1. Anti-infection
  2. HCV

Balapiravir (Synonyms: Ro 4588161; R1626)

Cat. No.: HY-10443 Purity: 98.11%
Handling Instructions

Balapiravir (R1626, Ro 4588161) is the prodrug of a nucleoside analogue inhibitor of the hepatitis C virus (HCV) RNA-dependent RNA polymerase (R1479, RG1479).

For research use only. We do not sell to patients.
Balapiravir Chemical Structure

Balapiravir Chemical Structure

CAS No. : 690270-29-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 264 In-stock
5 mg USD 240 In-stock
10 mg USD 396 In-stock
50 mg USD 1200 In-stock
100 mg   Get quote  
200 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Balapiravir (R1626, Ro 4588161) is the prodrug of a nucleoside analogue inhibitor of the hepatitis C virus (HCV) RNA-dependent RNA polymerase (R1479, RG1479). IC50 Value: Target: HCV Balapiravir(R-1626; R 1626; Ro 4588161) is useful for Anti HCV. Balapiravir (R1626) is the tri-isobutyrate ester prodrug of R1479 under clinical development to improve exposure of R1479 upon oral administration. Balapiravir was discontinued for safety reasons in 28-36% of patients (most often for lymphopenia) and the percentage of patients with serious adverse events (especially hematological, infection, ocular events) was dose related. Serious hematological adverse events (particularly neutropenia, lymphopenia) were more common in balapiravir recipients. Two deaths in the balapiravir/peginterferon alfa-2a/ribavirin combination groups were considered possibly related to study medication.

Clinical Trial
References
Molecular Weight

494.5

Formula

C₂₁H₃₀N₆O₈

CAS No.

690270-29-2

SMILES

O=C1N=C(N)C=CN1[[email protected]@H]2O[[email protected]](N=[N+]=[N-])(COC(C(C)C)=O)[[email protected]@H](OC(C(C)C)=O)[[email protected]]2OC(C(C)C)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 100 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 98.11%

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Product Name:
Balapiravir
Cat. No.:
HY-10443
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