19 Results for "

bufadienolide

" in MedChemExpress (MCE) Product Catalog:
Products (19)

19 Results for "bufadienolide" in MCE Product Catalog:

6
6 Publications Verification
Cat. No.: HY-N0880
CAS No.: 1108-68-5
Cinobufotalin is a cardiotonic steroids or bufadienolides, is extracted from the skin secretions of the giant toads. Cinobufotalin has been used as a cardiotonic, diuretic and a hemostatic agent, Cinobufotalin is also a potential anti-lung cancer agent .
loading...
    loading...
4
4 Cited Publications
Cat. No.: HY-N0876
CAS No.: 464-74-4
Arenobufagin is a natural bufadienolide that can be extracted from toad venom. Arenobufagin can induce apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway. Arenobufagin has potent antineoplastic activity against HCC HepG2 cells as well as corresponding multidrug-resistant HepG2/ADM cells. Arenobufagin can inhibit VEGF-mediated angiogenesis through suppression of VEGFR-2 signaling pathway .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-N0885
CAS No.: 472-26-4
Synonyms: Telobufotoxin; Telocinobufogenin
Telocinobufagin (Telobufotoxin; Telocinobufogenin) is an orally active bufadienolide with potential anti-tumor effects. Telocinobufagin exerts its anti-cancer effects on non-small cell carcinoma, osteosarcoma, thyroid cancer, breast cancer and head and neck squamous cell carcinoma by inhibiting the STAT3, JAK2/STAT3, LARP1-mTOR, PI3K/Akt/Snail and PLK1 pathways, and can also induce tumor cell apoptosis. Telocinobufagin enhances the Th1 immune response and protects against Salmonella typhimurium infection. Telocinobufagin has a strong cardiac-stimulating effect by inhibiting the activity of Na +/K +-ATPase, and it can promote renal fibrosis. Telocinobufagin demonstrates non-opioid analgesic effects in various acute pain models .
loading...
    loading...
Cat. No.: HY-N7994
CAS No.: 508-79-2
Hellebrigenol is a metabolite of bufadienolides with antitumor activity .
loading...
    loading...
Cat. No.: HY-N7019
CAS No.: 39844-86-5
19-Hydroxybufalin is a bufadienolide, inhibits epithelial-mesenchymal transition and attenuates the migration and invasion of PC3 cells .
loading...
    loading...
Cat. No.: HY-N12167
CAS No.: 465-20-3
Category:  

Microorganisms Steroids

Target:  

Others

3-epi-Bufalin (compound 2a) is the microbial transformation product of bufadienolide .
loading...
    loading...
Cat. No.: HY-W742100
CAS No.: 465-22-5
Target:  

Enterovirus

Research Areas:  

Infection

Scillarenin is a plant bufadienolide and cardiotonic agent. Scillarenin selectively inhibits replication of picornaviruses, in particular, rhinovirus .
loading...
    loading...
Cat. No.: HY-N4255
CAS No.: 20987-24-0
Resibufagin is a kind of bufadienolide isolated from the venom of Bufo bufo gargarizans, has anti-tumor activities .
loading...
    loading...
Cat. No.: HY-122401
CAS No.: 98205-50-6
Target:  

Insecticide

Research Areas:  

Infection

Daigremontianin is an insecticidal bufadienolide that can be isolated from K. daigremontiana x tubiflora. Daigremontianin shows insecticidal activity for silkworm .
loading...
    loading...
Cat. No.: HY-N16671
CAS No.: 465-19-0
Synonyms: Bufogenin B; Deacetylbufotalin
Target:  

Others

Desacetylbufotalin (Bufogenin B; Deacetylbufotalin) is a bufadienolide found in Chinese drug "Chan'Su". Desacetylbufotalin shows strong anti-proliferative activity on the of Hela cells (IC50 = 0.01 μM). Desacetylbufotalin can be used for the research of cancer, such as cervical cancer .
loading...
    loading...
Cat. No.: HY-N6575
CAS No.: 20143-97-9
7β-Hydroxybufalin is a bufadienolide. 7β-Hydroxybufalin can be isolated from the venom of Bufo bufo gargarizans. 7β-Hydroxybufalin inhibits α-glucosidase and acetylcholinesterase .
loading...
    loading...
Cat. No.: HY-129236
CAS No.: 13289-18-4
Target:  

Na+/K+ ATPase Apoptosis

Research Areas:  

Cancer

Hellebrin is a bufadienolide compound extracted from plants that can inhibit tumor cell growth. Hellebrigenin shows potential in overcoming cancer cells' resistance to apoptosis stimuli and has also demonstrated anti-proliferation effects in multidrug-resistant (MDR) cancer cell models. Hellebrin can act on Na+/K+-ATPase to regulate intracellular signaling pathways .
loading...
    loading...
Cat. No.: HY-N7017
CAS No.: 24512-59-2
19-Oxocinobufagin is a bufadienolide in toad venom .
loading...
    loading...
Cat. No.: HY-N0876R
CAS No.: 464-74-4
Arenobufagin is a natural bufadienolide that can be extracted from toad venom. Arenobufagin can induce apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway. Arenobufagin has potent antineoplastic activity against HCC HepG2 cells as well as corresponding multidrug-resistant HepG2/ADM cells. Arenobufagin can inhibit VEGF-mediated angiogenesis through suppression of VEGFR-2 signaling pathway .
loading...
    loading...
Cat. No.: HY-N19798
CAS No.: 131221-53-9
5α-4,5-Dihydroscillaren A is a bufadienolide that can be found in the bulbs of Urginea sanguinea .
loading...
    loading...
Cat. No.: HY-N13289
CAS No.: 2042-58-2
Category:  

Animals Steroids

Target:  

Others

12β-Hydroxyresibufogenin is a bufadienolide, which shows significant inhibitory activities against cancer cell lines .
loading...
    loading...
Cat. No.: HY-N6898
CAS No.: 4029-69-0
Target:  

Drug Derivative

Research Areas:  

Cancer

3-O-Acetylbufotalin is a derivate of bufadienolide, with anti-cancer activity .
loading...
    loading...
Cat. No.: HY-N13077
CAS No.: 62859-80-7
Category:  

Microorganisms Steroids

Target:  

Others

3-Oxo-resibufogenin is an important bufadienolide with significant biological activity and potential anti-cancer properties .
loading...
    loading...
Cat. No.: HY-N7020
CAS No.: 6691-83-4
Cinobufaginol is a natural bufadienolide isolated from toad venom which has been widely used for centuries in China to treat different diseases, especially for cancer. Cinobufaginol potently inhibits the activity against human nasopharyngeal carcinoma cell lines with IC50s of 803 μΜ and 1.270 μΜ for CNE-1 and CNE-2Z, respectively .
loading...
    loading...
  • 1