52 Results for "

cell spreading

" in MedChemExpress (MCE) Product Catalog:
Products (52)

52 Results for "cell spreading" in MCE Product Catalog:

66
Bemcentinib
Bemcentinib
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66 Publications Verification
Referencia número: HY-15150
No. CAS: 1037624-75-1
Pureza:  99.92%
Synonyms: R428; BGB324
Target:  

TAM Receptor

Áreas de investigación:  

Cancer

Bemcentinib (R428) is a selective and orally active Axl inhibitor with an IC50 of 14 nM. Bemcentinib retards cancer cell migration and invasion. Bemcentinib exhibits >100-fold selectivity for Axl versus Abl and 50- and >100-fold selectivity over TAM family kinases Mer and Tyro3, respectively, in cells. Bemcentinib blocks tumor spread and prolongs survival in models of metastatic breast cancer .
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17
Efavirenz
Efavirenz
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17 Cited Publications
Referencia número: HY-10572
No. CAS: 154598-52-4
Pureza:  99.93%
Synonyms: DMP 266; EFV; L-743726
Category:  

Infection Natural Products Endogenous metabolite Disease Research Fields Cancer

Target:  

Reverse Transcriptase HIV Autophagy Endogenous Metabolite Parasite

Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture .
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7
Foxy-5
Foxy-5
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7 Cited Publications
Referencia número: HY-P1416
No. CAS: 881188-51-8
Target:  

Wnt

Áreas de investigación:  

Cancer

Foxy-5, a WNT5A agonist, is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial cancer cells. Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model .
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7
Foxy-5 TFA
Foxy-5 TFA
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7 Cited Publications
Referencia número: HY-P1416A
Target:  

Wnt

Áreas de investigación:  

Cancer

Foxy-5 TFA, a WNT5A agonist, is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 TFA triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial cancer cells. Foxy-5 TFA effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model .
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1
Cyanine 3 Tyramide
Cyanine 3 Tyramide
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1 Cited Publications
Referencia número: HY-136248
No. CAS: 174961-75-2
Pureza:  96.15%
Synonyms: Tyramide-Cy3
Cyanine 3 Tyramide (Tyramide-Cy3) is an orange fluorescent dye used as a reporter fluorescent substrate for horseradish peroxidase (HRP)-catalyzed deposition, which serves as a signal amplification technique in immunoassays and in situ nucleic acid hybridization .
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Lactoferrin from Bovine milk
Lactoferrin from Bovine milk
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Referencia número: HY-P3161
No. CAS: 936541-36-5
Lactoferrin from Bovine milk is a substance released by neutrophils. Lactoferrin from Bovine milk is an orally active multifunctional iron binding glycoprotein. Lactoferrin from Bovine milk prevents cell adhesion, growth and spreading of cell colonies. Lactoferrin from Bovine milk also has antiviral activity and inhibits microbial and viral adhesion and entry into host cells. Besides, Lactoferrin from Bovine milk has anti-inflammatory, immunomodulatory, and anti-cancer activities .
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Laminin peptide CDPGYIGSR TFA
Laminin peptide CDPGYIGSR TFA
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Referencia número: HY-P0131A
No. CAS: 2828432-44-4
Synonyms: Laminin (925-933) TFA
Target:  

Drug Intermediate

Áreas de investigación:  

Neurological Disease Cancer

Laminin peptide CDPGYIGSR TFA (Laminin (925-933) TFA) is a peptide fragment derived from the laminin B1 chain that binds to laminin receptors, and acts as a ligand for the laminin receptor. Laminin peptide CDPGYIGSR TFA mediates cell spreading, induces the clustering of receptors with vinculin and α-actinin, regulates the actin cytoskeleton, promotes the formation of stress fibers, and enhances epithelial cell adhesion. Laminin peptide CDPGYIGSR TFA can be used in studies related to tumor metastasis and nerve injury .
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KLTWQELYQLKYKGI
KLTWQELYQLKYKGI
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Referencia número: HY-P5558
No. CAS: 917760-16-8
Target:  

VEGFR

Áreas de investigación:  

Neurological Disease

KLTWQELYQLKYKGI is a VEGF mimetic peptide designed based on the VEGF helix sequence 17-25, with the ability to activate VEGF receptors and exert pro-angiogenic biological activity. KLTWQELYQLKYKGI effectively promotes the attachment, spreading and proliferation of human umbilical vein endothelial cells. KLTWQELYQLKYKGI enhances the proliferation, migration and osteogenic differentiation of bone marrow stromal cells (BMSCs). KLTWQELYQLKYKGI synergistically accelerates angiogenesis and bone regeneration in rat cranial defect models. KLTWQELYQLKYKGI can be used for the research of brain tissue engineering and traumatic brain injury repair and biomaterials for bone tissue engineering and bone repair .
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Ristocetin A sulfate
Ristocetin A sulfate
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Referencia número: HY-138053
No. CAS: 90831-71-3
Synonyms: Ristomycin III
Target:  

Antibiotic

Áreas de investigación:  

Cardiovascular Disease Infection

Ristocetin A sulfate (Ristomycin III) is a glycopeptide antibiotic that binds to von Willebrand factor (VWF) and bacterial cell wall components. Ristocetin A sulfate interferes with the biosynthesis of bacterial peptidoglycan by inhibiting transpeptidation. As an inducer of platelet adhesion and aggregation, Ristocetin A sulfate drives conformational changes by binding to the A1 domain of VWF, thereby activating downstream signaling pathways and promoting cytoskeletal rearrangement. Ristocetin A sulfate not only enhances platelet adhesion and spreading on immobilized VWF, but also induces the formation of asymmetric dimers with anticooperativity between platelets and plasma VWF. Ristocetin A sulfate is widely used in studies related to thromboembolic diseases and bacterial infections .
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SIBA
SIBA
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Referencia número: HY-18684
No. CAS: 35899-54-8
Synonyms: 5'-Isobutylthioadenosine; 5'-Deoxy-5'-isobutylthioadenosine
Target:  

Nucleoside Antimetabolite/Analog HSV Parasite

Áreas de investigación:  

Infection Metabolic Disease Cancer

SIBA (5'-Isobutylthioadenosine) is a transmethylation inhibitor (SAH (HY-19528) analogue), with potent anti-proliferative activity. SIBA reversibly inhibits the production of HSV-1 by blocking methylation, specifically by blocking the 5' end-capping of viral mRNA. SIBA also inhibits the growth of tumour cells in vitro and metastatic spread in vivo. SIBA can be used in cancer, HSV-1 infection and anti-malaria studies .
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Fibronectin Adhesion-promoting Peptide
Fibronectin Adhesion-promoting Peptide
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Referencia número: HY-P0306
No. CAS: 125720-21-0
Synonyms: Heparin Binding Peptide
Target:  

Peptides

Áreas de investigación:  

Cardiovascular Disease

Fibronectin Adhesion-promoting Peptide (Heparin Binding Peptide) is one of the heparin-binding amino acid sequences found in the carboxy-terminal heparin-binding domain of fibronectin. It promotes assembly of mesenchymal stem cell (MSC) spheroids into larger aggregates. Fibronectin Adhesion-promoting Peptide directly promotes the adhesion, spreading, and migration of endothelial cells by reacting with heparin binding domains of cells .
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Obiltoxaximab
Obiltoxaximab
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Referencia número: HY-P9932
No. CAS: 1351337-07-9
Synonyms: ETI 204

Target:  

Bacterial

Áreas de investigación:  

Infection Cardiovascular Disease

Obiltoxaximab (ETI 204) is the second and potent anti-protective antigen (PA) monoclonal antibody with immunogenicity. Obiltoxaximab plays a central role in anthrax toxin assembly and target cell intoxication, promoting survival, and inhibiting bacterial spread to the periphery in animal models. Obiltoxaximab can be used in the research of inhalational anthrax, bacteremia and toxemia .
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RBC6
RBC6
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Referencia número: HY-125987
No. CAS: 381186-64-7
Pureza:  98.88%
Target:  

Ras

Áreas de investigación:  

Cancer

RBC6 is an inhibitor of GTPases RalA. RBC6 inhibits binding of Ral to its effector RALBP1. RBC6 also inhibits Ral-mediated cell spreading of murine embryonic fibroblasts, as well as anchorage-independent growth of human cancer celllines .
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TAN-1030A
TAN-1030A
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Referencia número: HY-N16039
No. CAS: 126221-76-9
Category:  

Alkaloids Microorganisms Indole Alkaloids

Target:  

β-glucuronidase

TAN-1030A is an indolocarbazole alkaloid with macrophage-activating properties. TAN-1030A induces spreading of a murine macrophage cell line, Mm 1, and augmentes the phagocytic activity, Fc gamma receptor expression and β-glucuronidase activity of murine macrophage cell lines, Mm 1 and J774A.1. TAN-1030A can activate macrophage functions in mice .
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GelMA, 30% methacrylation, Red Fluorescent
GelMA, 30% methacrylation, Red Fluorescent
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Referencia número: HY-158218
Synonyms: Gelatin Methacryloyl, 30% methacrylation, Red Fluorescent
Red Fluorescent Gelatin Methacryloyl (Red Fluorescent GelMA) is methacryloyl gelatin (GelMA) with red fluorescence, which is obtained by "grafting" fluorescent molecules on GelMA. Red Fluorescent Gelatin Methacryloyl acts as a scaffold and can be used to engineer tissue analogs from the vasculature to cartilage and bone, allowing cells to proliferate and spread . GelMA, 30% methacrylation, Red Fluorescent needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity.
Application: cell culture, biological 3D printing, tissue engineering, etc.
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DSPE-PEG2000-YIGSR
DSPE-PEG2000-YIGSR
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Referencia número: HY-172476
DSPE-PEG2000-YIGSR is a PEG compound which composed of DSPE and a biomimetic peptide YIGSR. YIGSR interacts with the 67 kDa laminin binding protein (LBP) and promotes adhesion and spreading of a large number of cell types including endothelial cells, fibroblasts and smooth muscle cells. DSPE-PEG2000-YIGSR can be used for drug delivery .
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Laminin peptide CDPGYIGSR
Laminin peptide CDPGYIGSR
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Referencia número: HY-P0131
No. CAS: 110590-60-8
Synonyms: Laminin (925-933)
Target:  

Drug Intermediate

Áreas de investigación:  

Neurological Disease Cancer

Laminin peptide CDPGYIGSR (Laminin (925-933)) is a peptide fragment derived from the laminin B1 chain that binds to laminin receptors, and acts as a ligand for the laminin receptor. Laminin peptide CDPGYIGSR mediates cell spreading, induces the clustering of receptors with vinculin and α-actinin, regulates the actin cytoskeleton, promotes the formation of stress fibers, and enhances epithelial cell adhesion. Laminin peptide CDPGYIGSR can be used in studies related to tumor metastasis and nerve injury .
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GelMA, 30% methacrylation, Green Fluorescent
GelMA, 30% methacrylation, Green Fluorescent
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Referencia número: HY-158217
Synonyms: Gelatin Methacryloyl, 30% methacrylation, Green Fluorescent
Green Fluorescent Gelatin Methacryloyl (Green Fluorescent GelMA) is methacryloyl gelatin (GelMA) with green fluorescence, which is obtained by "grafting" fluorescent molecules on GelMA. Green Fluorescent Gelatin Methacryloyl acts as a scaffold and can be used to engineer tissue analogs from the vasculature to cartilage and bone, allowing cells to proliferate and spread . GelMA, 30% methacrylation, Green Fluorescent needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity.
Application: cell culture, biological 3D printing, tissue engineering, etc.
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GelMA, 60% methacrylation, Green Fluorescent
GelMA, 60% methacrylation, Green Fluorescent
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Referencia número: HY-158217A
Synonyms: Gelatin Methacryloyl, 60% methacrylation, Green Fluorescent
Green Fluorescent Gelatin Methacryloyl (Green Fluorescent GelMA) is methacryloyl gelatin (GelMA) with green fluorescence, which is obtained by "grafting" fluorescent molecules on GelMA. Green Fluorescent Gelatin Methacryloyl acts as a scaffold and can be used to engineer tissue analogs from the vasculature to cartilage and bone, allowing cells to proliferate and spread . GelMA, 60% methacrylation, Green Fluorescent needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity.
Application: cell culture, biological 3D printing, tissue engineering, etc.
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G2-Peptide
G2-Peptide
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Referencia número: HY-P3795
No. CAS: 361443-81-4
Target:  

HSV

Áreas de investigación:  

Infection Neurological Disease

G2-Peptide is a 3-O-sulfated heparan sulfate (3-OS HS) binder and antiviral agent. G2-Peptide blocks herpesvirus attachment, entry, cell-to-cell spread and syncytium formation, and reduces viral protein translocation. G2-Peptide exhibits antiviral activity against both HSV-1 and HSV-2. G2-Peptide inhibits neural activity and impairs synapse assembly. G2-Peptide can be used in the research of genital herpes, ocular herpes infection and keratitis .
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