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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
Trypanosome brucei
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "Trypanosome brucei" in MCE Product Catalog:
Cat. No.: HY-N125722
CAS No.: 33538-71-5
Synonyms: Aabomycin A1
Cat. No.: HY-155531
CAS No.: 3052256-03-5
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PEX5-PEX14 PPI-IN-2 (compound 12) is a PEX14-PEX5 protein-protein interaction (PPI) inhibitor. PEX5-PEX14 PPI-IN-2 inhibits PEX14-PEX5 PPI with EC50 values of 5 and 17 µM in T. b. brucei and HepG2 cells, respectively. PEX5-PEX14 PPI-IN-2 can be used in the research of diseases related to trypanosome infection .
Cat. No.: HY-176253
CAS No.: 2601665-22-7
Antitrypanosomal agent 26 (Compound 1) is an allosteric trypanosome alternative oxidase (TAO) inhibitor. Antitrypanosomal agent 26 exhibits potent activity against African animal trypanosomes (e.g., Trypanosoma brucei, etc.) with an IC50 value of 1.3 nM for recombinant TAO. Antitrypanosomal agent 26 blocks the mitochondrial electron transport chain of trypanosomes and inhibits glucose-dependent respiration. Antitrypanosomal agent 26 is promising for research of African animal trypanosomiasis, such as bovine trypanosomiasis .
Cat. No.: HY-N1985
CAS No.: 84687-47-8
Category:
Triterpenes Tetracyclic Triterpenoids Terpenoids Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Leguminosae Extract Plants
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Cat. No.: HY-178064
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Antiparasitic agent-29 (Compound 5) is a Trypanosome alternative oxidase (TAO) inhibitor with an IC50 of 1.3 nM in Trypanosoma brucei. Antiparasitic agent-29 has a broad-spectrum antiparasitic activity against Trypanosoma and Leishmania spp. Antiparasitic agent-29 accumulates in parasite mitochondria, selectively disrupting its energy metabolism and has potent membrane-perturbing activity with no cross-resistance. Antiparasitic agent-29 shows low ecotoxicity in zebrafish and Daphnia magna models. Antiparasitic agent-29 can be used for parasitic diseases like surra and dourine research .
Cat. No.: HY-184074
CAS No.: 2152662-88-7
Enfiborole is an oxaborolane ester inhibitor with trypanocidal activity against parasites. Enfiborole displays IC50 values ≤ 20 nM against Trypanosoma brucei and Trypanosoma cruzi, and its IC50 against replicating trypanosomes ranges from 21 to 999 nM. Enfiborole inhibits the growth of Trypanosoma brucei, suppresses hypoxanthine incorporation in replicating trypanosomes, and inhibits the growth of Trypanosoma cruzi amastigotes. Enfiborole can be used in studies related to trypanosome infections .
Cat. No.: HY-187603
CAS No.: 211816-91-0
CGP 40215 is an S-adenosylmethionine decarboxylase inhibitor with an IC50 of 20.3 μM against Trypanosoma brucei brucei AdoMet decarboxylase. CGP 40215 blocks spermidine production and leads to putrescine accumulation. CGP 40215 inhibits polyamine biosynthesis in intact trypanosomes, acts synergistically with the ornithine decarboxylase inhibitor DFMO (HY-B0744) against CNS model infections, and ameliorates laboratory infections caused by multiple Trypanosoma brucei subspecies and Trypanosoma congolense isolates, including strains tolerant to standard trypanocides. CGP 40215 can be used for research on African trypanosomiasis and Chagas disease .
Cat. No.: HY-125188
CAS No.: 2306305-57-5
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NEU-4438 is an antimalarial agent. NEU-4438 inhibits DNA synthesis, reduces AMPK-γ, and increases Clathrin heavy chain. NEU-4438 exhibits antiparasitic activity against Trypanosoma brucei. NEU-4438 reduces trypanosome tissue burden in a chronic HAT mouse model .
Cat. No.: HY-183242
CAS No.: 120154-96-3
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Eilatin is a seven-ring pyridoacridine marine alkaloid with anticancer, antibacterial, and antiparasitic activities. Eilatin acts as a DNA intercalator with selectivity for electron-deficient polycyclic purines; it can chelate Ni 2+ ions and cleave DNA via hydroxyl radical generation. Eilatin induces the SOS response in bacteria, inhibits cancer cell proliferation, and induces cancer cell differentiation and reversion of transformation. The IC50 of Eilatin against Trypanosoma brucei brucei is 1.33 μM. Eilatin can be used in research related to colon tumors, neuroblastoma, chronic myeloid leukemia, acute myeloid leukemia, and trypanosome infections .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
