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Results for "

carbapenems

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (47) Bacterial (66) Beta-lactamase (15) Biochemical Assay Reagents (1) ERK (1) Interleukin Related (1) JNK (1) Melanocortin Receptor (2) NO Synthase (1) Oxytocin Receptor (1) p38 MAPK (1) Penicillin-binding protein (PBP) (4) Reactive Oxygen Species (ROS) (1) Reference Standards (6) Toll-like Receptor (TLR) (2) Vasopressin Receptor (2)
By Research Areas:	Cancer (7) Cardiovascular Disease (1) Endocrinology (3) Infection (70) Inflammation/Immunology (7) Metabolic Disease (2) Neurological Disease (4)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13678

Meropenem 30+ Cited Publications SM 7338	Penicillin-binding protein (PBP) Bacterial Antibiotic	Infection Cancer
Meropenem (SM 7338) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem has activity against susceptible and resistant *N. gonorrhoeae* (MIC value of 0.02-0.06 mg/mL), *H. influenzae* (MIC value of 0.03-0.12 mg/mL), and *H. ducreyi* (MIC value of 0.015-0.12 mg/mL) .

HY-B1369A

Imipenem Maximum Cited Publications 35 Publications Verification N-Formimidoyl thienamycin; MK0787	Antibiotic Bacterial	Infection
Imipenem (MK0787), a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections .

HY-B1369

Imipenem monohydrate 30+ Cited Publications N-Formimidoyl thienamycin monohydrate; MK0787 monohydrate	Antibiotic Bacterial	Infection
Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections .

HY-13678A

Meropenem trihydrate 30+ Cited Publications SM 7338 trihydrate	Penicillin-binding protein (PBP) Bacterial Antibiotic	Infection Cancer
Meropenem trihydrate (SM 7338 trihydrate) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem trihydrate has activity against susceptible and resistant *N. gonorrhoeae* (MIC value of 0.02-0.06 mg/mL), *H. influenzae* (MIC value of 0.03-0.12 mg/mL), and *H. ducreyi* (MIC value of 0.015-0.12 mg/mL) .

HY-A0076

Tebipenem 5+ Cited Publications LJC 11036	Bacterial Antibiotic	Infection
Tebipenem is an orally available carbapenem antibiotic, shows broad-spectrum activity against Gram-positive and -negative bacteria, except for Pseudomonas aeruginosa.

HY-147429

Zosurabalpin Abx MCP; RG6006	Antibiotic Bacterial	Infection
Zosurabalpin is a polypeptide antibiotic targeting LPS transporter (LptB₂FGC complex), which can block the transport of LPS and lead to endotoxin accumulation in cells, and has shown excellent antibacterial activity against Carbapenem-resistant Acinetobacter baumanni (CRAB) .

HY-13678S

Meropenem-d6 SM 7338-d₆	Bacterial Antibiotic	Infection
Meropenem-d₆ is the deuterium labeled Meropenem. Meropenem (SM 7338) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL) .

HY-W008806

N-(3-Oxohexanoyl)-L-homoserine lactone OHHL; N-(3-Oxohexanoyl)homoserine lactone	Bacterial	Infection Inflammation/Immunology
N-(3-Oxohexanoyl)-L-homoserine lactone (OHHL; N-(3-Oxohexanoyl)homoserine lactone) is a specific agonist of LuxR-type transcription factor CarR with a K_d of 1.8 μM. N-(3-Oxohexanoyl)-L-homoserine lactone activates CarR by inducing protein multimerization, promoting its binding to target DNA sequences in the carR-carA intergenic region, thereby upregulating the transcription of carbapenem biosynthesis genes. N-(3-Oxohexanoyl)-L-homoserine lactone acts as a quorum sensing signal molecule, enabling bacteria to coordinate the production of carbapenem antibiotics in a cell density-dependent manner. N-(3-Oxohexanoyl)-L-homoserine lactone is used to study bacterial quorum sensing mechanisms, especially the secondary metabolism and virulence factor regulatory pathways of Erwinia carotovora and Yersinia enterocolitica .

HY-111521

Meropenem-vaborbactam Carbavance	Antibiotic Bacterial Beta-lactamase	Infection
Meropenem-vaborbactam (Carbavance) is a Carbapenem Antibiotic and Boronic acid-based beta-lactamase inhibitor, is a fixed-dose combination product with potent in vitro activity against Enterobacteriaceae that are Klebsiella pneumoniae carbapenemase producers. Meropenem-vaborbactam exhibits activity against Pseudomonas aeruginosa isolates , with an MIC₅₀ of 0.5 μg/mL and an MIC₉₀ of 8 μg/mL .

HY-B0187A

Doripenem monohydrate 5+ Cited Publications S 4661 monohydrate	Bacterial Antibiotic	Infection
Doripenem (S 4661) monohydrate, a 1β-methyl parenteral carbapenem, has very broad-spectrum activity against Gram-positive and Gram-negative aerobic bacteria .

HY-B0187

Doripenem 5+ Cited Publications S 4661	Bacterial Antibiotic	Infection
Doripenem (S 4661), a 1β-methyl parenteral carbapenem, has very broad-spectrum activity against Gram-positive and Gram-negative aerobic bacteria .

HY-W561907

IMipenem and cilastatin sodium	Antibiotic Bacterial	Infection
IMipenem and cilastatin sodium is a broad-spectrum Carbapenem Antibiotic combination. Imipenem (HY-B1369A) is a Carbapenem antibiotic. IMipenem demonstrates excellent activity against gram-positive and gram-negative aerobic and anaerobic organisms. Cilastatin (HY-A0166) is a renal Dehydropeptidase inhibitor that inhibits the metabolism of Imipenem by renal brush-border enzymes, thus increasing imipenem concentrations in urine .

HY-13573

Biapenem 4 Publications Verification CLI 86815; L 627; LJC 10627	Beta-lactamase Bacterial Antibiotic	Infection
Biapenem (CLI 86815; L 627; LJC 10627) a parenteral carbapenem antibacterial agent with a broad spectrum.

HY-147349

Pilabactam sodium ANT3310 sodium	Beta-lactamase Bacterial	Infection
Pilabactam (ANT3310) sodium is a broad-spectrum covalent Serine β-Lactamase inhibitor, with IC₅₀ values ranging from 1 nM to 175 nM (a panel of Serine β-Lactamase). Pilabactam sodium potentiates activity of β-lactam antibiotics against Carbapenem-Resistant Enterobacterales (CRE) and Acinetobacter baumannii (CRAB). Pilabactam sodium can be used in the research of bacterial infection .

HY-B1369R

Imipenem monohydrate (Standard) N-Formimidoyl thienamycin monohydrate (Standard); MK0787 monohydrate (Standard)	Reference Standards Antibiotic Bacterial	Infection
Imipenem (monohydrate) (Standard) is the analytical standard of Imipenem (monohydrate). This product is intended for research and analytical applications. Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections .

HY-P1726

MSG606	Melanocortin Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
MSG606 is a selective melanocortin 1 receptor (MC1R) antagonist. MSG606 can abolish the neuroprotective effects of BMS-470539 (HY-15616) (MC1R agonist). MSG606 can inhibit cancer cell proliferation and transition from the G1 to the S phase. MSG606 can delay pain hypersensitivity and reduce cholesterol levels. MSG606 can be used for the researches of cancer, inflammation, neurological and metabolic disease, such as breast cancer and subarachnoid hemorrhage (SAH) .

HY-16955A

Plazomicin sulfate 1 Publications Verification ACHN 490 sulfate	Antibiotic Bacterial	Infection
Plazomicin (ACHN 490) sulfate is a semi-synthetic aminoglycoside Antibiotic. Plazomicin sulfate acts as a substrate for Aminoglycoside acetyltransferase and Aminoglycoside phosphotransferase. Plazomicin sulfaten is not modified by various common aminoglycoside-modifying enzymes. Plazomicin sulfate selectively inhibits MATE2-K. Plazomicin sulfate exhibits activity against multidrug-resistant bacteria, including carbapenem-resistant Enterobacterales .

HY-13678AR

Meropenem trihydrate (Standard) SM 7338 trihydrate (Standard)	Penicillin-binding protein (PBP) Reference Standards Bacterial Antibiotic	Infection Cancer
Meropenem (trihydrate) (Standard) is the analytical standard of Meropenem (trihydrate). This product is intended for research and analytical applications. Meropenem trihydrate (SM 7338 trihydrate) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem trihydrate has activity against susceptible and resistant *N. gonorrhoeae* (MIC value of 0.02-0.06 mg/mL), *H. influenzae* (MIC value of 0.03-0.12 mg/mL), and *H. ducreyi* (MIC value of 0.015-0.12 mg/mL) .

HY-B1127

Betamipron N-Benzoyl-β-alanine	Antibiotic Bacterial	Infection Endocrinology
Betamipron (N-benzoyl-β-alanine) is a carbapenem β-lactam antibiotic with antibacterial activity against most Gram-positive and Gram-negative aerobic and anaerobic bacteria. Betamipron can target and inhibit renal organic anion transporters, alleviate renal injury caused by Cisplatin (HY-17394), without interfering with the biological activity of cisplatin. Betamipron is often used in combination with panipenem, which can attenuate the renal effects induced by panipenem and slightly promote the proliferation of Clostridium difficile in the cecum. Betamipron can be used in studies related to renal injury and bacterial infection .

HY-137927

Benapenem	Antibiotic	Others
Benapenem is a carbapenem-type agent that belongs to the broad-spectrum β-lactam antibiotic class.

HY-125604

WCK-4234	Beta-lactamase Bacterial	Infection Inflammation/Immunology
WCK-4234 is a diazabicyclooctane β-lactamase inhibitor and susceptibility restorer. WCK-4234 lacks direct antibacterial activity. WCK-4234 inhibits class A, C, D β-lactamases and extended-spectrum β-lactamases to potentiate Imipenem (HY-B1369A) and Meropenem (HY-13678) activity against Gram-negative pathogens. WCK-4234 can be used for the research of gram-negative bacterial infections and β-lactamase-mediated carbapenem-resistant bacterial infections .

HY-B0187AR

Doripenem monohydrate (Standard) S 4661 monohydrate (Standard)	Reference Standards Bacterial Antibiotic	Infection
Doripenem (monohydrate) (Standard) is the analytical standard of Doripenem (monohydrate). This product is intended for research and analytical applications. Doripenem (S 4661) monohydrate, a 1β-methyl parenteral carbapenem, has very broad-spectrum activity against Gram-positive and Gram-negative aerobic bacteria .

HY-125416

Streptothricin F	Antibiotic Bacterial	Infection
Streptothricin F is a bactericidal antibiotic. Streptothricin F interacts with the 30S subunit of 70S ribosome. Streptothricin F shows rapid, bactericidal activity against highly drug-resistant, carbapenem-resistant Enterobacterales (CRE) (MIC₅₀ and MIC₉₀: 2 and 4 μM, respectively) and Acinetobacter baumannii .

HY-16955

Plazomicin ACHN 490	Antibiotic Bacterial	Infection Inflammation/Immunology
Plazomicin (ACHN 490) is a semi-synthetic aminoglycoside Antibiotic. Plazomicin acts as a substrate for Aminoglycoside acetyltransferase and Aminoglycoside phosphotransferase. Plazomicin is not modified by various common aminoglycoside-modifying enzymes. Plazomicin selectively inhibits MATE2-K. Plazomicin exhibits activity against multidrug-resistant bacteria, including carbapenem-resistant Enterobacterales .

HY-147349A

Pilabactam ANT3310	Bacterial Beta-lactamase	Infection
Pilabactam (ANT3310) is a broad-spectrum covalent Serine β-Lactamase inhibitor, with IC₅₀ values ranging from 1 nM to 175 nM (a panel of Serine β-Lactamase). Pilabactam potentiates activity of β-lactam antibiotics against Carbapenem-Resistant Enterobacterales (CRE) and Acinetobacter baumannii (CRAB). Pilabactam can be used in the research of bacterial infection .

HY-123022

Tomopenem CS-023; RO4908463; R-115685	Bacterial	Infection
Tomopenem (CS-023; RO4908463; R-115685) is a longer-half-life parenteral carbapenem. Tomopenem shows broad activity against 63 reference species. The activity of tomopenem against 293 clinical isolates is potent (MIC90, 0.06 to 4 μg/mL). Antianaerobic activity .

HY-13573R

Biapenem (Standard) CLI 86815 (Standard); L 627 (Standard); LJC 10627 (Standard)	Beta-lactamase Reference Standards Bacterial Antibiotic	Infection
Biapenem (Standard) is the analytical standard of Biapenem. This product is intended for research and analytical applications. Biapenem (CLI 86815; L 627; LJC 10627) a parenteral carbapenem antibacterial agent with a broad spectrum.

HY-A0076R

Tebipenem (Standard) LJC 11036 (Standard)	Reference Standards Bacterial Antibiotic	Infection
Tebipenem (Standard) is the analytical standard of Tebipenem. This product is intended for research and analytical applications. Tebipenem is an orally available carbapenem antibiotic, shows broad-spectrum activity against Gram-positive and -negative bacteria, except for Pseudomonas aeruginosa.

HY-W127616A

β-Sitosterol acetate, 95% Sitosteryl acetate, 95%	Bacterial	Infection
β-Sitosterol acetate, 95% (Sitosteryl acetate, 95%) is a sterol that can be isolated from Hechtia glomerata Zucc., which has antibacterial activity and has a MIC value of 100µg/mL against carbapenem-resistant Acinetobacter baumannii .

HY-106998

DC-756	Bacterial Antibiotic	Infection
DC-756 is a fluoroquinolone antibiotic. DC-756 possesses potent activity against Gram-positive and Gram-negative pathogens comparable to Trovafloxacin (HY-A0170), with MIC, against Ofloxacin (HY-B0125)-resistant strains 16-fold better than Trovafloxacin. DC-756 is well absorbed orally in rats and found to have good photostability. DC-756 can be used to study bacterial resistance .

HY-P0077

Merotocin	Oxytocin Receptor	Endocrinology
Merotocin is a selective, short-acting peptidic oxytocin receptor agonist. Merotocin can be used to support lactation .

HY-P1726A

MSG606 TFA	Melanocortin Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
MSG606 TFA is a selective melanocortin 1 receptor (MC1R) antagonist. MSG606 TFA can abolish the neuroprotective effects of BMS-470539 (HY-15616) (MC1R agonist). MSG606 TFA can inhibit cancer cell proliferation and transition from the G1 to the S phase. MSG606 TFA can delay pain hypersensitivity and reduce cholesterol levels. MSG606 TFA can be used for the researches of cancer, inflammation, neurological and metabolic disease, such as breast cancer and subarachnoid hemorrhage (SAH) .

HY-122699

LN-1-255 sodium	Beta-lactamase Bacterial	Infection
LN-1-255 sodium is a β-lactamase inhibitor. LN-1-255 sodium has broad-spectrum inhibitory effect on type D carbapenemases (CHDLs) with an IC₅₀ for OXA-48 of 3 nM, and it also has strong activity against OXA-23, OXA-24/40, etc. LN-1-255 sodium combined with carbapenem antibiotics has a synergistic effect. LN-1-255 sodium can be used to study the bacterial resistance crisis caused by CHDLs .

HY-178976

YL6113	Beta-lactamase	Infection
YL6113 is a potent and selective dual inhibitor of metallo-β-lactamases (MBLs) and serine-β-lactamases (SBLs). YL6113 shows inhibitory effect to MBLs, such as NDm-1, VIM-2, IMP-1, with IC₅₀ values of 0.25, 27.16 and 3.55 μM. YL6113 shows inhibitory effect to SBLs, such as KPC-2, AmpC, OXA-48, with IC₅₀ values of 0.2, 34.1 and 1.31 μM. YL6113 enhances the antibacterial efficacy of Meropenem (HY-13678) against carbapenem-resistant Gram-negative bacteria. YL6113 can be used for the research of infection .

HY-P0041A

F992 TFA	Vasopressin Receptor	Neurological Disease
F992 TFA is an antidiuretic peptide and vasopressin (antidiuretic hormone) analogue .

HY-P11250

HVF18-a3-d	Bacterial NO Synthase Interleukin Related Reactive Oxygen Species (ROS) Toll-like Receptor (TLR) ERK JNK p38 MAPK	Infection Inflammation/Immunology
HVF18-a3-d is an antimicrobial peptide. HVF18-a3-d reduces NO production. HVF18-a3-d inhibits the production of TNF-α and IL-6, reduces ROS production, and suppresses the TLR4 signaling pathway, as well as LPS-induced phosphorylation of ERK, JNK, and p38 MAPK. HVF18-a3-d exhibits antimicrobial activity against a variety of bacteria by disrupting their outer and inner membranes. HVF18-a3-d protects mice from fatal septic shock induced by Acinetobacter baumannii resistant to Carbapenem. HVF18-a3-d shows anti-inflammatory and antioxidant effects .

HY-176565

ZN148	Beta-lactamase	Infection
ZN148 is a zinc-chelating synthetic metallo-β-lactamase (MBL) inhibitor which attenuates MBL-mediated carbapenem resistance. ZN148 can restore the in vitro clinical susceptibility to carbapenems in >98% of a large international collection of MBL-producing clinical Enterobacterales strains. ZN148 can be utilized in research on anti MBL-producing bacteria .

HY-19246

DZ-2640	Antibiotic Bacterial	Infection
DZ-2640 is an orally active Carbapenem antibiotic, a prodrug of DU-6681 (HY-19247). DU-6681 exhibits antibacterial activity against a broad spectrum of gram-positive and -negative bacteria .

HY-105180

Lenapenem BO-2727 free acid	Bacterial Antibiotic	Infection
Lenapenem (BO-2727 free acid), a carbapenem antibiotic, has potent antibacterial activity against Gram-positive and Gram-negative bacteria including P. aeruginosa .

HY-178384

Antibacterial agent 294	Bacterial	Infection
Antibacterial agent 294 is an antibacterial agent. Antibacterial agent 294 shows antibacterial effect against carbapenem-resistant Acinetobacter baumannii (CRAB) with a MIC of 0.5 μg/mL. Antibacterial agent 294 can be used for the research of infection .

HY-122174

ME-1036 CP-5609	Antibiotic Bacterial	Infection
ME-1036 (CP-5609) is a carbapenem antibiotic. ME-1036 against resistant Gram-positive organisms, including Methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-resistant Enterococci (VRE), and ESBL-producing E. coli and K. pneumoniae but is not effective against P. aeruginosa .

HY-150260

SA09-Cu	Bacterial	Infection
SA09-Cu is a noncompetitive and potent NDM-1 inhibitor with an IC₅₀ of 9.6 nM. SA09-Cu can convert NDM-1 into an inactive state by oxidizing the Zn(II)-thiolate site of the enzyme and avoids to be reduced by intracellular thiols of bacteria. SA09-Cu exhibits excellent inhibition against a series of clinical NDM-1-producing carbapenem-resistant Enterobacteriaceae (CRE) in restoring the Meropenem (HY-13678) effect, and slows down the development of carbapenem resistance .

HY-W740053

Meropenem sodium	Penicillin-binding protein (PBP) Bacterial Antibiotic	Infection Cancer
Meropenem sodium is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem sodium has activity against susceptible and resistant *N. gonorrhoeae* (MIC value of 0.02-0.06 mg/mL), *H. influenzae* (MIC value of 0.03-0.12 mg/mL), and *H. ducreyi* (MIC value of 0.015-0.12 mg/mL) .

HY-N14182

Asparenomycin A	Antibiotic Bacterial	Infection
Asparenomycin A is a carbapenem antibiotic with strong β-lactamase inhibition activities .

HY-170803

KPC-IN-1	Bacterial	Infection
KPC-IN-1 (compound 1e) is an inhibitor of Klebsiella pneumoniae carbapenemase KPC-2 (IC₅₀=8.3 nM). KPC is a β-lactamase expressed in Gram-negative bacteria that hydrolyzes carbapenems. KPC causes significant bacterial resistance to carbapenem antibiotics .

HY-N14185

Asparenomycin C	Antibiotic Bacterial	Infection
Asparenomycin C is a carbapenem antibiotic with strong β-lactamase inhibition activities .

HY-N14183

Asparenomycin B	Antibiotic Bacterial	Infection
Asparenomycin B is a carbapenem antibiotic with strong β-lactamase inhibition activities .

HY-155202

YJ196	Beta-lactamase	Others
YJ196 (Compound 59) is a New Delhi Metallo-β-lactamase-1 (NDM-1) inhibitor .

HY-N14175

Epithienamycin C	Antibiotic Bacterial	Infection
Epithienamycin C is a carbapenem antibiotic. Epithienamycin C has anti-Gram-positive and Gram-negative bacteria activity .

HY-N14174

Epithienamycin A	Antibiotic Bacterial	Infection
Epithienamycin A is a carbapenem antibiotic. Epithienamycin A has anti-Gram-positive bacteria and anti-Gram-negative bacteria activity .

Cat. No.	Product Name

HY-L924

Boronic acid/boronic ester fragment library

1,488 compounds

Boronic acid and boronic ester represent a relatively novel and promising chemical structure in drug design. Boronic acid exists in an sp²-hybridized state, possessing an empty p-orbital that can act as a Lewis acid to accept lone pairs from heteroatoms (O, N, or S). This Lewis acidity enables it to form reversible covalent bonds with amino acid residues such as lysine, serine, threonine, and histidine. Currently, five FDA-approved drugs containing boronic acid or boronic ester predominantly involve such covalent binding mechanisms in their interactions with target proteins. Furthermore, boronic acid can serve as a bioisostere for carboxylic acids, phosphates, and phenolic groups, utilized to improve pharmacokinetic properties and enhance drug efficacy.

To date, five boron-containing drugs have been approved by the FDA. The unique properties of boronic acids and boronic esters confer significant potential in drug design, with applications spanning cancer therapy (e.g., multiple myeloma), anti-infectives (e.g., fungal infections, tuberculosis), anti-inflammatory treatments (e.g., atopic dermatitis), antibacterial agents (e.g., carbapenem-resistant bacterial infections), and Reactive Oxygen Species (ROS)-responsive prodrugs, among others. The MCE Boronic Acid/Boronic Ester Fragment Library, which contains 1,488 compounds, serves as a valuable tool for the development of boron-containing drugs.

Cat. No.	Product Name	Type

HY-W127616A

β-Sitosterol acetate, 95% Sitosteryl acetate, 95%	Biochemical Assay Reagents
β-Sitosterol acetate, 95% (Sitosteryl acetate, 95%) is a sterol that can be isolated from Hechtia glomerata Zucc., which has antibacterial activity and has a MIC value of 100µg/mL against carbapenem-resistant Acinetobacter baumannii .

HY-W740053

Meropenem sodium	Biochemical Assay Reagents
Meropenem sodium is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem sodium has activity against susceptible and resistant *N. gonorrhoeae* (MIC value of 0.02-0.06 mg/mL), *H. influenzae* (MIC value of 0.03-0.12 mg/mL), and *H. ducreyi* (MIC value of 0.015-0.12 mg/mL) .

Cat. No.	Product Name	Target	Research Area

HY-P1726

MSG606	Melanocortin Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
MSG606 is a selective melanocortin 1 receptor (MC1R) antagonist. MSG606 can abolish the neuroprotective effects of BMS-470539 (HY-15616) (MC1R agonist). MSG606 can inhibit cancer cell proliferation and transition from the G1 to the S phase. MSG606 can delay pain hypersensitivity and reduce cholesterol levels. MSG606 can be used for the researches of cancer, inflammation, neurological and metabolic disease, such as breast cancer and subarachnoid hemorrhage (SAH) .

HY-P0077

Merotocin	Oxytocin Receptor	Endocrinology
Merotocin is a selective, short-acting peptidic oxytocin receptor agonist. Merotocin can be used to support lactation .

HY-P1726A

MSG606 TFA	Melanocortin Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
MSG606 TFA is a selective melanocortin 1 receptor (MC1R) antagonist. MSG606 TFA can abolish the neuroprotective effects of BMS-470539 (HY-15616) (MC1R agonist). MSG606 TFA can inhibit cancer cell proliferation and transition from the G1 to the S phase. MSG606 TFA can delay pain hypersensitivity and reduce cholesterol levels. MSG606 TFA can be used for the researches of cancer, inflammation, neurological and metabolic disease, such as breast cancer and subarachnoid hemorrhage (SAH) .

HY-P0041A

F992 TFA	Vasopressin Receptor	Neurological Disease
F992 TFA is an antidiuretic peptide and vasopressin (antidiuretic hormone) analogue .

HY-P11250

HVF18-a3-d	Bacterial NO Synthase Interleukin Related Reactive Oxygen Species (ROS) Toll-like Receptor (TLR) ERK JNK p38 MAPK	Infection Inflammation/Immunology
HVF18-a3-d is an antimicrobial peptide. HVF18-a3-d reduces NO production. HVF18-a3-d inhibits the production of TNF-α and IL-6, reduces ROS production, and suppresses the TLR4 signaling pathway, as well as LPS-induced phosphorylation of ERK, JNK, and p38 MAPK. HVF18-a3-d exhibits antimicrobial activity against a variety of bacteria by disrupting their outer and inner membranes. HVF18-a3-d protects mice from fatal septic shock induced by Acinetobacter baumannii resistant to Carbapenem. HVF18-a3-d shows anti-inflammatory and antioxidant effects .

HY-P5691

P1	Bacterial	Infection Cancer
P1 is a broad-spectrum antimicrobial peptide. P1 shows antibacterial activity against Gram-positive and Gram-negative bacteria,such as B. anthracis spores and Carbapenem-resistant A. baumannii and K. pneumoniae .

HY-P2331

Actagardin Antibiotic A 3802-IV-3; Gardimycin	Antibiotic	Infection
Actagardin is a tetracyclic lantibiotic produced by several species of Actinoplanes. It is composed of macrocyclic rings formed by thioether bridges. Actagardin preferably targets Gram-positive bacteria, inhibiting the synthesis of peptidoglycan.

HY-P10014

Bibapcitide	Peptides	Cardiovascular Disease
Bibapcitide, a 26 amino acid, inhibits thrombosis .

HY-P0041

F992	Vasopressin Receptor	Neurological Disease
F992 is an antidiuretic peptide and vasopressin (antidiuretic hormone) analogue .

HY-P11720

M104 peptide	Beta-lactamase Bacterial	Infection
M104 peptide is an OXA-48 carbapenemase inhibitor and antibiotic potentiator. M104 peptide effectively blocks the binding and active site cavity of OXA-48 . M104 peptide restores Meropenem (HY-13678)’s antibacterial activity against OXA-48-producing Klebsiella pneumoniae. M104 peptide can be used for the research of Carbapenem-resistant Klebsiella pneumoniae infection .

HY-P11580

Pap12-6-10	Toll-like Receptor (TLR) Bacterial	Infection
Pap12-6-10 is an MD-2 ligand that binds to the hydrophobic pocket of MD-2 to inhibit the dimerization of the TLR4/MD-2 complex and downstream inflammatory signal transduction. Pap12-6-10 also binds to LPS to permeabilize bacterial cell membranes and induce oxidative stress, leading to bacterial death. Pap12-6-10 regulates LPS-induced inflammatory responses through the TLR4 signaling pathway and exhibits antibacterial activity against multidrug-resistant Gram-negative bacteria. Pap12-6-10 shows low tendency to induce drug resistance and low preclinical cytotoxicity, and it prevents organ damage in a mouse model of sepsis. Pap12-6-10 can be used for research related to Gram-negative sepsis and carbapenem-resistant Acinetobacter baumannii infections .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13678

Meropenem 30+ Cited Publications SM 7338	Infection Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Beta-lactam Antibiotics Source Classification	Penicillin-binding protein (PBP) Bacterial Antibiotic
Meropenem (SM 7338) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem has activity against susceptible and resistant *N. gonorrhoeae* (MIC value of 0.02-0.06 mg/mL), *H. influenzae* (MIC value of 0.03-0.12 mg/mL), and *H. ducreyi* (MIC value of 0.015-0.12 mg/mL) .

HY-B1369

Imipenem monohydrate 30+ Cited Publications N-Formimidoyl thienamycin monohydrate; MK0787 monohydrate	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Antibiotic Bacterial
Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections .

HY-B1369R

Imipenem monohydrate (Standard) N-Formimidoyl thienamycin monohydrate (Standard); MK0787 monohydrate (Standard)	Structural Classification Microorganisms Antibiotics Antibacterial Disease Research Other Antibiotics Source Classification	Reference Standards Antibiotic Bacterial
Imipenem (monohydrate) (Standard) is the analytical standard of Imipenem (monohydrate). This product is intended for research and analytical applications. Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections .

HY-125416

Streptothricin F	Microorganisms Source Classification	Antibiotic Bacterial
Streptothricin F is a bactericidal antibiotic. Streptothricin F interacts with the 30S subunit of 70S ribosome. Streptothricin F shows rapid, bactericidal activity against highly drug-resistant, carbapenem-resistant Enterobacterales (CRE) (MIC₅₀ and MIC₉₀: 2 and 4 μM, respectively) and Acinetobacter baumannii .

HY-N14182

Asparenomycin A	Natural Products Microorganisms Source Classification	Antibiotic Bacterial
Asparenomycin A is a carbapenem antibiotic with strong β-lactamase inhibition activities .

HY-N14185

Asparenomycin C	Natural Products Microorganisms Source Classification	Antibiotic Bacterial
Asparenomycin C is a carbapenem antibiotic with strong β-lactamase inhibition activities .

HY-N14183

Asparenomycin B	Natural Products Microorganisms Source Classification	Antibiotic Bacterial
Asparenomycin B is a carbapenem antibiotic with strong β-lactamase inhibition activities .

HY-N14175

Epithienamycin C	Microorganisms Antibiotics Beta-lactam Antibiotics Source Classification	Antibiotic Bacterial
Epithienamycin C is a carbapenem antibiotic. Epithienamycin C has anti-Gram-positive and Gram-negative bacteria activity .

HY-N14174

Epithienamycin A	Microorganisms Antibiotics Beta-lactam Antibiotics Source Classification	Antibiotic Bacterial
Epithienamycin A is a carbapenem antibiotic. Epithienamycin A has anti-Gram-positive bacteria and anti-Gram-negative bacteria activity .

HY-N14461

Pluracidomycin D	Natural Products Microorganisms Source Classification	Antibiotic Bacterial
Pluracidomycin D is a carbapenem antibiotic. Pluracidomycin D has anti-Gram-positive bacteria and Gram-negative bacteria activities .

HY-N14209

Epithienamycin D	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
Epithienamycin D is a carbapenem antibiotic. Epithienamycin D has anti-Gram-positive bacteria and anti-Gram-negative bacteria activity .

HY-N14210

Epithienamycin F	Natural Products Microorganisms Source Classification	Antibiotic Bacterial
Epithienamycin F is a carbapenem antibiotic. Epithienamycin F has anti-Gram-positive bacteria and anti-Gram-negative bacteria activity .

HY-N14458

Pluracidomycin A2 PLM A2	Microorganisms Antibiotics Beta-lactam Antibiotics Source Classification	Antibiotic Bacterial
Pluracidomycin A2 (PLM A2) is a carbapenem antibiotic and has anti-Gram-positive bacteria and Gram-negative bacteria activities .

HY-N14459

Pluracidomycin C2	Natural Products Microorganisms Source Classification	Antibiotic Bacterial
Pluracidomycin C2 is a carbapenem antibiotic. Pluracidomycin C2 has anti-Gram-positive bacteria and Gram-negative bacteria activities .

HY-N14460

Pluracidomycin C3	Natural Products Microorganisms Source Classification	Antibiotic Bacterial
Pluracidomycin C3 is a carbapenem antibiotic. Pluracidomycin C3 has anti-Gram-positive bacteria and Gram-negative bacteria activities .

HY-N14693

Pluracidomycin B	Structural Classification Microorganisms Antibiotics Source Classification	Antibiotic Bacterial
Pluracidomycin B is a carbapenem antibiotic. Pluracidomycin B has anti-Gram-positive bacteria and Gram-negative bacteria activity, and has the effect of inhibiting β-lactamase .

HY-N14694

Pluracidomycin C1	Structural Classification Microorganisms Antibiotics Beta-lactam Antibiotics Source Classification	Antibiotic Bacterial
Pluracidomycin C1 is a carbapenem antibiotic. Pluracidomycin C1 has anti-Gram-positive bacteria and Gram-negative bacteria activity, and has the effect of inhibiting β-lactamase .

HY-N14692

Pluracidomycin A1	Structural Classification Microorganisms Antibiotics Source Classification	Antibiotic Bacterial
Pluracidomycin A1 is a carbapenem antibiotic . Pluracidomycin A1 has anti-Gram-positive bacteria and Gram-negative bacteria activity, and has the effect of inhibiting β-lactamase .

Cat. No.	Product Name	Chemical Structure