps1, TTK) that can be used in the synthesis of PROTAC (HY-168543) .

HY-164955

TTK/PLK1-IN-1	Mps1 Polo-like Kinase (PLK)	Cancer
TTK/PLK1-IN-1 (Formula I) is the inhibitor for threonine tyrosine kinase (TTK) and polo-like kinase 1 (PLK1) with IC₅₀ of 7 nM and 72 nM. TTK/PLK1-IN-1 regulates spindle assembly checkpoint (SAC), and exhibits antitumor efficacy against TNBC .

HY-144308

RMS-07	Mps1	Others
RMS-07 is a covalent Monopolar Spindle Kinase 1 (MPS1/TTK) inhibitor, with an apparent IC₅₀ of 13.1 nM. RMS-07 targets a poorly conserved cysteine in the kinase's hinge region .

HY-162156

TTK inhibitor 4	Mps1	Cancer
TTK inhibitor 4 (compound 16) is a potent inhibitor of threonine tyrosine kinase (TTK), with the IC₅₀ value of 0.016 μM, that has anti-tumor activity .

HY-143905

*PROTAC TTK* degrader-2**	PROTACs	Cancer
PROTAC TTK degrader-2 is a potent *TTK* (threonine tyrosine kinase) PROTAC degrader, with DC₅₀ values of 3.1 and 12.4 nM in COLO-205 and HCT-116 cell, respectively. PROTAC TTK degrader-2 exhibits target degradation and anticancer efficacy in a xenograft mouse model of COLO-205 human colorectal cancer cells .

HY-123675

CFI-400936	Mps1	Cancer
CFI-400936 is a potent *TTK* inhibitor with an IC₅₀ of 3.6 nM. CFI-400936 has antitumor activity .

HY-149213

LSD1/TLK1-IN-1 J54; J3-54	Histone Demethylase TLK	Cancer
LSD1/TLK1-IN-1 is an orally active LSD1, TLK1, TLK2, *TTK* inhibitor with an LSD1 IC₅₀ of 0.247 μM. LSD1/TLK1-IN-1 suppresses phosphorylation of Nek1 at T141 and Rad9 at S328, abrogates the TLK1>Nek1>ATR>Chk1 axis, protects H3K4me1/2 from demethylation, and does not affect LSD2, MAO-A, or MAO-B. LSD1/TLK1-IN-1 induces apoptosis, bypasses cell-cycle arrest, suppresses tumor growth, acts as a weak D4R antagonist, downregulates PD-L1 expression, enhances T-cell killing response, inhibits gastric cancer cell proliferation, shows minimal toxicity, and has no significant effect on normal prostate cells. LSD1/TLK1-IN-1 can be used for the research of prostate cancer and gastric cancer .

HY-110347

Mps1-IN-1 dihydrochloride	Mps1	Cancer
Mps1-IN-1 dihydrochloride is a potent and ATP-competitive Mps1 kinase inhibitor with an IC₅₀ of 367 nM. Mps1-IN-1 dihydrochloride inhibit Mps1 mitotic kinase activity and abrogates spindle assembly checkpoint (SAC) function. Mps1-IN-1 dihydrochloride decreases the viability of both cancer and ‘normal’ cells .

HY-RS16792

Ttk Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ttk Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ttk gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ttk Mouse Pre-designed siRNA Set A Ttk Mouse Pre-designed siRNA Set A

HY-RS15226

TTK Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TTK Human Pre-designed siRNA Set A contains three designed siRNAs for TTK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TTK Human Pre-designed siRNA Set A TTK Human Pre-designed siRNA Set A

HY-160419

Mps1-IN-8	Mps1	Cancer
Mps1-IN-8 is a Mps1 inhibitor. Mps1-IN-8 can be used in the study of various tumors .

HY-116190

CFI-401870	Mps1 DNA/RNA Synthesis	Cancer
CFI-401870 is an orally active threonine tyrosine kinase (TTK (Mps1)) inhibitor with an IC₅₀ of 3.1 nM. CFI-401870 exhibits IC₅₀s against PLK4, KDR, AURKA and other kinases such as AURKB/INCENP were all greater than 1 μM.CFI-401870 inhibits the growth of various cancer cells, causing chromosome lag, an increase in aneuploidy and cell cycle arrest. CFI-401870 can be used for the study of cancers such as colon cancer .

HY-179430

TTK-IN-5	Mps1	Cancer
TTK-IN-5 is an orally active covalent threonine tyrosine kinase (TTK) inhibitor with selectivity (IC₅₀ = 8.918 nM). TTK-IN-5 exhibits anti-proliferative potencies against MDA-MB-231, A2780, HCT116, HCC1569 and MKN1 cell lines (IC₅₀ values of 0.113 μM, 0.476 μM, 3.136 μM, 3.649 μM, and 1.856 μM, respectively). TTK-IN-5 potently suppresses tumor growth without notable toxicity in A2780 and MDA-MB-231 xenograft mouse models. TTK-IN-5 can be used for the research of cancer such as breast cancer and ovarian cancer .

HY-RS23232

Ttk Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ttk Rat Pre-designed siRNA Set A contains three designed siRNAs for Ttk gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ttk Rat Pre-designed siRNA Set A Ttk Rat Pre-designed siRNA Set A

HY-116470

*Mps1/TTK-IN-1*	Mps1	Cancer
Mps1/TTK-IN-1 (Compound cpd-5), a derivative of NMS-P715 (HY-12382), is a Mps1 kinase inhibitor with an IC₅₀ of 9.2 nM and a K_d of 1.6 nM. Mps1/TTK-IN-1 specifically targets the ATP-binding pocket of the Mps1 kinase. Mps1/TTK-IN-1 maintains inhibitory activity against Mps1 drug-resistant mutants (C604Y, C604W) with IC₅₀ values of 170 and 19 nM and K_d values of 471 and 349 nM. Mps1/TTK-IN-1 can block the phosphorylation of kinetochore protein KNL1 mediated by Mps1, interfere with the spindle assembly checkpoint function, prevent the correct separation of chromosomes, and thereby inhibit the mitosis and proliferation of tumor cells .

HY-101340AR

Luvixasertib hydrochloride (Standard) CFI-402257 hydrochloride (Standard)	Mps1 Reference Standards	Cancer
Luvixasertib (hydrochloride) (Standard) is the analytical standard of Luvixasertib (hydrochloride) (HY-101340A). This product is intended for research and analytical applications. CFI-402257 hydrochloride is a highly selective and orally bioavailable TTK/Mps1 inhibitor with an IC50 of 1.7 nM for TTK in vitro. CFI-402257 hydrochloride has anti-cancer activity .

HY-108709R

CC-671 (Standard)	Reference Standards CDK	Cancer
CC-671 (Standard) is the analytical standard of CC-671 (HY-108709). This product is intended for research and analytical applications. CC-671 is a dual TTK protein K_inase/CDC2-like K_inase (CLK2) inhibitor with IC₅₀s of 0.005 and 0.006 μM for TTK and CLK2, respectively.

HY-RS21071

Ttbk2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ttbk2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ttbk2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ttbk2 Mouse Pre-designed siRNA Set A Ttbk2 Mouse Pre-designed siRNA Set A

HY-182928

LRRK2-IN-21	LRRK2 Mps1	Neurological Disease
LRRK2-IN-21 is a selective, blood-brain barrier-permeable LRRK2 kinase inhibitor with an IC₅₀ of 0.35 nM. LRRK2-IN-21 inhibits *TTK* kinase with an IC₅₀ of 70 nM. LRRK2-IN-21 is applicable to the research of Parkinson's disease .

Recombinant Proteins Recommended:

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P701653

	TTK Protein, Human (Active, sf9, GST, FLAG) TTK; Dual specificity protein kinase TTK; Phosphotyrosine picked threonine-protein kinase; PYT	Human	Sf9 insect cells
	The TTK protein is a highly efficient kinase that phosphorylates proteins on serine, threonine, and tyrosine residues, potentially regulating fundamental cellular processes. Notably, it phosphorylates MAD1L1, promoting mitotic checkpoint signaling, which is critical for accurate chromosome segregation. TTK Protein, Human (sf9, GST, FLAG) is the recombinant human-derived TTK protein, expressed by sf9 insect cells , with C-Flag, N-GST labeled tag.

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Cat. No.	Product Name		Classification

HY-143904

*PROTAC TTK* degrader-1**		PROTAC Synthesis
PROTAC TTK degrader-1 is a potent *TTK* (threonine tyrosine kinase) PROTAC degrader, with DC₅₀ values of 1.7 and 5.8 nM in COLO-205 and HCT-116 cell, respectively. PROTAC TTK degrader-1 exhibits target degradation and anticancer efficacy in a xenograft mouse model of COLO-205 human colorectal cancer cells .

HY-143905

*PROTAC TTK* degrader-2**		PROTAC Synthesis
PROTAC TTK degrader-2 is a potent *TTK* (threonine tyrosine kinase) PROTAC degrader, with DC₅₀ values of 3.1 and 12.4 nM in COLO-205 and HCT-116 cell, respectively. PROTAC TTK degrader-2 exhibits target degradation and anticancer efficacy in a xenograft mouse model of COLO-205 human colorectal cancer cells .

Ttk Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Ttk Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ttk gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

TTK Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TTK Human Pre-designed siRNA Set A contains three designed siRNAs for TTK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ttk Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Ttk Rat Pre-designed siRNA Set A contains three designed siRNAs for Ttk gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ttbk2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Ttbk2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ttbk2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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