Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
Trypsin-like proteasome
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "Trypsin-like proteasome" in MCE Product Catalog:
19
19 Publications Verification
Synonyms: Salinosporamide A; NPI-0052
Target:
1
Target:
Research Areas:
1
1 Cited Publications
Cat. No.: HY-18741
CAS No.: 1624602-30-7
Target:
Research Areas:
VR23 is a small molecule that potently inhibits the activities of trypsin-like proteasomes (IC50=1 nM), chymotrypsin-like proteasomes (IC50=50-100 nM), and caspase-like proteasomes (IC50=3 μM).
1
1 Cited Publications
Synonyms: Fluorogenic proteasome Substrate; Z-ARR-AMC
Target:
Research Areas:
Target:
Research Areas:
20S Proteasome activator 1 is a potent 20S proteasome activator with EC200 values of 0.3 μM, 0.7 μM and 1.8 μM for trypsin-like site, chymotrypsin-like site and caspase-like site. 20S Proteasome activator 1 translates well in a cellular system, preventing the accumulation of the pathogenic A53T mutant of α-synuclein. 20S Proteasome activator 1 can be used for researching neurodegenerative diseases .
Cat. No.: HY-135070
CAS No.: 929903-87-7
Synonyms: Ac-Arg-Leu-Arg-AMC
Target:
Research Areas:
Cat. No.: HY-P2483B
Target:
Research Areas:
Cat. No.: HY-P2483
CAS No.: 148796-86-5
Target:
Research Areas:
Cat. No.: HY-P5280
CAS No.: 1104011-51-9
Target:
Research Areas:
Cat. No.: HY-P11331
CAS No.: 1356828-49-3
Target:
Research Areas:
Cat. No.: HY-137897
CAS No.: 87779-49-5
Target:
Research Areas:
Cat. No.: HY-118522
CAS No.: 688737-95-3
TP-110 is a proteasome inhibitor. TP-110 specifically inhibits the protease-like activity of the 20S proteasome, but does not affect the trypsin-like or peptidyl-glutamyl peptide hydrolysis activity. TP-110 inhibits the NF-κB pathway, activates caspase-8, -9, and -3, and causes PARP cleavage, significantly reducing the levels of cIAP-1 and XIAP. TP-110 causes cell cycle arrest at the G2/M phase and promotes apoptosis of cancer cells. TP-110 can be used in cancer research of prostate cancer and multiple myeloma, etc .
Cat. No.: HY-126874
CAS No.: 688737-89-5
Synonyms: TP-101
Target:
Research Areas:
Tyropeptin A-4 (TP-101) is a potent proteasome inhibitor with the ability to inhibit mammalian 20S proteasome activity. Tyropeptin A-4 exerts its inhibitory effect by binding to the site responsible for trypsin-like activity. Tyropeptin A-4 derivative TP-104 has a 20-fold increase in inhibitory activity over Tyropeptin A. TP-110 specifically inhibits trypsin-like activity without affecting PGPH and trypsin-like activity .
Cat. No.: HY-P4514
CAS No.: 17278-97-6
Target:
Research Areas:
Cat. No.: HY-137281
CAS No.: 862891-04-1
Target:
Research Areas:
Cat. No.: HY-135070B
Synonyms: Ac-Arg-Leu-Arg-AMC TFA
Target:
Research Areas:
Cat. No.: HY-W753820A
Synonyms: Boc-Leu-Arg-Arg-AMC TFA
Target:
Research Areas:
Cat. No.: HY-W720448
CAS No.: 2733154-83-9
Cat. No.: HY-P11311
CAS No.: 1356828-46-0
Target:
Research Areas:
Cat. No.: HY-P2483A
Target:
Research Areas:
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
