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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
cFLIP
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "cFLIP" in MCE Product Catalog:
22
22 Publications Verification
Synonyms: Z/E-Guggulsterone
9
9 Cited Publications
Cat. No.: HY-N0831
CAS No.: 18085-97-7
Category:
Laburnum anagyroides Medic. Flavonoids Flavones Phenols Polyphenols Plants Compositae Disease Research Fields Inflammation/Immunology
Target:
1
1 Cited Publications
API-1 is a potent selective Akt/PKB inhibitor that reduces the level of phosphorylated Akt (IC50 = 0.8 μM). API-1 binds to the PH domain and inhibits Akt membrane translocation. API-1 induces c-FLIP degradation. API-1 reduces cell proliferation and induces apoptosis. API-1 decreases tumor growth in mouse xenograft model .
Cat. No.: HY-116497
CAS No.: 1627843-95-1
PH11 is a novel focal adhesion kinase (FAK) inhibitor that rapidly induces apoptosis in TRAIL-resistant PANC-1 cells when combined with TRAIL, but has no effect on normal human fibroblasts. The study found that PH11 downregulates c-FLIP through inhibition of FAK and phosphatidylinositol-3-kinase (PI3K)/AKT pathways, thereby restoring the TRAIL apoptotic pathway, suggesting that this combination therapy may provide an attractive therapeutic strategy for the safe and effective treatment of pancreatic cancer. PH11 selectively inhibits c-FLIP expression by modulating upstream signaling pathways and may represent an innovative therapeutic strategy. Although further work is needed to fully elucidate the mechanism of PH11-induced TRAIL sensitization, we believe that our results will provide a new approach to target c-FLIP without the risk of interfering with caspase-8 processing, which could potentially lead to TRAIL resistance. This study also suggests a role for the FAK/AKT signaling pathway in regulating c-FLIP expression in TRAIL-induced apoptosis, and this understanding will provide important clues to control the resistance mechanism to optimize the potential of TRAIL-based pancreatic cancer treatment.
Cat. No.: HY-107738R
CAS No.: 95975-55-6
Synonyms: Z/E-Guggulsterone (Standard)
Category:
Triterpenes Terpenoids Plants Burseraceae Commiphora wightii
Cat. No.: HY-RS02570
Target:
Research Areas:
CFLAR Human Pre-designed siRNA Set A contains three designed siRNAs for CFLAR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-149017
CAS No.: 2252278-57-0
Apoptosis inducer 7 (Compound 5I) induces apoptosis in cancer cells. Apoptosis inducer 7 inducrs cleavage of PARP, caspases, down-regulation of anti-apoptotic protein c-Flip and up regulation of pro-apoptotic protein Noxa. Apoptosis inducer 7 exhibits antitumor activity .
Cat. No.: HY-RS21525
Target:
Research Areas:
Cflar Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cflar gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-N0831R
CAS No.: 18085-97-7
Category:
Laburnum anagyroides Medic. Flavonoids Phenols Plants Compositae Disease Research Fields Inflammation/Immunology
Target:
Cat. No.: HY-182307
CAS No.: 1018153-87-1
Target:
Research Areas:
OH14 is a cellular FLICE-like inhibitory protein (cFLIP) inhibitor and TNF-related apoptosis-inducing ligand (TRAIL) sensitizer. OH14 selectively binds to the DED1 pocket of cFLIP, disrupting its recruitment to the TRAIL-death inducing signalling complex without affecting procaspase-8 recruitment to FADD, allowing procaspase-8 activation. OH14 promotes TRAIL-mediated apoptosis and impairs cell viability in breast cancer systems when combined with TRAIL. OH14 can be used for the research of breast cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
