WNT5A

Isoforms Recommended:	Wnt5

By Targets:	Wnt (8) CaSR (1) Endogenous Metabolite (1) Interleukin Related (1) PPAR (1) ROR (1) Small Interfering RNA (siRNA) (3) TNF Receptor (1) β-catenin (2)
By Research Areas:	Cancer (7) Inflammation/Immunology (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Targets Recommended: Wnt

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99201

Zilovertamab 2 Publications Verification UC-961; Cirmtuzumab	ROR Wnt	Cancer
Zilovertamab (UC-961) is a humanised monoclonal antibody against ROR1 that blocks Wnt5a-induced ROR1 signalling .

HY-123071

Box5 Maximum Cited Publications 11 Publications Verification	Wnt	Cancer
Box5 is a potent *Wnt5a* antagonist. Box5 inhibits Wnt5a signaling and inhibits Wnt5a-mediated Ca ²⁺ release. Box5 inhibits cell migration. Box5 has the potential for the research of melanoma .

HY-P1416

Foxy-5 5+ Cited Publications	Wnt	Cancer
Foxy-5, a *WNT5A* agonist, is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial cancer cells. Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model .

HY-12557

γ-Glutamylvaline γ-Glu-Val	Endogenous Metabolite CaSR Wnt TNF Receptor Interleukin Related PPAR β-catenin	Inflammation/Immunology
γ‑Glutamylvaline (γ-Glu-Val) is a calcium‑sensing receptor (CaSR) agonist. γ‑Glutamylvaline activates CaSR and facilitates its binding to β‑arrestin 2 to modulate inflammatory and metabolic homeostasis signaling. γ‑Glutamylvaline inhibits TNF‑α‑induced IL‑6/MCP‑1 and enhances adiponectin/PPARγ in adipocytes. γ‑Glutamylvaline upregulates *Wnt5a, restores β‑catenin* phosphorylation, and reduces serine‑phosphorylated IRS‑1 in adipocytes. γ-Glutamylvaline can be used for the research of low-grade chronic inflammation .

HY-116553

FzM1	Wnt β-catenin	Cancer
FzM1 is a negative allosteric modulator (NAM) of Frizzled receptor FZD4. FzM1 reduces WNT5A-dependent WNT responsive element (WRE) activity (log EC_50inh=?6.2). FzM1 binds to an allosteric binding site located in intracellular loop 3 (ICL3) of FZD4 and alters the conformation of the receptor, ultimately inhibiting the *WNT/β-catenin* cascade .

HY-123071A

Box5 TFA Maximum Cited Publications 11 Publications Verification	Wnt	Cancer
Box5 TFA is a potent *Wnt5a* antagonist. Box5 TFA inhibits Wnt5a signaling and inhibits Wnt5a-mediated Ca ²⁺ release. Box5 TFA inhibits cell migration. Box5 TFA has the potential for the research of melanoma .

HY-P1416A

Foxy-5 TFA 5+ Cited Publications	Wnt	Cancer
Foxy-5 TFA, a *WNT5A* agonist, is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 TFA triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial cancer cells. Foxy-5 TFA effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model .

HY-RS15837

WNT5A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
WNT5A Human Pre-designed siRNA Set A contains three designed siRNAs for WNT5A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

WNT5A Human Pre-designed siRNA Set A WNT5A Human Pre-designed siRNA Set A

HY-RS17616

Wnt5a Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Wnt5a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Wnt5a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Wnt5a Mouse Pre-designed siRNA Set A Wnt5a Mouse Pre-designed siRNA Set A

HY-RS24076

Wnt5a Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Wnt5a Rat Pre-designed siRNA Set A contains three designed siRNAs for Wnt5a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Wnt5a Rat Pre-designed siRNA Set A Wnt5a Rat Pre-designed siRNA Set A

HY-P5171

MDGCEL	Wnt	Cancer
MDGCEL is a *WNT5A* peptide, that acts as a WNT5A mimicks and exhibits WNT5A antagonistic activity .

Cat. No.	Product Name	Target	Research Area

HY-123071

Box5 Maximum Cited Publications 11 Publications Verification	Wnt	Cancer
Box5 is a potent *Wnt5a* antagonist. Box5 inhibits Wnt5a signaling and inhibits Wnt5a-mediated Ca ²⁺ release. Box5 inhibits cell migration. Box5 has the potential for the research of melanoma .

HY-P1416

Foxy-5 5+ Cited Publications	Wnt	Cancer
Foxy-5, a *WNT5A* agonist, is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial cancer cells. Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model .

HY-12557

γ-Glutamylvaline γ-Glu-Val	Endogenous Metabolite CaSR Wnt TNF Receptor Interleukin Related PPAR β-catenin	Inflammation/Immunology
γ‑Glutamylvaline (γ-Glu-Val) is a calcium‑sensing receptor (CaSR) agonist. γ‑Glutamylvaline activates CaSR and facilitates its binding to β‑arrestin 2 to modulate inflammatory and metabolic homeostasis signaling. γ‑Glutamylvaline inhibits TNF‑α‑induced IL‑6/MCP‑1 and enhances adiponectin/PPARγ in adipocytes. γ‑Glutamylvaline upregulates *Wnt5a, restores β‑catenin* phosphorylation, and reduces serine‑phosphorylated IRS‑1 in adipocytes. γ-Glutamylvaline can be used for the research of low-grade chronic inflammation .

HY-123071A

Box5 TFA Maximum Cited Publications 11 Publications Verification	Wnt	Cancer
Box5 TFA is a potent *Wnt5a* antagonist. Box5 TFA inhibits Wnt5a signaling and inhibits Wnt5a-mediated Ca ²⁺ release. Box5 TFA inhibits cell migration. Box5 TFA has the potential for the research of melanoma .

HY-P1416A

Foxy-5 TFA 5+ Cited Publications	Wnt	Cancer
Foxy-5 TFA, a *WNT5A* agonist, is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 TFA triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial cancer cells. Foxy-5 TFA effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model .

HY-P5171

MDGCEL	Wnt	Cancer
MDGCEL is a *WNT5A* peptide, that acts as a WNT5A mimicks and exhibits WNT5A antagonistic activity .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99201

Zilovertamab 2 Publications Verification UC-961; Cirmtuzumab	ROR Wnt	Cancer
Zilovertamab (UC-961) is a humanised monoclonal antibody against ROR1 that blocks Wnt5a-induced ROR1 signalling .

Species:	Human (1) Mouse (1)
Tag:	His (2)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P704313

	Wnt5a Protein, Mouse (His) 1 Publications Verification WNT5A; Protein WNT-5A; WNT5A	Mouse	E. coli
	The Wnt5a protein is a Frizzled receptor ligand that displays dual functions in the canonical Wnt pathway. Through FZD4, it activates β-catenin signaling/ together with ROR2, it inhibits this pathway, promoting β-catenin degradation and promoting cartilage formation while preventing tumor formation. Wnt5a Protein, Mouse (His) is the recombinant mouse-derived Wnt5a protein, expressed by E. coli, with C-6*His labeled tag.

HY-P702853

	Wnt5a Protein, Human (His) Protein WNT-5A	Human	E. coli
	Wnt5a Protein, Human (His) is the recombinant human-derived Wnt5a, expressed by E. coli , with N-6*His labeled tag. ,

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Host:	Mouse (2) Rabbit (3)
Reactivity:	Human (5)
Application:	IHC-P (2) ICC/IF (5) WB (3) FC (1) ELISA (2)
Isotype:	IgG (3) IgG1 (2)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (2) Monoclonal Antibody (1) Recombinant (2)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85411

	Wnt5a Antibody (YA5103) WNT5A; Protein WNT-5A	WB, ICC/IF, FC	Human
	Wnt5a Antibody (YA5103) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to Wnt5a.

HY-P80933

	Wnt5a Antibody (YA007) 1 Publications Verification WNT5A; Protein WNT-5A	WB, ICC/IF	Human
	Wnt5a Antibody (YA007) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Wnt5a.

HY-P80933A

	Wnt5a Antibody (YA007)(PBS only) WNT5A; Protein WNT-5A	WB, ICC/IF	Human
	Wnt5a Antibody (YA007) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Wnt5a.

HY-P84305

	Wnt5a Antibody (YA4002) hWNT5A	IHC-P, ICC/IF, ELISA	Human
	Wnt5a Antibody (YA4002) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Wnt5a.

HY-P84305A

	Wnt5a Antibody (YA4002)(PBS only) hWNT5A	IHC-P, ICC/IF, ELISA	Human
	Wnt5a Antibody (YA4002) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Wnt5a.

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Reactivity
Application
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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-RS15837

WNT5A Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
WNT5A Human Pre-designed siRNA Set A contains three designed siRNAs for WNT5A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17616

Wnt5a Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Wnt5a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Wnt5a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS24076

Wnt5a Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Wnt5a Rat Pre-designed siRNA Set A contains three designed siRNAs for Wnt5a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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