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Results for "

Tcf/4

" in MedChemExpress (MCE) Product Catalog:

22

Inhibitors & Agonists

3

Peptides

1

Natural
Products

1

Recombinant Proteins

1

Isotope-Labeled Compounds

4

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-100760
    Toxoflavin
    5+ Cited Publications

    Xanthothricin; Toxoflavine; PKF-118-310

    		 β-catenin Bacterial Antibiotic Histone Demethylase Infection Cancer
    Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor and antibiotic activity .
    Toxoflavin
  • HY-101486
    LF3
    Maximum Cited Publications
    14 Publications Verification

    		 β-catenin Cancer
    LF3 is an antagonist of the β-Catenin/TCF4 interaction with antitumor activity; has an IC50 of 1.65 μM .
    LF3
  • HY-B1360
    Chlorquinaldol
    5+ Cited Publications

    Chloquinan

    		 Antibiotic Bacterial Fungal β-catenin Apoptosis Infection Cancer
    Chlorquinaldol (Chloquinan) is an antibacterial agent with the potential use in topical skin conditions and vaginal infections. Chlorquinaldol is a β-catenin/TCF4 inhibitor, showing anti-proliferation, anti-migration, and apoptosis-inducing activity in cancer cells .
    Chlorquinaldol
  • HY-122649
    UU-T01

    		β-catenin Cancer
    UU-T01 is a β-catenin inhibitor with a KD of 0.531 μM. UU-T01 binds to the K435, R469 and K508 residues of β-catenin, disrupting the β-catenin/TCF4 protein-protein interaction .
    UU-T01
  • HY-N3393
    Lethedioside A

    		β-catenin Inflammation/Immunology
    Lethedioside A is a Enhancer of split 1 (Hes1) inhibitor with an IC50 of 9.5 μM. Lethedioside A inhibits Hes1 dimer formation. Lethedioside A exhibits weak inhibition of TCF4/β-catenin complex formation. Lethedioside A inhibits nitric oxide production by activated immune cells .
    Lethedioside A
  • HY-119966
    CCT036477

    		Wnt β-catenin PPAR CDK Cancer
    CCT036477 is a Wnt/β-catenin pathway inhibitor. CCT036477 blocks transcription at β-catenin without altering its levels. CCT036477 inhibits proliferation of various cancer cells, development of embryos, and expression of Wnt target genes (PPARδ, Cyclin D1, TCF4, and ID2) .
    CCT036477
  • HY-P10392B
    aStAx-35R TFA

    		β-catenin Wnt Cancer
    aStAx-35R TFA, a stapled peptide, antagonizes nuclear form of β-catenin and inhibits Wnt signaling. aStAx-35R TFA inhibits competitively the binding of β-catenin to TCF4. aStAx-35R TFA selectively induces growth inhibition of Wnt-dependent cancer cells .
    aStAx-35R TFA
  • HY-RS23870
    Tcf4 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Tcf4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tcf4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Tcf4 Rat Pre-designed siRNA Set A
    Tcf4 Rat Pre-designed siRNA Set A
  • HY-RS14307
    TCF4 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    TCF4 Human Pre-designed siRNA Set A contains three designed siRNAs for TCF4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    TCF4 Human Pre-designed siRNA Set A
    TCF4 Human Pre-designed siRNA Set A
  • HY-RS17416
    Tcf4 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Tcf4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tcf4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Tcf4 Mouse Pre-designed siRNA Set A
    Tcf4 Mouse Pre-designed siRNA Set A
  • HY-172393
    TCF4/β-catenin-IN-1

    		β-catenin Apoptosis Caspase MDM-2/p53 Bcl-2 Family Cytochrome P450 Cancer
    TCF4/β-catenin-IN-1 (Compound 8b) is an inhibitor of TCF4/β-catenin, and induces apoptosis. TCF4/β-catenin-IN-1 up-regulates p53, caspase-3, caspase-8, caspase-9 levels and Bax protein expression as well as down-regulates Bcl-2 protein expression. TCF4/β-catenin-IN-1 can inhibit CYP3A4, CYP1A2, CYP2C19, and shows promising cytotoxic activity in cancer cells .
    TCF4/β-catenin-IN-1
  • HY-124826
    BC21

    NSC 109268

    		 β-catenin Cancer
    BC21 (NSC 109268) is a β-catenin/Tcf4 inhibitor with an IC50 of 5 μM. BC21 effectively inhibits the binding of β-catenin to Tcf4-derived peptides and suppresses β-catenin/Tcf4-driven reporter gene activity. BC21 can be utilized in cancer research .
    BC21
  • HY-P10392
    aStAx-35R

    		β-catenin Wnt Cancer
    aStAx-35R, a stapled peptide, antagonizes nuclear form of β-catenin and inhibits Wnt signaling. aStAx-35R inhibits competitively the binding of β-catenin to TCF4. aStAx-35R selectively induces growth inhibition of Wnt-dependent cancer cells .
    aStAx-35R
  • HY-100760S
    Toxoflavin-13C4

    Xanthothricin-13C4; Toxoflavine-13C4; PKF-118-310-13C4

    		 Isotope-Labeled Compounds β-catenin Bacterial Antibiotic Infection Cancer
    Toxoflavin- 13C4 is the 13C-labeled Toxoflavin. Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity . Antibiotic properties.
    Toxoflavin-13C4
  • HY-100760R
    Toxoflavin (Standard)

    Xanthothricin (Standard); Toxoflavine (Standard); PKF-118-310 (Standard)

    		 Reference Standards β-catenin Bacterial Antibiotic Histone Demethylase Infection Cancer
    Toxoflavin (Standard) is the analytical standard of Toxoflavin. This product is intended for research and analytical applications. Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor and antibiotic activity[1][2].
    Toxoflavin (Standard)
  • HY-149858
    β-catenin-IN-7

    		Wnt Cancer
    β-catenin-IN-7 (Compound 9) is a β-catenin inhibitor. β-catenin-IN-7 inhibits the interaction between β-catenin and Tcf-4, and inhibits Wnt-dependent target gene expression. β-catenin-IN-7 has anti-cancer activity .
    β-catenin-IN-7
  • HY-B1360R
    Chlorquinaldol (Standard)

    Chloquinan (Standard)

    		 Antibiotic Bacterial Fungal β-catenin Reference Standards Apoptosis Infection Cancer
    Chlorquinaldol (Standard) is the analytical standard of Chlorquinaldol. This product is intended for research and analytical applications. Chlorquinaldol (Chloquinan) is an antibacterial agent with the potential use in topical skin conditions and vaginal infections. Chlorquinaldol is a β-catenin/TCF4 inhibitor, showing anti-proliferation, anti-migration, and apoptosis-inducing activity in cancer cells .
    Chlorquinaldol (Standard)
  • HY-157126
    Pterostilbene-isothiocyanate

    PTER-ITC

    		 β-catenin Cancer
    Pterostilbene-isothiocyanate (PTER-ITC) exhibits potent anticancereffects in vitro. Pterostilbene-isothiocyanate against human osteosarcoma cells by abrogating the β-catenin/TCF-4 interaction .
    Pterostilbene-isothiocyanate
  • HY-133093
    Murayaquinone

    PKF118-774

    		 Parasite β-catenin Infection Cancer
    Murayaquinone (PKF118-774) is a β-catenin/Tcf4 complex inhibitor with an IC50 of 2.4 μM. Murayaquinone is a nematicidal agent found in Streptomyces sp. AN140557 .
    Murayaquinone
  • HY-101486R
    LF3 (Standard)

    		β-catenin Reference Standards Cancer
    LF3 (Standard) is the analytical standard of LF3 (HY-101486). This product is intended for research and analytical applications. LF3 is an antagonist of the β-Catenin/TCF4 interaction with antitumor activity; has an IC50 of 1.65 μM .
    LF3 (Standard)
  • HY-P11660
    β-catenin-IN-10

    		β-catenin Wnt Androgen Receptor Cancer
    β-catenin-IN-10 is a β-catenin:TCF4 interaction inhibitor with an IC50 of 5.44 μM. β-catenin-IN-10 inhibits the Wnt and AR signaling pathways with IC50 values of 0.105 μM and 1.02 μM, respectively. β-catenin-IN-10 suppresses the proliferation of castration-resistant prostate cancer cells. β-catenin-IN-10 is applicable to research related to prostate cancer .
    β-catenin-IN-10
  • HY-181560
    SLD1121

    		Wnt β-catenin Metabolic Disease
    SLD1121 is an agonist of the Wnt/β-catenin signaling pathway that enhances Wnt signaling by targeting LRP6 (Kd: 4.52-7.49 nM). SLD1121 interacts with the intracellular domain of LRP6, stabilizes LRP6, promotes its nuclear translocation, and facilitates its binding to β-catenin, TCF4 or LEF1 in the nucleus, thereby inducing the expression of Wnt-regulated genes and stem cell-related genes. SLD1121 induces the transition of hair follicles from telogen to anagen in the mouse hair growth cycle and promotes hair growth in mice. SLD1121 is applicable to hair loss-related research .
    SLD1121

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