1. Anti-infection
    Cell Cycle/DNA Damage
  2. HCV
    DNA/RNA Synthesis
  3. Balapiravir

Balapiravir (Synonyms: Ro 4588161; R1626)

Cat. No.: HY-10443 Purity: 97.58%
Handling Instructions

Balapiravir (Ro 4588161; R1626) is an orally active prodrug of a nucleoside analogue inhibitor of the RNA-dependent RNA polymerase (RdRp) of HCV (R1479; 4'-Azidocytidine). Balapiravir has anti-HCV activity.

For research use only. We do not sell to patients.

Balapiravir Chemical Structure

Balapiravir Chemical Structure

CAS No. : 690270-29-2

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 264 In-stock
Estimated Time of Arrival: December 31
5 mg USD 240 In-stock
Estimated Time of Arrival: December 31
10 mg USD 396 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Balapiravir:

Top Publications Citing Use of Products
  • Biological Activity

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Description

Balapiravir (Ro 4588161; R1626) is an orally active prodrug of a nucleoside analogue inhibitor of the RNA-dependent RNA polymerase (RdRp) of HCV (R1479; 4'-Azidocytidine). Balapiravir has anti-HCV activity[1][2][3].

In Vivo

After oral dosing of the CD-1 mice with 28.1 mg/kg of balapiravir (Ro 4588161; R1626), R1479 reaches a Cmax and a minimum concentration in plasma (Cmin) of 24.38 μM and 6.34 μM, respectively, at 2 h and 24 h postdosing[3].

Clinical Trial
Molecular Weight

494.50

Formula

C₂₁H₃₀N₆O₈

CAS No.

690270-29-2

SMILES

O=C1N=C(N)C=CN1[[email protected]@H]2O[[email protected]](N=[N+]=[N-])(COC(C(C)C)=O)[[email protected]@H](OC(C(C)C)=O)[[email protected]]2OC(C(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (202.22 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0222 mL 10.1112 mL 20.2224 mL
5 mM 0.4044 mL 2.0222 mL 4.0445 mL
10 mM 0.2022 mL 1.0111 mL 2.0222 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.06 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.06 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.06 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 97.58%

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Keywords:

BalapiravirRo 4588161R1626Ro4588161Ro-4588161R 1626R-1626HCVDNA/RNA SynthesisHepatitis C virusorallynucleosideRdRpR14794'-AzidocytidineInhibitorinhibitorinhibit

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Balapiravir
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