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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
28 Results for "
anti-HCV activity
" in MedChemExpress (MCE) Product Catalog:
Products (28)
28 Results for "anti-HCV activity" in MCE Product Catalog:
5
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5
5 Cited Publications
Synonyms: Ro 4588161; R1626
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Balapiravir (Ro 4588161; R1626) is an orally active proagent of a nucleoside analogue inhibitor of the RNA-dependent RNA polymerase (RdRp) of HCV (R1479; 4'-Azidocytidine). Balapiravir has anti-HCV activity . Balapiravir is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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3 Cited Publications
Cat. No.: HY-N0588
CAS No.: 78763-58-3
Category:
Infection Campanulaceae Extract Triterpenes Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Plants Disease Research Fields
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Cat. No.: HY-N7765
CAS No.: 104987-36-2
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Cyclophilin inhibitor 1 is a potent and orally bioavailable cyclophilin A inhibitor, with a Kd of 5 nM, shows effective anti-HCV activity, with an EC50 of 98 nM for HCV 2a .
Cat. No.: HY-173011
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RJS308 is a selective Cyclophilin A (CypA) PROTAC degrader. RJS308 induces ubiquitin-dependent CypA degradation by recruiting the VHL E3 ligase complex, and forms a ternary complex with CypA and VHL/elongin C/elongin B. RJS308 exhibits anti-HIV-1 and anti-HCV activities. RJS308 can be used in studies related to viral infections .
Cat. No.: HY-173011A
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RJS308 TFA is a selective Cyclophilin A (CypA) PROTAC degrader. RJS308 TFA induces ubiquitin-dependent CypA degradation by recruiting the VHL E3 ligase complex, and forms a ternary complex with CypA and VHL/elongin C/elongin B. RJS308 TFA exhibits anti-HIV-1 and anti-HCV activities. RJS308 TFA can be used in studies related to viral infections .
Cat. No.: HY-W555382
CAS No.: 55396-45-7
Synonyms: 2-Nonylquinolin-4(1H)-one
Category:
Rutaceae Extract Alkaloids Ketones, Aldehydes, Acids Ruta graveolens Linn. Quinoline Alkaloids Plants
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Cat. No.: HY-17470R
CAS No.: 50924-49-7
Synonyms: NSC 289637 (Standard); HE 69 (Standard)
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Infection Alkaloids Quinoline Alkaloids Plants Other Families Extract Disease Research Fields
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Cat. No.: HY-146648
CAS No.: 1676100-30-3
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Cyclophilin inhibitor 3 (compound 7c) is a potent cyclophilin A (CypA) inhibitor with an potent anti-HCV activity (EC50 of 4.2 μM) .
Cat. No.: HY-128924
CAS No.: 1589093-01-5
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NIM258 is a potent nonimmunosuppressive cyclophilin inhibitor (cyclophilin A Kd = 1.2 nM) with anti-HCV activity (EC50 = 40 nM). NIM258 can be used for HCV infection research .
Cat. No.: HY-173009
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PROTAC CG167 is a selective bifunctional PROTAC degrader targeting CypA, with a DC50 of 123 nM. PROTAC CG167 drives ubiquitin-dependent and ubiquitin-like modification-dependent proteasomal degradation of CypA by recruiting the VHL E3 ligase complex. PROTAC CG167 exhibits anti-HIV‑1 and anti-HCV replication activities, and selectively reduces CypA levels in various cells. PROTAC CG167 can be used in studies related to viral infections .
Cat. No.: HY-157291
CAS No.: 872201-68-8
Antiviral agent 44 (compound 7b) is an antiviral agent that has anti-HCV activity in vitro .
Cat. No.: HY-129057
CAS No.: 581772-30-7
2',5-Difluoro-2'-deoxycytidine, compound 13, has potent anti-HCV activity and toxicity to ribosomal RNA (rRNA) .
Cat. No.: HY-169746
CAS No.: 1613591-70-0
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Antiviral agent 63 is a nucleoside analog with anti-HCV activity. Antiviral agent 63 can inhibit viral replication by inhibiting the activity of HCV RNA-dependent RNA polymerase or other virus-related enzymes .
Cat. No.: HY-115989
CAS No.: 3035807-39-4
HCV-IN-38 is a potent, selective and orally active HCV inhibitor (EC50=15 nM, SI=431). HCV-IN-38 has high anti-HCV activity and low cytotoxicity. HCV-IN-38 has a good safety and oral pharmacokinetic profile .
Cat. No.: HY-W555382S
Synonyms: 2-Nonylquinolin-4(1H)-one-d4
Cat. No.: HY-177299
CAS No.: 1255860-45-7
HCV NS5B polymerase-IN-3 (Compound 30a) is an inhibitor of the HCV NS5B polymerase. HCV NS5B polymerase-IN-3 exhibits anti-HCV activity in the Huh7 replicon cell line with an EC50 of 0.23 μM and shows no obvious cytotoxicity. HCV NS5B polymerase-IN-3 can be used in research related to the hepatitis C virus .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
