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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
41 Results for "
V1a
" in MedChemExpress (MCE) Product Catalog:
Products (41)
41 Results for "V1a" in MCE Product Catalog:
14
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Conivaptan (hydrochloride) is a non-peptide antagonist of vasopressin receptor, with Ki values of 0.48 and 3.04 nM for rat liver V1A receptor and rat kidney V2 receptor respectively.
3
3 Cited Publications
Cat. No.: HY-18345
CAS No.: 150375-75-0
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SR 49059 (SR-49059) is a potent, orally active, selective vasopressin V1a antagonist with a Ki vaule of 1.4 nM [1].
2
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Cardiovascular Disease Neurological Disease Metabolic Disease
RG7713 (RO5028442) is a highly potent, selective and brain-penetrant Vasopressin 1a (V1a) receptor antagonist with Kis of 1 nM (hV1a) and 39 nM (mV1a).
1
1 Cited Publications
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L-371,257 is an orally bioavailable, non-blood-brain barrier penetrant, selective and competitive antagonist of oxytocin receptor (pA2=8.4) with high affinity at both the oxytocin receptor (Ki=19 nM) and vasopressin V1a receptor (Ki=3.7 nM) [1] .
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LIT-001 is the first nonpeptide oxytocin receptor (OT-R) agonist (EC50=55 nM; Ki=226 nM). LIT-001 improves social interaction in a mouse model of autism [1].
Synonyms: FE 202158
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Cat. No.: HY-19381
CAS No.: 220460-92-4
Synonyms: VNA-932; WAY-VNA 932
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WAY-151932 is a vasopressin V2-receptor agonist with IC50 of 80.3 nM and 778 nM in human-V2 binding and V1a binding assay.
Cat. No.: HY-105239A
Purity: 98.77%
Synonyms: FE 202158 acetate
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SRX246 is a potent, BBB-penetrant, highly selective vasopressin 1a (V1a) receptor antagonist (Ki=0.3 nM for human V1a). SRX246 has no interaction at V1b and V2 receptors. SRX246 also displays negligible binding at 64 others receptors classes, including 35 G-proteincoupled receptors. SRX246 can be used for treatment of stress-related disorders [1].
Cat. No.: HY-P5535
CAS No.: 1488411-60-4
Synonyms: OCE-205
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Cat. No.: HY-N10985
CAS No.: 103450-96-0
Cat. No.: HY-P1390
CAS No.: 500170-27-4
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Cat. No.: HY-18347
CAS No.: 210101-16-9
Synonyms: YM 087 free base
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Conivaptan (YM 087 free base) is antagonist for vasopressin V1A receptor and vasopressin V2 receptor. Conivaptan ameliorates congestive heart failure, improves cardiac systolic function [1].
Cat. No.: HY-109133
CAS No.: 1914998-56-3
Synonyms: BAY 1753011
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Pecavaptan, a chemical probe, is an orally active and dual antagonist of V1a/V2 receptor (Ki=0.5 nM and 0.6 nM for human, respectively). Pecavaptan promotes an increase in urine production, which reduces the associated symptoms of water retention and edema [1].
Cat. No.: HY-P0049A
CAS No.: 75499-44-4
Synonyms: Arg8-vasopressin diacetate; AVP diacetate; ADH
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Cat. No.: HY-RS29446
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ATP6V1A Monkey Pre-designed siRNA Set A contains three designed siRNAs for ATP6V1A gene (Monkey), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P10325
CAS No.: 339532-29-5
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Cat. No.: HY-172814A
CAS No.: 3039925-73-7
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OT-R agonist 1 TFA (compound 5) is an oxytocin receptor agonist with an EC50 of 0.39 nM. OT-R agonist 1 TFA shows V1A antagonist activity with an EC50 of 2432 nM and can be used for study of CNS disorders [1].
Cat. No.: HY-P5006
CAS No.: 176714-12-8
Synonyms: d(CH2)5[Tyr(Me)2, Dab5]AVP
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Cat. No.: HY-P1390A
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
